Arid3c (AT-rich interaction domain 3C) - Rat Genome Database

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Gene: Arid3c (AT-rich interaction domain 3C) Mus musculus
Analyze
Symbol: Arid3c
Name: AT-rich interaction domain 3C (Ensembl:AT rich interactive domain 3C (BRIGHT-like))
RGD ID: 1617878
MGI Page MGI
Description: Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Orthologous to human ARID3C (AT-rich interaction domain 3C).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ARID domain-containing protein 3C; AT rich interactive domain 3C (Bright like); AT rich interactive domain 3C (BRIGHT-like); AT-rich interactive domain-containing protein 3C
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39441,723,830 - 41,731,226 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl441,723,836 - 41,731,142 (-)EnsemblGRCm39 Ensembl
GRCm38441,723,831 - 41,731,142 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl441,723,836 - 41,731,142 (-)EnsemblGRCm38mm10GRCm38
MGSCv37441,670,868 - 41,678,174 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36441,912,903 - 41,918,863 (-)NCBIMGSCv36mm8
Celera441,384,044 - 41,391,382 (-)NCBICelera
Cytogenetic Map4A5NCBI
cM Map422.01NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IDA)
membrane raft  (ISO)
nucleus  (IBA,IDA)

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10838570   PMID:11959810   PMID:12477932   PMID:15922553   PMID:21677750   PMID:21873635   PMID:21955986  


Genomics

Comparative Map Data
Arid3c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39441,723,830 - 41,731,226 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl441,723,836 - 41,731,142 (-)EnsemblGRCm39 Ensembl
GRCm38441,723,831 - 41,731,142 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl441,723,836 - 41,731,142 (-)EnsemblGRCm38mm10GRCm38
MGSCv37441,670,868 - 41,678,174 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36441,912,903 - 41,918,863 (-)NCBIMGSCv36mm8
Celera441,384,044 - 41,391,382 (-)NCBICelera
Cytogenetic Map4A5NCBI
cM Map422.01NCBI
ARID3C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38934,621,049 - 34,633,011 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl934,621,049 - 34,629,066 (-)EnsemblGRCh38hg38GRCh38
GRCh37934,621,046 - 34,629,063 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36934,611,455 - 34,618,011 (-)NCBINCBI36Build 36hg18NCBI36
Celera934,552,959 - 34,559,515 (-)NCBICelera
Cytogenetic Map9p13.3NCBI
HuRef934,575,737 - 34,582,294 (-)NCBIHuRef
CHM1_1934,621,235 - 34,627,787 (-)NCBICHM1_1
T2T-CHM13v2.0934,639,596 - 34,650,042 (-)NCBIT2T-CHM13v2.0
Arid3c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8561,685,511 - 61,692,821 (-)NCBIGRCr8
mRatBN7.2556,889,649 - 56,896,959 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl556,890,042 - 56,895,888 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx558,869,550 - 58,875,393 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0560,688,382 - 60,694,225 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0560,674,253 - 60,680,097 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0558,107,182 - 58,114,632 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl558,107,707 - 58,113,553 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0562,631,772 - 62,637,618 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4559,148,421 - 59,154,267 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera555,484,083 - 55,489,929 (-)NCBICelera
Cytogenetic Map5q22NCBI
Arid3c
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554721,504,032 - 1,510,590 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554721,503,448 - 1,510,965 (+)NCBIChiLan1.0ChiLan1.0
ARID3C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21189,974,694 - 89,982,711 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1989,975,061 - 89,989,017 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0934,457,638 - 34,466,425 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1935,267,063 - 35,275,057 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl935,267,063 - 35,275,057 (-)Ensemblpanpan1.1panPan2
ARID3C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11151,294,605 - 51,301,979 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1151,295,030 - 51,301,547 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1149,922,506 - 49,930,320 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01152,234,892 - 52,242,709 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1152,235,759 - 52,242,279 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11150,897,603 - 50,905,422 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01150,765,803 - 50,773,609 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01151,530,526 - 51,538,340 (-)NCBIUU_Cfam_GSD_1.0
Arid3c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947166,157,164 - 166,165,371 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365242,705,121 - 2,711,557 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365242,705,112 - 2,711,557 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARID3C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1032,172,871 - 32,180,604 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11032,171,233 - 32,187,239 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21036,312,954 - 36,321,471 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Arid3c
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473639,016,483 - 39,023,668 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473639,016,483 - 39,023,701 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Arid3c
57 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:609
Count of miRNA genes:289
Interacting mature miRNAs:316
Transcripts:ENSMUST00000084698, ENSMUST00000150809, ENSMUST00000159930, ENSMUST00000171251
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156268235Mouse
1302010Wta1_mweight adult 1 (mouse)Not determined4868324042683429Mouse
1558992Ses8_msalmonella enteritidis susceptibility 8 (mouse)Not determined4868324042683429Mouse
1301473Triglq1_mtriglyceride QTL 1 (mouse)Not determined4868324042683429Mouse
1302125Lxw1_mlupus BXSB x NZW 1 (mouse)Not determined4868324042683429Mouse
4141302Ssrq5_mstress response QTL 5 (mouse)Not determined868324042683430Mouse
10401905Sicd3_mseizure-induced cell death 3 (mouse)Not determined4939552543760862Mouse
10401115Pgia35_mproteoglycan induced arthritis 35 (mouse)Not determined41256237746562509Mouse
12880405Jcdq1_mjoint cartilage degeneration QTL 1 (mouse)41256237746562509Mouse
4142318Lyr2_mlymphoma resistance 2 (mouse)Not determined1401045763283678Mouse
4142047Mvwf3_mmodifier of von Willebrand factor 3 (mouse)Not determined14010457117072206Mouse
1301203Alcp8_malcohol preference locus 8 (mouse)Not determined41739516051395290Mouse
1301237Alcp7_malcohol preference locus 7 (mouse)Not determined41739516051395290Mouse
4141555Nbwa2_mNZB and NZW autoimmunity 2 (mouse)Not determined41789251551892635Mouse
4141911W6q15_mweight 6 weeks QTL 15 (mouse)Not determined1789261688982216Mouse
39128211Lwq22_mliver weight QTL 22 (mouse)41789261688982216Mouse
1357453Kidq4_mkidney weight QTL 4 (mouse)Not determined41789261688982216Mouse
25440481Moaq1_mmodifier of alien QTL 1 (mouse)41950000046000000Mouse
1302058Hrtfm3_mheart failure modifier 3 (mouse)Not determined42211194456112145Mouse
1300769Pcyts2_mplasmacytoma susceptibility 2 (mouse)Not determined42211194456112145Mouse
1301437Scon1_msucrose consumption 1 (mouse)Not determined42237344856373612Mouse
1302075Bdln6_mbody length 6 (mouse)Not determined42237344856373612Mouse
1301697Sluc18_msusceptibility to lung cancer 18 (mouse)Not determined42237344856373612Mouse
1302184Aaom1_mautoimmune aoritis in MRL mice 1 (mouse)Not determined42432229946332776Mouse
1300574Im2_mimmunoregulatory 2 (mouse)Not determined42807768262077816Mouse
1301586Stheal3_msoft tissue heal 3 (mouse)Not determined42865844262658566Mouse
1357877Synch1_msynechia 1 (mouse)Not determined42870992562710107Mouse
1301990Arvm1_mautoimmune renal vasculitis 1 (mouse)Not determined42933264663332776Mouse
4142290Ssrq9_mstress response QTL 9 (mouse)Not determined3439516046332776Mouse
1301792Hdlq10_mHDL QTL 10 (mouse)Not determined43585970769859853Mouse
1300977Mopkd1_mmodifier of polycystic kidney disease progression 1 (mouse)Not determined43655083970550967Mouse
26884449Sklq2_mskull length QTL 2, 5 week (mouse)436700000128993793Mouse
1302116Bbaa1_mB.burgdorferi-associated arthritis 1 (mouse)Not determined43825093072251078Mouse
10412178Habiir2_mhyperoxic acute lung injury imprinted region 2 (mouse)Not determined43945212663283678Mouse


Expression


Sequence


RefSeq Acc Id: ENSMUST00000084698   ⟹   ENSMUSP00000081748
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl441,724,139 - 41,730,286 (-)Ensembl
GRCm38.p6 Ensembl441,724,139 - 41,730,286 (-)Ensembl
RefSeq Acc Id: ENSMUST00000150809   ⟹   ENSMUSP00000116411
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl441,724,139 - 41,730,286 (-)Ensembl
GRCm38.p6 Ensembl441,724,139 - 41,730,286 (-)Ensembl
RefSeq Acc Id: ENSMUST00000171251   ⟹   ENSMUSP00000127678
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl441,723,836 - 41,731,142 (-)Ensembl
GRCm38.p6 Ensembl441,723,836 - 41,731,142 (-)Ensembl
RefSeq Acc Id: NM_001017362   ⟹   NP_001017362
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39441,723,830 - 41,731,226 (-)NCBI
GRCm38441,723,836 - 41,731,142 (-)NCBI
MGSCv37441,670,868 - 41,678,174 (-)RGD
Celera441,384,044 - 41,391,382 (-)RGD
cM Map4 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001252622   ⟹   NP_001239551
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39441,723,830 - 41,731,226 (-)NCBI
GRCm38441,723,836 - 41,731,142 (-)NCBI
Celera441,384,044 - 41,391,382 (-)ENTREZGENE
cM Map4 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011250077   ⟹   XP_011248379
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39441,723,831 - 41,729,911 (-)NCBI
GRCm38441,723,831 - 41,728,045 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001017362   ⟸   NM_001017362
- Peptide Label: isoform 1
- UniProtKB: B2RUN0 (UniProtKB/Swiss-Prot),   A6PWV5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001239551   ⟸   NM_001252622
- Peptide Label: isoform 2
- UniProtKB: B7ZP08 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011248379   ⟸   XM_011250077
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000116411   ⟸   ENSMUST00000150809
RefSeq Acc Id: ENSMUSP00000081748   ⟸   ENSMUST00000084698
RefSeq Acc Id: ENSMUSP00000127678   ⟸   ENSMUST00000171251
Protein Domains
ARID   REKLES

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A6PWV5-F1-model_v2 AlphaFold A6PWV5 1-409 view protein structure

Promoters
RGD ID:6883122
Promoter ID:EPDNEW_M5012
Type:single initiation site
Name:Arid3c_1
Description:Mus musculus AT rich interactive domain 3C (BRIGHT-like) , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38441,731,226 - 41,731,286EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3650624 AgrOrtholog
Ensembl Genes ENSMUSG00000066224 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000084698.12 UniProtKB/Swiss-Prot
  ENSMUST00000150809 ENTREZGENE
  ENSMUST00000150809.3 UniProtKB/TrEMBL
  ENSMUST00000171251 ENTREZGENE
  ENSMUST00000171251.8 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.150.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ARI3A/B/C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ARID_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ARID_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  REKLES_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:3650624 ENTREZGENE
NCBI Gene 550619 ENTREZGENE
PANTHER AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 3C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR15348 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ARID UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Arid3c PhenoGen
PROSITE ARID UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  REKLES UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART ARID UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BRIGHT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF46774 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6PWV5 ENTREZGENE, UniProtKB/Swiss-Prot
  B2RUN0 ENTREZGENE
  B7ZP08 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary B2RUN0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-06-27 Arid3c  AT-rich interaction domain 3C  Arid3c  AT rich interactive domain 3C (BRIGHT-like)  Symbol and/or name change 5135510 APPROVED