Rnaseh2b (ribonuclease H2, subunit B) - Rat Genome Database

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Gene: Rnaseh2b (ribonuclease H2, subunit B) Mus musculus
Analyze
Symbol: Rnaseh2b
Name: ribonuclease H2, subunit B
RGD ID: 1617554
MGI Page MGI
Description: Acts upstream of or within several processes, including in utero embryonic development; positive regulation of fibroblast proliferation; and regulation of cell cycle phase transition. Part of ribonuclease H2 complex. Is expressed in several structures, including brain; gut; hemolymphoid system; skin; and testis. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome. Orthologous to human RNASEH2B (ribonuclease H2 subunit B).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1110019N06Rik; 2610207P08Rik; deleted in lymphocytic leukemia 8 homolog; Dleu; Dleu8; ribonuclease H2 subunit B; ribonuclease HI subunit B; RNase H2 subunit B
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm18399  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391462,569,517 - 62,610,445 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1462,530,038 - 62,610,441 (+)EnsemblGRCm39 Ensembl
GRCm381462,332,068 - 62,372,996 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1462,292,589 - 62,372,992 (+)EnsemblGRCm38mm10GRCm38
MGSCv371462,950,942 - 62,991,829 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361461,286,215 - 61,327,102 (+)NCBIMGSCv36mm8
Celera1460,101,639 - 60,143,101 (+)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1433.19NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleoplasm  (IBA,ISO)
nucleus  (IEA)
ribonuclease H2 complex  (IBA,IDA,IPI,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. Mouse MP Annotation Import Pipeline RGD automated import pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10725249   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11125038   PMID:11217851   PMID:12466851   PMID:12477932   PMID:12904583   PMID:14610273  
PMID:15489334   PMID:16141072   PMID:16141073   PMID:17967808   PMID:18799693   PMID:19923215   PMID:21267068   PMID:21677750   PMID:21873635   PMID:22579044   PMID:22802351   PMID:23603115  
PMID:23744109   PMID:26903602   PMID:27009121   PMID:28738408   PMID:29016854   PMID:29662492   PMID:30154151   PMID:30273559   PMID:30973865   PMID:32325033   PMID:32886170   PMID:34321999  
PMID:34599932   PMID:34655526   PMID:35140396   PMID:35477763   PMID:36542058   PMID:37335136  


Genomics

Comparative Map Data
Rnaseh2b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391462,569,517 - 62,610,445 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1462,530,038 - 62,610,441 (+)EnsemblGRCm39 Ensembl
GRCm381462,332,068 - 62,372,996 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1462,292,589 - 62,372,992 (+)EnsemblGRCm38mm10GRCm38
MGSCv371462,950,942 - 62,991,829 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361461,286,215 - 61,327,102 (+)NCBIMGSCv36mm8
Celera1460,101,639 - 60,143,101 (+)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1433.19NCBI
RNASEH2B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381350,909,678 - 50,970,460 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1350,909,747 - 51,024,120 (+)EnsemblGRCh38hg38GRCh38
GRCh371351,483,814 - 51,544,596 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361350,381,928 - 50,428,901 (+)NCBINCBI36Build 36hg18NCBI36
Celera1332,532,888 - 32,593,597 (+)NCBICelera
Cytogenetic Map13q14.3NCBI
HuRef1332,272,725 - 32,333,508 (+)NCBIHuRef
CHM1_11351,451,357 - 51,512,138 (+)NCBICHM1_1
T2T-CHM13v2.01350,124,630 - 50,185,409 (+)NCBIT2T-CHM13v2.0
Rnaseh2b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81540,717,252 - 40,770,826 (+)NCBIGRCr8
mRatBN7.21536,541,200 - 36,592,016 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1536,541,218 - 36,584,118 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1538,417,594 - 38,460,476 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01539,568,229 - 39,611,111 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01538,001,910 - 38,044,798 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01545,422,010 - 45,472,792 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1545,422,010 - 45,464,892 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01549,197,404 - 49,248,205 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41541,554,754 - 41,597,638 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11541,570,453 - 41,613,336 (+)NCBI
Celera1536,231,039 - 36,273,907 (+)NCBICelera
Cytogenetic Map15p12NCBI
Rnaseh2b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554314,291,688 - 4,351,178 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554314,291,687 - 4,368,169 (+)NCBIChiLan1.0ChiLan1.0
RNASEH2B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21452,348,075 - 52,411,842 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11350,991,902 - 51,055,679 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01332,047,830 - 32,108,573 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11350,804,013 - 50,839,440 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1350,795,701 - 50,852,909 (+)Ensemblpanpan1.1panPan2
RNASEH2B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.122944,399 - 1,010,479 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl22931,751 - 991,223 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha22974,899 - 1,043,575 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.022933,922 - 992,941 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl22910,307 - 992,878 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.122855,278 - 913,961 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.022894,348 - 961,862 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.022922,842 - 981,538 (-)NCBIUU_Cfam_GSD_1.0
Rnaseh2b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945160,307,255 - 160,355,963 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365653,791,329 - 3,840,016 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365653,791,305 - 3,839,991 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RNASEH2B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1116,825,128 - 16,911,969 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11116,825,799 - 16,911,959 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
RNASEH2B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1328,791,490 - 28,856,542 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl328,791,748 - 28,841,733 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605714,998,872 - 15,066,688 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rnaseh2b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247483,246,707 - 3,339,443 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rnaseh2b
1557 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:519
Count of miRNA genes:377
Interacting mature miRNAs:433
Transcripts:ENSMUST00000022499, ENSMUST00000156608, ENSMUST00000166879, ENSMUST00000169728
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357589Kdnw2_mkidney weight 2 (mouse)Not determined1420887473121269804Mouse
1357527Epfpq1_mepididymal fat percentage QTL 1 (mouse)Not determined142106245071885801Mouse
10043886Cia49_mcollagen induced arthritis QTL 49 (mouse)Not determined142999699463997133Mouse
27226774Tibl15_mtibia length 15, 10 week (mouse)143032195787937436Mouse
1300909Ath13_matherosclerosis 13 (mouse)Not determined143033525064335381Mouse
1300998Cia17_mcollagen induced arthritis 17 (mouse)Not determined143033525064335381Mouse
1300625Cosz2_mcocaine seizure 2 (mouse)Not determined143504579768785736Mouse
10043887Cia50_mcollagen induced arthritis QTL 50 (mouse)Not determined143743018571430320Mouse
4142419Tgq26_mtriglyceride QTL 26 (mouse)Not determined4033731974337319Mouse
1301777Bglq15_mbody growth late QTL 15 (mouse)Not determined144296241676962593Mouse
1301424Skull21_mskull morphology 21 (mouse)Not determined144296241676962593Mouse
1300805Mors3_mmodifier of obesity related sterility 3 (mouse)Not determined144303727077037418Mouse
1301091Bbaa21_mB.burgdorferi-associated arthritis 21 (mouse)Not determined144306584777066045Mouse
4141400Nilac8_mnicotine induced locomotor activity 8 (mouse)Not determined144306584777066045Mouse
1300605El5_mepilepsy 5 (mouse)Not determined144945542583455556Mouse
4142364Pbwg18_mpostnatal body weight growth 18 (mouse)Not determined145228198486282125Mouse
1301489Lbm10_mlean body mass 10 (mouse)Not determined145376129687761529Mouse
12880432Fgf23lq3_mFGF23 serum level QTL 3 (mouse)145393744087937440Mouse
10043889Cia52_mcollagen induced arthritis QTL 52 (mouse)Not determined145608238190082509Mouse
1301562Hwq1_mheart weight quantitative locus 1 (mouse)Not determined145654674590546941Mouse
1357565wrmod1_mwobbler modifier 1 (mouse)Not determined1458179640101859473Mouse
11039527Ccc2_mcolitis susceptibility in the Collaborative Cross 2 (mouse)145991861294138217Mouse
1300666Fembm2_mfemoral bone morphometry 2 (mouse)Not determined146239746096397680Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000022499   ⟹   ENSMUSP00000022499
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1462,569,517 - 62,610,441 (+)Ensembl
GRCm38.p6 Ensembl1462,332,068 - 62,372,992 (+)Ensembl
RefSeq Acc Id: ENSMUST00000156608
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1462,584,748 - 62,592,776 (+)Ensembl
GRCm38.p6 Ensembl1462,347,299 - 62,355,327 (+)Ensembl
RefSeq Acc Id: ENSMUST00000166879   ⟹   ENSMUSP00000129165
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1462,530,038 - 62,591,007 (+)Ensembl
GRCm38.p6 Ensembl1462,292,589 - 62,353,558 (+)Ensembl
RefSeq Acc Id: ENSMUST00000169728   ⟹   ENSMUSP00000132267
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1462,569,574 - 62,601,549 (+)Ensembl
GRCm38.p6 Ensembl1462,332,125 - 62,364,100 (+)Ensembl
RefSeq Acc Id: NM_026001   ⟹   NP_080277
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391462,569,517 - 62,610,445 (+)NCBI
GRCm381462,332,068 - 62,372,996 (+)NCBI
MGSCv371462,950,942 - 62,991,829 (+)RGD
Celera1460,101,639 - 60,143,101 (+)RGD
cM Map14 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_080277   ⟸   NM_026001
- UniProtKB: Q9D014 (UniProtKB/Swiss-Prot),   Q80ZV0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000129165   ⟸   ENSMUST00000166879
RefSeq Acc Id: ENSMUSP00000022499   ⟸   ENSMUST00000022499
RefSeq Acc Id: ENSMUSP00000132267   ⟸   ENSMUST00000169728
Protein Domains
Rnh202 triple barrel

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q80ZV0-F1-model_v2 AlphaFold Q80ZV0 1-308 view protein structure

Promoters
RGD ID:8682662
Promoter ID:EPDNEW_M19361
Type:multiple initiation site
Name:Rnaseh2b_1
Description:Mus musculus ribonuclease H2, subunit B , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381462,332,093 - 62,332,153EPDNEW
RGD ID:6825343
Promoter ID:MM_KWN:17151
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day2,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:OTTMUST00000047290
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361462,950,781 - 62,951,392 (+)MPROMDB
RGD ID:6825345
Promoter ID:MM_KWN:17152
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:OTTMUST00000047291
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361462,965,656 - 62,966,422 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1914403 AgrOrtholog
Ensembl Genes ENSMUSG00000021932 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000022499 ENTREZGENE
  ENSMUST00000022499.13 UniProtKB/Swiss-Prot
  ENSMUST00000166879.8 UniProtKB/TrEMBL
  ENSMUST00000169728.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.20.120 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.20.25.530 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro RNase_H2_suB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNase_H2_suB_wHTH UniProtKB/Swiss-Prot
  Rnh202_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:67153 UniProtKB/Swiss-Prot
MGD MGI:1914403 ENTREZGENE
NCBI Gene 67153 ENTREZGENE
PANTHER PTHR13383 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RIBONUCLEASE H2 SUBUNIT B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam RNase_H2-Ydr279 UniProtKB/Swiss-Prot
  Ydr279_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rnaseh2b PhenoGen
UniProt E9PYC5_MOUSE UniProtKB/TrEMBL
  F6WF94_MOUSE UniProtKB/TrEMBL
  Q80ZV0 ENTREZGENE
  Q9D014 ENTREZGENE
  RNH2B_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q9D014 UniProtKB/Swiss-Prot