Tpbgl (trophoblast glycoprotein-like) - Rat Genome Database

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Gene: Tpbgl (trophoblast glycoprotein-like) Mus musculus
Analyze
Symbol: Tpbgl
Name: trophoblast glycoprotein-like
RGD ID: 1618101
MGI Page MGI
Description: Predicted to be involved in negative regulation of canonical Wnt signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human TPBGL (trophoblast glycoprotein like).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 6430704N06; EG245190; Gm4980; hypothetical protein LOC100503386; hypothetical protein LOC245190; uncharacterized protein LOC100503386
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39799,273,274 - 99,276,310 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl799,273,289 - 99,276,310 (-)EnsemblGRCm39 Ensembl
GRCm38799,624,067 - 99,627,103 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl799,624,082 - 99,627,103 (-)EnsemblGRCm38mm10GRCm38
MGSCv377106,772,591 - 106,774,849 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367106,772,343 - 106,777,643 (-)NCBIMGSCv36mm8
Celera799,949,700 - 99,951,957 (-)NCBICelera
Cytogenetic Map7E1NCBI
cM Map754.11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:16141072   PMID:16141073   PMID:21873635  


Genomics

Comparative Map Data
Tpbgl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39799,273,274 - 99,276,310 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl799,273,289 - 99,276,310 (-)EnsemblGRCm39 Ensembl
GRCm38799,624,067 - 99,627,103 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl799,624,082 - 99,627,103 (-)EnsemblGRCm38mm10GRCm38
MGSCv377106,772,591 - 106,774,849 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367106,772,343 - 106,777,643 (-)NCBIMGSCv36mm8
Celera799,949,700 - 99,951,957 (-)NCBICelera
Cytogenetic Map7E1NCBI
cM Map754.11NCBI
TPBGL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381175,240,774 - 75,243,704 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1175,240,774 - 75,243,704 (+)EnsemblGRCh38hg38GRCh38
GRCh371174,951,819 - 74,954,749 (+)NCBIGRCh37GRCh37hg19GRCh37
Celera1172,257,978 - 72,259,799 (+)NCBICelera
Cytogenetic Map11q13.4NCBI
HuRef1171,250,303 - 71,252,377 (+)NCBIHuRef
CHM1_11174,835,553 - 74,838,352 (+)NCBICHM1_1
T2T-CHM13v2.01175,170,381 - 75,173,311 (+)NCBIT2T-CHM13v2.0
Tpbgl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81163,335,851 - 163,338,677 (-)NCBIGRCr8
mRatBN7.21153,923,722 - 153,926,548 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1153,925,098 - 153,926,252 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1161,919,369 - 161,922,195 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01169,099,496 - 169,102,322 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01161,973,047 - 161,975,873 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01164,588,032 - 164,591,872 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1164,589,408 - 164,590,562 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01170,791,702 - 170,794,758 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41156,958,302 - 156,958,973 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1152,009,093 - 152,012,933 (-)NCBICelera
Cytogenetic Map1q32NCBI
Tpbgl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541416,582,232 - 16,583,481 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541416,580,847 - 16,583,930 (-)NCBIChiLan1.0ChiLan1.0
TPBGL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2976,171,015 - 76,174,184 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11177,213,698 - 77,216,872 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01170,300,350 - 70,303,524 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
TPBGL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12123,312,723 - 23,317,887 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2123,314,357 - 23,315,535 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2123,077,805 - 23,081,082 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02123,515,137 - 23,518,413 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12123,313,629 - 23,316,921 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02123,509,726 - 23,513,016 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02123,427,704 - 23,430,996 (-)NCBIUU_Cfam_GSD_1.0
Tpbgl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494762,476,008 - 62,479,035 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364984,076,084 - 4,077,253 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364984,074,869 - 4,079,796 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TPBGL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.199,502,193 - 9,507,470 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TPBGL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1166,463,987 - 66,467,860 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl166,465,198 - 66,466,349 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604359,343,749 - 59,347,611 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tpbgl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248171,849,056 - 1,850,225 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248171,846,286 - 1,850,672 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tpbgl
117 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:543
Count of miRNA genes:368
Interacting mature miRNAs:399
Transcripts:ENSMUST00000178124
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718728794119485380Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
26884404Huml1_mhumerus length 1, 5 week (mouse)730199425108999207Mouse
1301082Bbaa16_mB.burgdorferi-associated arthritis 16 (mouse)Not determined736280015116416877Mouse
1300791Abbp3_mA/J and C57BL/6 blood pressure 3 (mouse)Not determined739673887103510010Mouse
10043926Bw1n_mbody weight 1 in NSY (mouse)Not determined745161966118693530Mouse
13208555Lgth10_mbody length 10 (mouse)751649748125599172Mouse
27226751Femd5_mfemur midshaft diameter 5, 10 week (mouse)753249748143153737Mouse
25823170Hrsq7_mhost response to SARS QTL 7, log titer (mouse)754819589116822815Mouse
27226778Femd11_mfemur midshaft diameter 11, 16 week (mouse)756949748134001729Mouse
26884408Bzwq13_mbi-zygomatic width QTL 13, 16 week (mouse)761749748121399223Mouse
27095916Scvln15_msacral vertebrae length 2, 16 week (mouse)761749748123699223Mouse
25314305Vmm6_mvariable multisystem mineralization 6, eye (mouse)761849748102749207Mouse
26884440Sklq4_mskull length QTL 4, 5 week (mouse)765249748126499172Mouse
11553865Stmm1c_mskin tumor modifier of MSM 1c (mouse)76578898699788986Mouse
11553866Stmm1d_mskin tumor modifier of MSM 1d (mouse)76578898699788986Mouse
1301826Pgia3_mproteoglycan induced arthritis 3 (mouse)Not determined767290094101290240Mouse
1301784Ses2_msalmonella enteritidis susceptibility 2 (mouse)Not determined767290094101290240Mouse
1300620Pgia21_mproteoglycan induced arthritis 21 (mouse)Not determined767290094101290240Mouse
26884418Bzwq7_mbi-zygomatic width QTL 7, 10 week (mouse)767849748105449207Mouse
27226715Metcl3_mmetatarsal-calcaneal length 3, 5 week (mouse)767849748119499223Mouse
26884444Sklq8_mskull length QTL 8, 10 week (mouse)767849748124199223Mouse
26884451Sklq14_mskull length QTL 14, 16 week (mouse)767849748124999172Mouse
1300654Bomd1_mbone mineral density 1 (mouse)Not determined768365595102365702Mouse
27095907Scvln4_msacral vertebrae length 2, 5 week (mouse)769949748120499223Mouse
1301155Bpq7_mblood pressure QTL 7 (mouse)Not determined770143137104143379Mouse
10043973Obq29_mobesity QTL 29 (mouse)Not determined772263372106263372Mouse
27095910Pglq13_mpelvic girdle length QTL 13, 16 week (mouse)773049748125699172Mouse
27095933Ulnl3_mulna length 3, 5 week (mouse)773149748143153737Mouse
11553869Stmm2b_mskin tumor modifier of MSM 2a (mouse)773725965107725965Mouse
27226745Metcl9_mmetatarsal-calcaneal length 9, 10 week (mouse)774849748122199223Mouse
27226781Tibl3_mtibia length 3, 5 week (mouse)774849748122199223Mouse
1301566Adip3_madiposity 3 (mouse)Not determined775394215109394346Mouse
14746989Manh62_mmandible shape 62 (mouse)775742528109742528Mouse
26884398Humsd6_mhumerus midshaft diameter 6, 16 week (mouse)778649748136901729Mouse
10412110Cctq1_mcentral corneal thickness QTL 1 (mouse)Not determined780551681114551791Mouse
4142500Morq1_mmodifier of Rs1 QTL 1 (mouse)Not determined80551681114551791Mouse
27095930Ulnl10_mulna length 10, 16 week (mouse)780849748126699172Mouse
27095923Pglq3_mpelvic girdle length QTL 3, 5 week (mouse)781249748124199223Mouse
27095903Scvln10_msacral vertebrae length 2, 10 week (mouse)781449748126499172Mouse
27226765Tibl18_mtibia length 18, 16 week (mouse)781849748126499172Mouse
27226763Feml20_mfemur length 20, 16 week (mouse)785049208124199223Mouse
1301997Cia7_mcollagen induced arthritis QTL 7 (mouse)Not determined785365595112533819Mouse
1301647Elpt_melevated leptin (mouse)Not determined786500186120500329Mouse
1301188Heal6_mwound healing/regeneration 6 (mouse)Not determined787043932121044066Mouse
1302062Stheal6_msoft tissue heal 6 (mouse)Not determined787043932121044066Mouse
13463473Hbbcq4_mhemoglobin concentration QTL 4 (mouse)787043932121044066Mouse
1301781Capsq3_mcapsaicin sensitivity related QTL 3 (mouse)Not determined787143137119485380Mouse
27226769Tibl12_mtibia length 12, 10 week (mouse)787249208126499172Mouse
27226790Feml15_mfemur length 15, 10 week (mouse)787249208126499172Mouse
27095929Pglq8_mpelvic girdle length QTL 8, 10 week (mouse)787849208108099207Mouse
1357664Nba3_mNew Zealand Black autoimmunity 3 (mouse)Not determined791482996125483156Mouse
1301937Skull10_mskull morphology 10 (mouse)Not determined791482996125483156Mouse
13464255Ifvrq2_minfluenza virus resistance QTL 2 (mouse)792500698106455693Mouse
1300528Ssial3_msusceptibility to sialadenitis 3 (mouse)Not determined793391848127392041Mouse
1301478Eae26_msusceptibility to experimental allergic encephalomyelitis 26 (mouse)Not determined798164922132165010Mouse
13524850Asrq7_macoustic startle response 7 (mouse)798394974132394974Mouse

Markers in Region
UniSTS:490712  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38799,625,494 - 99,626,718UniSTSGRCm38
MGSCv377106,774,004 - 106,775,228UniSTSGRCm37
Cytogenetic Map7E2UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000178124   ⟹   ENSMUSP00000137154
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl799,273,289 - 99,276,310 (-)Ensembl
GRCm38.p6 Ensembl799,624,082 - 99,627,103 (-)Ensembl
RefSeq Acc Id: NM_001195529   ⟹   NP_001182458
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39799,273,274 - 99,276,310 (-)NCBI
GRCm38799,624,067 - 99,627,103 (-)ENTREZGENE
Celera799,949,685 - 99,952,724 (-)ENTREZGENE
cM Map7 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_001182458 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAC27948 (Get FASTA)   NCBI Sequence Viewer  
  EDL16397 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000137154
  ENSMUSP00000137154.2
GenBank Protein Q8C013 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_001182458   ⟸   NM_001195529
- Peptide Label: precursor
- UniProtKB: Q8C013 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000137154   ⟸   ENSMUST00000178124

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8C013-F1-model_v2 AlphaFold Q8C013 1-384 view protein structure

Promoters
RGD ID:6841215
Promoter ID:MM_KWN:51677
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:AK032609_GM4980
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv367106,774,336 - 106,774,836 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3646425 AgrOrtholog
Ensembl Genes ENSMUSG00000096606 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000178124 ENTREZGENE
  ENSMUST00000178124.3 UniProtKB/Swiss-Prot
Gene3D-CATH 3.80.10.10 UniProtKB/Swiss-Prot
InterPro Cys-rich_flank_reg_C UniProtKB/Swiss-Prot
  Leu-rich_rpt UniProtKB/Swiss-Prot
  Leu-rich_rpt_typical-subtyp UniProtKB/Swiss-Prot
  LRR_dom_sf UniProtKB/Swiss-Prot
KEGG Report mmu:100503386 UniProtKB/Swiss-Prot
MGD MGI:3646425 ENTREZGENE
NCBI Gene 100503386 ENTREZGENE
PANTHER LP06937P UniProtKB/Swiss-Prot
  TROPHOBLAST GLYCOPROTEIN-LIKE UniProtKB/Swiss-Prot
Pfam LRR_8 UniProtKB/Swiss-Prot
  LRRCT UniProtKB/Swiss-Prot
PhenoGen Tpbgl PhenoGen
SMART LRR_TYP UniProtKB/Swiss-Prot
  LRRCT UniProtKB/Swiss-Prot
Superfamily-SCOP L domain-like UniProtKB/Swiss-Prot
UniProt Q8C013 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-01 Tpbgl  trophoblast glycoprotein-like  Gm4980  predicted gene 4980  Symbol and/or name change 5135510 APPROVED