Mtg1 (mitochondrial ribosome-associated GTPase 1) - Rat Genome Database

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Gene: Mtg1 (mitochondrial ribosome-associated GTPase 1) Mus musculus
Analyze
Symbol: Mtg1
Name: mitochondrial ribosome-associated GTPase 1
RGD ID: 1619019
MGI Page MGI
Description: Predicted to enable GTPase activity. Predicted to be involved in mitochondrial translation; regulation of mitochondrial translation; and regulation of respiratory system process. Predicted to act upstream of or within regulation of translation. Located in mitochondrion. Orthologous to human MTG1 (mitochondrial ribosome associated GTPase 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Gm169; GTP binding protein 7 (putative); GTP-binding protein 7; Gtpb; Gtpbp7; MGC28365; mitochondrial GTPase 1; mitochondrial GTPase 1 homolog
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397139,717,477 - 139,730,699 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7139,717,477 - 139,730,699 (+)EnsemblGRCm39 Ensembl
GRCm387140,137,564 - 140,150,786 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7140,137,564 - 140,150,786 (+)EnsemblGRCm38mm10GRCm38
MGSCv377147,323,463 - 147,336,685 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367139,988,975 - 140,001,935 (+)NCBIMGSCv36mm8
Celera7139,935,736 - 139,948,958 (+)NCBICelera
Cytogenetic Map7F4NCBI
cM Map785.16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:15489334   PMID:16141072   PMID:16141073   PMID:18614015  
PMID:21677750   PMID:21873635   PMID:30550785   PMID:30707992  


Genomics

Comparative Map Data
Mtg1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397139,717,477 - 139,730,699 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7139,717,477 - 139,730,699 (+)EnsemblGRCm39 Ensembl
GRCm387140,137,564 - 140,150,786 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7140,137,564 - 140,150,786 (+)EnsemblGRCm38mm10GRCm38
MGSCv377147,323,463 - 147,336,685 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367139,988,975 - 140,001,935 (+)NCBIMGSCv36mm8
Celera7139,935,736 - 139,948,958 (+)NCBICelera
Cytogenetic Map7F4NCBI
cM Map785.16NCBI
MTG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810133,394,157 - 133,422,520 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10133,394,094 - 133,422,520 (+)EnsemblGRCh38hg38GRCh38
GRCh3710135,207,661 - 135,236,024 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610135,057,611 - 135,084,164 (+)NCBINCBI36Build 36hg18NCBI36
Celera10128,283,666 - 128,310,098 (-)NCBICelera
Cytogenetic Map10q26.3NCBI
HuRef10128,751,344 - 128,777,690 (+)NCBIHuRef
CHM1_110135,489,478 - 135,516,035 (+)NCBICHM1_1
T2T-CHM13v2.010134,349,129 - 134,377,446 (+)NCBIT2T-CHM13v2.0
Mtg1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81204,361,176 - 204,373,917 (+)NCBIGRCr8
mRatBN7.21194,931,543 - 194,944,278 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1194,931,531 - 194,944,277 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1203,292,454 - 203,305,150 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01210,422,005 - 210,434,696 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01203,095,845 - 203,108,535 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01212,606,753 - 212,619,493 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1212,606,777 - 212,619,493 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01219,521,181 - 219,533,912 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1192,608,824 - 192,621,564 (+)NCBICelera
Cytogenetic Map1q41NCBI
Mtg1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547711,041,045 - 11,057,574 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495547711,040,381 - 11,057,912 (+)NCBIChiLan1.0ChiLan1.0
MTG1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28145,523,103 - 145,549,405 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110145,528,488 - 145,557,486 (+)NCBINHGRI_mPanPan1
PanPan1.110134,309,587 - 134,337,550 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10134,309,587 - 134,337,550 (+)Ensemblpanpan1.1panPan2
MTG1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha2841,024,762 - 41,039,003 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02841,603,851 - 41,617,878 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2841,603,794 - 41,618,385 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12841,089,091 - 41,103,097 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02841,077,611 - 41,091,618 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02841,480,536 - 41,494,562 (+)NCBIUU_Cfam_GSD_1.0
Mtg1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244072136,037,183 - 6,049,240 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648619,513,990 - 19,523,829 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648619,512,043 - 19,524,132 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MTG1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14141,372,246 - 141,384,315 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114141,372,244 - 141,384,314 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214153,754,915 - 153,766,971 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MTG1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12653,240,858 - 53,255,989 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2653,240,644 - 53,256,062 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605441,378,834 - 41,394,253 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mtg1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473713,298,236 - 13,310,747 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473713,297,687 - 13,310,598 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mtg1
545 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:782
Count of miRNA genes:493
Interacting mature miRNAs:576
Transcripts:ENSMUST00000036977, ENSMUST00000124253, ENSMUST00000140579, ENSMUST00000141070, ENSMUST00000150667, ENSMUST00000155723
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
27226751Femd5_mfemur midshaft diameter 5, 10 week (mouse)753249748143153737Mouse
27095933Ulnl3_mulna length 3, 5 week (mouse)773149748143153737Mouse
14700684Civq1_mcerebral infarct volume QTL 1 (mouse)7109707335143707335Mouse
14700687Civq5_mcerebral infarct volume QTL 5 (mouse)7109707335143707335Mouse
14700688Civq6_mcerebral infarct volume QTL 6 (mouse)7109707335143707335Mouse
11059562Lmr21b_mleishmaniasis resistance 21b (mouse)7110967235144967336Mouse
10402499Lmr21_mleishmaniasis resistance 21 (mouse)Not determined7110967235144967336Mouse
1302032Alcp12_malcohol preference locus 12 (mouse)Not determined7111166122144995196Mouse
1301898Alcp14_malcohol preference locus 14 (mouse)Not determined7111166122144995196Mouse
1300670Sluc19_msusceptibility to lung cancer 19 (mouse)Not determined7111166122144995196Mouse
4142444Femwf5_mfemur work to failure 5 (mouse)Not determined112552248144995196Mouse
1300747Skts2_mskin tumor susceptibility 2 (mouse)Not determined7112922733144995196Mouse
1300677Bmd9_mbone mineral density 9 (mouse)Not determined7116634089144995196Mouse
1357711Adbg1_madult body growth 1 (mouse)Not determined7118693381144398314Mouse
1301773Stheal7_msoft tissue heal 7 (mouse)Not determined7119132573144995196Mouse
1301590Pbwg3_mpostnatal body weight growth 3 (mouse)Not determined7127311241144995196Mouse
1300566Sluc8_msusceptibility to lung cancer 8 (mouse)Not determined7127398151144995196Mouse
14746988Manh63_mmandible shape 63 (mouse)7127735437144995196Mouse

Markers in Region
UniSTS:235801  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387140,150,671 - 140,150,977UniSTSGRCm38
MGSCv377147,336,570 - 147,336,876UniSTSGRCm37
Celera7139,948,843 - 139,949,149UniSTS
Cytogenetic Map7F4UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000036977   ⟹   ENSMUSP00000036491
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7139,717,477 - 139,730,699 (+)Ensembl
GRCm38.p6 Ensembl7140,137,564 - 140,150,786 (+)Ensembl
RefSeq Acc Id: ENSMUST00000124253   ⟹   ENSMUSP00000147668
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7139,717,876 - 139,720,176 (+)Ensembl
GRCm38.p6 Ensembl7140,137,963 - 140,140,263 (+)Ensembl
RefSeq Acc Id: ENSMUST00000140579
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7139,720,134 - 139,727,074 (+)Ensembl
GRCm38.p6 Ensembl7140,140,221 - 140,147,161 (+)Ensembl
RefSeq Acc Id: ENSMUST00000141070
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7139,717,576 - 139,727,386 (+)Ensembl
GRCm38.p6 Ensembl7140,137,663 - 140,147,473 (+)Ensembl
RefSeq Acc Id: ENSMUST00000150667
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7139,717,562 - 139,722,051 (+)Ensembl
GRCm38.p6 Ensembl7140,137,649 - 140,142,138 (+)Ensembl
RefSeq Acc Id: ENSMUST00000155723
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7139,728,872 - 139,730,360 (+)Ensembl
GRCm38.p6 Ensembl7140,148,959 - 140,150,447 (+)Ensembl
RefSeq Acc Id: ENSMUST00000211171   ⟹   ENSMUSP00000147754
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7139,717,598 - 139,725,918 (+)Ensembl
GRCm38.p6 Ensembl7140,137,685 - 140,146,005 (+)Ensembl
RefSeq Acc Id: NM_199301   ⟹   NP_955005
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397139,717,477 - 139,730,699 (+)NCBI
GRCm387140,137,564 - 140,150,786 (+)ENTREZGENE
MGSCv377147,323,463 - 147,336,685 (+)RGD
Celera7139,935,736 - 139,948,958 (+)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006536170   ⟹   XP_006536233
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397139,717,767 - 139,730,528 (+)NCBI
GRCm387140,137,854 - 140,150,615 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030242335   ⟹   XP_030098195
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397139,717,594 - 139,730,528 (+)NCBI
GRCm387140,137,777 - 140,150,615 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036152879   ⟹   XP_036008772
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397139,717,767 - 139,730,528 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_955005   ⟸   NM_199301
- UniProtKB: Q3UMX2 (UniProtKB/Swiss-Prot),   Q3UN50 (UniProtKB/Swiss-Prot),   Q8R2R6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006536233   ⟸   XM_006536170
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_030098195   ⟸   XM_030242335
- Peptide Label: isoform X2
RefSeq Acc Id: ENSMUSP00000147668   ⟸   ENSMUST00000124253
RefSeq Acc Id: ENSMUSP00000147754   ⟸   ENSMUST00000211171
RefSeq Acc Id: ENSMUSP00000036491   ⟸   ENSMUST00000036977
RefSeq Acc Id: XP_036008772   ⟸   XM_036152879
- Peptide Label: isoform X1
Protein Domains
CP-type G

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8R2R6-F1-model_v2 AlphaFold Q8R2R6 1-326 view protein structure

Promoters
RGD ID:8666005
Promoter ID:EPDNEW_M11034
Type:initiation region
Name:Mtg1_1
Description:Mus musculus mitochondrial ribosome-associated GTPase 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm387140,137,632 - 140,137,692EPDNEW
RGD ID:6841585
Promoter ID:MM_KWN:53152
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_199301,   OTTMUST00000072053,   OTTMUST00000072054,   OTTMUST00000072056
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv367147,323,404 - 147,323,904 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2685015 AgrOrtholog
Ensembl Genes ENSMUSG00000039018 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000036977 ENTREZGENE
  ENSMUST00000036977.9 UniProtKB/Swiss-Prot
  ENSMUST00000124253.3 UniProtKB/TrEMBL
  ENSMUST00000211171.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1580.10 UniProtKB/Swiss-Prot
  3.40.50.300 UniProtKB/Swiss-Prot
InterPro G_CP_dom UniProtKB/Swiss-Prot
  GTP-bd_ortho_bundle_sf UniProtKB/Swiss-Prot
  GTP_binding_domain UniProtKB/Swiss-Prot
  GTPase_MTG1 UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
KEGG Report mmu:212508 UniProtKB/Swiss-Prot
MGD MGI:2685015 ENTREZGENE
NCBI Gene 212508 ENTREZGENE
PANTHER MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1 UniProtKB/Swiss-Prot
  MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1 UniProtKB/Swiss-Prot
  MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1 UniProtKB/TrEMBL
  MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1 UniProtKB/TrEMBL
Pfam MMR_HSR1 UniProtKB/Swiss-Prot
PhenoGen Mtg1 PhenoGen
PIRSF MG442 UniProtKB/Swiss-Prot
PRINTS GTP1OBG UniProtKB/Swiss-Prot
PROSITE G_CP UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
UniProt A0A1B0GRU5_MOUSE UniProtKB/TrEMBL
  A0A1B0GS14_MOUSE UniProtKB/TrEMBL
  MTG1_MOUSE UniProtKB/Swiss-Prot
  Q3UMX2 ENTREZGENE
  Q3UN50 ENTREZGENE
  Q8R2R6 ENTREZGENE
UniProt Secondary Q3UMX2 UniProtKB/Swiss-Prot
  Q3UN50 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-29 Mtg1  mitochondrial ribosome-associated GTPase 1    mitochondrial GTPase 1 homolog (S. cerevisiae)  Symbol and/or name change 5135510 APPROVED