Piwil4 (piwi-like RNA-mediated gene silencing 4) - Rat Genome Database

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Gene: Piwil4 (piwi-like RNA-mediated gene silencing 4) Mus musculus
Analyze
Symbol: Piwil4
Name: piwi-like RNA-mediated gene silencing 4
RGD ID: 1618776
MGI Page MGI
Description: Enables piRNA binding activity. Involved in negative regulation of transposition; nucleic acid metabolic process; and spermatogenesis. Located in nucleus and piP-body. Is expressed in embryo; germ cell of testis; testis; and trunk unsegmented mesenchyme. Orthologous to human PIWIL4 (piwi like RNA-mediated gene silencing 4).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 9230101H05Rik; mAgo5; Miw; Miwi2; piwi-like 4; piwi-like homolog 4; piwi-like protein 4
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39914,613,072 - 14,651,968 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl914,607,526 - 14,652,036 (-)EnsemblGRCm39 Ensembl
GRCm38914,701,776 - 14,740,672 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl914,696,230 - 14,740,733 (-)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl914,696,230 - 14,740,740 (-)EnsemblGRCm38mm10GRCm38
MGSCv37914,506,802 - 14,545,177 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36914,452,751 - 14,491,126 (-)NCBIMGSCv36mm8
Celera911,982,833 - 12,021,209 (-)NCBICelera
Cytogenetic Map9A2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IDA,ISO)
cytosol  (TAS)
mitochondrion  (ISO)
nucleoplasm  (ISO,TAS)
nucleus  (IDA,ISO)
P granule  (IBA,IDA)
piP-body  (IDA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Mouse MP Annotation Import Pipeline RGD automated import pipeline
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12414724   PMID:12466851   PMID:16141072   PMID:16141073   PMID:16787967   PMID:17395546   PMID:18381894   PMID:18922463  
PMID:19584108   PMID:20011505   PMID:20059948   PMID:20439430   PMID:20534472   PMID:20547853   PMID:21267068   PMID:21383078   PMID:21397847   PMID:21566194   PMID:21687940   PMID:21873635  
PMID:22008794   PMID:22020280   PMID:22902560   PMID:23714778   PMID:24058407   PMID:24067652   PMID:24183939   PMID:24376547   PMID:24464225   PMID:24939875   PMID:25238487   PMID:25416063  
PMID:25503965   PMID:25762440   PMID:25772451   PMID:26109049   PMID:26279574   PMID:26669262   PMID:27072294   PMID:27626653   PMID:27655786   PMID:28115634   PMID:28461596   PMID:28530707  
PMID:28633017   PMID:28920925   PMID:29437694   PMID:29941866   PMID:30108053   PMID:30304676   PMID:30805989   PMID:30951587   PMID:32325033   PMID:32381626   PMID:32674113   PMID:32719317  
PMID:34650118   PMID:34912016  


Genomics

Comparative Map Data
Piwil4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39914,613,072 - 14,651,968 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl914,607,526 - 14,652,036 (-)EnsemblGRCm39 Ensembl
GRCm38914,701,776 - 14,740,672 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl914,696,230 - 14,740,733 (-)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl914,696,230 - 14,740,740 (-)EnsemblGRCm38mm10GRCm38
MGSCv37914,506,802 - 14,545,177 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36914,452,751 - 14,491,126 (-)NCBIMGSCv36mm8
Celera911,982,833 - 12,021,209 (-)NCBICelera
Cytogenetic Map9A2NCBI
PIWIL4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381194,567,368 - 94,621,421 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1194,543,840 - 94,621,421 (+)EnsemblGRCh38hg38GRCh38
GRCh371194,300,534 - 94,354,587 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361193,940,182 - 93,994,234 (+)NCBINCBI36Build 36hg18NCBI36
Build 341193,940,181 - 93,994,234NCBI
Celera1191,588,283 - 91,642,396 (+)NCBICelera
Cytogenetic Map11q21NCBI
HuRef1190,365,674 - 90,419,786 (+)NCBIHuRef
CHM1_11194,183,460 - 94,237,568 (+)NCBICHM1_1
T2T-CHM13v2.01194,574,415 - 94,628,468 (+)NCBIT2T-CHM13v2.0
Piwil4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2811,536,520 - 11,579,883 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl811,536,520 - 11,579,761 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx815,521,749 - 15,564,552 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0813,819,492 - 13,862,295 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0811,795,101 - 11,837,796 (-)NCBIRnor_WKY
Rnor_6.0813,208,774 - 13,251,970 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl813,208,774 - 13,251,812 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0813,150,647 - 13,192,599 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4811,491,035 - 11,534,564 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1811,491,034 - 11,534,564 (-)NCBI
Celera813,007,375 - 13,049,493 (-)NCBICelera
Cytogenetic Map8q12NCBI
Piwil4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955605331,633 - 398,528 (-)NCBIChiLan1.0ChiLan1.0
PIWIL4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11193,098,926 - 93,151,404 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1193,097,709 - 93,150,981 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01189,572,252 - 89,628,251 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PIWIL4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1216,319,986 - 6,391,149 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl216,319,987 - 6,366,787 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha216,330,852 - 6,377,361 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0216,500,351 - 6,547,075 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl216,500,352 - 6,547,201 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1216,287,775 - 6,334,256 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0216,350,835 - 6,397,206 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0216,399,353 - 6,446,079 (-)NCBIUU_Cfam_GSD_1.0
Piwil4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494779,489,052 - 79,535,015 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936674355,302 - 402,388 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PIWIL4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl926,703,340 - 26,751,854 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1926,679,960 - 26,751,856 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2930,436,750 - 30,505,677 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PIWIL4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1185,768,124 - 85,817,426 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl185,768,287 - 85,817,000 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604339,958,043 - 40,009,359 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Piwil4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473539,220,242 - 39,285,794 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1000
Count of miRNA genes:521
Interacting mature miRNAs:636
Transcripts:ENSMUST00000076946, ENSMUST00000115643, ENSMUST00000115644, ENSMUST00000136399
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142326Tgq19_mtriglyceride QTL 19 (mouse)Not determined121060750Mouse
1300899Chol6_mcholesterol 6 (mouse)Not determined9129902913Mouse
13434920Dcollq1_mdifferential colonization level QTL 1 (mouse)9130341840Mouse
35673312Ari7_mantibody response to influenza 7, day 45, IgG3 (mouse)9780000122211296Mouse
1300849Sles4_msystemic lupus erythmatosus suppressor 4 (mouse)Not determined9910756237306370Mouse
13504833Bglu19_mblood glucose level 19 (mouse)9991076843910768Mouse
1300532Tbs2_mtuberculosis severity 2 (mouse)Not determined91236997046370114Mouse
10043917Obq37_mobesity QTL 37 (mouse)Not determined91339117547391175Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000076946   ⟹   ENSMUSP00000076213
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl914,613,654 - 14,652,029 (-)Ensembl
GRCm38.p6 Ensembl914,702,358 - 14,740,733 (-)Ensembl
RefSeq Acc Id: ENSMUST00000115643
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl914,613,075 - 14,629,769 (-)Ensembl
GRCm38.p6 Ensembl914,701,779 - 14,718,473 (-)Ensembl
RefSeq Acc Id: ENSMUST00000115644   ⟹   ENSMUSP00000111308
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl914,613,074 - 14,652,036 (-)Ensembl
GRCm38.p6 Ensembl914,701,778 - 14,740,740 (-)Ensembl
RefSeq Acc Id: ENSMUST00000136399   ⟹   ENSMUSP00000120851
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl914,607,526 - 14,616,366 (-)Ensembl
GRCm38.p6 Ensembl914,696,230 - 14,705,070 (-)Ensembl
RefSeq Acc Id: NM_001368831   ⟹   NP_001355760
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39914,613,072 - 14,651,968 (-)NCBI
GRCm38914,701,776 - 14,740,672 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001368832   ⟹   NP_001355761
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39914,613,072 - 14,651,968 (-)NCBI
GRCm38914,701,776 - 14,740,672 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001368836   ⟹   NP_001355765
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39914,613,072 - 14,629,683 (-)NCBI
GRCm38914,701,776 - 14,718,387 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006510433   ⟹   XP_006510496
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39914,613,074 - 14,637,968 (-)NCBI
GRCm38914,701,778 - 14,726,672 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036155070   ⟹   XP_036010963
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39914,614,359 - 14,641,231 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036155071   ⟹   XP_036010964
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39914,613,074 - 14,629,174 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_006510496   ⟸   XM_006510433
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001355761   ⟸   NM_001368832
- Peptide Label: isoform 2
RefSeq Acc Id: NP_001355760   ⟸   NM_001368831
- Peptide Label: isoform 1
- UniProtKB: Q8CC75 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: NP_001355765   ⟸   NM_001368836
- Peptide Label: isoform 3
RefSeq Acc Id: ENSMUSP00000076213   ⟸   ENSMUST00000076946
RefSeq Acc Id: ENSMUSP00000111308   ⟸   ENSMUST00000115644
RefSeq Acc Id: ENSMUSP00000120851   ⟸   ENSMUST00000136399
RefSeq Acc Id: XP_036010964   ⟸   XM_036155071
- Peptide Label: isoform X3
RefSeq Acc Id: XP_036010963   ⟸   XM_036155070
- Peptide Label: isoform X2
Protein Domains
PAZ   Piwi

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8CGT6-F1-model_v2 AlphaFold Q8CGT6 1-848 view protein structure

Promoters
RGD ID:6844955
Promoter ID:MM_KWN:56396
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   Lung
Transcripts:ENSMUST00000115643
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36914,522,444 - 14,522,944 (-)MPROMDB
RGD ID:8668814
Promoter ID:EPDNEW_M12438
Type:single initiation site
Name:Piwil4_1
Description:Mus musculus piwi-like RNA-mediated gene silencing 4 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M12439  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38914,718,387 - 14,718,447EPDNEW
RGD ID:8668816
Promoter ID:EPDNEW_M12439
Type:initiation region
Name:Piwil4_2
Description:Mus musculus piwi-like RNA-mediated gene silencing 4 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M12438  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38914,740,672 - 14,740,732EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3041167 AgrOrtholog
Ensembl Genes ENSMUSG00000036912 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000076213.4 UniProtKB/TrEMBL
  ENSMUSP00000111308 ENTREZGENE
  ENSMUSP00000111308.4 UniProtKB/TrEMBL
  ENSMUSP00000120851.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000076946.4 UniProtKB/TrEMBL
  ENSMUST00000115643 ENTREZGENE
  ENSMUST00000115644 ENTREZGENE
  ENSMUST00000115644.10 UniProtKB/TrEMBL
  ENSMUST00000136399.8 UniProtKB/TrEMBL
Gene3D-CATH 3.30.420.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro PAZ_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAZ_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Piwi UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNaseH-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNaseH_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:3041167 ENTREZGENE
NCBI Gene 330890 ENTREZGENE
Pfam PAZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Piwi UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Piwil4 PhenoGen
PROSITE PAZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PIWI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PAZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Piwi UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF101690 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF53098 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0R4J0Y7_MOUSE UniProtKB/TrEMBL
  A0A6Q6QBZ6_MOUSE UniProtKB/TrEMBL
  F6VRE5_MOUSE UniProtKB/TrEMBL
  PIWL4_MOUSE UniProtKB/Swiss-Prot
  Q8CC75 ENTREZGENE
  Q8CGT6 ENTREZGENE
UniProt Secondary A6P4B9 UniProtKB/Swiss-Prot
  A6X963 UniProtKB/Swiss-Prot
  A6X964 UniProtKB/Swiss-Prot
  Q8CC75 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-02-27 Piwil4  piwi-like RNA-mediated gene silencing 4    piwi-like homolog 4 (Drosophila)  Symbol and/or name change 5135510 APPROVED