Klhl36 (kelch-like 36) - Rat Genome Database

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Gene: Klhl36 (kelch-like 36) Mus musculus
Analyze
Symbol: Klhl36
Name: kelch-like 36
RGD ID: 1618140
MGI Page MGI
Description: Predicted to enable cullin family protein binding activity. Orthologous to human KLHL36 (kelch like family member 36).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: kelch-like protein 36; MGC37805
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398120,588,970 - 120,603,728 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8120,589,005 - 120,603,734 (+)EnsemblGRCm39 Ensembl
GRCm388119,862,231 - 119,876,989 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8119,862,266 - 119,876,995 (+)EnsemblGRCm38mm10GRCm38
MGSCv378122,386,205 - 122,400,889 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368122,748,282 - 122,762,966 (+)NCBIMGSCv36mm8
Celera8124,078,901 - 124,093,589 (+)NCBICelera
Cytogenetic Map8E1NCBI
cM Map868.52NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:14610273   PMID:15449545   PMID:15489334   PMID:16141072   PMID:16141073   PMID:19799774  
PMID:21267068   PMID:21677750   PMID:21873635   PMID:28378742   PMID:36288084  


Genomics

Comparative Map Data
Klhl36
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398120,588,970 - 120,603,728 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8120,589,005 - 120,603,734 (+)EnsemblGRCm39 Ensembl
GRCm388119,862,231 - 119,876,989 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8119,862,266 - 119,876,995 (+)EnsemblGRCm38mm10GRCm38
MGSCv378122,386,205 - 122,400,889 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368122,748,282 - 122,762,966 (+)NCBIMGSCv36mm8
Celera8124,078,901 - 124,093,589 (+)NCBICelera
Cytogenetic Map8E1NCBI
cM Map868.52NCBI
KLHL36
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381684,648,511 - 84,667,686 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1684,648,511 - 84,667,686 (+)EnsemblGRCh38hg38GRCh38
GRCh371684,682,117 - 84,701,292 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361683,239,632 - 83,253,417 (+)NCBINCBI36Build 36hg18NCBI36
Build 341683,239,631 - 83,253,416NCBI
Celera1668,984,322 - 68,998,096 (+)NCBICelera
Cytogenetic Map16q24.1NCBI
HuRef1670,435,069 - 70,448,923 (+)NCBIHuRef
CHM1_11686,093,710 - 86,107,492 (+)NCBICHM1_1
T2T-CHM13v2.01690,714,793 - 90,733,970 (+)NCBIT2T-CHM13v2.0
Klhl36
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81964,830,218 - 64,851,251 (+)NCBIGRCr8
mRatBN7.21947,921,590 - 47,942,627 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1947,921,590 - 47,942,620 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1954,715,923 - 54,736,945 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01955,396,664 - 55,417,692 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01957,609,612 - 57,630,578 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01952,515,022 - 52,536,055 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1952,515,022 - 52,536,476 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01963,259,151 - 63,280,351 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41950,145,835 - 50,166,861 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1947,178,205 - 47,199,290 (+)NCBICelera
Cytogenetic Map19q12NCBI
Klhl36
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955541205,170 - 219,164 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955541205,170 - 218,943 (+)NCBIChiLan1.0ChiLan1.0
KLHL36
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21894,396,499 - 94,417,355 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan116100,313,658 - 100,334,489 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01665,314,253 - 65,335,194 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11684,656,009 - 84,676,221 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1684,656,009 - 84,670,664 (+)Ensemblpanpan1.1panPan2
KLHL36
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1567,828,301 - 67,854,113 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl567,832,694 - 67,846,013 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha567,842,892 - 67,868,693 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0568,061,929 - 68,087,690 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl568,066,701 - 68,077,131 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1568,076,370 - 68,102,190 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0567,911,501 - 67,937,143 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0568,326,142 - 68,351,975 (-)NCBIUU_Cfam_GSD_1.0
Klhl36
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934927,638,706 - 27,658,171 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366413,388,887 - 3,403,581 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366413,392,253 - 3,403,575 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KLHL36
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl64,067,403 - 4,080,075 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.164,062,563 - 4,080,183 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
KLHL36
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1570,050,442 - 70,064,859 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl570,050,757 - 70,064,682 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660475,680,033 - 5,699,789 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Klhl36
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247461,526,185 - 1,539,525 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Klhl36
550 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:151
Count of miRNA genes:147
Interacting mature miRNAs:149
Transcripts:ENSMUST00000034287
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871740461124622354Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71740461124622354Mouse
27095912Pglq14_mpelvic girdle length QTL 14, 16 week (mouse)874126628126826739Mouse
27226796Scvln16_msacral vertebrae length 2, 16 week (mouse)889726628130027694Mouse
1357494Obsty2_mobesity 2 (mouse)Not determined896245241129745061Mouse
12880431Fgf23lq2_mFGF23 serum level QTL 2 (mouse)897626632130127694Mouse
11252141Fdr2_mfat response to dietary restriction 2 (mouse)898390634130127694Mouse
1301481Lith11_mlithogenic gene 11 (mouse)Not determined898563635130127694Mouse
1302105Im1_mImmunoregulatory 1 (mouse)Not determined899828531130127694Mouse
1301080Sluc9_msusceptibility to lung cancer 9 (mouse)Not determined899828531130127694Mouse
4141435Fbtq3_mfemoral bone trait QTL 3 (mouse)Not determined8100965309130127694Mouse
1301316Dntcs1_mdental caries susceptibility 1 (mouse)Not determined8103443553127781786Mouse
11532691Sluc38_msusceptibility to lung cancer 38 (mouse)8105033977130127694Mouse
11532692Sluc38a_msusceptibility to lung cancer 38a (mouse)8105033977130127694Mouse
14746994Manh65_mmandible shape 65 (mouse)8106489629130127694Mouse
10412273Fcd1_mfunctional capillary density 1 (mouse)Not determined8110415083130127694Mouse
10412274Leci1_mleukocyte endothelial cell interactions 1 (mouse)Not determined8110415083130127694Mouse
12904938Edlmmq7_mextensor digitorum longus muscle mass QTL 7 (mouse)8111481497130127694Mouse
12904960Gmmq6_mgastrocnemius muscle mass QTL 6 (mouse)8111481497130127694Mouse
4141546Mrdq3_mmodifier of retinal degeneration QTL 3 (mouse)Not determined114439420126055880Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000034287   ⟹   ENSMUSP00000034287
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl8120,589,011 - 120,603,734 (+)Ensembl
GRCm38.p6 Ensembl8119,862,272 - 119,876,995 (+)Ensembl
RefSeq Acc Id: ENSMUST00000212636
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl8120,589,005 - 120,597,455 (+)Ensembl
GRCm38.p6 Ensembl8119,862,266 - 119,870,716 (+)Ensembl
RefSeq Acc Id: ENSMUST00000212970
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl8120,589,008 - 120,596,456 (+)Ensembl
GRCm38.p6 Ensembl8119,862,269 - 119,869,717 (+)Ensembl
RefSeq Acc Id: NM_146219   ⟹   NP_666331
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm398120,589,044 - 120,603,728 (+)NCBI
GRCm388119,862,305 - 119,876,989 (+)NCBI
MGSCv378122,386,205 - 122,400,889 (+)RGD
Celera8124,078,901 - 124,093,589 (+)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: XR_001778433
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm398120,588,970 - 120,603,728 (+)NCBI
GRCm388119,862,231 - 119,876,403 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_666331 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH25816 (Get FASTA)   NCBI Sequence Viewer  
  BAD21385 (Get FASTA)   NCBI Sequence Viewer  
  BAE33936 (Get FASTA)   NCBI Sequence Viewer  
  BAE37699 (Get FASTA)   NCBI Sequence Viewer  
  EDL11618 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000034287
  ENSMUSP00000034287.9
GenBank Protein Q8R124 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_666331   ⟸   NM_146219
- UniProtKB: Q3U0B9 (UniProtKB/Swiss-Prot),   Q6KAS2 (UniProtKB/Swiss-Prot),   Q8R124 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000034287   ⟸   ENSMUST00000034287
Protein Domains
BACK   BTB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8R124-F1-model_v2 AlphaFold Q8R124 1-613 view protein structure

Promoters
RGD ID:8668443
Promoter ID:EPDNEW_M12252
Type:multiple initiation site
Name:Klhl36_1
Description:Mus musculus kelch-like 36 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm388119,862,269 - 119,862,329EPDNEW
RGD ID:6843374
Promoter ID:MM_KWN:55915
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Liver,   Lung,   Spleen
Transcripts:ENSMUST00000034287,   UC009NQL.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv368122,385,944 - 122,386,444 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2385305 AgrOrtholog
Ensembl Genes ENSMUSG00000031828 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000034287 ENTREZGENE
  ENSMUST00000034287.10 UniProtKB/Swiss-Prot
Gene3D-CATH 1.25.40.420 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.120.10.80 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro BACK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BTB-kelch_protein UniProtKB/Swiss-Prot
  BTB/POZ_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kelch-typ_b-propeller UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kelch_1 UniProtKB/Swiss-Prot
  SKP1/BTB/POZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:234796 UniProtKB/Swiss-Prot
MGD MGI:2385305 ENTREZGENE
NCBI Gene 234796 ENTREZGENE
PANTHER LD33804P UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR45632:SF4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BACK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kelch_1 UniProtKB/Swiss-Prot
  Kelch_5 UniProtKB/TrEMBL
PhenoGen Klhl36 PhenoGen
PIRSF Kelch-like_protein_gigaxonin UniProtKB/Swiss-Prot
PROSITE BTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART BACK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kelch UniProtKB/Swiss-Prot
Superfamily-SCOP SSF117281 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54695 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt KLH36_MOUSE UniProtKB/Swiss-Prot
  Q3TPN6_MOUSE UniProtKB/TrEMBL
  Q3U0B9 ENTREZGENE
  Q6KAS2 ENTREZGENE
  Q8R124 ENTREZGENE
UniProt Secondary Q3U0B9 UniProtKB/Swiss-Prot
  Q6KAS2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-01-22 Klhl36  kelch-like 36    kelch-like 36 (Drosophila)  Symbol and/or name change 5135510 APPROVED