Cplx4 (complexin 4) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Cplx4 (complexin 4) Mus musculus
Analyze
Symbol: Cplx4
Name: complexin 4
RGD ID: 1618169
MGI Page MGI
Description: Enables SNARE binding activity. Acts upstream of or within regulation of neurotransmitter secretion. Located in synapse. Is expressed in retina outer nuclear layer. Orthologous to human CPLX4 (complexin 4).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: A930004D23Rik; complexin IV; complexin-4; CPX IV; CPXIV; Gm957
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391866,088,793 - 66,103,249 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1866,088,793 - 66,103,308 (-)EnsemblGRCm39 Ensembl
GRCm381865,955,722 - 65,970,178 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1865,955,722 - 65,970,237 (-)EnsemblGRCm38mm10GRCm38
MGSCv371866,115,376 - 66,129,832 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361866,081,091 - 66,095,547 (-)NCBIMGSCv36mm8
Celera1867,231,480 - 67,246,133 (-)NCBICelera
Cytogenetic Map18E1NCBI
cM Map1839.05NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:15226823   PMID:15489334   PMID:15911881   PMID:16000319   PMID:16141072   PMID:16141073  
PMID:19386896   PMID:19553439   PMID:20809954   PMID:21677750   PMID:21873635   PMID:22694764   PMID:25692331   PMID:27335398  


Genomics

Comparative Map Data
Cplx4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391866,088,793 - 66,103,249 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1866,088,793 - 66,103,308 (-)EnsemblGRCm39 Ensembl
GRCm381865,955,722 - 65,970,178 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1865,955,722 - 65,970,237 (-)EnsemblGRCm38mm10GRCm38
MGSCv371866,115,376 - 66,129,832 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361866,081,091 - 66,095,547 (-)NCBIMGSCv36mm8
Celera1867,231,480 - 67,246,133 (-)NCBICelera
Cytogenetic Map18E1NCBI
cM Map1839.05NCBI
CPLX4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381859,295,402 - 59,318,649 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1859,275,156 - 59,318,649 (-)EnsemblGRCh38hg38GRCh38
GRCh371856,962,634 - 56,985,881 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361855,113,634 - 55,136,861 (-)NCBINCBI36Build 36hg18NCBI36
Build 341855,113,633 - 55,136,861NCBI
Celera1853,680,459 - 53,703,698 (-)NCBICelera
Cytogenetic Map18q21.32NCBI
HuRef1853,671,733 - 53,694,958 (-)NCBIHuRef
CHM1_11856,957,885 - 56,981,131 (-)NCBICHM1_1
T2T-CHM13v2.01859,496,922 - 59,520,136 (-)NCBIT2T-CHM13v2.0
Cplx4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81861,751,336 - 61,774,669 (-)NCBIGRCr8
mRatBN7.21859,481,360 - 59,504,716 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1859,481,986 - 59,497,778 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1861,575,835 - 61,591,591 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01862,274,518 - 62,290,277 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01860,102,422 - 60,118,153 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01861,657,216 - 61,672,641 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1861,656,758 - 61,672,663 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01860,853,137 - 60,868,237 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41862,536,597 - 62,552,045 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11862,596,573 - 62,625,246 (+)NCBI
Celera1857,603,426 - 57,618,765 (-)NCBICelera
Cytogenetic Map18q12.1NCBI
Cplx4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540243,434,238 - 43,455,860 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540243,435,939 - 43,455,704 (-)NCBIChiLan1.0ChiLan1.0
CPLX4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21776,841,468 - 76,864,177 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11862,535,428 - 62,556,791 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01852,691,095 - 52,713,697 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11856,017,614 - 56,040,108 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1855,998,958 - 56,040,108 (-)Ensemblpanpan1.1panPan2
CPLX4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1116,900,078 - 16,922,914 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl116,900,826 - 16,922,140 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha117,875,766 - 17,898,049 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0116,777,368 - 16,799,659 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl116,778,048 - 16,798,885 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1116,813,009 - 16,835,276 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0116,734,296 - 16,756,037 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0116,995,255 - 17,017,558 (+)NCBIUU_Cfam_GSD_1.0
Cplx4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494430,176,497 - 30,196,224 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364975,415,354 - 5,440,072 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364975,415,525 - 5,435,259 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CPLX4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1161,634,735 - 161,675,730 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11161,632,403 - 161,663,161 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21179,211,481 - 179,240,574 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CPLX4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11820,409,634 - 20,443,586 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1820,419,154 - 20,442,284 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660605,125,948 - 5,171,418 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cplx4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247924,691,133 - 4,722,782 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247924,691,133 - 4,722,782 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cplx4
629 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:390
Count of miRNA genes:279
Interacting mature miRNAs:317
Transcripts:ENSMUST00000025397
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357603Mom3_mmodifier of Min 3 (mouse)Not determined181403002367098962Mouse
25823173Hrsq12_mhost response to SARS QTL 12, hemorrhage (mouse)182489588178339555Mouse
1357690Vtbt19_mvertebral trabecular bone trait 19 (mouse)Not determined183309104367091221Mouse
1301771Pcyts6_mplasmacytoma susceptibility 6 (mouse)Not determined183565863269658851Mouse
4142366Chlq10_mcirculating hormone level QTL 10 (mouse)Not determined183629102270291180Mouse
15039381Ltgq8_mliver triglyceride QTL 8 (mouse)183820656972206569Mouse
15039383Mvlq5_mmicrovesicular liver lesion QTL 5 (mouse)183820656972206569Mouse
15039384Liviq1_mliver inflammation QTL 1 (mouse)183820656972206569Mouse
15039386Mvlq4_mmacrovesicular liver lesion QTL 4 (mouse)183820656972206569Mouse
12050070Nabq2_mnasal bone morphology QTL 2 (mouse)183910367773103793Mouse
1357639Obsty4_mobesity 4 (mouse)Not determined183961991484638778Mouse
1301902Hrtfm4_mheart failure modifier 4 (mouse)Not determined184331112077311343Mouse
1301215Thcr_mT helper cell response (mouse)Not determined184513060468778777Mouse
12904745Carcdq2_mcardiac collagen deposition QTL 2 (mouse)184642328780423287Mouse
11039493Ltpr8d_mLeishmania tropica response 8d (mouse)184687490380875042Mouse
11039494Ltpr8b_mLeishmania tropica response 8b (mouse)184687490380875042Mouse
1357630Tgq1_mtriglyceride QTL 1 (mouse)Not determined185105215685052311Mouse
11252137Modvl5_mmodifier of vacuolated lens 5 (mouse)185105215685052311Mouse
10412244Par5_mpulmonary adenoma resistance 5 (mouse)Not determined185166830085668468Mouse
1302099Hdlq30_mHDL QTL 30 (mouse)Not determined185166830085668468Mouse
1301853Heal9_mwound healing/regeneration 9 (mouse)Not determined185280527686805416Mouse
1302050Radpf4_mradiation pulmonary fibrosis 4 (mouse)Not determined185296615668778777Mouse
4142443Pgis1_mproteoglycan induced spondylitis 1 (mouse)Not determined185329102276914293Mouse
1301500Szs4_mseizure susceptibility 4 (mouse)Not determined185497587385514143Mouse
12880410V125Dq13_mvitamin D active form serum level QTL 13 (mouse)185643307190433071Mouse
12880430Fgf23lq4_mFGF23 serum level QTL 4 (mouse)185643307190433071Mouse
10412183Sstapa2_mSuseptibility to Staphylococus aureus infection 2 (mouse)Not determined185679463066952485Mouse
12880428V125Dq14_mvitamin D active form serum level QTL 14 (mouse)185743307190720763Mouse
1301353Lbw6_mlupus NZB x NZW 6 (mouse)Not determined185756233890720763Mouse
4141132Eae18_mexperimental allergic encephalomyelitis susceptibility 18 (mouse)Not determined5759055982604728Mouse
4140971Mbmq1_mmale body mass QTL 1 (mouse)Not determined5799028190720763Mouse
12910791Pwgrq8_mpre-weaning growth rate QTL 8 (mouse)185802139969349142Mouse
11049564Lmr29_mleishmaniasis resistance 29 (mouse)185918009290720763Mouse
11039495Ltpr8c_mLeishmania tropica response 8c (mouse)185918009290720763Mouse
11039492Ltpr8a_mLeishmania tropica response 8a (mouse)185918009290720763Mouse
1301103Pgia11_mproteoglycan induced arthritis 11 (mouse)Not determined185991418490720763Mouse
1302109Sluc28_msusceptibility to lung cancer 28 (mouse)Not determined185993532190720763Mouse
38455998Cdtm1_mCD62L+ CD8 TM cells 1 (mouse)186013307280043215Mouse
4142239Idd21.2_minsulin dependent diabetes susceptibility 21.2 (mouse)Not determined186127244874562414Mouse
1558803W3q16_mweight 3 weeks QTL 16 (mouse)Not determined186127244881491831Mouse
1558782Orgwq9_morgan weight QTL 9 (mouse)Not determined186127244882604728Mouse
11039518Ltpr8_mLeishmania tropica response 8 (mouse)186387490376180241Mouse
13824986Flal2_mfatty liver accumulation QTL 2, females only (mouse)186413307166133071Mouse

Markers in Region
RH139312  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381865,965,173 - 65,965,400UniSTSGRCm38
MGSCv371866,124,827 - 66,125,054UniSTSGRCm37
Celera1867,241,120 - 67,241,352UniSTS
Cytogenetic Map18E1UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000025397   ⟹   ENSMUSP00000025397
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1866,088,793 - 66,103,308 (-)Ensembl
GRCm38.p6 Ensembl1865,955,722 - 65,970,237 (-)Ensembl
RefSeq Acc Id: ENSMUST00000236894
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1866,089,844 - 66,100,753 (-)Ensembl
GRCm38.p6 Ensembl1865,956,773 - 65,967,682 (-)Ensembl
RefSeq Acc Id: NM_145493   ⟹   NP_663468
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391866,088,793 - 66,103,249 (-)NCBI
GRCm381865,955,722 - 65,970,178 (-)ENTREZGENE
MGSCv371866,115,376 - 66,129,832 (-)RGD
Celera1867,231,480 - 67,246,133 (-)RGD
cM Map18 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_663468 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH16082 (Get FASTA)   NCBI Sequence Viewer  
  AAP22134 (Get FASTA)   NCBI Sequence Viewer  
  BAC31843 (Get FASTA)   NCBI Sequence Viewer  
  EDL09675 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000025397
  ENSMUSP00000025397.6
GenBank Protein Q80WM3 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_663468   ⟸   NM_145493
- UniProtKB: Q8C8Y0 (UniProtKB/Swiss-Prot),   Q91WE5 (UniProtKB/Swiss-Prot),   Q80WM3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000025397   ⟸   ENSMUST00000025397

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q80WM3-F1-model_v2 AlphaFold Q80WM3 1-160 view protein structure

Promoters
RGD ID:13678042
Promoter ID:EPDNEW_M23170
Type:initiation region
Name:Cplx4_1
Description:Mus musculus complexin 4 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381865,970,193 - 65,970,253EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2685803 AgrOrtholog
Ensembl Genes ENSMUSG00000024519 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000025397 ENTREZGENE
  ENSMUST00000025397.7 UniProtKB/Swiss-Prot
Gene3D-CATH Single Helix bin UniProtKB/Swiss-Prot
InterPro Synaphin UniProtKB/Swiss-Prot
KEGG Report mmu:225644 UniProtKB/Swiss-Prot
MGD MGI:2685803 ENTREZGENE
NCBI Gene 225644 ENTREZGENE
PANTHER COMPLEXIN-4 UniProtKB/Swiss-Prot
  PTHR16705 UniProtKB/Swiss-Prot
Pfam Synaphin UniProtKB/Swiss-Prot
PhenoGen Cplx4 PhenoGen
UniProt CPLX4_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q8C8Y0 ENTREZGENE
  Q91WE5 ENTREZGENE
UniProt Secondary Q8C8Y0 UniProtKB/Swiss-Prot
  Q91WE5 UniProtKB/Swiss-Prot