Cplane2 (ciliogenesis and planar polarity effector 2) - Rat Genome Database

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Gene: Cplane2 (ciliogenesis and planar polarity effector 2) Mus musculus
Analyze
Symbol: Cplane2
Name: ciliogenesis and planar polarity effector 2
RGD ID: 1618278
MGI Page MGI
Description: Enables GTPase activity. Acts upstream of or within several processes, including axoneme assembly; endocardial cushion fusion; and regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning. Located in centriole and ciliary transition zone. Is active in ciliary base. Used to study VACTERL association and visceral heterotaxy. Orthologous to human CPLANE2 (ciliogenesis and planar polarity effector complex subunit 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 6330545A04Rik; b2b2804C; b2b2804Clo; b2b2827C; b2b2827Clo; Gm723; miro domain-containing protein C1orf89 homolog; REM2 and RAB-like small GTPase 1; REM2- and Rab-like small GTPase 1; RP23-18M1.2; Rs; Rsg1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394140,941,249 - 140,947,425 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4140,941,267 - 140,954,067 (+)EnsemblGRCm39 Ensembl
GRCm384141,213,940 - 141,220,114 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4141,213,956 - 141,226,756 (+)EnsemblGRCm38mm10GRCm38
MGSCv374140,769,871 - 140,776,029 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364140,486,032 - 140,498,832 (+)NCBIMGSCv36mm8
Celera4143,022,021 - 143,028,178 (+)NCBICelera
Cytogenetic Map4D3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:16141072   PMID:16141073   PMID:21677750   PMID:25807483   PMID:29038301  


Genomics

Comparative Map Data
Cplane2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394140,941,249 - 140,947,425 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4140,941,267 - 140,954,067 (+)EnsemblGRCm39 Ensembl
GRCm384141,213,940 - 141,220,114 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4141,213,956 - 141,226,756 (+)EnsemblGRCm38mm10GRCm38
MGSCv374140,769,871 - 140,776,029 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364140,486,032 - 140,498,832 (+)NCBIMGSCv36mm8
Celera4143,022,021 - 143,028,178 (+)NCBICelera
Cytogenetic Map4D3NCBI
CPLANE2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38116,231,692 - 16,237,183 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl116,231,692 - 16,237,183 (-)EnsemblGRCh38hg38GRCh38
GRCh37116,558,187 - 16,563,678 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36116,430,782 - 16,436,033 (-)NCBINCBI36Build 36hg18NCBI36
Celera115,038,074 - 15,043,551 (-)NCBICelera
Cytogenetic Map1p36.13NCBI
HuRef115,075,377 - 15,080,854 (-)NCBIHuRef
CHM1_1116,356,774 - 16,362,251 (-)NCBICHM1_1
T2T-CHM13v2.0115,673,027 - 15,678,517 (-)NCBIT2T-CHM13v2.0
Cplane2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25153,515,507 - 153,516,455 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5153,515,376 - 153,522,508 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5156,204,086 - 156,205,034 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.05157,977,363 - 157,978,311 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.05157,966,550 - 157,967,498 (+)NCBIRnor_WKY
Rnor_6.05159,735,008 - 159,735,956 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5159,734,838 - 159,742,774 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05163,450,671 - 163,451,619 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45160,070,852 - 160,071,800 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera5151,879,790 - 151,880,738 (+)NCBICelera
Cytogenetic Map5q36NCBI
Cplane2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555272,060,063 - 2,064,152 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555272,060,063 - 2,064,152 (+)NCBIChiLan1.0ChiLan1.0
CPLANE2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1116,362,655 - 16,368,063 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl116,362,655 - 16,368,063 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0115,368,318 - 15,373,815 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
CPLANE2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1281,468,095 - 81,473,646 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl281,469,802 - 81,473,947 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha278,003,974 - 78,009,873 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0282,113,892 - 82,119,809 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl282,114,303 - 82,119,797 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1278,866,880 - 78,872,778 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0279,884,128 - 79,890,023 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0280,951,959 - 80,957,861 (+)NCBIUU_Cfam_GSD_1.0
Cplane2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505837,901,089 - 37,905,887 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049364743,725,871 - 3,730,634 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CPLANE2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl675,345,259 - 75,349,943 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1675,345,153 - 75,350,544 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2669,660,313 - 69,665,330 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CPLANE2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120116,067,791 - 116,073,844 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20116,068,092 - 116,076,905 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605419,562,987 - 19,569,045 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cplane2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247642,350,780 - 2,358,495 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247642,350,780 - 2,358,514 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301452Elsgp1_melevated serum gp70 1 (mouse)Not determined4121342649155342753Mouse
1300933Cdcs9_mcytokine deficiency colitis susceptibility 9 (mouse)Not determined4125230872156860686Mouse
1301815Sles2_msystemic lupus erythmatosus suppressor 2 (mouse)Not determined494957579150676858Mouse
1301823Bmd7_mbone mineral density 7 (mouse)Not determined488982069151654550Mouse
1301525Lmb1_mlupus in MRL and B6 F2 cross (mouse)Not determined4124264957150676858Mouse
1301584Lrdg2_mlight induced retinal degeneration 2 (mouse)Not determined4129465811151654550Mouse
1301964Bw8q2_mbody weight at 8 weeks QTL 2 (mouse)Not determined4119864433153864536Mouse
1301982Pltiq1_mphospholipid transfer protein inducibility QTL 1 (mouse)Not determined4124621281156860686Mouse
1302149Tlsr2_mthymic lymphoma suppressor region 2 (mouse)Not determined4124264957142230960Mouse
1302078Sluc21_msusceptibility to lung cancer 21 (mouse)Not determined4117401141151401275Mouse
1302102Bis1_mbeta-carboline-induced seizures 1 (mouse)Not determined4119864433153864536Mouse
4141001Tgq17_mtriglyceride QTL 17 (mouse)Not determined112523489146523489Mouse
4141065Shali2_msurvival time to hyperoxic acute lung injury 2 (mouse)Not determined124055093141572792Mouse
1300780Cocrb16_mcocaine related behavior 16 (mouse)Not determined4138943725156860686Mouse
1300781Lith8_mlithogenic gene 8 (mouse)Not determined4107264957141265153Mouse
1300803Sluc6_msusceptibility to lung cancer 6 (mouse)Not determined4120674005154674151Mouse
1300809Ccrs2_mcorpus callosum hemisphere surface size 2 (mouse)Not determined4107264957141265153Mouse
1300839Dyscalc2_mdystrophic cardiac calcinosis 2 (mouse)Not determined4111009051145009280Mouse
1300858Tafat_mtally ho associated mesenteric fat pad weight (mouse)Not determined4124621281156860686Mouse
1300874Gasa2_mgastritis type A susceptibility locus 2 (mouse)Not determined4133010494156860686Mouse
1300621Tpnr1_mthermal pain response 1 (mouse)Not determined4125230872156860686Mouse
1300537Ap3q_malcohol preference 3 QTL (mouse)Not determined4134654451156860686Mouse
1300553Athsq1_matherosclerosis susceptibility QTL 1 (mouse)Not determined4137617848151654550Mouse
1357534Cinda3_mcytokine induced activation 3 (mouse)Not determined4137617848142289472Mouse
1300663Start2_mstartle response 2 (mouse)Not determined4107264957141265153Mouse
1300743Skull6_mskull morphology 6 (mouse)Not determined4111009051145009280Mouse
1301382Arvm2_mautoimmune renal vasculitis 2 (mouse)Not determined4107791564141791756Mouse
1300917Gasa1_mgastritis type A susceptibility locus 1 (mouse)Not determined4124055093142438020Mouse
1357800Tgq3_mtriglyceride QTL 3 (mouse)Not determined4107055093141055180Mouse
1301108Scon2_msucrose consumption 2 (mouse)Not determined4134654451156860686Mouse
4141180Ssic1_msusceptibility to small intestinal cancer 1 (mouse)Not determined120674005154674151Mouse
4141184Tb2r1_mTGF-beta2 responsiveness 1 (mouse)Not determined137674005150676858Mouse
1301267Bcmd2_mB cell maturation defect 2 (mouse)Not determined4133154678150789451Mouse
4142139Adip12_madiposity 12 (mouse)Not determined4124621281156860686Mouse
10047132Albq19_malbuminuria QTL 19 (mouse)Not determined4112824389146824389Mouse
10043985Stheal12_msoft tissue heal 12 (mouse)Not determined4121342649155342753Mouse
10043996Gct5_mgranulosa cell tumorigenesis 5 (mouse)Not determined4127784226156860686Mouse
10045620Heal22_mwound healing/regeneration 22 (mouse)Not determined4125230872156860686Mouse
10412210Cypr6_mcytokine production 6 (mouse)Not determined4120617848154617995Mouse
4142481Gct1_mgranulosa cell tumorigenesis 1 (mouse)Not determined4127784226156860686Mouse
4142493Femwf13_mfemur work to failure 13 (mouse)Not determined116154678150154782Mouse
4142061Chlq16_mcirculating hormone level QTL 16 (mouse)Not determined4121342649155342753Mouse
4142077Ignpq2_mIgA nephropathy QTL 2 (mouse)Not determined4133676733156860686Mouse
25314312Syncl2_msynaptonemal complex length 2 (mouse)465718237146584457Mouse
13503348Bntq18_mbone traits QTL 18 (mouse)4120617848154617995Mouse
10755521Hct1_mhematocrit 1 (mouse)4108477692142477692Mouse
13208562Wght7_mweight 7 (mouse)490888237148084457Mouse
10755520Rbc1_mred blood cell count 1 (mouse)4108477692142477692Mouse
12910797Pwgrq4_mpre-weaning growth rate QTL 4 (mouse)4105835310141433838Mouse
14746982Manh56_mmandible shape 56 (mouse)4117815917151815917Mouse
11533916Mts1_mmammary tumor susceptibility 1 (mouse)4125289325156860686Mouse
12910794Pwbwq8_mpost-weaning body weight QTL 8 (mouse)4105835310141433838Mouse
10755531Lymph3_mlymphocyte differential 3 (mouse)4124553483156860686Mouse
10755522Hgb1_mhemoglobin 1 (mouse)4108477692142477692Mouse
27226757Femd1_mfemur midshaft diameter 1, 5 week (mouse)4123993793144326570Mouse
15039385Mvlq3_mmacrovesicular liver lesion QTL 3 (mouse)4112182386146182386Mouse
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156268235Mouse
12910808Pwbwq9_mpost-weaning body weight QTL 9 (mouse)4105835310141433838Mouse
12910813Pwbwq4_mpre-weaning body weight QTL 4 (mouse)4105835310141433838Mouse
26884445Sklq7_mskull length QTL 7, 10 week (mouse)468018237150884457Mouse
26884437Sklq13_mskull length QTL 13, 16 week (mouse)457700000155684457Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:469
Count of miRNA genes:342
Interacting mature miRNAs:376
Transcripts:ENSMUST00000097813, ENSMUST00000125175, ENSMUST00000151475
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000097813   ⟹   ENSMUSP00000095422
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4140,941,267 - 140,947,459 (+)Ensembl
GRCm38.p6 Ensembl4141,213,956 - 141,220,148 (+)Ensembl
RefSeq Acc Id: ENSMUST00000125175
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4140,941,756 - 140,945,985 (+)Ensembl
GRCm38.p6 Ensembl4141,214,445 - 141,218,674 (+)Ensembl
RefSeq Acc Id: ENSMUST00000151475
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4140,945,957 - 140,954,067 (+)Ensembl
GRCm38.p6 Ensembl4141,218,646 - 141,226,756 (+)Ensembl
RefSeq Acc Id: NM_001081174   ⟹   NP_001074643
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394140,941,267 - 140,947,425 (+)NCBI
GRCm384141,213,956 - 141,220,114 (+)NCBI
MGSCv374140,769,871 - 140,776,029 (+)RGD
Celera4143,022,021 - 143,028,178 (+)RGD
cM Map4 ENTREZGENE
Sequence:
RefSeq Acc Id: XR_003955035
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394140,941,249 - 140,947,313 (+)NCBI
GRCm384141,213,940 - 141,220,002 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001074643 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein A2A825 (Get FASTA)   NCBI Sequence Viewer  
  AAI47766 (Get FASTA)   NCBI Sequence Viewer  
  AAI47768 (Get FASTA)   NCBI Sequence Viewer  
  EDL13352 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001074643   ⟸   NM_001081174
- UniProtKB: A2A825 (UniProtKB/Swiss-Prot),   B2RWG6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000095422   ⟸   ENSMUST00000097813

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A2A825-F1-model_v2 AlphaFold A2A825 1-258 view protein structure

Promoters
RGD ID:6834723
Promoter ID:MM_KWN:40462
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Liver,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000097813,   ENSMUST00000105793,   OTTMUST00000023581
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364140,768,926 - 140,770,072 (+)MPROMDB
RGD ID:6885306
Promoter ID:EPDNEW_M6099
Type:multiple initiation site
Name:Rsg1_1
Description:Mus musculus REM2 and RAB-like small GTPase 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm384141,213,965 - 141,214,025EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1923416 AgrOrtholog
Ensembl Genes ENSMUSG00000073733 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000095422 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000097813 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RSG1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:76166 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1923416 ENTREZGENE
NCBI Gene 76166 ENTREZGENE
PANTHER PTHR14983 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ras UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cplane2 PhenoGen
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A2A825 ENTREZGENE
  B2RWG6 ENTREZGENE, UniProtKB/TrEMBL
  CPLN2_MOUSE UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-02-26 Cplane2  ciliogenesis and planar polarity effector 2  Rsg1  REM2 and RAB-like small GTPase 1  Symbol and/or name change 5135510 APPROVED
2012-09-19 Rsg1  REM2 and RAB-like small GTPase 1  6330545A04Rik  RIKEN cDNA 6330545A04 gene  Symbol and/or name change 5135510 APPROVED