Bst2 (bone marrow stromal cell antigen 2) - Rat Genome Database

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Gene: Bst2 (bone marrow stromal cell antigen 2) Mus musculus
Analyze
Symbol: Bst2
Name: bone marrow stromal cell antigen 2
RGD ID: 1619156
MGI Page MGI
Description: Predicted to enable metalloendopeptidase inhibitor activity and protein homodimerization activity. Involved in several processes, including negative regulation of intracellular transport of viral material; negative regulation of viral genome replication; and response to interferon-gamma. Located in cell surface. Is expressed in retina. Human ortholog(s) of this gene implicated in acquired immunodeficiency syndrome and endometrial cancer. Orthologous to human BST2 (bone marrow stromal cell antigen 2); INTERACTS WITH 1,1-dichloroethene; 1,2-dichloroethane; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2310015I10Rik; bone marrow stromal antigen 2; Bst-; Bst-2; C87040; CD317; DAMP-1; DAMP-1 protein homolog; GRE; GREG; HM1.24 antigen; tetherin
RGD Orthologs
Human
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39871,986,899 - 71,990,116 (-)NCBIGRCm39mm39
GRCm39 Ensembl871,986,899 - 71,990,100 (-)Ensembl
GRCm38871,534,255 - 71,537,472 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl871,534,255 - 71,537,456 (-)EnsemblGRCm38mm10GRCm38
MGSCv37874,058,158 - 74,061,336 (-)NCBIGRCm37mm9NCBIm37
MGSCv36874,463,248 - 74,466,427 (-)NCBImm8
Celera874,044,534 - 74,047,712 (-)NCBICelera
Cytogenetic Map8B3.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (EXP)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1-chloro-2,4-dinitrobenzene  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
3-chloropropane-1,2-diol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (ISO)
6alpha-methylprednisolone  (ISO)
acetamide  (ISO)
aconitine  (ISO)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
antirheumatic drug  (ISO)
arsenous acid  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (ISO)
butan-1-ol  (ISO)
cadmium atom  (EXP,ISO)
carbon nanotube  (EXP)
chlordecone  (EXP)
chloroprene  (ISO)
cobalt dichloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (EXP)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
flusilazole  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
Genipin  (EXP)
glutathione  (ISO)
hydroquinone  (ISO)
hydroquinone O-beta-D-glucopyranoside  (ISO)
imiquimod  (EXP)
kojic acid  (ISO)
levofloxacin  (ISO)
lipopolysaccharide  (EXP)
lithium chloride  (ISO)
mercury dibromide  (ISO)
methamphetamine  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
mitoxantrone  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
nitrofen  (ISO)
oxaliplatin  (ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenylmercury acetate  (ISO)
piroxicam  (ISO)
prednisolone  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
serpentine asbestos  (ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
sodium arsenite  (ISO)
sodium aurothiomalate  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
tamoxifen  (EXP,ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (ISO)
thalidomide  (EXP)
titanium dioxide  (EXP)
tofacitinib  (ISO)
toluene 2,4-diisocyanate  (EXP)
topotecan  (ISO)
Triptolide  (ISO)
trovafloxacin  (ISO)
tungsten  (EXP)
valproic acid  (ISO)
vancomycin  (EXP)
vinclozolin  (ISO)
vitamin E  (ISO)
zidovudine  (ISO)

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
1. Chen C, etal., J Craniomaxillofac Surg. 2018 Nov;46(11):1899-1904. doi: 10.1016/j.jcms.2018.08.008. Epub 2018 Aug 29.
2. Fang KH, etal., Laryngoscope. 2014 Sep;124(9):E354-60. doi: 10.1002/lary.24700. Epub 2014 May 27.
3. Hiramatsu K, etal., Cancer Sci. 2015 Oct;106(10):1474-8. doi: 10.1111/cas.12738.
4. Jones PH, etal., Retrovirology. 2012 Jan 27;9:10. doi: 10.1186/1742-4690-9-10.
5. Jones PH, etal., Virology. 2013 Sep;444(1-2):124-39. doi: 10.1016/j.virol.2013.05.042. Epub 2013 Jun 25.
6. Kamada AJ, etal., J Acquir Immune Defic Syndr. 2016 Jul 1;72(3):237-41. doi: 10.1097/QAI.0000000000000949.
7. Li SX, etal., J Immunol. 2014 Jul 1;193(1):306-16. doi: 10.4049/jimmunol.1400490. Epub 2014 May 28.
8. Liberatore RA, etal., J Virol. 2017 May 26;91(12). pii: JVI.02286-16. doi: 10.1128/JVI.02286-16. Print 2017 Jun 15.
9. Mahauad-Fernandez WD, etal., J Gen Virol. 2014 Nov;95(Pt 11):2450-61. doi: 10.1099/vir.0.068643-0. Epub 2014 Jul 22.
10. Mukai S, etal., Ann Surg Oncol. 2017 Feb;24(2):594-602. doi: 10.1245/s10434-016-5100-z. Epub 2016 Feb 1.
11. RGD automated import pipeline
12. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. RGD automated import pipeline for gene-chemical interactions
14. Wainwright DA, etal., Exp Mol Pathol. 2011 Aug;91(1):440-6. doi: 10.1016/j.yexmp.2011.04.012. Epub 2011 May 1.
15. Yokoyama T, etal., Int J Cancer. 2013 Jan 15;132(2):472-84. doi: 10.1002/ijc.27679. Epub 2012 Jul 9.
Additional References at PubMed
PMID:8889548   PMID:10329429   PMID:10349636   PMID:10725249   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:15489334   PMID:16141072  
PMID:16141073   PMID:16602821   PMID:16920966   PMID:17251550   PMID:19903902   PMID:20686043   PMID:21084286   PMID:21555533   PMID:21873635   PMID:21919738   PMID:22025715   PMID:22327075  
PMID:22457621   PMID:23303646   PMID:23341629   PMID:23702480   PMID:24036213   PMID:24195843   PMID:25499888   PMID:26311886   PMID:26566124   PMID:26627457   PMID:26846717   PMID:27224923  
PMID:27928916   PMID:30550785   PMID:33245890   PMID:33357430  


Genomics

Comparative Map Data
Bst2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39871,986,899 - 71,990,116 (-)NCBIGRCm39mm39
GRCm39 Ensembl871,986,899 - 71,990,100 (-)Ensembl
GRCm38871,534,255 - 71,537,472 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl871,534,255 - 71,537,456 (-)EnsemblGRCm38mm10GRCm38
MGSCv37874,058,158 - 74,061,336 (-)NCBIGRCm37mm9NCBIm37
MGSCv36874,463,248 - 74,466,427 (-)NCBImm8
Celera874,044,534 - 74,047,712 (-)NCBICelera
Cytogenetic Map8B3.3NCBI
BST2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1917,402,939 - 17,405,630 (-)EnsemblGRCh38hg38GRCh38
GRCh381917,402,939 - 17,405,630 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371917,513,748 - 17,516,439 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361917,374,755 - 17,377,384 (-)NCBINCBI36hg18NCBI36
Build 341917,374,755 - 17,377,384NCBI
Celera1917,415,480 - 17,418,112 (-)NCBI
Cytogenetic Map19p13.11NCBI
HuRef1917,079,843 - 17,082,475 (-)NCBIHuRef
CHM1_11917,513,253 - 17,515,885 (-)NCBICHM1_1
Bst2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21618,217,404 - 18,220,979 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1618,217,407 - 18,220,979 (-)Ensembl
Rnor_6.01619,938,781 - 19,942,353 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1619,938,784 - 19,942,353 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01619,800,345 - 19,803,919 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41618,698,545 - 18,701,768 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11618,698,545 - 18,701,766 (-)NCBI
Celera1618,422,354 - 18,425,936 (-)NCBICelera
Cytogenetic Map16p14NCBI
BST2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11917,863,991 - 17,866,728 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1917,863,991 - 17,866,728 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01916,890,257 - 16,892,989 (-)NCBIMhudiblu_PPA_v0panPan3
BST2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12045,383,757 - 45,387,420 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2045,383,915 - 45,387,178 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2045,297,396 - 45,301,618 (+)NCBI
ROS_Cfam_1.02045,870,847 - 45,875,081 (+)NCBI
UMICH_Zoey_3.12045,107,273 - 45,111,493 (+)NCBI
UNSW_CanFamBas_1.02045,517,170 - 45,521,565 (+)NCBI
UU_Cfam_GSD_1.02045,793,007 - 45,797,236 (+)NCBI
Ccdc194
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118203,948,837 - 203,952,227 (+)NCBI
SpeTri2.0NW_0049365963,492,733 - 3,501,347 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BST2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl260,305,252 - 60,309,936 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1260,305,306 - 60,308,295 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213111,049,463 - 111,049,577 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BST2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1615,900,396 - 15,903,072 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl615,900,011 - 15,903,060 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660743,533,612 - 3,536,289 (+)NCBIVero_WHO_p1.0
Bst2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624908588,925 - 591,033 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
C87040  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38871,534,264 - 71,534,479UniSTSGRCm38
MGSCv37874,058,163 - 74,058,378UniSTSGRCm37
Celera874,044,539 - 74,044,754UniSTS
Cytogenetic Map8B3.3UniSTS
Whitehead/MRC_RH8762.31UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)83970925694689598Mouse
1301544Iba3_minduction of brown adipocytes 3 (mouse)Not determined84429488078295025Mouse
1301717Adip4_madiposity 4 (mouse)Not determined84763703081637146Mouse
10766453Char11_mP. chabaudi malaria resistance QTL 11 (mouse)84763703081637146Mouse
1301441Skull11_mskull morphology 11 (mouse)Not determined84773713481737254Mouse
1357715Alaa3_malopecia areata 3 (mouse)Not determined84879293982793021Mouse
14746987Manh64_mmandible shape 64 (mouse)85005330684053306Mouse
14747005Mancz7_mmandible centroid size 7 (mouse)85005330684053306Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85188219185882191Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85428781788287993Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85470661488706763Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85554502889545028Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85820147992201479Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85840977692409776Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86078685094786976Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6346010797460107Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86393954797939696Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined86535776899357920Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined86560020799600347Mouse
10766466Char12_mP. chabaudi malaria resistance QTL 12 (mouse)86826982782600347Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined870305375104305495Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined870305375104305495Mouse
1558780Idd22_minsulin dependent diabetes susceptibility 22 (mouse)Not determined871102903105103009Mouse
4141395Char2a_mP. chabaudi malaria resistance QTL 2a (mouse)Not determined7113678390202598Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71287817123895615Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871287817123895615Mouse
1301872Cd4ts3_mCD4 T cell subset 3 (mouse)Not determined871396181105396393Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:149
Count of miRNA genes:136
Interacting mature miRNAs:144
Transcripts:ENSMUST00000051672
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000051672   ⟹   ENSMUSP00000051921
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl871,986,899 - 71,990,100 (-)Ensembl
GRCm38.p6 Ensembl871,534,255 - 71,537,456 (-)Ensembl
RefSeq Acc Id: ENSMUST00000212386
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl871,988,449 - 71,989,975 (-)Ensembl
GRCm38.p6 Ensembl871,535,805 - 71,537,331 (-)Ensembl
RefSeq Acc Id: NM_198095   ⟹   NP_932763
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39871,986,899 - 71,990,116 (-)NCBI
GRCm38871,534,255 - 71,537,472 (-)NCBI
MGSCv37874,058,158 - 74,061,336 (-)RGD
Celera874,044,534 - 74,047,712 (-)RGD
cM Map8 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_932763   ⟸   NM_198095
- UniProtKB: Q8R2Q8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000051921   ⟸   ENSMUST00000051672

Promoters
RGD ID:8667405
Promoter ID:EPDNEW_M11734
Type:initiation region
Name:Bst2_1
Description:Mus musculus bone marrow stromal cell antigen 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38871,537,429 - 71,537,489EPDNEW
RGD ID:6842862
Promoter ID:MM_KWN:54793
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_198095
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36874,061,211 - 74,061,897 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1916800 AgrOrtholog
Ensembl Genes ENSMUSG00000046718 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000051921 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000051672 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro BST2 UniProtKB/Swiss-Prot
KEGG Report mmu:69550 UniProtKB/Swiss-Prot
MGD MGI:1916800 ENTREZGENE
NCBI Gene 69550 ENTREZGENE
PANTHER PTHR15190 UniProtKB/Swiss-Prot
Pfam BST2 UniProtKB/Swiss-Prot
PhenoGen Bst2 PhenoGen
UniProt BST2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q8CEY7 UniProtKB/Swiss-Prot