Cops9 (COP9 signalosome subunit 9) - Rat Genome Database

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Gene: Cops9 (COP9 signalosome subunit 9) Mus musculus
Analyze
Symbol: Cops9
Name: COP9 signalosome subunit 9
RGD ID: 1619199
MGI Page MGI
Description: Predicted to be involved in several processes, including cellular response to UV; cytoplasmic sequestering of protein; and negative regulation of protein neddylation. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of COP9 signalosome and chromatin. Orthologous to human COPS9 (COP9 signalosome subunit 9).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1110002M09Rik; COP9 signalosome complex subunit 9; hypothetical protein LOC66915; myeloma overexpressed 2; myeloma-overexpressed gene 2 protein homolog; Myeo; Myeov2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm4730  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39192,564,867 - 92,569,707 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl192,564,867 - 92,569,707 (-)EnsemblGRCm39 Ensembl
GRCm38192,637,145 - 92,641,985 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl192,637,145 - 92,641,985 (-)EnsemblGRCm38mm10GRCm38
MGSCv37194,533,722 - 94,538,562 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36194,467,551 - 94,472,391 (-)NCBIMGSCv36mm8
Celera195,581,052 - 95,585,891 (-)NCBICelera
Cytogenetic Map1DNCBI
cM Map146.55NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:14610273   PMID:16141072   PMID:16141073   PMID:21267068  
PMID:21677750   PMID:21873635   PMID:25737280  


Genomics

Comparative Map Data
Cops9
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39192,564,867 - 92,569,707 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl192,564,867 - 92,569,707 (-)EnsemblGRCm39 Ensembl
GRCm38192,637,145 - 92,641,985 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl192,637,145 - 92,641,985 (-)EnsemblGRCm38mm10GRCm38
MGSCv37194,533,722 - 94,538,562 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36194,467,551 - 94,472,391 (-)NCBIMGSCv36mm8
Celera195,581,052 - 95,585,891 (-)NCBICelera
Cytogenetic Map1DNCBI
cM Map146.55NCBI
COPS9
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382240,126,548 - 240,136,347 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2240,126,563 - 240,136,807 (-)EnsemblGRCh38hg38GRCh38
GRCh372241,065,980 - 241,075,764 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362240,714,653 - 240,724,437 (-)NCBINCBI36Build 36hg18NCBI36
Celera2234,739,018 - 234,748,802 (-)NCBICelera
Cytogenetic Map2q37.3NCBI
HuRef2232,823,878 - 232,833,679 (-)NCBIHuRef
CHM1_12241,071,605 - 241,081,395 (-)NCBICHM1_1
T2T-CHM13v2.02240,619,322 - 240,629,121 (-)NCBIT2T-CHM13v2.0
Cops9
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr89100,657,276 - 100,662,206 (-)NCBIGRCr8
mRatBN7.2993,209,843 - 93,214,774 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl993,209,843 - 93,213,317 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx9101,645,777 - 101,650,703 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09106,781,547 - 106,786,473 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09105,137,697 - 105,142,623 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0999,813,332 - 99,818,262 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl999,813,332 - 99,818,262 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0999,478,497 - 99,483,427 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4991,858,160 - 91,863,090 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera990,746,832 - 90,751,762 (-)NCBICelera
Cytogenetic Map9q36NCBI
Cops9
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555421,131,110 - 1,135,871 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555421,131,110 - 1,135,871 (+)NCBIChiLan1.0ChiLan1.0
COPS9
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213142,780,324 - 142,787,110 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B142,795,290 - 142,802,076 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B127,373,916 - 127,379,543 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B246,186,565 - 246,196,506 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B246,186,565 - 246,196,471 (-)Ensemblpanpan1.1panPan2
COPS9
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ROS_Cfam_1.02550,750,815 - 50,754,214 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12550,592,674 - 50,596,080 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02550,338,835 - 50,342,222 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02550,616,326 - 50,619,735 (-)NCBIUU_Cfam_GSD_1.0
Cops9
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303191,923,586 - 191,927,491 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049367451,291,702 - 1,295,834 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
COPS9
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15139,260,478 - 139,264,211 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115139,260,471 - 139,264,252 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215153,946,107 - 153,950,286 (+)NCBISscrofa10.2Sscrofa10.2susScr3
COPS9
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110126,163,883 - 126,169,915 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604073,237,545 - 73,243,101 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cops9
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248474,679,059 - 4,683,969 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248474,679,059 - 4,684,041 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cops9
56 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:676
Count of miRNA genes:368
Interacting mature miRNAs:415
Transcripts:ENSMUST00000097642, ENSMUST00000112999, ENSMUST00000129730, ENSMUST00000148508, ENSMUST00000154129
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357488Splq3_mspleen weight QTL 3 (mouse)Not determined134760138150193871Mouse
13452395Leusq2_mleucocytosis susceptibility QTL 2 (mouse)180245593126386517Mouse
1558860W10q7_mweight 10 weeks QTL 7 (mouse)Not determined134760138150193871Mouse
1300989Lrdg1_mlight induced retinal degeneration 1 (mouse)Not determined173755175147125370Mouse
12790991Aath1_maortic arch atherosclerosis 1 (mouse)186483929120483929Mouse
1300976Bmd19_mbone mineral density 19 (mouse)Not determined173266214108838414Mouse
1357847Jckm2_mjuvenile cystic kidney modifier 2 (mouse)Not determined174991977133290937Mouse
27095931Pglq1_mpelvic girdle length QTL 1, 5 week (mouse)175976637128527737Mouse
27095928Pglq6_mpelvic girdle length QTL 6, 10 week (mouse)175976637148775742Mouse
12050069Nabq1_mnasal bone morphology QTL 1 (mouse)179858683113858791Mouse
11667074Led2_mlate embryonic death 2 (mouse)185696027117195081Mouse
1301304Hrq3_mheart rate quantitative locus 3 (mouse)Not determined173615692107615830Mouse
1357721Sle17_msystematic lupus erythematosus susceptibility 17 (mouse)Not determined139132808126445310Mouse
4141329Mleu1_mmyeloid leukemia survival 1 (mouse)Not determined89786512123786512Mouse
1301748Abbp1_mA/J and C57BL/6 blood pressure 1 (mouse)Not determined162946755120529678Mouse
1302146Cocrb1_mcocaine related behavior 1 (mouse)Not determined170133533104139557Mouse
26884448Sklq1_mskull length QTL 1, 5 week (mouse)175976637181327565Mouse
12791004Aath7_maortic arch atherosclerosis 7 (mouse)182832635116832635Mouse
27095918Ulnl1_mulna length 1, 5 week (mouse)167339159129727737Mouse
1357439Popoa_mpremature ovulation and primary oocyte arrest (mouse)Not determined182643189135615379Mouse
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
10412185Hcs9_mhepatocarcinogenesis susceptibility 9 (mouse)Not determined163854690189303617Mouse
4141914Gcsfis_mG-CSF induced splenomegaly (mouse)Not determined74516235148715579Mouse
10412238Alpq5_malcohol preference QTL 5 (mouse)Not determined182832635116832635Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145783900189303617Mouse
1357753Kidq2_mkidney weight QTL 2 (mouse)Not determined134760138150193871Mouse
1301350Nidd4k_mNidd4 on KK-A (mouse)Not determined782291982147125370Mouse
15039333Nmrs1_mNAFLD-associated magnetic resonance shift 1 (mouse)189786512123786512Mouse
1300841Ssial1_msusceptibility to sialadenitis 1 (mouse)Not determined163920002153557562Mouse
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
4142291Aec2_mautoimmune exocrinopathy 2 (mouse)Not determined52457737182250592Mouse
1558928Mord2_mmodifier of retinal degeneration 2 (mouse)Not determined177123115110536075Mouse
4141347Reb1_mrepetitive behavior 1 (mouse)Not determined91468266100413667Mouse
4142394Mssq1_mmandible size and shape QTL 1 (mouse)Not determined73615692107615830Mouse
1300821Lore1_mloss of righting induced by ethanol 1 (mouse)Not determined17554919192941077Mouse
14697706Stsl3a_mSalmonella typhimurium susceptibility locus 3a (mouse)17747663795827725Mouse
4141725Wbcq4_mwhite blood cell quantitative locus 4 (mouse)Not determined179858683113858791Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000097642   ⟹   ENSMUSP00000095247
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl192,564,867 - 92,569,707 (-)Ensembl
GRCm38.p6 Ensembl192,637,145 - 92,641,985 (-)Ensembl
RefSeq Acc Id: ENSMUST00000112999   ⟹   ENSMUSP00000108623
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl192,564,867 - 92,568,286 (-)Ensembl
GRCm38.p6 Ensembl192,637,145 - 92,640,564 (-)Ensembl
RefSeq Acc Id: ENSMUST00000129730
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl192,567,092 - 92,569,707 (-)Ensembl
GRCm38.p6 Ensembl192,639,370 - 92,641,985 (-)Ensembl
RefSeq Acc Id: ENSMUST00000148508   ⟹   ENSMUSP00000123716
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl192,564,867 - 92,569,645 (-)Ensembl
GRCm38.p6 Ensembl192,637,145 - 92,641,923 (-)Ensembl
RefSeq Acc Id: ENSMUST00000154129
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl192,564,867 - 92,567,631 (-)Ensembl
GRCm38.p6 Ensembl192,637,145 - 92,639,909 (-)Ensembl
RefSeq Acc Id: NM_001163425   ⟹   NP_001156897
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39192,564,867 - 92,569,707 (-)NCBI
GRCm38192,637,145 - 92,641,985 (-)ENTREZGENE
MGSCv37194,533,722 - 94,538,562 (-)RGD
Celera195,581,052 - 95,585,891 (-)RGD
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_028108
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39192,564,867 - 92,569,670 (-)NCBI
GRCm38192,637,145 - 92,641,948 (-)NCBI
MGSCv37194,533,722 - 94,538,562 (-)RGD
Celera195,581,052 - 95,585,891 (-)RGD
cM Map1 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001156897   ⟸   NM_001163425
- UniProtKB: Q3U898 (UniProtKB/Swiss-Prot),   B2RVT1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000108623   ⟸   ENSMUST00000112999
RefSeq Acc Id: ENSMUSP00000123716   ⟸   ENSMUST00000148508
RefSeq Acc Id: ENSMUSP00000095247   ⟸   ENSMUST00000097642

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q3U898-F1-model_v2 AlphaFold Q3U898 1-57 view protein structure

Promoters
RGD ID:6874504
Promoter ID:EPDNEW_M703
Type:multiple initiation site
Name:Cops9_1
Description:Mus musculus COP9 signalosome subunit 9 , transcript variant1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38192,641,961 - 92,642,021EPDNEW
RGD ID:6818134
Promoter ID:MM_KWN:1652
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   ES_Cell,   MEF_B6
Transcripts:ENSMUST00000112999,   OTTMUST00000052506
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36194,536,906 - 94,538,097 (-)MPROMDB
RGD ID:6818125
Promoter ID:MM_KWN:1653
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000052502,   OTTMUST00000052503,   OTTMUST00000052504
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36194,538,281 - 94,538,781 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1914165 AgrOrtholog
Ensembl Genes ENSMUSG00000073616 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000097642 ENTREZGENE
  ENSMUST00000097642.4 UniProtKB/Swiss-Prot
  ENSMUST00000112999.8 UniProtKB/TrEMBL
  ENSMUST00000148508 ENTREZGENE
  ENSMUST00000148508.2 UniProtKB/TrEMBL
InterPro CSN9_metazoa UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:66915 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1914165 ENTREZGENE
NCBI Gene 66915 ENTREZGENE
PANTHER COP9 SIGNALOSOME COMPLEX SUBUNIT 9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR28562 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MYEOV2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cops9 PhenoGen
UniProt B2RVT1 ENTREZGENE, UniProtKB/TrEMBL
  CSN9_MOUSE UniProtKB/Swiss-Prot
  D3Z159_MOUSE UniProtKB/TrEMBL
  F6VAI7_MOUSE UniProtKB/TrEMBL
  Q3U898 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-01-24 Cops9  COP9 signalosome subunit 9  Myeov2  myeloma overexpressed 2  Symbol and/or name change 5135510 APPROVED