Mrln (myoregulin) - Rat Genome Database
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Gene: Mrln (myoregulin) Mus musculus
Analyze
Symbol: Mrln
Name: myoregulin
RGD ID: 1619153
MGI Page MGI
Description: Exhibits enzyme inhibitor activity. Involved in negative regulation of calcium ion binding activity; negative regulation of calcium ion transport; and response to wounding. Localizes to sarcoplasmic reticulum membrane. Is expressed in several structures, including diaphragm; heart; leg muscle; somite; and tongue. Orthologous to human MRLN (myoregulin).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 2310015B20Rik; hypothetical protein LOC69563; Lin; Linc-RAM; M; Mln; RIKEN cDNA 2310015B20
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391070,040,494 - 70,055,541 (+)NCBIGRCm39mm39
GRCm39 Ensembl1070,040,494 - 70,055,541 (+)Ensembl
GRCm381070,204,664 - 70,219,711 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1070,204,664 - 70,219,711 (+)EnsemblGRCm38mm10GRCm38
MGSCv371069,667,415 - 69,682,459 (+)NCBIGRCm37mm9NCBIm37
MGSCv361069,592,753 - 69,615,068 (+)NCBImm8
Celera1071,295,780 - 71,310,827 (+)NCBICelera
Cytogenetic Map10B5.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
1. RGD automated import pipeline
2. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:16141072   PMID:16141073   PMID:24917243   PMID:25640239   PMID:27923914   PMID:28091529   PMID:29364044  


Genomics

Comparative Map Data
Mrln
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391070,040,494 - 70,055,541 (+)NCBIGRCm39mm39
GRCm39 Ensembl1070,040,494 - 70,055,541 (+)Ensembl
GRCm381070,204,664 - 70,219,711 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1070,204,664 - 70,219,711 (+)EnsemblGRCm38mm10GRCm38
MGSCv371069,667,415 - 69,682,459 (+)NCBIGRCm37mm9NCBIm37
MGSCv361069,592,753 - 69,615,068 (+)NCBImm8
Celera1071,295,780 - 71,310,827 (+)NCBICelera
Cytogenetic Map10B5.3NCBI
MRLN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1059,736,692 - 59,756,041 (-)EnsemblGRCh38hg38GRCh38
GRCh381059,736,692 - 59,753,455 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371061,496,450 - 61,513,213 (-)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map10q21.2NCBI
HuRef1055,484,351 - 55,500,804 (-)NCBIHuRef
CHM1_11061,778,903 - 61,795,356 (-)NCBICHM1_1
Mrln
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22018,406,789 - 18,423,805 (-)NCBI
Rnor_6.02019,703,628 - 19,720,596 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02021,840,428 - 21,857,392 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera2019,793,904 - 19,808,868 (-)NCBICelera
Cytogenetic Map20p11NCBI
Mrln
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542513,320,062 - 13,333,423 (-)NCBIChiLan1.0ChiLan1.0
MRLN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11058,485,998 - 58,502,225 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01056,270,995 - 56,287,646 (-)NCBIMhudiblu_PPA_v0panPan3
MRLN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1411,934,651 - 11,947,006 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha412,132,128 - 12,144,478 (-)NCBI
ROS_Cfam_1.0412,197,215 - 12,209,616 (-)NCBI
UMICH_Zoey_3.1412,173,776 - 12,186,177 (-)NCBI
UNSW_CanFamBas_1.0412,292,720 - 12,305,120 (-)NCBI
UU_Cfam_GSD_1.0412,603,697 - 12,616,098 (-)NCBI
Mrln
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_ltri_2NW_02440721369,130,961 - 69,142,813 (+)NCBI
SpeTri2.0NW_0049366143,217,820 - 3,229,048 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MRLN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11463,124,188 - 63,152,845 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21468,099,575 - 68,127,654 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MRLN
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1971,539,795 - 71,555,307 (+)NCBI
Vero_WHO_p1.0NW_02366604832,425,299 - 32,440,415 (+)NCBI
Mrln
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247913,827,395 - 3,841,119 (+)NCBI


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357740Obsty3_mobesity 3 (mouse)Not determined108359714116355075Mouse
1301386Sysbp1_msystolic blood pressure 1 (mouse)Not determined101023252187565233Mouse
1357825Kidpq2_mkidney weight percentage QTL 2 (mouse)Not determined101282830784243920Mouse
1357656Hrtq3_mheart weight QTL 3 (mouse)Not determined101282830784243920Mouse
1357864Scfpq1_msubcutaneous fat pad percentage QTL 1 (mouse)Not determined101282830784243920Mouse
1357893Lvrq4_mliver weight QTL 4 (mouse)Not determined101282830784243920Mouse
4142380W3q11_mweight 3 weeks QTL 11 (mouse)Not determined1282830784243920Mouse
4141943W6q6_mweight 6 weeks QTL 6 (mouse)Not determined1282830784243920Mouse
4141956Egq7_mearly growth QTL 7 (mouse)Not determined1282830784243920Mouse
4142272W10q5_mweight 10 weeks QTL 5 (mouse)Not determined1282830784243920Mouse
39128215Lwq17_mliver weight QTL 17 (mouse)101282830784243920Mouse
1302067Scc9_mcolon tumor susceptibility 9 (mouse)Not determined1018383585125739363Mouse
27226772Tibl13_mtibia length 13, 10 week (mouse)1019000000129800000Mouse
1558757Eae34_mexperimental allergic encephalomyelitis susceptibility 34 (mouse)Not determined1021532255114381325Mouse
26884403Cvht8_mcranial vault height 8, 16 week (mouse)102300000091200000Mouse
26884426Cvht1_mcranial vault height 1, 5 week (mouse)1024800000121200000Mouse
27095920Pglq9_mpelvic girdle length QTL 9, 10 week (mouse)103390000071000000Mouse
27095911Pglq15_mpelvic girdle length QTL 15, 16 week (mouse)1039300000129800000Mouse
27226764Tibl19_mtibia length 19, 16 week (mouse)1039300000129800000Mouse
4141070Ltgq1_mliver triglyceride QTL 1 (mouse)Not determined4140150475401504Mouse
26884411Bzwq8_mbi-zygomatic width QTL 8, 10 week (mouse)1045000000116100000Mouse
26884407Bzwq14_mbi-zygomatic width QTL 14, 16 wee (mouse)1045600000120800000Mouse
4142313Angvq1_mangiogenesis by VEGF QTL 1 (mouse)Not determined4684430782655287Mouse
4141159Phl2_mprogressive hearing loss 2 (mouse)Not determined104809840370276821Mouse
1302150Bbaa18_mB.burgdorferi-associated arthritis 18 (mouse)Not determined104950223383502378Mouse
4142169Pbwg16_mpostnatal body weight growth 16 (mouse)Not determined105001240884012633Mouse
1300597Skull14_mskull morphology 14 (mouse)Not determined105001240884012633Mouse
10045641Jckm3_mjuvenile cystic kidney modifier 3 (mouse)Not determined105001240884012633Mouse
1301966Lifespan2_mlife span 2 (mouse)Not determined105001244384012618Mouse
1357737Hpcr2_mhepatocarcinogen resistance 2 (mouse)Not determined105001244384012618Mouse
1300882Ath17_matherosclerosis 17 (mouse)Not determined105125566085255809Mouse
1301502Eae17_msusceptibility to experimental allergic encephalomyelitis 17 (mouse)Not determined105125566085255809Mouse
1301380Cia8_mcollagen induced arthritis QTL 8 (mouse)Not determined105161730482655287Mouse
14746991Manh68_mmandible shape 68 (mouse)105244466786444667Mouse
1301787Bsc1_mbrain size control 1 (mouse)Not determined105868113592681262Mouse
26884450Sklq15_mskull length QTL 15, 16 week (mouse)1059500000122500000Mouse
13208560Wght9_mweight 9 (mouse)1060000000121000000Mouse
26884424Zlq9_mzygomatic length QTL 9, 16 week (mouse)1064100000116100000Mouse
1302060El3_mepilepsy 3 (mouse)Not determined106565510499655287Mouse
1300533Aem3_manti-erythrocyte autoantibody modifier 3 (mouse)Not determined106565510499655287Mouse
1301737Insq9_minsulin QTL 9 (mouse)Not determined106565510499655287Mouse
1302035Lmb4_mlupus in MRL and B6 F2 cross (mouse)Not determined106701240892422811Mouse
26884447Sklq9_mskull length QTL 9, 10 week (mouse)1067500000111900000Mouse
26884430Zlq5_mzygomatic length QTL 5, 10 week (mouse)1068000000125000000Mouse
26884405Huml2_mhumerus length 2, 5 week (mouse)1069900000132500000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:34
Count of miRNA genes:34
Interacting mature miRNAs:34
Transcripts:ENSMUST00000020090
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000020090   ⟹   ENSMUSP00000150523
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1070,204,667 - 70,219,711 (+)Ensembl
RefSeq Acc Id: ENSMUST00000187318
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1070,204,725 - 70,210,946 (+)Ensembl
RefSeq Acc Id: ENSMUST00000188568
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1070,204,664 - 70,215,285 (+)Ensembl
RefSeq Acc Id: ENSMUST00000189468
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1070,216,897 - 70,219,710 (+)Ensembl
RefSeq Acc Id: ENSMUST00000190199   ⟹   ENSMUSP00000149291
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1070,204,710 - 70,219,580 (+)Ensembl
RefSeq Acc Id: NM_001304739   ⟹   NP_001291668
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391070,040,494 - 70,055,541 (+)NCBI
GRCm381070,204,664 - 70,219,711 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017314076   ⟹   XP_017169565
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391070,051,591 - 70,055,541 (+)NCBI
GRCm381070,215,764 - 70,219,711 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001291668 (Get FASTA)   NCBI Sequence Viewer  
  XP_017169565 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAB26234 (Get FASTA)   NCBI Sequence Viewer  
  EDL31981 (Get FASTA)   NCBI Sequence Viewer  
  Q9CV60 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001291668   ⟸   NM_001304739
- UniProtKB: Q9CV60 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017169565   ⟸   XM_017314076
- Peptide Label: isoform X1
- UniProtKB: Q9CV60 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000150523   ⟸   ENSMUST00000020090
RefSeq Acc Id: ENSMUSP00000149291   ⟸   ENSMUST00000190199

Promoters
RGD ID:8672240
Promoter ID:EPDNEW_M14150
Type:multiple initiation site
Name:Mrln_1
Description:Mus musculus myoregulin , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381070,204,664 - 70,204,724EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1916813 AgrOrtholog
Ensembl Genes ENSMUSG00000019933 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000149291 UniProtKB/TrEMBL
  ENSMUSP00000150523 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000020090 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000190199 UniProtKB/TrEMBL
KEGG Report mmu:69563 UniProtKB/Swiss-Prot
MGD MGI:1916813 ENTREZGENE
NCBI Gene 69563 ENTREZGENE
PhenoGen Mrln PhenoGen
UniProt A0A1L1SR31_MOUSE UniProtKB/TrEMBL
  MLN_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-04-21 Mrln  myoregulin    RIKEN cDNA 2310015B20 gene  Symbol and/or name change 5135510 APPROVED
2015-02-24 Mrln  RIKEN cDNA 2310015B20 gene  2310015B20Rik    Symbol and/or name change 5135510 APPROVED