Sertm1 (serine rich and transmembrane domain containing 1) - Rat Genome Database

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Gene: Sertm1 (serine rich and transmembrane domain containing 1) Mus musculus
Analyze
Symbol: Sertm1
Name: serine rich and transmembrane domain containing 1
RGD ID: 1617974
MGI Page MGI
Description: Predicted to be located in membrane. Predicted to be active in intracellular membrane-bounded organelle. Orthologous to human SERTM1 (serine rich and transmembrane domain containing 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 6030405A18Rik; hypothetical protein LOC329641; serine-rich and transmembrane domain-containing protein 1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39354,804,489 - 54,823,308 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl354,804,489 - 54,823,308 (-)EnsemblGRCm39 Ensembl
GRCm38354,897,068 - 54,915,887 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl354,897,068 - 54,915,887 (-)EnsemblGRCm38mm10GRCm38
MGSCv37354,700,990 - 54,719,809 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36354,985,000 - 55,003,816 (-)NCBIMGSCv36mm8
Celera354,614,372 - 54,633,236 (-)NCBICelera
Cytogenetic Map3CNCBI
cM Map325.9NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:16141072   PMID:16141073   PMID:21491433   PMID:21873635  


Genomics

Comparative Map Data
Sertm1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39354,804,489 - 54,823,308 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl354,804,489 - 54,823,308 (-)EnsemblGRCm39 Ensembl
GRCm38354,897,068 - 54,915,887 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl354,897,068 - 54,915,887 (-)EnsemblGRCm38mm10GRCm38
MGSCv37354,700,990 - 54,719,809 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36354,985,000 - 55,003,816 (-)NCBIMGSCv36mm8
Celera354,614,372 - 54,633,236 (-)NCBICelera
Cytogenetic Map3CNCBI
cM Map325.9NCBI
SERTM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381336,674,020 - 36,697,839 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1336,674,020 - 36,697,839 (+)EnsemblGRCh38hg38GRCh38
GRCh371337,248,157 - 37,271,976 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361336,146,049 - 36,169,976 (+)NCBINCBI36Build 36hg18NCBI36
Celera1318,315,266 - 18,339,185 (+)NCBICelera
Cytogenetic Map13q13.3NCBI
HuRef1318,059,921 - 18,083,839 (+)NCBIHuRef
CHM1_11337,215,582 - 37,239,524 (+)NCBICHM1_1
T2T-CHM13v2.01335,893,537 - 35,917,348 (+)NCBIT2T-CHM13v2.0
Sertm1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82141,237,054 - 141,256,669 (-)NCBIGRCr8
mRatBN7.22139,086,905 - 139,106,528 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2139,086,908 - 139,106,459 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2145,661,782 - 145,681,337 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02143,773,217 - 143,792,778 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02138,405,662 - 138,425,219 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02144,303,700 - 144,323,509 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2144,303,703 - 144,323,254 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02163,721,926 - 163,741,550 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42144,126,896 - 144,146,447 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2133,570,885 - 133,590,426 (-)NCBICelera
Cytogenetic Map2q26NCBI
Sertm1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554319,363,917 - 9,384,620 (-)NCBIChiLan1.0ChiLan1.0
SERTM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21436,203,976 - 36,227,808 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11327,310,268 - 27,331,723 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01317,891,403 - 17,915,307 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11336,322,504 - 36,346,403 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1336,343,668 - 36,343,991 (+)Ensemblpanpan1.1panPan2
SERTM1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1253,961,256 - 3,983,412 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl253,963,326 - 3,963,649 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha253,991,057 - 4,059,697 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0254,059,710 - 4,128,385 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl254,059,719 - 4,083,541 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1253,966,561 - 4,035,191 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0253,962,863 - 4,031,504 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0254,025,509 - 4,094,203 (-)NCBIUU_Cfam_GSD_1.0
Sertm1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945165,113,090 - 165,134,998 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647230,817,230 - 30,839,048 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647230,817,214 - 30,839,049 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SERTM1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1112,576,563 - 12,600,660 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11112,576,593 - 12,600,665 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21112,523,609 - 12,546,062 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SERTM1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1315,239,010 - 15,241,745 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl315,239,028 - 15,239,348 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605729,045,959 - 29,070,190 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sertm1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624776618,413 - 638,546 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624776616,518 - 638,621 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sertm1
739 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1568
Count of miRNA genes:484
Interacting mature miRNAs:599
Transcripts:ENSMUST00000070342, ENSMUST00000162201
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33265060142405761Mouse
1558925Hivan1_mHIV-associated nephropathy 1 (mouse)Not determined3758617468716946Mouse
4142399Aec1_mautoimmune exocrinopathy 1 (mouse)Not determined7586174102690034Mouse
4141116Lgaq4_mlate growth adjusted QTL 4 (mouse)Not determined1024922183184946Mouse
4141255W10q3_mweight 10 weeks QTL 3 (mouse)Not determined1024922183184946Mouse
4141563Lgq3_mlate growth QTL 3 (mouse)Not determined1024922183184946Mouse
39128206Lwq18_mliver weight QTL 18 (mouse)31024922183184946Mouse
1357584Splq6_mspleen weight QTL 6 (mouse)Not determined31024922183184946Mouse
1357440Hrtpq1_mheart weight percentage QTL 1 (mouse)Not determined31024922183184946Mouse
26884427Cvht4_mcranial vault height 4, 10 week (mouse)316054164109707316Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316504164130163649Mouse
26884422Cvht7_mcranial vault height 7, 16 week (mouse)328954149118893649Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330067588147304689Mouse
1300961Bh4p_mbar holding four paws (mouse)Not determined33183785465837997Mouse
12910778Pwgrq13_mpost-weaning growth rate QTL 13 (mouse)33263576058017363Mouse
12910781Pwgrq12_mpost-weaning growth rate QTL 12 (mouse)33263576058017363Mouse
10412073Ssen2_msuseptibility to Sendai virus 2 (mouse)Not determined33353546567535615Mouse
9587784Afw13_mabdominal fat weight QTL 13 (mouse)Not determined33375204567752228Mouse
10043882Bwtq13_mbody weight QTL 13 (mouse)Not determined33375204567752228Mouse
15039332Nmrs6_mNAFLD-associated magnetic resonance shift 6 (mouse)33417074168170741Mouse
15039336Nmrs2_mNAFLD-associated magnetic resonance shift 2 (mouse)33457610368576103Mouse
18337272Bmd46_mbone mineral density 46, males (mouse)33540742169407421Mouse
14746977Manh53_mmandible shape 53 (mouse)33592528069925280Mouse
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337174862143353183Mouse
1300587Aod2_mautoimmune ovarian dysgenesis 2 (mouse)Not determined33717974268716946Mouse
11041901Lmr11b_mleishmaniasis resistance 11b (mouse)33970410273704231Mouse
11039513Ltpr3a_mLeishmania tropica response 3a (mouse)33970410273704231Mouse
1301585Cd4ts1_mCD4 T cell subset 1 (mouse)Not determined33970410273704231Mouse
10755516Amzn1_manatomical modifier of Zfp423 1 (mouse)33970410273704231Mouse
13208566Bmiq5_mbody mass index QTL 5 (mouse)340954435115793649Mouse
26884389Skwq10_mskull length QTL 10, 16 week (mouse)34395443565307421Mouse
26884380Skwq1_mskull length QTL 1, 5 week (mouse)343954435101607316Mouse
4141079Ath23_matherosclerosis 23 (mouse)Not determined4935758183357581Mouse
1300895Hdl5_mHDL level 5 (mouse)Not determined34949500583495118Mouse
1301824Susp_msuppressor of superoxide production (mouse)Not determined34949500583495118Mouse
26884378Skwq6_mskull length QTL 6, 10 week (mouse)351907421102307316Mouse
26884382Bzwq1_mbi-zygomatic width QTL 1, 5 week (mouse)352207421137205761Mouse
1357585Manln3_mmandible length 3 (mouse)Not determined35262550986625745Mouse
1301917Tshp4_mtooth shape 4 (mouse)Not determined35262550986625745Mouse
1300593Skull4_mskull morphology 4 (mouse)Not determined35262550986625745Mouse
13464139Nhdlq17_mnon-HDL QTL 17 (mouse)35292318386923183Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000070342   ⟹   ENSMUSP00000064870
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl354,804,492 - 54,823,308 (-)Ensembl
GRCm38.p6 Ensembl354,897,071 - 54,915,887 (-)Ensembl
RefSeq Acc Id: ENSMUST00000162201   ⟹   ENSMUSP00000124102
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl354,804,489 - 54,822,452 (-)Ensembl
GRCm38.p6 Ensembl354,897,068 - 54,915,031 (-)Ensembl
RefSeq Acc Id: NM_177854   ⟹   NP_808522
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39354,804,489 - 54,823,308 (-)NCBI
GRCm38354,897,068 - 54,915,887 (-)ENTREZGENE
MGSCv37354,700,990 - 54,719,809 (-)RGD
Celera354,614,372 - 54,633,236 (-)RGD
cM Map3 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_808522 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH58995 (Get FASTA)   NCBI Sequence Viewer  
  BAC27339 (Get FASTA)   NCBI Sequence Viewer  
  EDL35287 (Get FASTA)   NCBI Sequence Viewer  
  EDL35288 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000064870
  ENSMUSP00000064870.4
  ENSMUSP00000124102.2
GenBank Protein Q8CD78 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_808522   ⟸   NM_177854
- UniProtKB: Q8CD78 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000064870   ⟸   ENSMUST00000070342
RefSeq Acc Id: ENSMUSP00000124102   ⟸   ENSMUST00000162201

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8CD78-F1-model_v2 AlphaFold Q8CD78 1-107 view protein structure

Promoters
RGD ID:6880668
Promoter ID:EPDNEW_M3785
Type:multiple initiation site
Name:Sertm1_1
Description:Mus musculus serine rich and transmembrane domain containing1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38354,915,879 - 54,915,939EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3607715 AgrOrtholog
Ensembl Genes ENSMUSG00000056306 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000070342 ENTREZGENE
  ENSMUST00000070342.4 UniProtKB/Swiss-Prot
  ENSMUST00000162201.3 UniProtKB/Swiss-Prot
InterPro SERTM UniProtKB/Swiss-Prot
KEGG Report mmu:329641 UniProtKB/Swiss-Prot
MGD MGI:3607715 ENTREZGENE
NCBI Gene 329641 ENTREZGENE
PANTHER PTHR35660 UniProtKB/Swiss-Prot
  SERINE-RICH AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 1 UniProtKB/Swiss-Prot
Pfam SRTM1 UniProtKB/Swiss-Prot
PhenoGen Sertm1 PhenoGen
UniProt Q8CD78 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-09-25 Sertm1  serine rich and transmembrane domain containing 1  6030405A18Rik  RIKEN cDNA 6030405A18 gene  Symbol and/or name change 5135510 APPROVED