Ccl21b (chemokine (C-C motif) ligand 21B (leucine)) - Rat Genome Database

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Gene: Ccl21b (chemokine (C-C motif) ligand 21B (leucine)) Mus musculus
No known orthologs.
Symbol: Ccl21b
Name: chemokine (C-C motif) ligand 21B (leucine)
RGD ID: 1618403
Description: Predicted to enable CCR chemokine receptor binding activity and chemokine activity. Predicted to be involved in several processes, including cellular response to cytokine stimulus; leukocyte chemotaxis; and positive regulation of intracellular signal transduction. Predicted to act upstream of or within leukocyte chemotaxis and negative regulation of myeloid cell differentiation. Located in external side of plasma membrane. Is expressed in branchial arch; hemolymphoid system; and renal vasculature. Orthologous to human CCL21 (C-C motif chemokine ligand 21); INTERACTS WITH 1-chloro-2,4-dinitrobenzene; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 6CKBAC; 6CKBAC1; 6Cki; 6Ckine; AI159701; beta chemokine exodus-2; beta-chemokine exodus-2; C-C motif chemokine 21a; C-C motif chemokine 21b; C-C motif chemokine 21c; Ccl21-leu; Ccl21a; Ccl21c; chemokine (C-C motif) ligand 21C (leucine); CKb9; Exodus; exodus-2; S; Scya; Scya2; Scya21; Scya21a; Scya21b; Scya21c; secondary lymphoid organ chemokine; SLC; small inducible cytokine A21; small-inducible cytokine A21a; small-inducible cytokine A21b; small-inducible cytokine A21c; TCA; TCA4; thymus-derived chemotactic agent 4
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39442,173,120 - 42,256,825 (+)NCBIGRCm39mm39
GRCm39 Ensembl442,255,693 - 42,256,825 (+)Ensembl
GRCm38442,173,120 - 42,256,825 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl442,255,693 - 42,256,825 (+)EnsemblGRCm38mm10GRCm38
MGSCv37441,774,243 - 41,775,337 (+)NCBIGRCm37mm9NCBIm37
MGSCv36441,774,204 - 41,775,337 (+)NCBImm8
Cytogenetic Map4A5NCBI
cM Map422.12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of GTPase activity  (ISO)
antimicrobial humoral immune response mediated by antimicrobial peptide  (ISO)
cell chemotaxis  (ISO)
cellular response to interferon-gamma  (IBA)
cellular response to interleukin-1  (IBA)
cellular response to tumor necrosis factor  (IBA)
chemokine-mediated signaling pathway  (IBA)
dendritic cell chemotaxis  (ISO)
eosinophil chemotaxis  (IBA)
establishment of T cell polarity  (ISO)
G protein-coupled receptor signaling pathway  (IBA,ISO)
inflammatory response  (IBA)
killing of cells of other organism  (ISO)
leukocyte chemotaxis  (ISO)
lymphocyte chemotaxis  (IBA)
mesangial cell-matrix adhesion  (ISO)
monocyte chemotaxis  (IBA)
negative regulation of dendritic cell apoptotic process  (ISO)
negative regulation of leukocyte tethering or rolling  (ISO)
negative regulation of myeloid cell differentiation  (ISO)
neutrophil chemotaxis  (IBA)
positive regulation of actin filament polymerization  (ISO)
positive regulation of cell adhesion mediated by integrin  (ISO)
positive regulation of cell motility  (ISO)
positive regulation of cell-matrix adhesion  (ISO)
positive regulation of ERK1 and ERK2 cascade  (IBA,ISO)
positive regulation of filopodium assembly  (ISO)
positive regulation of GTPase activity  (IBA)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (ISO)
positive regulation of JNK cascade  (ISO)
positive regulation of myeloid dendritic cell chemotaxis  (ISO)
positive regulation of neutrophil chemotaxis  (ISO)
positive regulation of phosphatidylinositol 3-kinase activity  (ISO)
positive regulation of protein kinase activity  (ISO)
positive regulation of protein kinase B signaling  (ISO)
positive regulation of pseudopodium assembly  (ISO)
release of sequestered calcium ion into cytosol  (ISO)
response to prostaglandin E  (ISO)
ruffle organization  (ISO)

Cellular Component

Molecular Function


Additional References at PubMed
PMID:9257816   PMID:9300671   PMID:9419363   PMID:9531599   PMID:9548511   PMID:10329455   PMID:10523616   PMID:11093154   PMID:11123313   PMID:11801632   PMID:11927535   PMID:11944948  
PMID:12055211   PMID:12080938   PMID:12093871   PMID:12477932   PMID:12648490   PMID:14617751   PMID:15302902   PMID:15470021   PMID:15489334   PMID:15919372   PMID:16025002   PMID:16095489  
PMID:16141072   PMID:16210592   PMID:16367909   PMID:16622017   PMID:16815646   PMID:16966615   PMID:16973962   PMID:17176958   PMID:17382312   PMID:17721537   PMID:17947663   PMID:18287559  
PMID:18606653   PMID:18802011   PMID:18809240   PMID:19008373   PMID:19164599   PMID:19234195   PMID:19398761   PMID:19468303   PMID:19783990   PMID:19923453   PMID:20889506   PMID:21441897  
PMID:21750661   PMID:21873635   PMID:21937690   PMID:23750244   PMID:24368807   PMID:25398010   PMID:25620669   PMID:28336912   PMID:28709801   PMID:29077526  


Position Markers
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4A5UniSTS
cM Map413.34UniSTS
cM Map413.3UniSTS
cM Map413.3UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4A5UniSTS
cM Map413.3UniSTS
cM Map413.34UniSTS
cM Map413.3UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4A5UniSTS
cM Map413.34UniSTS
cM Map413.3UniSTS
cM Map413.3UniSTS
cM Map413.3UniSTS
cM Map413.34UniSTS
cM Map413.3UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4A5UniSTS
cM Map413.34UniSTS
cM Map413.3UniSTS

QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156183778Mouse
1302125Lxw1_mlupus BXSB x NZW 1 (mouse)Not determined4868324042683429Mouse
1302010Wta1_mweight adult 1 (mouse)Not determined4868324042683429Mouse
1558992Ses8_msalmonella enteritidis susceptibility 8 (mouse)Not determined4868324042683429Mouse
1301473Triglq1_mtriglyceride QTL 1 (mouse)Not determined4868324042683429Mouse
4141302Ssrq5_mstress response QTL 5 (mouse)Not determined868324042683430Mouse
10401905Sicd3_mseizure-induced cell death 3 (mouse)Not determined4939552543760862Mouse
10401115Pgia35_mproteoglycan induced arthritis 35 (mouse)Not determined41256237746562509Mouse
12880405Jcdq1_mjoint cartilage degeneration QTL 1 (mouse)41256237746562509Mouse
4142318Lyr2_mlymphoma resistance 2 (mouse)Not determined1401045763365441Mouse
4142047Mvwf3_mmodifier of von Willebrand factor 3 (mouse)Not determined14010457117215009Mouse
1301203Alcp8_malcohol preference locus 8 (mouse)Not determined41739516051395290Mouse
1301237Alcp7_malcohol preference locus 7 (mouse)Not determined41739516051395290Mouse
4141555Nbwa2_mNZB and NZW autoimmunity 2 (mouse)Not determined41789251551892635Mouse
4141911W6q15_mweight 6 weeks QTL 15 (mouse)Not determined1789261689063979Mouse
1357645Lvrq9_mliver weight QTL 9 (mouse)Not determined41789261689063979Mouse
1357453Kidq4_mkidney weight QTL 4 (mouse)Not determined41789261689063979Mouse
39128211Lwq22_mliver weight QTL 22 (mouse)41789261689063979Mouse
25440481Moaq1_mmodifier of alien QTL 1 (mouse)41950000046000000Mouse
1300769Pcyts2_mplasmacytoma susceptibility 2 (mouse)Not determined42211194456112145Mouse
1302058Hrtfm3_mheart failure modifier 3 (mouse)Not determined42211194456112145Mouse
1302075Bdln6_mbody length 6 (mouse)Not determined42237344856373612Mouse
1301437Scon1_msucrose consumption 1 (mouse)Not determined42237344856373612Mouse
1301697Sluc18_msusceptibility to lung cancer 18 (mouse)Not determined42237344856373612Mouse
1302184Aaom1_mautoimmune aoritis in MRL mice 1 (mouse)Not determined42432229946332776Mouse
1300574Im2_mimmunoregulatory 2 (mouse)Not determined42807768262077816Mouse
1301586Stheal3_msoft tissue heal 3 (mouse)Not determined42865844262658566Mouse
1357877Synch1_msynechia 1 (mouse)Not determined42870992562710107Mouse
1301990Arvm1_mautoimmune renal vasculitis 1 (mouse)Not determined42933264663332776Mouse
4142290Ssrq9_mstress response QTL 9 (mouse)Not determined3439516046332776Mouse
1301792Hdlq10_mHDL QTL 10 (mouse)Not determined43585970769859853Mouse
1300977Mopkd1_mmodifier of polycystic kidney disease progression 1 (mouse)Not determined43655083970550967Mouse
26884449Sklq2_mskull length QTL 2, 5 week (mouse)436700000129100000Mouse
1302116Bbaa1_mB.burgdorferi-associated arthritis 1 (mouse)Not determined43825093072251078Mouse
10412178Habiir2_mhyperoxic acute lung injury imprinted region 2 (mouse)Not determined43945212663365441Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:188
Count of miRNA genes:164
Interacting mature miRNAs:177
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.



Reference Sequences
RefSeq Acc Id: ENSMUST00000178864   ⟹   ENSMUSP00000137149
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl442,255,693 - 42,256,825 (+)Ensembl
GRCm38.p6 Ensembl442,255,693 - 42,256,825 (+)Ensembl
RefSeq Acc Id: NM_001378605   ⟹   NP_001365534
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm39442,173,120 - 42,256,825 (+)NCBI
GRCm38442,173,120 - 42,256,825 (+)NCBI
RefSeq Acc Id: NM_011335   ⟹   NP_035465
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm39442,173,120 - 42,256,825 (+)NCBI
GRCm38442,173,120 - 42,256,825 (+)NCBI
MGSCv37441,774,243 - 41,775,337 (+)RGD
RefSeq Acc Id: XM_036163528   ⟹   XP_036019421
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39442,254,584 - 42,256,825 (+)NCBI
RefSeq Acc Id: XM_036163529   ⟹   XP_036019422
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39442,248,301 - 42,256,825 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_035465   ⟸   NM_011335
- Peptide Label: isoform 1 precursor
- UniProtKB: P86793 (UniProtKB/Swiss-Prot),   P86792 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001365534   ⟸   NM_001378605
- Peptide Label: isoform 2
RefSeq Acc Id: ENSMUSP00000137149   ⟸   ENSMUST00000178864
RefSeq Acc Id: XP_036019422   ⟸   XM_036163529
- Peptide Label: isoform X2
RefSeq Acc Id: XP_036019421   ⟸   XM_036163528
- Peptide Label: isoform X1

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1349182 AgrOrtholog
Ensembl Genes ENSMUSG00000073878 UniProtKB/Swiss-Prot
  ENSMUSG00000094065 UniProtKB/Swiss-Prot
  ENSMUSG00000095675 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSG00000096596 UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000095727 UniProtKB/Swiss-Prot
  ENSMUSP00000095732 UniProtKB/Swiss-Prot
  ENSMUSP00000136903 UniProtKB/Swiss-Prot
  ENSMUSP00000137149 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000098123 UniProtKB/Swiss-Prot
  ENSMUST00000098128 UniProtKB/Swiss-Prot
  ENSMUST00000178168 UniProtKB/Swiss-Prot
  ENSMUST00000178864 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro CCL21 UniProtKB/Swiss-Prot
  Chemokine_b/g/d UniProtKB/Swiss-Prot
  Chemokine_IL8-like_dom UniProtKB/Swiss-Prot
  Interleukin_8-like_sf UniProtKB/Swiss-Prot
KEGG Report mmu:100042493 UniProtKB/Swiss-Prot
  mmu:100504239 UniProtKB/Swiss-Prot
  mmu:100504346 UniProtKB/Swiss-Prot
  mmu:100862177 UniProtKB/Swiss-Prot
NCBI Gene 100042493 ENTREZGENE
PANTHER PTHR12015 UniProtKB/Swiss-Prot
  PTHR12015:SF72 UniProtKB/Swiss-Prot
Pfam IL8 UniProtKB/Swiss-Prot
PhenoGen Ccl21b PhenoGen
SMART SCY UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54117 UniProtKB/Swiss-Prot
UniProt CC21B_MOUSE UniProtKB/Swiss-Prot
  CC21C_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary O09002 UniProtKB/Swiss-Prot
  O09006 UniProtKB/Swiss-Prot
  P84443 UniProtKB/Swiss-Prot
  Q5M8M5 UniProtKB/Swiss-Prot
  Q91V84 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-27 Ccl21b  chemokine (C-C motif) ligand 21B (leucine)  Ccl21b  chemokine (C-C motif) ligand 21B  Symbol and/or name change 5135510 APPROVED