Epsti1 (epithelial stromal interaction 1) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Epsti1 (epithelial stromal interaction 1) Mus musculus
Analyze
Symbol: Epsti1
Name: epithelial stromal interaction 1 (Ensembl:epithelial stromal interaction 1 (breast))
RGD ID: 1618236
MGI Page MGI
Description: Is expressed in central nervous system; retina; retina inner nuclear layer; and retina outer nuclear layer. Orthologous to human EPSTI1 (epithelial stromal interaction 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2310046K10Rik; 5033415K03Rik; BRE; BRESI1; epithelial stromal interaction 1 (breast); epithelial-stromal interaction protein 1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391478,141,679 - 78,240,096 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1478,141,679 - 78,240,097 (+)EnsemblGRCm39 Ensembl
GRCm381477,904,239 - 78,002,656 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1477,904,239 - 78,002,657 (+)EnsemblGRCm38mm10GRCm38
MGSCv371478,304,046 - 78,402,463 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361476,638,546 - 76,736,808 (+)NCBIMGSCv36mm8
Celera1475,422,555 - 75,520,932 (+)NCBICelera
Cytogenetic Map14D3NCBI
cM Map1441.08NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4-hydroxynon-2-enal  (EXP)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
chloroprene  (EXP)
choline  (EXP)
chromium(6+)  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
Cuprizon  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP)
diarsenic trioxide  (ISO)
dinophysistoxin 1  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
ethyl methanesulfonate  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
fructose  (EXP)
furan  (ISO)
gentamycin  (ISO)
glucose  (EXP)
glyphosate  (EXP)
hydrogen peroxide  (ISO)
L-methionine  (EXP)
lidocaine  (ISO)
lipopolysaccharide  (ISO)
mercury dibromide  (ISO)
methoxychlor  (ISO)
methylmercury chloride  (ISO)
nickel atom  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP)
potassium chromate  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenite  (ISO)
Soman  (ISO)
succimer  (EXP)
sunitinib  (ISO)
tamoxifen  (EXP)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
zidovudine  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:14610273   PMID:15226823   PMID:16141072   PMID:16141073   PMID:16934000   PMID:21677750  
PMID:29217193   PMID:32554809   PMID:35778487  


Genomics

Comparative Map Data
Epsti1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391478,141,679 - 78,240,096 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1478,141,679 - 78,240,097 (+)EnsemblGRCm39 Ensembl
GRCm381477,904,239 - 78,002,656 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1477,904,239 - 78,002,657 (+)EnsemblGRCm38mm10GRCm38
MGSCv371478,304,046 - 78,402,463 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361476,638,546 - 76,736,808 (+)NCBIMGSCv36mm8
Celera1475,422,555 - 75,520,932 (+)NCBICelera
Cytogenetic Map14D3NCBI
cM Map1441.08NCBI
EPSTI1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381342,886,388 - 42,992,241 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1342,886,388 - 42,992,271 (-)EnsemblGRCh38hg38GRCh38
GRCh371343,460,524 - 43,566,377 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361342,360,122 - 42,464,377 (-)NCBINCBI36Build 36hg18NCBI36
Build 341342,360,121 - 42,464,377NCBI
Celera1324,519,978 - 24,622,563 (-)NCBICelera
Cytogenetic Map13q14.11NCBI
HuRef1324,264,416 - 24,368,626 (-)NCBIHuRef
CHM1_11343,428,059 - 43,533,952 (-)NCBICHM1_1
T2T-CHM13v2.01342,106,432 - 42,210,657 (-)NCBIT2T-CHM13v2.0
Epsti1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81559,692,712 - 59,791,376 (+)NCBIGRCr8
mRatBN7.21553,283,964 - 53,382,192 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1553,284,216 - 53,382,191 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1557,417,604 - 57,515,564 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01558,535,948 - 58,633,920 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01555,360,511 - 55,458,802 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01560,084,966 - 60,190,360 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1560,084,918 - 60,190,363 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01563,762,909 - 63,865,564 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41558,989,876 - 59,088,931 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1552,880,729 - 52,978,481 (+)NCBICelera
Cytogenetic Map15q11NCBI
Epsti1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955518788,961 - 919,784 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955518790,815 - 919,869 (-)NCBIChiLan1.0ChiLan1.0
EPSTI1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21442,373,947 - 42,477,696 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11333,477,595 - 33,581,105 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01324,058,760 - 24,162,261 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
EPSTI1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1227,862,068 - 7,956,077 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl227,862,175 - 8,108,299 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha227,854,631 - 7,948,531 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0228,067,355 - 8,161,200 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl228,067,370 - 8,319,214 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1227,772,478 - 7,866,431 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0227,829,444 - 7,923,799 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0227,839,883 - 7,933,794 (+)NCBIUU_Cfam_GSD_1.0
Epsti1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945153,084,595 - 153,173,543 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936747900,889 - 989,590 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EPSTI1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1124,116,986 - 24,216,215 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11124,116,991 - 24,216,219 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21124,760,267 - 24,865,232 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EPSTI1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1320,955,649 - 21,128,997 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl321,022,117 - 21,128,503 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605723,064,565 - 23,239,629 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Epsti1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474812,162,314 - 12,269,031 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474812,162,530 - 12,266,381 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Epsti1
3107 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:395
Count of miRNA genes:302
Interacting mature miRNAs:328
Transcripts:ENSMUST00000022591, ENSMUST00000169978
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300605El5_mepilepsy 5 (mouse)Not determined144945542583455556Mouse
1300551Lprm3_mlymphoproliferation modifier 3 (mouse)Not determined1471221224105221344Mouse
1300666Fembm2_mfemoral bone morphometry 2 (mouse)Not determined146239746096397680Mouse
1301489Lbm10_mlean body mass 10 (mouse)Not determined145376129687761529Mouse
1301844Pgia29_mproteoglycan induced arthritis 29 (mouse)Not determined1474352296108352384Mouse
1301562Hwq1_mheart weight quantitative locus 1 (mouse)Not determined145654674590546941Mouse
1357589Kdnw2_mkidney weight 2 (mouse)Not determined1420887473121269804Mouse
1357565wrmod1_mwobbler modifier 1 (mouse)Not determined1458179640101859473Mouse
1558819Ossc2_mosteosarcoma susceptibility 2 (mouse)Not determined1474394976108395093Mouse
1558823Tbbmd6_mtotal body bone mineral density 6 (mouse)Not determined1477073696111073787Mouse
4142364Pbwg18_mpostnatal body weight growth 18 (mouse)Not determined145228198486282125Mouse
10043889Cia52_mcollagen induced arthritis QTL 52 (mouse)Not determined145608238190082509Mouse
11039527Ccc2_mcolitis susceptibility in the Collaborative Cross 2 (mouse)145991861294138217Mouse
10054475Ossc3_mosteosarcoma susceptibility 3 (mouse)Not determined1470863768104863926Mouse
12880432Fgf23lq3_mFGF23 serum level QTL 3 (mouse)145393744087937440Mouse
27226774Tibl15_mtibia length 15, 10 week (mouse)143032195787937436Mouse
14928314Manh77_mmandible shape 77 (mouse)1476767790110767790Mouse
14747006Mancz12_mmandible centroid size 12 (mouse)1470071977104071977Mouse

Markers in Region
D14Mit242  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381477,923,492 - 77,923,613UniSTSGRCm38
MGSCv371478,323,299 - 78,323,420UniSTSGRCm37
Celera1475,441,774 - 75,441,893UniSTS
Cytogenetic Map14D3UniSTS
cM Map1444.4UniSTS
Whitehead Genetic1452.5UniSTS
Whitehead_YAC14 UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_029495 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_178825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC125130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC136019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI592213 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK017174 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK030289 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK077223 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK077376 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK135710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK136055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY239223 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY239224 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC020120 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC021821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE628578 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY719992 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466535 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000022591   ⟹   ENSMUSP00000022591
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1478,141,679 - 78,240,097 (+)Ensembl
GRCm38.p6 Ensembl1477,904,239 - 78,002,657 (+)Ensembl
RefSeq Acc Id: ENSMUST00000169978   ⟹   ENSMUSP00000130138
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1478,141,847 - 78,201,614 (+)Ensembl
GRCm38.p6 Ensembl1477,904,407 - 77,964,174 (+)Ensembl
RefSeq Acc Id: ENSMUST00000227903   ⟹   ENSMUSP00000154502
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1478,141,847 - 78,201,616 (+)Ensembl
GRCm38.p6 Ensembl1477,904,407 - 77,964,176 (+)Ensembl
RefSeq Acc Id: NM_029495   ⟹   NP_083771
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391478,141,679 - 78,240,096 (+)NCBI
GRCm381477,904,239 - 78,002,656 (+)ENTREZGENE
MGSCv371478,304,046 - 78,402,463 (+)RGD
Celera1475,422,555 - 75,520,932 (+)RGD
cM Map14 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_178825   ⟹   NP_849147
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391478,141,679 - 78,201,618 (+)NCBI
GRCm381477,904,239 - 77,964,178 (+)NCBI
MGSCv371478,304,046 - 78,402,463 (+)RGD
Celera1475,422,555 - 75,520,932 (+)RGD
cM Map14 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_083771   ⟸   NM_029495
- Peptide Label: isoform a
- UniProtKB: Q8VDW6 (UniProtKB/Swiss-Prot),   Q80WK5 (UniProtKB/Swiss-Prot),   Q8VDI1 (UniProtKB/Swiss-Prot),   A0A140T8I6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_849147   ⟸   NM_178825
- Peptide Label: isoform b
- UniProtKB: Q9D3Q7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000022591   ⟸   ENSMUST00000022591
RefSeq Acc Id: ENSMUSP00000154502   ⟸   ENSMUST00000227903
RefSeq Acc Id: ENSMUSP00000130138   ⟸   ENSMUST00000169978

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8VDI1-F1-model_v2 AlphaFold Q8VDI1 1-314 view protein structure

Promoters
RGD ID:8683046
Promoter ID:EPDNEW_M19554
Type:initiation region
Name:Epsti1_1
Description:Mus musculus epithelial stromal interaction 1 , transcript varianta, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381477,904,406 - 77,904,466EPDNEW
RGD ID:6824902
Promoter ID:MM_KWN:17526
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Spleen
Transcripts:ENSMUST00000022591,   NM_029495,   UC007USD.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361478,304,039 - 78,304,539 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1915168 AgrOrtholog
Ensembl Genes ENSMUSG00000022014 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000022591 ENTREZGENE
  ENSMUST00000022591.16 UniProtKB/TrEMBL
  ENSMUST00000169978.2 UniProtKB/TrEMBL
  ENSMUST00000227903 ENTREZGENE
  ENSMUST00000227903.2 UniProtKB/Swiss-Prot
InterPro EPSTI1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:108670 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1915168 ENTREZGENE
NCBI Gene 108670 ENTREZGENE
PANTHER EPITHELIAL-STROMAL INTERACTION PROTEIN 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR22529 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Epsti1 PhenoGen
UniProt A0A140T8I6 ENTREZGENE, UniProtKB/TrEMBL
  ESIP1_MOUSE UniProtKB/Swiss-Prot
  Q80WK5 ENTREZGENE
  Q8VDI1 ENTREZGENE
  Q8VDW6 ENTREZGENE
  Q9D3Q7 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q80WK5 UniProtKB/Swiss-Prot
  Q8VDW6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-07-04 Epsti1  epithelial stromal interaction 1  Epsti1  epithelial stromal interaction 1 (breast)  Symbol and/or name change 5135510 APPROVED