Cyp2b23 (cytochrome P450, family 2, subfamily b, polypeptide 23) - Rat Genome Database

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Gene: Cyp2b23 (cytochrome P450, family 2, subfamily b, polypeptide 23) Mus musculus
Analyze
No known orthologs.
Symbol: Cyp2b23
Name: cytochrome P450, family 2, subfamily b, polypeptide 23
RGD ID: 1618108
MGI Page MGI
Description: Predicted to enable heme binding activity and monooxygenase activity. Predicted to be involved in several processes, including epoxygenase P450 pathway; steroid metabolic process; and xenobiotic catabolic process. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in several diseases, including acute myeloid leukemia; drug dependence (multiple); human immunodeficiency virus infectious disease; neonatal abstinence syndrome; and nicotine dependence. Orthologous to human CYP2B6 (cytochrome P450 family 2 subfamily B member 6).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: EG243881
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39726,364,652 - 26,389,788 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl726,364,652 - 26,385,862 (-)EnsemblGRCm39 Ensembl
GRCm38726,665,227 - 26,686,430 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl726,665,227 - 26,686,437 (-)EnsemblGRCm38mm10GRCm38
MGSCv37727,450,246 - 27,471,449 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36726,373,987 - 26,395,190 (-)NCBIMGSCv36mm8
Celera721,248,395 - 21,271,173 (-)NCBICelera
Cytogenetic Map7A3NCBI
cM Map715.33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:14610273   PMID:17964055   PMID:21873635   PMID:22083726   PMID:37196079  


Genomics

Variants

.
Variants in Cyp2b23
1585 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:226
Count of miRNA genes:201
Interacting mature miRNAs:211
Transcripts:ENSMUST00000077356
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300722Sle3_msystemic lupus erythmatosus susceptibility 3 (mouse)Not determined7351172887142720Mouse
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
4141566Femwf8_mfemur work to failure 8 (mouse)Not determined1303248547032621Mouse
1301041Prnr2_mprion resistance 2 (mouse)Not determined71872879439674033Mouse
12904742Litsq2_mlitter size QTL 2 (mouse)72267388756674033Mouse
1301622Eae12_msusceptibility to experimental allergic encephalomyelitis 12 (mouse)Not determined71928001553280104Mouse
11354952Pdcc1_mplasmacytoid dentritic cell compartment 1 (mouse)72306653157066531Mouse
38501068Tip1_mtuberculosis immunophenotype 1, spleen CFU (mouse)7360299972549748Mouse
25314314Sccor1_msynaptonemal complex length to mean MLH1 count ratio 1 (mouse)71333392547349748Mouse
10449139Eosn1_meosinophil differential 1 (mouse)71248087746480877Mouse
1301052Bhr6_mbronchial hyperresponsiveness 6 (mouse)Not determined71984225053842367Mouse
11522751Cocia17_mcocaine-induced activity, QTL 17 (mouse)71313520447135204Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
1301572Sluc30_msusceptibility to lung cancer 30 (mouse)Not determined7243169636431844Mouse
1357699Nhdlq6_mnon-HDL QTL 6 (mouse)Not determined7998886743988984Mouse
10449158Eosn3_meosinophil differential 3 (mouse)71248087746480877Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718728794119485380Mouse
1558893Spir1_mStreptococcus pneumoniae infection resistance 1 (mouse)Not determined71030579844305936Mouse
1301709Bdt4_mbone density traits 4 (mouse)Not determined72288857256888716Mouse
1559016Drsi_mDCC-related Spp1 induction (mouse)Not determined71663729349159331Mouse

Markers in Region
Cyp2b10  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7A3UniSTS
cM Map76.5UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000077356   ⟹   ENSMUSP00000076578
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl726,364,652 - 26,385,862 (-)Ensembl
GRCm38.p6 Ensembl726,665,227 - 26,686,437 (-)Ensembl
RefSeq Acc Id: NM_001081148   ⟹   NP_001074617
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39726,364,652 - 26,385,855 (-)NCBI
GRCm38726,665,227 - 26,686,430 (-)NCBI
MGSCv37727,450,246 - 27,471,449 (-)RGD
Celera721,248,395 - 21,271,173 (-)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_036153083   ⟹   XP_036008976
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39726,364,652 - 26,389,788 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001074617 (Get FASTA)   NCBI Sequence Viewer  
  XP_036008976 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI00377 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000076578
  ENSMUSP00000076578.7
RefSeq Acc Id: NP_001074617   ⟸   NM_001081148
- Peptide Label: precursor
- UniProtKB: E9Q593 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000076578   ⟸   ENSMUST00000077356
RefSeq Acc Id: XP_036008976   ⟸   XM_036153083
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-E9Q593-F1-model_v2 AlphaFold E9Q593 1-491 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3646735 AgrOrtholog
Ensembl Genes ENSMUSG00000040650 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000077356 ENTREZGENE
  ENSMUST00000077356.7 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/TrEMBL
InterPro Cyt_P450 UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/TrEMBL
  Cyt_P450_E_grp-I UniProtKB/TrEMBL
  Cyt_P450_E_grp-I_CYP2B-like UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/TrEMBL
  Cytochrome_P450_fam2 UniProtKB/TrEMBL
KEGG Report mmu:243881 UniProtKB/TrEMBL
MGD MGI:3646735 ENTREZGENE
NCBI Gene 243881 ENTREZGENE
PANTHER CYTOCHROME P450 508A4-RELATED UniProtKB/TrEMBL
  CYTOCHROME P450-RELATED UniProtKB/TrEMBL
Pfam p450 UniProtKB/TrEMBL
PhenoGen Cyp2b23 PhenoGen
PRINTS EP450I UniProtKB/TrEMBL
  EP450ICYP2B UniProtKB/TrEMBL
  P450 UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/TrEMBL
Superfamily-SCOP Cytochrome_P450 UniProtKB/TrEMBL
UniProt E9Q593 ENTREZGENE, UniProtKB/TrEMBL
  Q497U6_MOUSE UniProtKB/TrEMBL