Shisa2 (shisa family member 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Shisa2 (shisa family member 2) Mus musculus
Analyze
Symbol: Shisa2
Name: shisa family member 2
RGD ID: 1618173
MGI Page MGI
Description: Acts upstream of or within negative regulation of Wnt signaling pathway and negative regulation of fibroblast growth factor receptor signaling pathway. Located in endoplasmic reticulum. Is expressed in several structures, including embryo ectoderm; embryo mesenchyme; gut; primitive endoderm; and sensory organ. Orthologous to human SHISA2 (shisa family member 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 9430059P22Rik; MAd; MAd2; mS; mShisa; protein shisa-2 homolog; s; shisa; shisa homolog 2; shisa-like protein 2; Tmem46; transmembrane protein 46
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391459,862,730 - 59,869,109 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1459,862,757 - 59,869,109 (+)EnsemblGRCm39 Ensembl
GRCm381459,625,281 - 59,631,660 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1459,625,308 - 59,631,660 (+)EnsemblGRCm38mm10GRCm38
MGSCv371460,244,118 - 60,250,497 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361458,579,418 - 58,585,765 (+)NCBIMGSCv36mm8
Celera1457,427,718 - 57,434,097 (+)NCBICelera
Cytogenetic Map14C3NCBI
cM Map1431.49NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2-palmitoylglycerol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
5-aza-2'-deoxycytidine  (ISO)
acrylamide  (EXP)
all-trans-retinoic acid  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
carbamazepine  (ISO)
carbon nanotube  (EXP,ISO)
chloroethene  (EXP)
chloroprene  (EXP)
chlorpyrifos  (EXP)
choline  (EXP)
chrysene  (EXP)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumestrol  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dioxygen  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
folic acid  (EXP)
hydralazine  (ISO)
indole-3-methanol  (ISO)
iron dichloride  (ISO)
L-methionine  (EXP)
manganese(II) chloride  (ISO)
methamphetamine  (ISO)
methylmercury chloride  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
ochratoxin A  (ISO)
ozone  (EXP)
panobinostat  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
phenylmercury acetate  (ISO)
potassium chromate  (ISO)
progesterone  (EXP)
raloxifene  (ISO)
SB 431542  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
tamoxifen  (EXP)
temozolomide  (ISO)
tetrachloromethane  (EXP)
tetraphene  (EXP)
thapsigargin  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triptonide  (EXP)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Mouse MP Annotation Import Pipeline RGD automated import pipeline
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:15489334   PMID:16141072   PMID:16141073   PMID:16773659   PMID:17481602   PMID:20562862  
PMID:21267068   PMID:21553379   PMID:21873635   PMID:23364326   PMID:25082703   PMID:26494787   PMID:28885142   PMID:30007221   PMID:30478225   PMID:31776260   PMID:33298461   PMID:34108685  
PMID:35103284   PMID:35175194   PMID:35905011   PMID:37321213  


Genomics

Comparative Map Data
Shisa2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391459,862,730 - 59,869,109 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1459,862,757 - 59,869,109 (+)EnsemblGRCm39 Ensembl
GRCm381459,625,281 - 59,631,660 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1459,625,308 - 59,631,660 (+)EnsemblGRCm38mm10GRCm38
MGSCv371460,244,118 - 60,250,497 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361458,579,418 - 58,585,765 (+)NCBIMGSCv36mm8
Celera1457,427,718 - 57,434,097 (+)NCBICelera
Cytogenetic Map14C3NCBI
cM Map1431.49NCBI
SHISA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381326,044,597 - 26,052,016 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1326,044,597 - 26,052,016 (-)EnsemblGRCh38hg38GRCh38
GRCh371326,618,735 - 26,626,154 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361325,516,735 - 25,523,198 (-)NCBINCBI36Build 36hg18NCBI36
Celera137,686,949 - 7,693,412 (-)NCBICelera
Cytogenetic Map13q12.13NCBI
HuRef137,436,767 - 7,443,244 (-)NCBIHuRef
CHM1_11326,586,869 - 26,593,340 (-)NCBICHM1_1
T2T-CHM13v2.01325,258,479 - 25,265,905 (-)NCBIT2T-CHM13v2.0
Shisa2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81537,982,913 - 37,987,211 (+)NCBIGRCr8
mRatBN7.21533,806,715 - 33,811,013 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1533,805,958 - 33,811,013 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1535,666,380 - 35,670,677 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01536,817,057 - 36,821,354 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01535,267,861 - 35,272,159 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01539,945,095 - 39,949,393 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1539,945,095 - 39,949,393 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01543,763,011 - 43,767,309 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41538,740,511 - 38,744,809 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1533,515,522 - 33,519,820 (+)NCBICelera
Cytogenetic Map15p12NCBI
Shisa2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554975,433,050 - 5,459,680 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554975,453,682 - 5,459,680 (-)NCBIChiLan1.0ChiLan1.0
SHISA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21425,644,213 - 25,650,807 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11316,752,327 - 16,758,929 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0137,337,763 - 7,345,166 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11325,687,174 - 25,693,594 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1325,687,174 - 25,693,594 (-)Ensemblpanpan1.1panPan2
SHISA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha2513,542,704 - 13,549,314 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02513,608,738 - 13,614,776 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2513,608,738 - 13,614,062 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12513,491,729 - 13,497,758 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02513,487,731 - 13,493,761 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02513,535,502 - 13,541,553 (+)NCBIUU_Cfam_GSD_1.0
Shisa2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945115,666,071 - 115,672,773 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936688278,789 - 285,153 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936688278,789 - 285,129 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SHISA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl113,806,302 - 3,812,170 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1113,806,297 - 3,812,170 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2113,039,207 - 3,044,963 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SHISA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.135,391,982 - 5,397,028 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl35,392,461 - 5,396,931 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605739,029,376 - 39,035,890 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Shisa2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477612,461,903 - 12,468,508 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477612,462,553 - 12,469,593 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Shisa2
210 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:380
Count of miRNA genes:311
Interacting mature miRNAs:329
Transcripts:ENSMUST00000053949
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357589Kdnw2_mkidney weight 2 (mouse)Not determined1420887473121269804Mouse
1357527Epfpq1_mepididymal fat percentage QTL 1 (mouse)Not determined142106245071885801Mouse
13506929Recrq10_mrecombination rate in male meiosis QTL 10 (mouse)142792195761137449Mouse
10043886Cia49_mcollagen induced arthritis QTL 49 (mouse)Not determined142999699463997133Mouse
27226774Tibl15_mtibia length 15, 10 week (mouse)143032195787937436Mouse
1300909Ath13_matherosclerosis 13 (mouse)Not determined143033525064335381Mouse
1300998Cia17_mcollagen induced arthritis 17 (mouse)Not determined143033525064335381Mouse
1300625Cosz2_mcocaine seizure 2 (mouse)Not determined143504579768785736Mouse
10043887Cia50_mcollagen induced arthritis QTL 50 (mouse)Not determined143743018571430320Mouse
4142419Tgq26_mtriglyceride QTL 26 (mouse)Not determined4033731974337319Mouse
1301777Bglq15_mbody growth late QTL 15 (mouse)Not determined144296241676962593Mouse
1301424Skull21_mskull morphology 21 (mouse)Not determined144296241676962593Mouse
1300805Mors3_mmodifier of obesity related sterility 3 (mouse)Not determined144303727077037418Mouse
1301091Bbaa21_mB.burgdorferi-associated arthritis 21 (mouse)Not determined144306584777066045Mouse
4141400Nilac8_mnicotine induced locomotor activity 8 (mouse)Not determined144306584777066045Mouse
4141484Hcbip1_mhexachlorobenzene induced porphyria 1 (mouse)Not determined4733525059962593Mouse
1300605El5_mepilepsy 5 (mouse)Not determined144945542583455556Mouse
4142364Pbwg18_mpostnatal body weight growth 18 (mouse)Not determined145228198486282125Mouse
1301489Lbm10_mlean body mass 10 (mouse)Not determined145376129687761529Mouse
12880432Fgf23lq3_mFGF23 serum level QTL 3 (mouse)145393744087937440Mouse
10043889Cia52_mcollagen induced arthritis QTL 52 (mouse)Not determined145608238190082509Mouse
1301562Hwq1_mheart weight quantitative locus 1 (mouse)Not determined145654674590546941Mouse
1357565wrmod1_mwobbler modifier 1 (mouse)Not determined1458179640101859473Mouse

Markers in Region
Shisa2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381459,630,113 - 59,630,361UniSTSGRCm38
MGSCv371460,248,950 - 60,249,198UniSTSGRCm37
Celera1457,432,550 - 57,432,798UniSTS
Cytogenetic Map14D1UniSTS
cM Map14 UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000053949   ⟹   ENSMUSP00000059391
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1459,862,757 - 59,869,109 (+)Ensembl
GRCm38.p6 Ensembl1459,625,308 - 59,631,660 (+)Ensembl
RefSeq Acc Id: ENSMUST00000224155
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1459,864,638 - 59,867,126 (+)Ensembl
GRCm38.p6 Ensembl1459,627,189 - 59,629,677 (+)Ensembl
RefSeq Acc Id: NM_145463   ⟹   NP_663438
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391459,862,730 - 59,869,109 (+)NCBI
GRCm381459,625,281 - 59,631,660 (+)ENTREZGENE
MGSCv371460,244,118 - 60,250,497 (+)RGD
Celera1457,427,718 - 57,434,097 (+)RGD
cM Map14 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_663438   ⟸   NM_145463
- Peptide Label: precursor
- UniProtKB: Q0NZZ5 (UniProtKB/Swiss-Prot),   Q8BN61 (UniProtKB/Swiss-Prot),   Q8QZV2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000059391   ⟸   ENSMUST00000053949

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8QZV2-F1-model_v2 AlphaFold Q8QZV2 1-295 view protein structure

Promoters
RGD ID:8682606
Promoter ID:EPDNEW_M19333
Type:multiple initiation site
Name:Shisa2_1
Description:Mus musculus shisa family member 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381459,625,312 - 59,625,372EPDNEW
RGD ID:6825417
Promoter ID:MM_KWN:17097
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   ES_Cell,   Lung,   Spleen
Transcripts:NM_145463_SHISA2
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361460,244,156 - 60,244,677 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2444716 AgrOrtholog
Ensembl Genes ENSMUSG00000044461 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000053949 ENTREZGENE
  ENSMUST00000053949.7 UniProtKB/Swiss-Prot
InterPro Shisa UniProtKB/Swiss-Prot
KEGG Report mmu:219134 UniProtKB/Swiss-Prot
MGD MGI:2444716 ENTREZGENE
NCBI Gene 219134 ENTREZGENE
PANTHER PROTEIN SHISA-2 HOMOLOG UniProtKB/Swiss-Prot
  PTHR31395 UniProtKB/Swiss-Prot
Pfam Shisa UniProtKB/Swiss-Prot
PhenoGen Shisa2 PhenoGen
UniProt Q0NZZ5 ENTREZGENE
  Q8BN61 ENTREZGENE
  Q8QZV2 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q0NZZ5 UniProtKB/Swiss-Prot
  Q8BN61 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-10-21 Shisa2  shisa family member 2    shisa homolog 2 (Xenopus laevis)  Symbol and/or name change 5135510 APPROVED