Lmod3 (leiomodin 3 (fetal)) - Rat Genome Database

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Gene: Lmod3 (leiomodin 3 (fetal)) Mus musculus
Analyze
Symbol: Lmod3
Name: leiomodin 3 (fetal)
RGD ID: 1617991
MGI Page MGI
Description: Predicted to enable actin monomer binding activity and tropomyosin binding activity. Involved in skeletal muscle fiber development. Located in A band. Is expressed in several structures, including ganglia; heart; limb segment; nose; and skeletal musculature. Used to study nemaline myopathy 10. Human ortholog(s) of this gene implicated in nemaline myopathy 10. Orthologous to human LMOD3 (leiomodin 3); INTERACTS WITH 1,2-dichloroethane; 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 5430424A14Rik; leiomodin-3; MGC156399
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39697,215,491 - 97,230,137 (-)NCBIGRCm39mm39
GRCm39 Ensembl697,215,495 - 97,229,720 (-)Ensembl
GRCm38697,238,530 - 97,253,217 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl697,238,534 - 97,252,759 (-)EnsemblGRCm38mm10GRCm38
MGSCv37697,188,522 - 97,202,774 (-)NCBIGRCm37mm9NCBIm37
MGSCv36697,203,991 - 97,218,243 (-)NCBImm8
Celera699,097,915 - 99,112,153 (-)NCBICelera
Cytogenetic Map6D3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal adrenal gland morphology  (IEA)
abnormal coat/hair pigmentation  (IEA)
abnormal eye morphology  (IEA)
abnormal gait  (IEA)
abnormal heart morphology  (IEA)
abnormal kidney morphology  (IEA)
abnormal sarcomere morphology  (IAGP)
abnormal skeletal muscle fiber morphology  (IAGP)
abnormal skeletal muscle morphology  (IEA)
abnormal skin morphology  (IEA)
abnormal spleen morphology  (IEA)
abnormal startle reflex  (IEA)
abnormal urinary bladder morphology  (IEA)
abnormal vocalization  (IEA)
abnormal Z line morphology  (IAGP)
blind uterus  (IEA)
cachexia  (IAGP)
centrally nucleated skeletal muscle fibers  (IAGP)
decreased body length  (IEA)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased bone mineral content  (IEA)
decreased bone mineral density  (IEA)
decreased cardiac muscle contractility  (IAGP)
decreased grip strength  (IAGP)
decreased lean body mass  (IAGP)
decreased lymphocyte cell number  (IEA)
decreased prepulse inhibition  (IEA)
decreased skeletal muscle fiber size  (IAGP)
decreased skeletal muscle size  (IAGP)
decreased startle reflex  (IEA)
decreased total body fat amount  (IEA)
enlarged heart  (IEA)
enlarged kidney  (IEA)
enlarged lymph nodes  (IEA)
enlarged spleen  (IEA)
enlarged thymus  (IEA)
enlarged urinary bladder  (IEA)
hypoactivity  (IEA)
improved glucose tolerance  (IEA)
increased blood urea nitrogen level  (IEA)
increased erythrocyte cell number  (IEA)
increased hematocrit  (IEA)
increased hemoglobin content  (IEA)
increased lean body mass  (IEA)
increased neutrophil cell number  (IEA)
increased skeletal muscle glycogen level  (IAGP)
increased total body fat amount  (IEA)
muscle weakness  (IAGP)
postnatal growth retardation  (IAGP)
skeletal muscle fiber atrophy  (IAGP)
small heart  (IEA)
small kidney  (IEA)
References

References - curated
1. RGD automated import pipeline
2. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:16096065   PMID:16141072   PMID:16141073   PMID:21267068   PMID:21873635   PMID:22157009  
PMID:24960163   PMID:25774500   PMID:25904789   PMID:26035871   PMID:26487682   PMID:26637667   PMID:28292896   PMID:28826497   PMID:29078393   PMID:32325033   PMID:32980291  


Genomics

Comparative Map Data
Lmod3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39697,215,491 - 97,230,137 (-)NCBIGRCm39mm39
GRCm39 Ensembl697,215,495 - 97,229,720 (-)Ensembl
GRCm38697,238,530 - 97,253,217 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl697,238,534 - 97,252,759 (-)EnsemblGRCm38mm10GRCm38
MGSCv37697,188,522 - 97,202,774 (-)NCBIGRCm37mm9NCBIm37
MGSCv36697,203,991 - 97,218,243 (-)NCBImm8
Celera699,097,915 - 99,112,153 (-)NCBICelera
Cytogenetic Map6D3NCBI
LMOD3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl369,106,065 - 69,123,032 (-)EnsemblGRCh38hg38GRCh38
GRCh38369,106,065 - 69,122,595 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37369,155,216 - 69,171,746 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36369,238,730 - 69,254,407 (-)NCBINCBI36hg18NCBI36
Celera369,084,149 - 69,099,857 (-)NCBI
Cytogenetic Map3p14.1NCBI
HuRef369,157,117 - 69,172,666 (-)NCBIHuRef
CHM1_1369,107,257 - 69,122,963 (-)NCBICHM1_1
Lmod3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24129,843,964 - 129,858,684 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl4129,843,970 - 129,858,244 (-)Ensembl
Rnor_6.04129,604,378 - 129,619,136 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4129,604,267 - 129,619,142 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04194,105,870 - 194,120,578 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44131,958,969 - 131,973,266 (-)NCBIRGSC3.4rn4RGSC3.4
Celera4118,720,105 - 118,734,466 (-)NCBICelera
Cytogenetic Map4q34NCBI
Lmod3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542118,728,692 - 18,743,974 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542118,728,993 - 18,744,326 (+)NCBIChiLan1.0ChiLan1.0
LMOD3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1370,409,700 - 70,424,652 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl370,410,288 - 70,424,702 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0369,042,870 - 69,058,704 (-)NCBIMhudiblu_PPA_v0panPan3
LMOD3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12022,612,916 - 22,629,207 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2022,612,946 - 22,629,214 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2022,587,390 - 22,603,662 (+)NCBI
ROS_Cfam_1.02022,638,734 - 22,655,016 (+)NCBI
UMICH_Zoey_3.12022,333,633 - 22,349,893 (+)NCBI
UNSW_CanFamBas_1.02022,675,875 - 22,692,165 (+)NCBI
UU_Cfam_GSD_1.02022,746,668 - 22,762,961 (+)NCBI
Lmod3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049421,510,935 - 1,520,742 (+)NCBI
SpeTri2.0NW_0049366031,510,330 - 1,520,741 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LMOD3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11350,541,407 - 50,554,346 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21355,672,243 - 55,685,067 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LMOD3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12230,132,993 - 30,149,769 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2230,135,153 - 30,148,740 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666041136,643,470 - 136,647,453 (+)NCBIVero_WHO_p1.0
Lmod3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247733,686,669 - 3,702,986 (-)NCBIHetGla_female_1.0hetGla2


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301876Bits2_mbitterness sensitivity 2 (mouse)Not determined670425898104426034Mouse
1301244Ichs_mimmediate cutaneous hypersensitivity QTL (mouse)Not determined690795610124795846Mouse
10043864T2dm4sa_mtype 2 diabetes mellitus 4 in SMXA RI mice (mouse)Not determined683713869147052561Mouse
1301813Skl3_mskeletal size (tail length) 3 (mouse)Not determined670425898104426034Mouse
1300954Fcsa1_mfemoral cross-sectional area 1 (mouse)Not determined671981024105981170Mouse
25440480Moaq2_mmodifier of alien QTL 2 (mouse)61117500000Mouse
4142416Egq11_mearly growth QTL 11 (mouse)Not determined96655951146633626Mouse
10412208Cypr4_mcytokine production 4 (mouse)Not determined675716503109716697Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648720000125360000Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673500000134700000Mouse
1301369Im4_mimmunoregulatory 4 (mouse)Not determined66348473897484905Mouse
11532719Sluc45_msusceptibility to lung cancer 45 (mouse)69260730698258933Mouse
4141578Obrq1_mobesity resistance QTL 1 (mouse)Not determined92607306112004738Mouse
1301262Gasa3_mgastritis type A susceptibility locus 3 (mouse)Not determined689005405123005603Mouse
1300650Bw18_mbody weight QTL 18 (mouse)Not determined666713869100714031Mouse
11353842Bmiq4_mbody mass index QTL 4 (mouse)692607306146429238Mouse
1357683Igf1sl1_mIGF-1 serum levels 1 (mouse)Not determined652161713116155267Mouse
1301687Mnic2_mmacronutrient intake (mouse)Not determined686806805113544602Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46935985136423692Mouse
1301320Ots1_movarian teratoma susceptibility 1 (mouse)Not determined675447583104503555Mouse
1301744Hdlq11_mHDL QTL 11 (mouse)Not determined687503360121503555Mouse
1301034Egrm2_mearly growth rate (mouse)Not determined670425898104426034Mouse
1300869Stheal5_msoft tissue heal 5 (mouse)Not determined671575060105575178Mouse
11040599Lmr4b_mleishmaniasis resistance 4b (mouse)696347325130347522Mouse
4141376Dbm1_mdiabetes modifier 1 (mouse)Not determined678629504121115387Mouse
14696731Pairq1_mP. aeruginosa infection resistance QTL 1 (mouse)681500000102200000Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139100000Mouse
10043901Pfat5_mpredicted fat percentage 5 (mouse)Not determined675607306109607450Mouse
1300704Cia3_mcollagen induced arthritis QTL 3 (mouse)Not determined696347325130347522Mouse
11251720Ewc4_methanol withdrawal and consumption 4 (mouse)684122513118122513Mouse
4141940W6q5_mweight 6 weeks QTL 5 (mouse)Not determined96655951146633626Mouse
1301521Pas1c_mpulmonary adenoma susceptibility 1c (mouse)Not determined671981024105981170Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648720000148450000Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645314059128835032Mouse
1357555Tesq2_mtestis weight QTL 2 (mouse)Not determined696655951146633626Mouse
1301292Cfbw2_mcystic fibrosis body weight 2 (mouse)Not determined695004651129004738Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648726556125356785Mouse
1357875Pfat2_mpredicted fat percentage 2 (mouse)Not determined676463949110464093Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:153
Count of miRNA genes:129
Interacting mature miRNAs:142
Transcripts:ENSMUST00000095655
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000095655   ⟹   ENSMUSP00000093315
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl697,215,495 - 97,229,720 (-)Ensembl
GRCm38.p6 Ensembl697,238,534 - 97,252,759 (-)Ensembl
RefSeq Acc Id: NM_001081157   ⟹   NP_001074626
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39697,215,493 - 97,229,718 (-)NCBI
GRCm38697,238,532 - 97,252,757 (-)NCBI
MGSCv37697,188,522 - 97,202,774 (-)RGD
Celera699,097,915 - 99,112,153 (-)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006506270   ⟹   XP_006506333
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39697,215,491 - 97,230,137 (-)NCBI
GRCm38697,238,530 - 97,253,217 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006506271   ⟹   XP_006506334
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39697,215,491 - 97,229,728 (-)NCBI
GRCm38697,238,530 - 97,252,749 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001074626 (Get FASTA)   NCBI Sequence Viewer  
  XP_006506333 (Get FASTA)   NCBI Sequence Viewer  
  XP_006506334 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI17773 (Get FASTA)   NCBI Sequence Viewer  
  AAI27158 (Get FASTA)   NCBI Sequence Viewer  
  E9QA62 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001074626   ⟸   NM_001081157
- UniProtKB: E9QA62 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006506333   ⟸   XM_006506270
- Peptide Label: isoform X1
- UniProtKB: E9QA62 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006506334   ⟸   XM_006506271
- Peptide Label: isoform X1
- UniProtKB: E9QA62 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000093315   ⟸   ENSMUST00000095655
Protein Domains
WH2

Promoters
RGD ID:6890520
Promoter ID:EPDNEW_M8711
Type:multiple initiation site
Name:Lmod3_1
Description:Mus musculus leiomodin 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38697,252,757 - 97,252,817EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2444169 AgrOrtholog
Ensembl Genes ENSMUSG00000044086 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000093315 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000095655 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.80.10.10 UniProtKB/Swiss-Prot
InterPro LMOD3 UniProtKB/Swiss-Prot
  LRR_dom_sf UniProtKB/Swiss-Prot
  TMOD UniProtKB/Swiss-Prot
KEGG Report mmu:320502 UniProtKB/Swiss-Prot
MGD MGI:2444169 ENTREZGENE
NCBI Gene 320502 ENTREZGENE
PANTHER PTHR10901 UniProtKB/Swiss-Prot
  PTHR10901:SF3 UniProtKB/Swiss-Prot
Pfam Tropomodulin UniProtKB/Swiss-Prot
PhenoGen Lmod3 PhenoGen
UniProt E9QA62 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A0AUN8 UniProtKB/Swiss-Prot
  A0JP45 UniProtKB/Swiss-Prot