Gfod1 (glucose-fructose oxidoreductase domain containing 1) - Rat Genome Database

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Gene: Gfod1 (glucose-fructose oxidoreductase domain containing 1) Mus musculus
Analyze
Symbol: Gfod1
Name: glucose-fructose oxidoreductase domain containing 1
RGD ID: 1618795
MGI Page MGI
Description: Predicted to enable nucleotide binding activity and oxidoreductase activity. Predicted to be located in extracellular region. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and integumental system. Orthologous to human GFOD1 (Gfo/Idh/MocA-like oxidoreductase domain containing 1).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 9630032O13; AI850995; glucose-fructose oxidoreductase domain-containing protein 1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391343,348,716 - 43,457,648 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1343,348,721 - 43,457,648 (-)EnsemblGRCm39 Ensembl
GRCm381343,195,240 - 43,304,172 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1343,195,245 - 43,304,172 (-)EnsemblGRCm38mm10GRCm38
MGSCv371343,290,888 - 43,399,541 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361343,206,491 - 43,315,144 (-)NCBIMGSCv36mm8
Celera1344,280,698 - 44,382,534 (-)NCBICelera
Cytogenetic Map13A4NCBI
cM Map1321.41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:14610273   PMID:16141072   PMID:16141073   PMID:21267068   PMID:24194600  
PMID:32325033  


Genomics

Comparative Map Data
Gfod1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391343,348,716 - 43,457,648 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1343,348,721 - 43,457,648 (-)EnsemblGRCm39 Ensembl
GRCm381343,195,240 - 43,304,172 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1343,195,245 - 43,304,172 (-)EnsemblGRCm38mm10GRCm38
MGSCv371343,290,888 - 43,399,541 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361343,206,491 - 43,315,144 (-)NCBIMGSCv36mm8
Celera1344,280,698 - 44,382,534 (-)NCBICelera
Cytogenetic Map13A4NCBI
cM Map1321.41NCBI
GFOD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38613,357,830 - 13,487,600 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl613,357,830 - 13,487,662 (-)EnsemblGRCh38hg38GRCh38
GRCh37613,358,062 - 13,487,832 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36613,471,798 - 13,595,766 (-)NCBINCBI36Build 36hg18NCBI36
Build 34613,471,797 - 13,595,766NCBI
Celera614,596,764 - 14,720,992 (-)NCBICelera
Cytogenetic Map6p24.1-p23NCBI
HuRef613,300,564 - 13,425,556 (-)NCBIHuRef
CHM1_1613,365,916 - 13,490,156 (-)NCBICHM1_1
T2T-CHM13v2.0613,231,072 - 13,361,100 (-)NCBIT2T-CHM13v2.0
Gfod1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81721,606,090 - 21,710,922 (+)NCBIGRCr8
mRatBN7.21721,400,142 - 21,504,972 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1721,399,479 - 21,499,938 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1721,288,730 - 21,388,660 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01722,892,397 - 22,992,325 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01721,215,832 - 21,315,760 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01723,818,370 - 23,924,393 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1723,823,632 - 23,923,792 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01725,770,445 - 25,873,980 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41727,226,626 - 27,329,614 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11727,229,072 - 27,332,230 (+)NCBI
Celera1721,097,591 - 21,196,450 (+)NCBICelera
Cytogenetic Map17p14NCBI
Gfod1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554651,235,917 - 1,332,775 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554651,235,917 - 1,338,072 (+)NCBIChiLan1.0ChiLan1.0
GFOD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2528,012,303 - 28,141,747 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1624,002,319 - 24,130,958 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0613,203,295 - 13,332,651 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1613,581,106 - 13,704,047 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl613,582,487 - 13,704,047 (-)Ensemblpanpan1.1panPan2
GFOD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13512,812,561 - 12,819,777 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3512,818,750 - 12,819,613 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3512,763,354 - 12,876,838 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03512,916,963 - 13,024,629 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3512,918,134 - 13,024,497 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13512,738,239 - 12,851,418 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03512,791,778 - 12,905,146 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03514,114,357 - 14,228,153 (-)NCBIUU_Cfam_GSD_1.0
Gfod1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494611,604,222 - 11,704,023 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493655232,504 - 127,289 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493655226,918 - 127,259 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GFOD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl79,735,660 - 9,853,788 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.179,735,649 - 9,854,278 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2710,083,096 - 10,193,298 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GFOD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11758,660,293 - 58,785,914 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1758,660,419 - 58,783,663 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604413,408,204 - 13,533,893 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gfod1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475612,766,505 - 12,904,881 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475612,765,352 - 12,876,364 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gfod1
2951 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2101
Count of miRNA genes:784
Interacting mature miRNAs:1043
Transcripts:ENSMUST00000055341
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884393Humsd7_mhumerus midshaft diameter 7, 16 week (mouse)13395000076048119Mouse
1558898Hpi1_mhapatic PMN infiltration 1 (mouse)Not determined13441402553101640Mouse
10402494Igmsc1_mimmunoglobulin M secreting cells 1 (mouse)Not determined131716854544918560Mouse
1301880Hypt_mhypertension (mouse)Not determined131815679252156924Mouse
13463469Gssq1_mglomerulosclerosis severity QTL 1 (mouse)131906090853061050Mouse
12880423V25Dq7_mvitamin D inactive form serum level QTL 7 (mouse)131958398353583983Mouse
1301015Sysbp2_msystolic blood pressure 2 (mouse)Not determined132047761259821605Mouse
4142147Mvwf4_mmodifier of von Willebrand factor 4 (mouse)Not determined20477612112898424Mouse
1357591Tesq1_mtestis weight QTL 1 (mouse)Not determined132061551255720517Mouse
4142009Pregq3_mpregnancy QTL 3 (mouse)Not determined132061551272385189Mouse
10045618Heal17_mwound healing/regeneration 17 (mouse)Not determined132074693954747056Mouse
4142489Ath25_matherosclerosis 25 (mouse)Not determined2583652959836529Mouse
10401111Pgia40_mproteoglycan induced arthritis 40 (mouse)Not determined132791846961918560Mouse
1300710Pcd4ts2_mp-glycoprotein positive CD4 T cell subset 2 (mouse)Not determined132821044262210544Mouse
1357802Vtbt15_mvertebral trabecular bone trait 15 (mouse)Not determined132821737962217515Mouse
10045621Heal21_mwound healing/regeneration 21 (mouse)Not determined132821737962217515Mouse
10755533Chol18_mcholesterol 18 (mouse)133096946764969467Mouse
10755517Chol15_mcholesterol 15 (mouse)133096946764969467Mouse
12738439Twq4_mtestis weight QTL 4 (mouse)133112911065129110Mouse
14696729Kidlq2_mkidney weight, left QTL 2 (mouse)133134473665344736Mouse
1301299Sluc23_msusceptibility to lung cancer 23 (mouse)Not determined133492194368922081Mouse
10412235Scgq5_mspontaneous crescentic glomerulonephritis QTL 5 (mouse)Not determined133606090896239162Mouse
1357587Pfat3_mpredicted fat percentage 3 (mouse)Not determined133610153070101640Mouse
1301734Acsns2_mAngiostrongylus costaricensis nematode susceptibility 2 (mouse)Not determined133610153070101640Mouse
1300561Heal7_mwound healing/regeneration 7 (mouse)Not determined133614482070144904Mouse
1300862Cfbw5_mcystic fibrosis body weight 5 (mouse)Not determined133872035872720517Mouse
1300985Bmd13_mbone mineral density 13 (mouse)Not determined133962924973629397Mouse
1302157Bwem2_mbody weight day 30 males 2 (mouse)Not determined133962924973629397Mouse
1301801Cpfd5_mcerebellum pattern fissures (mouse)Not determined133962924973629397Mouse
15039353Nmrs35_mNAFLD-associated magnetic resonance shift 35 (mouse)134058825374588253Mouse
1300668Pas10_mpulmonary adenoma susceptibility 10 (mouse)Not determined134148904275489158Mouse

Markers in Region
AI850995  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381343,195,371 - 43,195,492UniSTSGRCm38
MGSCv371343,290,740 - 43,290,861UniSTSGRCm37
Celera1344,280,550 - 44,280,671UniSTS
Cytogenetic Map13A4UniSTS
Whitehead/MRC_RH13445.44UniSTS
D13Mit276  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381343,268,476 - 43,268,602UniSTSGRCm38
MGSCv371343,363,845 - 43,363,971UniSTSGRCm37
Celera1344,353,931 - 44,354,057UniSTS
Cytogenetic Map13A4UniSTS
cM Map1324.0UniSTS
Whitehead/MRC_RH13445.44UniSTS
stSG606770  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381343,268,495 - 43,269,102UniSTSGRCm38
MGSCv371343,363,864 - 43,364,471UniSTSGRCm37
Celera1344,353,950 - 44,354,557UniSTS
Cytogenetic Map13A4UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000055341   ⟹   ENSMUSP00000062662
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1343,348,721 - 43,457,648 (-)Ensembl
GRCm38.p6 Ensembl1343,195,245 - 43,304,172 (-)Ensembl
RefSeq Acc Id: ENSMUST00000222779   ⟹   ENSMUSP00000152216
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1343,418,901 - 43,456,881 (-)Ensembl
GRCm38.p6 Ensembl1343,265,425 - 43,303,405 (-)Ensembl
RefSeq Acc Id: NM_001033399   ⟹   NP_001028571
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391343,348,995 - 43,457,648 (-)NCBI
GRCm381343,195,519 - 43,304,172 (-)NCBI
MGSCv371343,290,888 - 43,399,541 (-)RGD
Celera1344,280,698 - 44,382,534 (-)RGD
cM Map13 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006516932   ⟹   XP_006516995
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391343,348,716 - 43,456,708 (-)NCBI
GRCm381343,195,240 - 43,303,232 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001028571 (Get FASTA)   NCBI Sequence Viewer  
  XP_006516995 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI39027 (Get FASTA)   NCBI Sequence Viewer  
  AAI39028 (Get FASTA)   NCBI Sequence Viewer  
  BAE27925 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000062662
  ENSMUSP00000062662.6
  ENSMUSP00000152216.2
GenBank Protein Q3UHD2 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001028571   ⟸   NM_001033399
- Peptide Label: precursor
- UniProtKB: B9EI39 (UniProtKB/Swiss-Prot),   Q3UHD2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006516995   ⟸   XM_006516932
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000152216   ⟸   ENSMUST00000222779
RefSeq Acc Id: ENSMUSP00000062662   ⟸   ENSMUST00000055341
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q3UHD2-F1-model_v2 AlphaFold Q3UHD2 1-390 view protein structure

Promoters
RGD ID:8680198
Promoter ID:EPDNEW_M18129
Type:initiation region
Name:Gfod1_1
Description:Mus musculus glucose-fructose oxidoreductase domain containing1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381343,304,174 - 43,304,234EPDNEW
RGD ID:6823923
Promoter ID:MM_KWN:13931
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   Brain,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_001033399,   UC007QFY.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361343,399,221 - 43,400,442 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2145304 AgrOrtholog
Ensembl Genes ENSMUSG00000051335 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000055341 ENTREZGENE
  ENSMUST00000055341.7 UniProtKB/Swiss-Prot
  ENSMUST00000222779.2 UniProtKB/TrEMBL
Gene3D-CATH NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Oxidoreductase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OxRdtase_C UniProtKB/Swiss-Prot
KEGG Report mmu:328232 UniProtKB/Swiss-Prot
MGD MGI:2145304 ENTREZGENE
NCBI Gene 328232 ENTREZGENE
PANTHER BCDNA.GH03377 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLUCOSE-FRUCTOSE OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam GFO_IDH_MocA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GFO_IDH_MocA_C UniProtKB/Swiss-Prot
PhenoGen Gfod1 PhenoGen
Superfamily-SCOP Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain UniProtKB/Swiss-Prot
  SSF51735 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1Y7VIZ4_MOUSE UniProtKB/TrEMBL
  B9EI39 ENTREZGENE
  GFOD1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary B9EI39 UniProtKB/Swiss-Prot