Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dichloroethane | affects expression | EXP | | 6480464 | ethylene dichloride affects the expression of CDH4 mRNA | CTD | PMID:28960355 | 2,3,7,8-tetrachlorodibenzodioxine | increases methylation | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased methylation of CDH4 gene | CTD | PMID:21212295 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of CDH4 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the reaction [AHR protein binds to CDH4 promoter] | CTD | PMID:19654925 | 2,4-dinitrobenzenesulfonic acid | decreases expression | EXP | | 6480464 | 2 and 4-dinitrobenzenesulfonic acid results in decreased expression of CDH4 mRNA | CTD | PMID:30116771 | 2-palmitoylglycerol | increases expression | ISO | CDH4 (Homo sapiens) | 6480464 | 2-palmitoylglycerol results in increased expression of CDH4 mRNA | CTD | PMID:37199045 | 4,4'-sulfonyldiphenol | decreases expression | EXP | | 6480464 | bisphenol S results in decreased expression of CDH4 mRNA | CTD | PMID:30951980 | 6-propyl-2-thiouracil | increases expression | ISO | Cdh4 (Rattus norvegicus) | 6480464 | Propylthiouracil results in increased expression of CDH4 mRNA | CTD | PMID:24780913 | 6-propyl-2-thiouracil | decreases expression | ISO | Cdh4 (Rattus norvegicus) | 6480464 | Propylthiouracil results in decreased expression of CDH4 mRNA | CTD | PMID:30047161 | 8-Br-cAMP | decreases expression | ISO | CDH4 (Homo sapiens) | 6480464 | 8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of CDH4 mRNA | CTD | PMID:22079614 | acrylamide | decreases expression | ISO | CDH4 (Homo sapiens) | 6480464 | Acrylamide results in decreased expression of CDH4 mRNA | CTD | PMID:32763439 | aflatoxin B1 | decreases methylation | ISO | CDH4 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of CDH4 exon | CTD | PMID:30157460 | aflatoxin B1 | affects methylation | ISO | CDH4 (Homo sapiens) | 6480464 | Aflatoxin B1 affects the methylation of CDH4 intron | CTD | PMID:30157460 | Aflatoxin B2 alpha | increases methylation | ISO | CDH4 (Homo sapiens) | 6480464 | aflatoxin B2 results in increased methylation of CDH4 intron | CTD | PMID:30157460 | amitrole | decreases expression | ISO | Cdh4 (Rattus norvegicus) | 6480464 | Amitrole results in decreased expression of CDH4 mRNA | CTD | PMID:30047161 | ammonium chloride | affects expression | ISO | Cdh4 (Rattus norvegicus) | 6480464 | Ammonium Chloride affects the expression of CDH4 mRNA | CTD | PMID:16483693 | aristolochic acid A | increases expression | ISO | CDH4 (Homo sapiens) | 6480464 | aristolochic acid I results in increased expression of CDH4 mRNA | CTD | PMID:33212167 | arsane | affects methylation | ISO | CDH4 (Homo sapiens) | 6480464 | Arsenic affects the methylation of CDH4 gene | CTD | PMID:25304211 | arsenic atom | affects methylation | ISO | CDH4 (Homo sapiens) | 6480464 | Arsenic affects the methylation of CDH4 gene | CTD | PMID:25304211 | atrazine | affects methylation | ISO | Cdh4 (Rattus norvegicus) | 6480464 | Atrazine affects the methylation of CDH4 gene | CTD | PMID:28931070 and PMID:35440735 | benzo[a]pyrene | multiple interactions | EXP | | 6480464 | Benzo(a)pyrene affects the reaction [AHR protein binds to CDH4 promoter] | CTD | PMID:19654925 | benzo[a]pyrene | decreases methylation | EXP | | 6480464 | Benzo(a)pyrene results in decreased methylation of CDH4 intron | CTD | PMID:27901495 | benzo[a]pyrene | increases methylation | ISO | CDH4 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of CDH4 promoter | CTD | PMID:27901495 | benzo[a]pyrene | affects methylation | ISO | CDH4 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of CDH4 intron | CTD | PMID:30157460 | benzo[a]pyrene | decreases expression | EXP | | 6480464 | Benzo(a)pyrene results in decreased expression of CDH4 mRNA | CTD | PMID:21569818 | benzo[a]pyrene diol epoxide I | decreases expression | ISO | CDH4 (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:20382639 | benzo[e]pyrene | affects methylation | ISO | CDH4 (Homo sapiens) | 6480464 | benzo(e)pyrene affects the methylation of CDH4 intron | CTD | PMID:30157460 | bisphenol A | decreases expression | ISO | Cdh4 (Rattus norvegicus) | 6480464 | bisphenol A results in decreased expression of CDH4 mRNA | CTD | PMID:25181051 | bisphenol A | multiple interactions | ISO | CDH4 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in decreased methylation of CDH4 gene | CTD | PMID:31601247 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of CDH4 mRNA | CTD | PMID:30245210 | bisphenol A | increases expression | ISO | Cdh4 (Rattus norvegicus) | 6480464 | bisphenol A results in increased expression of CDH4 mRNA | CTD | PMID:30816183 and PMID:34947998 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of CDH4 mRNA | CTD | PMID:30951980 | bisphenol F | decreases expression | EXP | | 6480464 | bisphenol F results in decreased expression of CDH4 mRNA | CTD | PMID:30951980 | butanal | decreases expression | ISO | CDH4 (Homo sapiens) | 6480464 | butyraldehyde results in decreased expression of CDH4 mRNA | CTD | PMID:26079696 | carbon nanotube | decreases expression | EXP | | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | CGP 52608 | multiple interactions | ISO | CDH4 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to CDH4 gene] | CTD | PMID:28238834 | chlordecone | affects response to substance | ISO | CDH4 (Homo sapiens) | 6480464 | CDH4 gene SNP affects the susceptibility to Chlordecone | CTD | PMID:25622337 | choline | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CDH4 gene | CTD | PMID:20938992 | cisplatin | decreases expression | EXP | | 6480464 | Cisplatin results in decreased expression of CDH4 mRNA | CTD | PMID:25270620 | cisplatin | multiple interactions | ISO | CDH4 (Homo sapiens) | 6480464 | Cisplatin promotes the reaction [jinfukang results in decreased expression of CDH4 mRNA] and jinfukang promotes the reaction [Cisplatin results in decreased expression of CDH4 mRNA] | CTD | PMID:27392435 | cisplatin | decreases expression | ISO | CDH4 (Homo sapiens) | 6480464 | Cisplatin results in decreased expression of CDH4 mRNA | CTD | PMID:27392435 | clobetasol | decreases expression | EXP | | 6480464 | Clobetasol results in decreased expression of CDH4 mRNA | CTD | PMID:27462272 | clofibrate | increases expression | EXP | | 6480464 | Clofibrate results in increased expression of CDH4 mRNA | CTD | PMID:17585979 | dimethylarsinic acid | increases expression | EXP | | 6480464 | Cacodylic Acid results in increased expression of CDH4 mRNA | CTD | PMID:17441966 | dimethylarsinic acid | multiple interactions | EXP | | 6480464 | OGG1 protein inhibits the reaction [Cacodylic Acid results in increased expression of CDH4 mRNA] | CTD | PMID:17441966 | ethanol | affects expression | EXP | | 6480464 | Ethanol affects the expression of CDH4 mRNA | CTD | PMID:30319688 | ethanol | affects splicing | EXP | | 6480464 | Ethanol affects the splicing of CDH4 mRNA | CTD | PMID:30319688 | ethanol | increases expression | EXP | | 6480464 | Ethanol results in increased expression of CDH4 mRNA | CTD | PMID:30319688 | folic acid | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CDH4 gene | CTD | PMID:20938992 | fulvestrant | multiple interactions | ISO | CDH4 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in decreased methylation of CDH4 gene | CTD | PMID:31601247 | geldanamycin | increases expression | ISO | CDH4 (Homo sapiens) | 6480464 | geldanamycin results in increased expression of CDH4 mRNA | CTD | PMID:26705709 | irinotecan | decreases expression | ISO | CDH4 (Homo sapiens) | 6480464 | Irinotecan analog results in decreased expression of CDH4 mRNA | CTD | PMID:18927307 | L-methionine | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CDH4 gene | CTD | PMID:20938992 | lead(0) | affects methylation | ISO | CDH4 (Homo sapiens) | 6480464 | Lead affects the methylation of CDH4 gene | CTD | PMID:31636367 | lipopolysaccharide | decreases expression | EXP | | 6480464 | Lipopolysaccharides results in decreased expression of CDH4 mRNA | CTD | PMID:30942577 | methapyrilene | affects methylation | ISO | CDH4 (Homo sapiens) | 6480464 | Methapyrilene affects the methylation of CDH4 intron | CTD | PMID:30157460 | methimazole | decreases expression | ISO | Cdh4 (Rattus norvegicus) | 6480464 | Methimazole results in decreased expression of CDH4 mRNA | CTD | PMID:30047161 | methotrexate | decreases expression | ISO | CDH4 (Homo sapiens) | 6480464 | Methotrexate results in decreased expression of CDH4 mRNA | CTD | PMID:17379860 | mono(2-ethylhexyl) phthalate | increases expression | ISO | CDH4 (Homo sapiens) | 6480464 | mono-(2-ethylhexyl)phthalate results in increased expression of CDH4 mRNA | CTD | PMID:36695872 | N,N-diethyl-m-toluamide | multiple interactions | ISO | Cdh4 (Rattus norvegicus) | 6480464 | [Permethrin co-treated with DEET] results in increased methylation of CDH4 gene | CTD | PMID:33148267 | N-nitrosodiethylamine | increases expression | ISO | Cdh4 (Rattus norvegicus) | 6480464 | Diethylnitrosamine results in increased expression of CDH4 mRNA | CTD | PMID:20360939 | niclosamide | increases expression | ISO | CDH4 (Homo sapiens) | 6480464 | Niclosamide results in increased expression of CDH4 mRNA | CTD | PMID:36318118 | Nor-9-carboxy-delta9-THC | multiple interactions | ISO | CDH4 (Homo sapiens) | 6480464 | [Cannabinoids results in increased abundance of 11-nor-delta(9)-tetrahydrocannabinol-9-carboxylic acid] which affects the methylation of CDH4 gene | CTD | PMID:30521419 | paracetamol | decreases expression | ISO | CDH4 (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of CDH4 mRNA | CTD | PMID:22230336 and PMID:26690555 | paraquat | decreases expression | ISO | Cdh4 (Rattus norvegicus) | 6480464 | Paraquat results in decreased expression of CDH4 mRNA | CTD | PMID:32680482 | permethrin | multiple interactions | ISO | Cdh4 (Rattus norvegicus) | 6480464 | [Permethrin co-treated with DEET] results in increased methylation of CDH4 gene | CTD | PMID:33148267 | potassium chromate | decreases expression | ISO | CDH4 (Homo sapiens) | 6480464 | potassium chromate(VI) results in decreased expression of CDH4 mRNA | CTD | PMID:22714537 | progesterone | decreases expression | EXP | | 6480464 | Progesterone results in decreased expression of CDH4 mRNA | CTD | PMID:22238285 | Ptaquiloside | decreases expression | EXP | | 6480464 | ptaquiloside results in decreased expression of CDH4 mRNA | CTD | PMID:23274088 | silicon dioxide | increases expression | ISO | CDH4 (Homo sapiens) | 6480464 | Silicon Dioxide analog results in increased expression of CDH4 mRNA | CTD | PMID:25895662 | silicon dioxide | decreases expression | ISO | CDH4 (Homo sapiens) | 6480464 | Silicon Dioxide analog results in decreased expression of CDH4 mRNA | CTD | PMID:23806026 | sodium arsenite | affects methylation | ISO | CDH4 (Homo sapiens) | 6480464 | sodium arsenite affects the methylation of CDH4 gene | CTD | PMID:28589171 | sodium arsenite | decreases expression | ISO | CDH4 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of CDH4 mRNA | CTD | PMID:34032870 | sodium arsenite | increases expression | ISO | CDH4 (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of CDH4 mRNA | CTD | PMID:29301061 | sunitinib | increases expression | ISO | CDH4 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of CDH4 mRNA | CTD | PMID:31533062 | temozolomide | increases expression | ISO | CDH4 (Homo sapiens) | 6480464 | Temozolomide results in increased expression of CDH4 mRNA | CTD | PMID:31758290 | triazines | multiple interactions | EXP | | 6480464 | Triazines inhibits the reaction [IDH2 protein mutant form results in increased expression of CDH4 mRNA] | CTD | PMID:27469509 | trichostatin A | decreases expression | ISO | CDH4 (Homo sapiens) | 6480464 | trichostatin A results in decreased expression of CDH4 mRNA | CTD | PMID:24935251 | trimellitic anhydride | decreases expression | EXP | | 6480464 | trimellitic anhydride results in decreased expression of CDH4 mRNA | CTD | PMID:19042947 | triptonide | increases expression | EXP | | 6480464 | triptonide results in increased expression of CDH4 mRNA | CTD | PMID:33045310 | urethane | decreases expression | ISO | CDH4 (Homo sapiens) | 6480464 | Urethane results in decreased expression of CDH4 mRNA | CTD | PMID:28818685 | valproic acid | increases methylation | ISO | CDH4 (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of CDH4 gene | CTD | PMID:29154799 | valproic acid | decreases expression | ISO | Cdh4 (Rattus norvegicus) | 6480464 | Valproic Acid results in decreased expression of CDH4 mRNA | CTD | PMID:29427782 | valproic acid | affects expression | ISO | CDH4 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of CDH4 mRNA | CTD | PMID:25979313 | zoledronic acid | increases expression | ISO | CDH4 (Homo sapiens) | 6480464 | zoledronic acid results in increased expression of CDH4 mRNA | CTD | PMID:24714768 | |