Lyrm2 (LYR motif containing 2) - Rat Genome Database

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Gene: Lyrm2 (LYR motif containing 2) Mus musculus
Analyze
Symbol: Lyrm2
Name: LYR motif containing 2
RGD ID: 1617427
MGI Page MGI
Description: Predicted to be involved in mitochondrial respiratory chain complex I assembly. Located in mitochondrion. Orthologous to human LYRM2 (LYR motif containing 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2610208E05Rik; LYR motif-containing protein 2; novel complex 1 (LYR family) protein; RP23-301P13.1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39432,800,259 - 32,802,268 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl432,800,253 - 32,801,559 (+)EnsemblGRCm39 Ensembl
GRCm38432,800,259 - 32,802,268 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl432,800,253 - 32,801,559 (+)EnsemblGRCm38mm10GRCm38
MGSCv37432,887,234 - 32,889,243 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36433,128,878 - 33,130,863 (+)NCBIMGSCv36mm8
Celera432,539,655 - 32,541,664 (+)NCBICelera
Cytogenetic Map4A5NCBI
cM Map414.42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
mitochondrion  (HDA,IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:14610273   PMID:15489334   PMID:16141072   PMID:16141073  
PMID:18614015   PMID:21873635   PMID:32325033  


Genomics

Comparative Map Data
Lyrm2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39432,800,259 - 32,802,268 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl432,800,253 - 32,801,559 (+)EnsemblGRCm39 Ensembl
GRCm38432,800,259 - 32,802,268 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl432,800,253 - 32,801,559 (+)EnsemblGRCm38mm10GRCm38
MGSCv37432,887,234 - 32,889,243 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36433,128,878 - 33,130,863 (+)NCBIMGSCv36mm8
Celera432,539,655 - 32,541,664 (+)NCBICelera
Cytogenetic Map4A5NCBI
cM Map414.42NCBI
LYRM2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38689,632,224 - 89,638,747 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl689,568,144 - 89,638,749 (-)EnsemblGRCh38hg38GRCh38
GRCh37690,341,943 - 90,348,466 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36690,398,664 - 90,405,195 (-)NCBINCBI36Build 36hg18NCBI36
Celera690,760,915 - 90,767,451 (-)NCBICelera
Cytogenetic Map6q15NCBI
HuRef687,558,887 - 87,565,423 (-)NCBIHuRef
CHM1_1690,439,537 - 90,446,073 (-)NCBICHM1_1
T2T-CHM13v2.0690,841,594 - 90,848,122 (-)NCBIT2T-CHM13v2.0
Lyrm2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8551,994,540 - 51,996,818 (+)NCBIGRCr8
mRatBN7.2547,198,192 - 47,200,470 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl547,198,185 - 47,201,611 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx549,340,036 - 49,342,314 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0550,939,194 - 50,941,472 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0550,884,663 - 50,886,941 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0548,047,913 - 48,050,191 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl548,047,913 - 48,050,187 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0552,635,558 - 52,637,836 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4549,094,373 - 49,096,651 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera545,957,501 - 45,959,779 (+)NCBICelera
Cytogenetic Map5q21NCBI
Lyrm2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541116,361,413 - 16,362,878 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541116,361,061 - 16,362,913 (-)NCBIChiLan1.0ChiLan1.0
LYRM2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25109,712,762 - 109,719,905 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16107,618,004 - 107,622,669 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0687,508,920 - 87,514,494 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1690,749,675 - 90,787,842 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl690,769,748 - 90,787,842 (-)Ensemblpanpan1.1panPan2
LYRM2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11248,846,168 - 48,850,095 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1248,847,859 - 48,850,011 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1248,653,797 - 48,656,735 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01249,655,971 - 49,658,824 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1249,656,838 - 49,658,732 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11248,971,169 - 48,974,092 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01248,872,326 - 48,875,264 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01249,064,717 - 49,067,655 (-)NCBIUU_Cfam_GSD_1.0
Lyrm2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494683,863,196 - 83,864,925 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365102,605,918 - 2,610,958 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365102,605,964 - 2,607,674 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LYRM2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl157,651,684 - 57,654,886 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1157,651,682 - 57,654,895 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2164,551,585 - 64,554,795 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LYRM2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11314,396,532 - 14,398,806 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1314,397,100 - 14,398,558 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040190,711,744 - 190,715,743 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lyrm2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247994,527,628 - 4,530,434 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Lyrm2
100 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:249
Count of miRNA genes:219
Interacting mature miRNAs:234
Transcripts:ENSMUST00000062802, ENSMUST00000130321, ENSMUST00000135833
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156268235Mouse
1302010Wta1_mweight adult 1 (mouse)Not determined4868324042683429Mouse
1558992Ses8_msalmonella enteritidis susceptibility 8 (mouse)Not determined4868324042683429Mouse
1301473Triglq1_mtriglyceride QTL 1 (mouse)Not determined4868324042683429Mouse
1302125Lxw1_mlupus BXSB x NZW 1 (mouse)Not determined4868324042683429Mouse
4141302Ssrq5_mstress response QTL 5 (mouse)Not determined868324042683430Mouse
10401905Sicd3_mseizure-induced cell death 3 (mouse)Not determined4939552543760862Mouse
10401115Pgia35_mproteoglycan induced arthritis 35 (mouse)Not determined41256237746562509Mouse
12880405Jcdq1_mjoint cartilage degeneration QTL 1 (mouse)41256237746562509Mouse
4142318Lyr2_mlymphoma resistance 2 (mouse)Not determined1401045763283678Mouse
4142047Mvwf3_mmodifier of von Willebrand factor 3 (mouse)Not determined14010457117072206Mouse
1301203Alcp8_malcohol preference locus 8 (mouse)Not determined41739516051395290Mouse
1301237Alcp7_malcohol preference locus 7 (mouse)Not determined41739516051395290Mouse
4141555Nbwa2_mNZB and NZW autoimmunity 2 (mouse)Not determined41789251551892635Mouse
4141911W6q15_mweight 6 weeks QTL 15 (mouse)Not determined1789261688982216Mouse
39128211Lwq22_mliver weight QTL 22 (mouse)41789261688982216Mouse
1357453Kidq4_mkidney weight QTL 4 (mouse)Not determined41789261688982216Mouse
25440481Moaq1_mmodifier of alien QTL 1 (mouse)41950000046000000Mouse
1302058Hrtfm3_mheart failure modifier 3 (mouse)Not determined42211194456112145Mouse
1300769Pcyts2_mplasmacytoma susceptibility 2 (mouse)Not determined42211194456112145Mouse
1301437Scon1_msucrose consumption 1 (mouse)Not determined42237344856373612Mouse
1302075Bdln6_mbody length 6 (mouse)Not determined42237344856373612Mouse
1301697Sluc18_msusceptibility to lung cancer 18 (mouse)Not determined42237344856373612Mouse
1302184Aaom1_mautoimmune aoritis in MRL mice 1 (mouse)Not determined42432229946332776Mouse
1300574Im2_mimmunoregulatory 2 (mouse)Not determined42807768262077816Mouse
1301586Stheal3_msoft tissue heal 3 (mouse)Not determined42865844262658566Mouse
1357877Synch1_msynechia 1 (mouse)Not determined42870992562710107Mouse
1301990Arvm1_mautoimmune renal vasculitis 1 (mouse)Not determined42933264663332776Mouse
12903995Opfaq2_mopen field activity QTL 2 (mouse)43034341933824057Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000062802   ⟹   ENSMUSP00000061451
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl432,800,253 - 32,801,383 (+)Ensembl
GRCm38.p6 Ensembl432,800,253 - 32,801,383 (+)Ensembl
RefSeq Acc Id: ENSMUST00000130321
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl432,800,282 - 32,800,975 (+)Ensembl
GRCm38.p6 Ensembl432,800,282 - 32,800,975 (+)Ensembl
RefSeq Acc Id: ENSMUST00000135833
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl432,800,279 - 32,801,559 (+)Ensembl
GRCm38.p6 Ensembl432,800,279 - 32,801,559 (+)Ensembl
RefSeq Acc Id: NM_175364   ⟹   NP_780573
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39432,800,259 - 32,802,268 (+)NCBI
GRCm38432,800,259 - 32,802,268 (+)ENTREZGENE
MGSCv37432,887,234 - 32,889,243 (+)RGD
Celera432,539,655 - 32,541,664 (+)RGD
cM Map4 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_780573 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH28533 (Get FASTA)   NCBI Sequence Viewer  
  BAC32093 (Get FASTA)   NCBI Sequence Viewer  
  EDL05501 (Get FASTA)   NCBI Sequence Viewer  
  EDL05502 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000061451
  ENSMUSP00000061451.5
GenBank Protein Q8R033 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_780573   ⟸   NM_175364
- UniProtKB: A2ANY7 (UniProtKB/Swiss-Prot),   Q8R033 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000061451   ⟸   ENSMUST00000062802

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8R033-F1-model_v2 AlphaFold Q8R033 1-88 view protein structure

Promoters
RGD ID:6882970
Promoter ID:EPDNEW_M4936
Type:multiple initiation site
Name:Lyrm2_1
Description:Mus musculus LYR motif containing 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38432,800,282 - 32,800,342EPDNEW
RGD ID:6835605
Promoter ID:MM_KWN:36981
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000011046,   OTTMUST00000011047,   OTTMUST00000011048
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36432,886,964 - 32,887,464 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1917573 AgrOrtholog
Ensembl Genes ENSMUSG00000045854 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000062802 ENTREZGENE
  ENSMUST00000062802.5 UniProtKB/Swiss-Prot
InterPro Complex1_LYR UniProtKB/Swiss-Prot
  Complex1_LYR_LYRM2 UniProtKB/Swiss-Prot
KEGG Report mmu:108755 UniProtKB/Swiss-Prot
MGD MGI:1917573 ENTREZGENE
NCBI Gene 108755 ENTREZGENE
PANTHER LYR MOTIF-CONTAINING PROTEIN 2 UniProtKB/Swiss-Prot
  LYR MOTIF-CONTAINING PROTEIN 2 UniProtKB/Swiss-Prot
Pfam Complex1_LYR UniProtKB/Swiss-Prot
PhenoGen Lyrm2 PhenoGen
UniProt A2ANY7 ENTREZGENE
  LYRM2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A2ANY7 UniProtKB/Swiss-Prot