Tmprss11a (transmembrane protease, serine 11a) - Rat Genome Database

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Gene: Tmprss11a (transmembrane protease, serine 11a) Mus musculus
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Symbol: Tmprss11a
Name: transmembrane protease, serine 11a
RGD ID: 1617402
MGI Page MGI
Description: Predicted to have serine-type peptidase activity. Predicted to be involved in proteolysis in other organism and viral entry into host cell. Predicted to localize to extracellular region and integral component of plasma membrane. Is expressed in bladder; eye; foregut; male reproductive gland or organ; and pituitary gland. Orthologous to human TMPRSS11A (transmembrane serine protease 11A); INTERACTS WITH 2,2',4,4',5,5'-hexachlorobiphenyl; 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: airway trypsin-like protease 1; DESC-3; Gm7; serine protease DESC3; transmembrane protease serine 11A
RGD Orthologs
Human
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39586,558,269 - 86,617,034 (-)NCBIGRCm39mm39
GRCm39 Ensembl586,558,269 - 86,616,849 (-)Ensembl
GRCm38586,410,410 - 86,469,175 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl586,410,410 - 86,468,990 (-)EnsemblGRCm38mm10GRCm38
MGSCv37586,839,435 - 86,898,015 (-)NCBIGRCm37mm9NCBIm37
MGSCv36587,484,971 - 87,543,551 (-)NCBImm8
Celera583,639,113 - 83,697,451 (-)NCBICelera
Cytogenetic Map5E1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:10349636   PMID:10725249   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:16141072   PMID:16141073   PMID:21853097   PMID:29976755   PMID:31501243  
PMID:32325033  


Genomics

Comparative Map Data
Tmprss11a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39586,558,269 - 86,617,034 (-)NCBIGRCm39mm39
GRCm39 Ensembl586,558,269 - 86,616,849 (-)Ensembl
GRCm38586,410,410 - 86,469,175 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl586,410,410 - 86,468,990 (-)EnsemblGRCm38mm10GRCm38
MGSCv37586,839,435 - 86,898,015 (-)NCBIGRCm37mm9NCBIm37
MGSCv36587,484,971 - 87,543,551 (-)NCBImm8
Celera583,639,113 - 83,697,451 (-)NCBICelera
Cytogenetic Map5E1NCBI
TMPRSS11A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl467,909,395 - 67,964,140 (-)EnsemblGRCh38hg38GRCh38
GRCh38467,909,395 - 67,963,493 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37468,775,113 - 68,829,211 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36468,458,614 - 68,511,827 (-)NCBINCBI36hg18NCBI36
Celera466,238,428 - 66,291,616 (-)NCBI
Cytogenetic Map4q13.2NCBI
HuRef464,689,116 - 64,742,288 (-)NCBIHuRef
CHM1_1468,813,094 - 68,866,308 (-)NCBICHM1_1
Tmprss11a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21421,624,881 - 21,665,284 (+)NCBI
Rnor_6.0 Ensembl1423,245,653 - 23,283,092 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01423,226,735 - 23,284,515 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01423,136,021 - 23,173,398 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1421,079,097 - 21,138,292 (+)NCBICelera
Cytogenetic Map14p21NCBI
TMPRSS11A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1462,481,403 - 62,533,929 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl462,481,403 - 62,533,929 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0456,087,123 - 56,139,951 (+)NCBIMhudiblu_PPA_v0panPan3
TMPRSS11A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11358,412,487 - 58,484,166 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1358,432,305 - 58,482,573 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1358,349,009 - 58,384,157 (-)NCBI
ROS_Cfam_1.01359,128,326 - 59,158,878 (-)NCBI
UMICH_Zoey_3.11358,771,278 - 58,806,522 (-)NCBI
UNSW_CanFamBas_1.01358,266,629 - 58,317,564 (-)NCBI
UU_Cfam_GSD_1.01359,272,292 - 59,307,463 (-)NCBI
LOC101971520
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528517,973,627 - 18,025,045 (+)NCBI
SpeTri2.0NW_004936582550,285 - 588,538 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC100525933
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl865,636,850 - 65,683,866 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1865,635,551 - 65,684,004 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2870,060,270 - 70,105,495 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TMPRSS11A
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.171,005,831 - 1,046,469 (+)NCBI
ChlSab1.1 Ensembl71,006,205 - 1,046,428 (+)Ensembl
Vero_WHO_p1.0NW_0236660661,085,894 - 1,148,646 (+)NCBI
Tmprss11a
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624761877,313 - 951,663 (+)NCBI

Position Markers
Tmprss11a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5E1UniSTS
cM Map5 UniSTS
UniSTS:235208  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38586,410,459 - 86,410,658UniSTSGRCm38
MGSCv37586,839,484 - 86,839,683UniSTSGRCm37
Celera583,639,162 - 83,639,361UniSTS
Cytogenetic Map5E1UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301693Sle6_msystemic lupus erythematosus susceptibility 6 (mouse)Not determined5884069387693978Mouse
11341716Rvfs3_mRift Valley fever susceptibility 3 (mouse)526236236138457140Mouse
4140990Lgq6_mlate growth QTL 6 (mouse)Not determined31975890100630065Mouse
4141219W10q16_mweight 10 weeks QTL 16 (mouse)Not determined31975890100630065Mouse
1301524Lmb2_mlupus in MRL and B6 F2 cross (mouse)Not determined537424144112317856Mouse
11041665Lmr24_mleishmaniasis resistance 24 (mouse)552537120107173175Mouse
11041899Lmr24a_mleishmaniasis resistance 24a (mouse)552537120107173175Mouse
4142064Tmc1m4_mTmc1 modifier 4 (mouse)Not determined554342835126924008Mouse
1301243Bmd2_mbone mineral density 2 (mouse)Not determined555230992100307666Mouse
4142317Rgcs1_mretinal ganglion cell susceptible 1 (mouse)Not determined55230992108614761Mouse
13464248Ahl13_mage related hearing loss, early onset 13 (mouse)55548853189488652Mouse
10043962Obq27_mobesity QTL 27 (mouse)Not determined55612831290128312Mouse
10044005Ahl7_mage related hearing loss 7 (mouse)Not determined55816984192169980Mouse
11040589Lmr3a_mleishmaniasis resistance 3a (mouse)55945495493455133Mouse
11040590Lmr3b_mleishmaniasis resistance 3b (mouse)55945495493455133Mouse
11040591Lmr3c_mleishmaniasis resistance 3c (mouse)55945495493455133Mouse
11040592Lmr3d_mleishmaniasis resistance 3d (mouse)55945495493455133Mouse
1301843Listr1_mlisteriosis resistance 1 (mouse)Not determined56009823494098356Mouse
13464247Ahl14_mage related hearing loss, early onset 14 (mouse)56025521594255313Mouse
4142428Modvl1_mmodifier of vacuolated lens 1 (mouse)Not determined6250272196502841Mouse
1301010ahl2_mage related hearing loss 2 (mouse)Not determined56250272196502841Mouse
11252124Modvl6_mmodifier of vacuolated lens 6 (mouse)56250272196502841Mouse
13464250Ahl15_mage related hearing loss, early onset 15 (mouse)56250272196502841Mouse
10045972Tir5_mtrypanosome infection response 5 (mouse)Not determined563548099104239199Mouse
11049560Lmr24d_mleishmaniasis resistance 24d (mouse)56422703098227149Mouse
12904739M2fscn2_mmodifier 2 of FSCN2 (mouse)566381814100381814Mouse
12904740M1fscn2_mmodifier 1 of Fscn2 (mouse)566381814100381814Mouse
26884395Humsd2_mhumerus midshaft diameter 2, 10 week (mouse)569900000132500000Mouse
10043993Hbnr10_mHeligmosomoides bakeri nematode resistance 10 (mouse)Not determined572271017106271152Mouse
27226719Tibw6_mtibia width 6, proximal, 16 week (mouse)572700000140000000Mouse
13506928Recrq8_mrecombination rate in male meiosis QTL 8 (mouse)574300000132500000Mouse
25314315Mlh1fc4_mMLH1 foci count 4 (mouse)574300000132500000Mouse
4141124Dshv2_mdorsal hippocampal volume 2 (mouse)Not determined57515468797871944Mouse
1357431Cia27_mcollagen induced arthritis 27 (mouse)Not determined575154687119880564Mouse
4141438Skmw13_mskeletal muscle weight 13 (mouse)Not determined576042404110042620Mouse
4141505Chlq14_mcirculating hormone level QTL 14 (mouse)Not determined576132927110133058Mouse
1301691Cdcs10_mcytokine deficiency colitis susceptibility 10 (mouse)Not determined576132927110133058Mouse
1300986Hdlq2_mHDL QTL 2 (mouse)Not determined576132927110133058Mouse
1300931Cocrb6_mcocaine related behavior 6 (mouse)Not determined576297205110297366Mouse
1301829Thyls2_mthymic lymphoma susceptibility 2 (mouse)Not determined576297205110297366Mouse
1301713Dbsty2_mdiabesity 2 (mouse)Not determined576297205110297366Mouse
13464249Ahl16_mage related hearing loss, early onset 16 (mouse)576297205110297366Mouse
12910784Pwgrq15_mpost-weaning growth rate QTL 15 (mouse)57702797697510356Mouse
12910816Ogrq2_moverall growth rate QTL 2 (mouse)57702797697510356Mouse
10401246Bglu13_mblood glucose level 13 (mouse)Not determined579391781113391927Mouse
10755524Mono1_mmonocyte differential 1 (mouse)580701400114701400Mouse
1301419Cypr3_mcytokine production 3 (mouse)Not determined580871790114871944Mouse
10401245Bglu18_mblood glucose level 18 (mouse)Not determined582690609116690738Mouse
13464242Ahl17_mage related hearing loss, early onset 17 (mouse)582690609116690738Mouse
12738408Lfibq5_mliver fibrosis QTL 5 (mouse)58463599489818182Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:295
Count of miRNA genes:242
Interacting mature miRNAs:260
Transcripts:ENSMUST00000101073
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000101073   ⟹   ENSMUSP00000098634
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl586,410,410 - 86,468,990 (-)Ensembl
RefSeq Acc Id: ENSMUST00000198504
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl586,415,288 - 86,418,345 (-)Ensembl
RefSeq Acc Id: NM_001033233   ⟹   NP_001028405
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39586,558,269 - 86,616,849 (-)NCBI
GRCm38586,410,410 - 86,468,990 (-)NCBI
MGSCv37586,839,435 - 86,898,015 (-)RGD
Celera583,639,113 - 83,697,451 (-)RGD
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006534840   ⟹   XP_006534903
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39586,558,269 - 86,617,034 (-)NCBI
GRCm38586,410,410 - 86,469,175 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001028405 (Get FASTA)   NCBI Sequence Viewer  
  XP_006534903 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAE25202 (Get FASTA)   NCBI Sequence Viewer  
  Q3UQ41 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001028405   ⟸   NM_001033233
- UniProtKB: Q3UQ41 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006534903   ⟸   XM_006534840
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000098634   ⟸   ENSMUST00000101073
Protein Domains
Peptidase S1   SEA

Promoters
RGD ID:6887012
Promoter ID:EPDNEW_M6957
Type:initiation region
Name:Tmprss11a_1
Description:Mus musculus transmembrane protease, serine 11a , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38586,469,085 - 86,469,145EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2684853 AgrOrtholog
Ensembl Genes ENSMUSG00000072845 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000098634 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000101073 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot
  3.30.70.960 UniProtKB/Swiss-Prot
InterPro Pept_S1A_HAT/DESC1 UniProtKB/Swiss-Prot
  Peptidase_S1_PA UniProtKB/Swiss-Prot
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot
  Peptidase_S1A UniProtKB/Swiss-Prot
  SEA_dom UniProtKB/Swiss-Prot
  SEA_dom_sf UniProtKB/Swiss-Prot
  Trypsin_dom UniProtKB/Swiss-Prot
  TRYPSIN_HIS UniProtKB/Swiss-Prot
  TRYPSIN_SER UniProtKB/Swiss-Prot
KEGG Report mmu:194597 UniProtKB/Swiss-Prot
MGD MGI:2684853 ENTREZGENE
NCBI Gene 194597 ENTREZGENE
Pfam SEA UniProtKB/Swiss-Prot
  Trypsin UniProtKB/Swiss-Prot
PhenoGen Tmprss11a PhenoGen
PIRSF TMPRSS11ABCDE UniProtKB/Swiss-Prot
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot
PROSITE SEA UniProtKB/Swiss-Prot
  TRYPSIN_DOM UniProtKB/Swiss-Prot
  TRYPSIN_HIS UniProtKB/Swiss-Prot
  TRYPSIN_SER UniProtKB/Swiss-Prot
SMART Tryp_SPc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot
  SSF82671 UniProtKB/Swiss-Prot
UniProt Q3UQ41 ENTREZGENE, UniProtKB/Swiss-Prot