Flvcr1 (feline leukemia virus subgroup C cellular receptor 1) - Rat Genome Database

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Gene: Flvcr1 (feline leukemia virus subgroup C cellular receptor 1) Mus musculus
Analyze
Symbol: Flvcr1
Name: feline leukemia virus subgroup C cellular receptor 1
RGD ID: 1618983
MGI Page MGI
Description: Predicted to enable heme binding activity; heme transmembrane transporter activity; and organic cation transmembrane transporter activity. Acts upstream of or within several processes, including chordate embryonic development; embryonic digit morphogenesis; and spleen development. Located in mitochondrial membrane and plasma membrane. Is expressed in several structures, including duodenum; ectoplacental cone; immune system; placenta; and yolk sac. Used to study Diamond-Blackfan anemia. Orthologous to human FLVCR1 (FLVCR choline and heme transporter 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 9630055N22Rik; eline leukemia virus subgroup C cellular receptor 1; feline leukemia virus subgroup C receptor; feline leukemia virus subgroup C receptor-related protein 1; FLVCR; heme transporter FLVCR1; major facilitator superfamily domain containing 7B; Mfsd7; Mfsd7b
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391190,738,029 - 190,758,387 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1190,738,044 - 190,758,355 (-)EnsemblGRCm39 Ensembl
GRCm381191,005,832 - 191,026,190 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1191,005,847 - 191,026,158 (-)EnsemblGRCm38mm10GRCm38
MGSCv371192,829,711 - 192,850,069 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361192,706,447 - 192,726,805 (-)NCBIMGSCv36mm8
Celera1197,930,699 - 197,951,041 (-)NCBICelera
Cytogenetic Map1H6NCBI
cM Map196.28NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IBA)
mitochondrion  (IBA,ISO)
plasma membrane  (IDA,IEA,ISO)

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
2. Mouse MP Annotation Import Pipeline RGD automated import pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:16141072   PMID:16141073   PMID:18258918   PMID:21873635   PMID:22058337   PMID:23187127  
PMID:24021674   PMID:24486949   PMID:25582857   PMID:26067085   PMID:26551679   PMID:27006955   PMID:29229999   PMID:32554809   PMID:36631598   PMID:37100056   PMID:38187761   PMID:38412099  
PMID:39019006   PMID:39237990  


Genomics

Comparative Map Data
Flvcr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391190,738,029 - 190,758,387 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1190,738,044 - 190,758,355 (-)EnsemblGRCm39 Ensembl
GRCm381191,005,832 - 191,026,190 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1191,005,847 - 191,026,158 (-)EnsemblGRCm38mm10GRCm38
MGSCv371192,829,711 - 192,850,069 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361192,706,447 - 192,726,805 (-)NCBIMGSCv36mm8
Celera1197,930,699 - 197,951,041 (-)NCBICelera
Cytogenetic Map1H6NCBI
cM Map196.28NCBI
FLVCR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381212,858,275 - 212,899,363 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1212,858,275 - 212,899,363 (+)EnsemblGRCh38hg38GRCh38
GRCh371213,031,617 - 213,072,705 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361211,098,220 - 211,135,379 (+)NCBINCBI36Build 36hg18NCBI36
Celera1186,257,592 - 186,295,983 (+)NCBICelera
Cytogenetic Map1q32.3NCBI
HuRef1183,708,670 - 183,749,562 (+)NCBIHuRef
CHM1_11214,303,965 - 214,345,035 (+)NCBICHM1_1
T2T-CHM13v2.01212,103,255 - 212,144,367 (+)NCBIT2T-CHM13v2.0
Flvcr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr813105,117,402 - 105,139,780 (-)NCBIGRCr8
mRatBN7.213102,586,263 - 102,608,647 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl13102,586,257 - 102,608,661 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.013109,578,294 - 109,624,235 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13109,578,074 - 109,629,482 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013114,211,863 - 114,224,490 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.013114,180,812 - 114,183,817 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera13102,055,793 - 102,074,779 (-)NCBICelera
Cytogenetic Map13q27NCBI
Flvcr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554064,674,140 - 4,702,763 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554064,673,797 - 4,702,858 (-)NCBIChiLan1.0ChiLan1.0
FLVCR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2136,504,306 - 36,545,327 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1136,468,659 - 36,509,726 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01188,425,697 - 188,466,721 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11193,284,158 - 193,321,962 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1193,284,158 - 193,320,554 (+)Ensemblpanpan1.1panPan2
FLVCR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1711,001,155 - 11,038,910 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl711,001,101 - 11,035,980 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha710,576,761 - 10,614,312 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0710,707,668 - 10,745,429 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl710,707,433 - 10,745,177 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1710,630,123 - 10,667,529 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0710,731,550 - 10,769,463 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0710,856,188 - 10,893,897 (+)NCBIUU_Cfam_GSD_1.0
Flvcr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934463,453,117 - 63,486,909 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936557692,489 - 726,965 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936557693,445 - 727,166 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FLVCR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9130,541,660 - 130,570,702 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19130,543,911 - 130,570,486 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29143,470,869 - 143,497,447 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FLVCR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12516,656,219 - 16,688,397 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2516,652,246 - 16,688,376 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605517,151,582 - 17,183,388 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Flvcr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477118,239,437 - 18,270,408 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Flvcr1
676 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:614
Count of miRNA genes:413
Interacting mature miRNAs:482
Transcripts:ENSMUST00000085635
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
1301202Yaa4_mY-linked autoimmune acceleration 4 (mouse)Not determined1158468817192468938Mouse
4141245Cq2_mcholesterol QTL 2 (mouse)Not determined1157456299191456436Mouse
1300823Ath9_matherosclerosis 9 (mouse)Not determined1160112768194112883Mouse
1558802Skmw6_mskeletal muscle weight 6 (mouse)Not determined1167954584195154279Mouse
1300948Fglu2_mfasting glucose 2 (mouse)Not determined1157456299191456436Mouse
1301652Cpfd2_mcerebellum pattern fissures (mouse)Not determined1172303451195154279Mouse
12790987Tgl5_mtriglyceride 5 (mouse)1160097157194097157Mouse
1301339Hdlq15_mHDL QTL 15 (mouse)Not determined1165873675195154279Mouse
11059556Lmr20b_mleishmaniasis resistance 20b (mouse)1158468817192468938Mouse
11059557Lmr20a_mleishmaniasis resistance 20a (mouse)1158468817192468938Mouse
11059558Lmr20c_mleishmaniasis resistance 20c (mouse)1158468817192468938Mouse
10043863Swrl5_mSWR lupus locus 5 (mouse)Not determined1172303451195154279Mouse
12790988Phdlc5_mplasma HDL cholesterol 5 (mouse)9160097157194097157Mouse
1301596Elnt_mescape latencies during navigation task (mouse)Not determined1162145207194111528Mouse
11049575Lmr8b_mleishmaniasis resistance 8b (mouse)1172303451195154279Mouse
1301251Scc3_mcolon tumor susceptibility 3 (mouse)Not determined1168213823195154279Mouse
1301632Bw8q1_mbody weight at 8 weeks QTL 1 (mouse)Not determined1161201261195154279Mouse
4141483Femwf7_mfemur work to failure 7 (mouse)Not determined167462514195154279Mouse
12792983Liq1_mlimb inflammation QTL 1 (mouse)1167586086191225397Mouse
1302023Orch4_mautoimmune orchitis resistance 4 (mouse)Not determined1175211318195154279Mouse
1300745Gvhd1_mgraft-versus-host disease 1 (mouse)Not determined1157456299191456436Mouse
10412162Nobq3_mNew Zealand obese QTL 3 (mouse)Not determined1103933405191225397Mouse
10402498Lmr20_mleishmaniasis resistance 20 (mouse)Not determined1158468817192468938Mouse
1302158Fembrs5_mfemur breaking strength 5 (mouse)Not determined1167462514195154279Mouse
1301132Mors1_mmodifier of obesity related sterility 1 (mouse)Not determined1170379500195154279Mouse
1357620Aaj1_manxiety in A/J 1 (mouse)Not determined1180832317191851043Mouse
1301431Pcho1_mplasma cholesterol 1 (mouse)Not determined1159262573193262693Mouse
1300727Mptp1_mMPTP sensitivity 1 (mouse)Not determined1171632048192681050Mouse
1559024Zit1_mzinc induced tolerance 1 (mouse)Not determined1167462514195154279Mouse
1357692Axtq1_manxiety QTL 1 (mouse)Not determined1180832317191851043Mouse
12880429V25Dq1_mvitamin D inactive form serum level QTL 1 (mouse)1172632197195154279Mouse
1301565Mnotch_mmodifier of Notch (mouse)Not determined1157456299191456436Mouse
12880426V25Dq2_mvitamin D inactive form serum level QTL 2 (mouse)1172532197195154279Mouse
1300732Melm2_mmelanoma modifier 2 (mouse)Not determined1157456299191456436Mouse
1357732Tbbmd1_mtotal body bone mineral density 1 (mouse)Not determined1171983110195154279Mouse
1301602Bslm4_mbasal locomotor activity 4 (mouse)Not determined1157456299191456436Mouse
1301216Cbm1_mcerebellum weight 1 (mouse)Not determined1157456299191456436Mouse
1300842Sle9_msystematic lupus erythematosus susceptibility 9 (mouse)Not determined1158468817192468938Mouse
11532690Sluc37_msusceptibility to lung cancer 37 (mouse)1175468817194111528Mouse

Markers in Region
Flvcr1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1H6UniSTS
cM Map1 UniSTS
UniSTS:234309  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381191,005,879 - 191,006,079UniSTSGRCm38
MGSCv371192,829,758 - 192,829,958UniSTSGRCm37
Celera1197,930,746 - 197,930,946UniSTS
Cytogenetic Map1H6UniSTS
UniSTS:234310  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381191,007,138 - 191,007,359UniSTSGRCm38
MGSCv371192,831,017 - 192,831,238UniSTSGRCm37
Celera1197,932,005 - 197,932,226UniSTS
Cytogenetic Map1H6UniSTS


Sequence


Ensembl Acc Id: ENSMUST00000085635   ⟹   ENSMUSP00000082777
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1190,738,044 - 190,758,355 (-)Ensembl
GRCm38.p6 Ensembl1191,005,847 - 191,026,158 (-)Ensembl
Ensembl Acc Id: ENSMUST00000191946   ⟹   ENSMUSP00000141578
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1190,757,106 - 190,758,321 (-)Ensembl
GRCm38.p6 Ensembl1191,024,909 - 191,026,124 (-)Ensembl
Ensembl Acc Id: ENSMUST00000192666   ⟹   ENSMUSP00000141985
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1190,738,046 - 190,758,164 (-)Ensembl
GRCm38.p6 Ensembl1191,005,849 - 191,025,967 (-)Ensembl
Ensembl Acc Id: ENSMUST00000193399
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1190,745,177 - 190,747,592 (-)Ensembl
GRCm38.p6 Ensembl1191,012,980 - 191,015,395 (-)Ensembl
Ensembl Acc Id: ENSMUST00000194589
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1190,738,047 - 190,740,652 (-)Ensembl
GRCm38.p6 Ensembl1191,005,850 - 191,008,455 (-)Ensembl
Ensembl Acc Id: ENSMUST00000194917
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1190,738,044 - 190,744,108 (-)Ensembl
GRCm38.p6 Ensembl1191,005,847 - 191,011,911 (-)Ensembl
RefSeq Acc Id: NM_001081259   ⟹   NP_001074728
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391190,738,029 - 190,758,387 (-)NCBI
GRCm381191,005,832 - 191,026,190 (-)NCBI
MGSCv371192,829,711 - 192,850,069 (-)RGD
Celera1197,930,699 - 197,951,041 (-)RGD
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001313747   ⟹   NP_001300676
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391190,738,029 - 190,758,387 (-)NCBI
GRCm381191,005,832 - 191,026,190 (-)NCBI
Sequence:
RefSeq Acc Id: NM_198025   ⟹   NP_932142
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391190,757,106 - 190,758,387 (-)NCBI
GRCm381191,024,909 - 191,026,190 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001074728   ⟸   NM_001081259
- Peptide Label: isoform 1
- UniProtKB: B2RXV4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001300676   ⟸   NM_001313747
- Peptide Label: isoform 2
- UniProtKB: B2RXV4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_932142   ⟸   NM_198025
- Peptide Label: isoform 3
- UniProtKB: A0A0A6YWJ7 (UniProtKB/TrEMBL),   A0A0A6YXG8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000082777   ⟸   ENSMUST00000085635
Ensembl Acc Id: ENSMUSP00000141578   ⟸   ENSMUST00000191946
Ensembl Acc Id: ENSMUSP00000141985   ⟸   ENSMUST00000192666

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B2RXV4-F1-model_v2 AlphaFold B2RXV4 1-560 view protein structure

Promoters
RGD ID:6876088
Promoter ID:EPDNEW_M1495
Type:single initiation site
Name:Flvcr1_1
Description:Mus musculus feline leukemia virus subgroup C cellular receptor1 , transcript variant 3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381191,026,188 - 191,026,248EPDNEW
RGD ID:6818069
Promoter ID:MM_KWN:3296
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Lung
Transcripts:NM_001081259
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361192,849,749 - 192,850,249 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2444881 AgrOrtholog
Ensembl Genes ENSMUSG00000066595 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000085635 ENTREZGENE
  ENSMUST00000085635.6 UniProtKB/Swiss-Prot
  ENSMUST00000191946 ENTREZGENE
  ENSMUST00000191946.2 UniProtKB/TrEMBL
  ENSMUST00000192666.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro MFS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MFS_dom UniProtKB/Swiss-Prot
  MFS_trans_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SLC49-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:226844 UniProtKB/Swiss-Prot
MGD MGI:2444881 ENTREZGENE
NCBI Gene 226844 ENTREZGENE
PANTHER FELINE LEUKEMIA VIRUS SUBGROUP C RECEPTOR-RELATED PROTEIN 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAJOR FACILITATOR SUPERFAMILY PROTEIN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MFS_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Flvcr1 PhenoGen
PROSITE MFS UniProtKB/Swiss-Prot
Superfamily-SCOP SSF103473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0A6YWJ7 ENTREZGENE, UniProtKB/TrEMBL
  A0A0A6YXG8 ENTREZGENE, UniProtKB/TrEMBL
  B2RXV4 ENTREZGENE, UniProtKB/Swiss-Prot
  Q0P6A9_MOUSE UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-08-22 Flvcr1  feline leukemia virus subgroup C cellular receptor 1  Mfsd7b  major facilitator superfamily domain containing 7B  Symbol and/or name change 5135510 APPROVED