Flg2 (filaggrin family member 2) - Rat Genome Database

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Gene: Flg2 (filaggrin family member 2) Mus musculus
Analyze
Symbol: Flg2
Name: filaggrin family member 2
RGD ID: 1618159
MGI Page MGI
Description: Predicted to enable calcium ion binding activity and transition metal ion binding activity. Predicted to be involved in cell adhesion; epidermis morphogenesis; and establishment of skin barrier. Is active in cornified envelope. Human ortholog(s) of this gene implicated in peeling skin syndrome 6. Orthologous to human FLG2 (filaggrin 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: EG229574; filaggrin 2; filaggrin-2; FLG-2; intermediate filament-associated protein
RGD Orthologs
Human
Rat
Dog
Pig
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
NCBI Annotation Information: Annotation category: suggests misassembly
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39393,104,585 - 93,128,701 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl393,104,585 - 93,128,698 (+)EnsemblGRCm39 Ensembl
GRCm38393,197,273 - 93,221,377 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl393,197,278 - 93,221,391 (+)EnsemblGRCm38mm10GRCm38
MGSCv37393,001,195 - 93,025,299 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36393,282,676 - 93,306,780 (+)NCBIMGSCv36mm8
Celera393,874,983 - 93,885,159 (-)NCBICelera
Cytogenetic Map3F2.1NCBI
cM Map340.14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:16141072   PMID:16141073   PMID:21267068   PMID:21873635   PMID:22417302   PMID:26644517   PMID:29198823  
PMID:31823782   PMID:34905516  


Genomics

Comparative Map Data
Flg2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39393,104,585 - 93,128,701 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl393,104,585 - 93,128,698 (+)EnsemblGRCm39 Ensembl
GRCm38393,197,273 - 93,221,377 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl393,197,278 - 93,221,391 (+)EnsemblGRCm38mm10GRCm38
MGSCv37393,001,195 - 93,025,299 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36393,282,676 - 93,306,780 (+)NCBIMGSCv36mm8
Celera393,874,983 - 93,885,159 (-)NCBICelera
Cytogenetic Map3F2.1NCBI
cM Map340.14NCBI
FLG2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381152,348,735 - 152,360,006 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1152,348,735 - 152,360,006 (-)EnsemblGRCh38hg38GRCh38
GRCh371152,321,211 - 152,332,482 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361150,587,837 - 150,599,106 (-)NCBINCBI36Build 36hg18NCBI36
Celera1125,432,241 - 125,443,280 (-)NCBICelera
Cytogenetic Map1q21.3NCBI
HuRef1123,694,923 - 123,706,192 (-)NCBIHuRef
CHM1_11153,716,564 - 153,727,833 (-)NCBICHM1_1
T2T-CHM13v2.01151,485,285 - 151,496,556 (-)NCBIT2T-CHM13v2.0
Flg2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22178,789,792 - 178,802,232 (+)NCBImRatBN7.2mRatBN7.2
Rnor_6.02193,480,880 - 193,485,463 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2193,483,793 - 193,485,313 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02211,378,205 - 211,386,432 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42186,206,294 - 186,219,364 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2171,459,695 - 171,471,100 (-)NCBICelera
Cytogenetic Map2q34NCBI
LOC483211
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11761,311,558 - 61,323,059 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
LOC110260322
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1496,992,602 - 96,997,794 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1

Variants

.
Variants in Flg2
657 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:40
Count of miRNA genes:40
Interacting mature miRNAs:40
Transcripts:ENSMUST00000098884
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884378Skwq6_mskull length QTL 6, 10 week (mouse)351907421102307316Mouse
1302052Etohcta4_methanol conditioned taste aversion 4 (mouse)Not determined391000105125008748Mouse
11049572Lmr11c_mleishmaniasis resistance 11c (mouse)372139967106140094Mouse
1357583Sle18_msystematic lupus erythematosus susceptibility 18 (mouse)Not determined387208904125316236Mouse
1300595Tmevd2_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 2 (mouse)Not determined375463302109463549Mouse
12738440Twq3_mtestis weight QTL 3 (mouse)387228015121228015Mouse
26884380Skwq1_mskull length QTL 1, 5 week (mouse)343954435101607316Mouse
1301904Iba2_minduction of brown adipocytes 2 (mouse)Not determined382147043116147184Mouse
11041900Lmr11a_mleishmaniasis resistance 11a (mouse)383463991117464137Mouse
11039511Ltpr3c_mLeishmania tropica response 3c (mouse)383463991117464137Mouse
1301398Rapop3_mradiation-induced apoptosis 3 (mouse)Not determined390511217100464137Mouse
11039509Ltpr3e_mLeishmania tropica response 3e (mouse)383463991117464137Mouse
4142178Ctrq2_mC. trachomatis resistance QTL 2 (mouse)Not determined389139967137453008Mouse
11039507Ltpr3g_mLeishmania tropica response 3g (mouse)383463991117464137Mouse
4142099Cq3_mcholesterol QTL 3 (mouse)Not determined384888918118889067Mouse
1301349Pgia26_mproteoglycan induced arthritis 26 (mouse)Not determined392251533126251650Mouse
4142399Aec1_mautoimmune exocrinopathy 1 (mouse)Not determined7586174102690034Mouse
26884427Cvht4_mcranial vault height 4, 10 week (mouse)316054164109707316Mouse
25314313Syncl1_msynaptonemal complex length 1 (mouse)367907333128393649Mouse
10766455Sle22_msystematic lupus erythematosus susceptibility 22 (mouse)390376936124377072Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316504164130163649Mouse
13208566Bmiq5_mbody mass index QTL 5 (mouse)340954435115793649Mouse
1301947Pcfm3_mperiosteal circumference and femur length 3 (mouse)Not determined381084652115084797Mouse
14746984Manh54_mmandible shape 54 (mouse)385289152119289152Mouse
11251721Ewc3_methanol withdrawal and consumption 3 (mouse)369568554103568554Mouse
26884382Bzwq1_mbi-zygomatic width QTL 1, 5 week (mouse)352207421137205761Mouse
11039519Ltpr3_mLeishmania tropica response 3 (mouse)356704102100464137Mouse
4141294Bmd24_mbone mineral density 24 (mouse)Not determined36174006195740241Mouse
11039512Ltpr3b_mLeishmania tropica response 3b (mouse)383463991117464137Mouse
1301392Eae3_msusceptibility to experimental allergic encephalomyelitis 3 (mouse)Not determined379548730113548837Mouse
11039510Ltpr3d_mLeishmania tropica response 3d (mouse)383463991117464137Mouse
1301422Sle11_msystematic lupus erythematosus susceptibility 11 (mouse)Not determined370208904104209042Mouse
1300982Lmr11_mleishmaniasis resistance 11 (mouse)Not determined372139967106140094Mouse
1301272Cfsw1_mcystic fibrosis survival to weaning 1 (mouse)Not determined383882912117883044Mouse
14747001Mancz4_mmandible centroid size 4 (mouse)390378017124378017Mouse
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33265060142405761Mouse
26884422Cvht7_mcranial vault height 7, 16 week (mouse)328954149118893649Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330067588147304689Mouse
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337174862143353183Mouse
1301971Cia5_mcollagen induced arthritis QTL 5 (mouse)Not determined366046658100046795Mouse
1301791Char4_mP. chabaudi malaria resistance QTL 4 (mouse)Not determined369625509100655290Mouse
11039508Ltpr3f_mLeishmania tropica response 3f (mouse)383463991117464137Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000098884   ⟹   ENSMUSP00000096482
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl393,107,517 - 93,128,100 (+)Ensembl
GRCm38.p6 Ensembl393,200,210 - 93,220,793 (+)Ensembl
RefSeq Acc Id: ENSMUST00000194707
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl393,104,585 - 93,128,698 (+)Ensembl
GRCm38.p6 Ensembl393,197,278 - 93,221,391 (+)Ensembl
RefSeq Acc Id: NM_001013804   ⟹   NP_001013826
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39393,104,585 - 93,128,701 (+)NCBI
GRCm38393,197,273 - 93,221,377 (+)ENTREZGENE
MGSCv37393,001,195 - 93,025,299 (+)RGD
Celera393,874,983 - 93,885,159 (-)RGD
cM Map3 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_001013826 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAZ99028 (Get FASTA)   NCBI Sequence Viewer  
  ADB44811 (Get FASTA)   NCBI Sequence Viewer  
  ADB44812 (Get FASTA)   NCBI Sequence Viewer  
  BAC29615 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000096482.4
  ENSMUSP00000160002
GenBank Protein Q2VIS4 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_001013826   ⟸   NM_001013804
- Sequence:
RefSeq Acc Id: ENSMUSP00000096482   ⟸   ENSMUST00000098884
Protein Domains
EF-hand

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q2VIS4-F1-model_v2 AlphaFold Q2VIS4 1-2362 view protein structure

Promoters
RGD ID:6881468
Promoter ID:EPDNEW_M4185
Type:multiple initiation site
Name:Flg2_1
Description:Mus musculus filaggrin family member 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38393,197,278 - 93,197,338EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3645678 AgrOrtholog
Ensembl Genes ENSMUSG00000049133 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000098884.4 UniProtKB/TrEMBL
  ENSMUST00000194707 ENTREZGENE
Gene3D-CATH EF-hand UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro EF-hand-dom_pair UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S-100_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S100/CaBP-9k_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S100_Ca-bd_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:229574 UniProtKB/Swiss-Prot
MGD MGI:3645678 ENTREZGENE
NCBI Gene 229574 ENTREZGENE
PANTHER FILAGGRIN-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FILAGGRIN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam S_100 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Flg2 PhenoGen
PROSITE EF_HAND_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S100_CABP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_100 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt E7BVC8_MOUSE UniProtKB/TrEMBL
  E7BVC9_MOUSE UniProtKB/TrEMBL
  E9QPZ3_MOUSE UniProtKB/TrEMBL
  FILA2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q8CB36 UniProtKB/Swiss-Prot