Irgc (immunity related GTPase cinema) - Rat Genome Database

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Gene: Irgc (immunity related GTPase cinema) Mus musculus
Analyze
Symbol: Irgc
Name: immunity related GTPase cinema
RGD ID: 1617396
MGI Page MGI
Description: Predicted to enable GTPase activity. Involved in positive regulation of flagellated sperm motility. Located in lipid droplet and sperm mitochondrial sheath. Orthologous to human IRGC (immunity related GTPase cinema).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: F630044M05Rik; gene model 1102, (NCBI); Gm1102; Gm474; Ifgge; Ii; Iigp5; immunity related GTPase cinema 1; immunity-related GTPase cinema 1; immunity-related GTPase family, cinema 1; interferon inducible GTPase 5; interferon inducible GTPase family member 5; interferon-gamma-inducible GTPase Ifgge protein; interferon-inducible GTPase 5; Irgc1; similar to hypothetical protein R30953_1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39724,131,344 - 24,145,107 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl724,131,347 - 24,151,722 (-)EnsemblGRCm39 Ensembl
GRCm38724,431,919 - 24,445,682 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl724,431,922 - 24,452,297 (-)EnsemblGRCm38mm10GRCm38
MGSCv37725,216,945 - 25,230,701 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36724,140,686 - 24,154,442 (-)NCBIMGSCv36mm8
Celera719,056,292 - 19,060,313 (-)NCBICelera
Cytogenetic Map7A3NCBI
cM Map710.74NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:16141072   PMID:16141073   PMID:21267068   PMID:21677750   PMID:21873635   PMID:28378742   PMID:35618043  
PMID:37195149   PMID:38355793  


Genomics

Comparative Map Data
Irgc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39724,131,344 - 24,145,107 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl724,131,347 - 24,151,722 (-)EnsemblGRCm39 Ensembl
GRCm38724,431,919 - 24,445,682 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl724,431,922 - 24,452,297 (-)EnsemblGRCm38mm10GRCm38
MGSCv37725,216,945 - 25,230,701 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36724,140,686 - 24,154,442 (-)NCBIMGSCv36mm8
Celera719,056,292 - 19,060,313 (-)NCBICelera
Cytogenetic Map7A3NCBI
cM Map710.74NCBI
IRGC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381943,716,076 - 43,720,021 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1943,716,076 - 43,720,021 (+)EnsemblGRCh38hg38GRCh38
GRCh371944,220,228 - 44,224,173 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361948,912,078 - 48,916,013 (+)NCBINCBI36Build 36hg18NCBI36
Celera1941,023,793 - 41,027,752 (+)NCBICelera
Cytogenetic Map19q13.31NCBI
HuRef1940,652,422 - 40,656,381 (+)NCBIHuRef
CHM1_11944,222,341 - 44,226,300 (+)NCBICHM1_1
T2T-CHM13v2.01946,538,808 - 46,542,768 (+)NCBIT2T-CHM13v2.0
Irgc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8189,148,056 - 89,151,838 (-)NCBIGRCr8
mRatBN7.2180,020,114 - 80,025,797 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl180,020,079 - 80,025,802 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx185,413,689 - 85,417,369 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0193,963,614 - 93,967,294 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0187,169,500 - 87,173,180 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0181,291,739 - 81,295,517 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl181,291,765 - 81,295,442 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0182,554,278 - 82,558,015 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4179,675,031 - 79,678,711 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1179,753,144 - 79,756,822 (-)NCBI
Celera174,474,520 - 74,478,200 (-)NCBICelera
Cytogenetic Map1q21NCBI
Irgc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555551,443,822 - 1,445,213 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555551,442,188 - 1,445,305 (+)NCBIChiLan1.0ChiLan1.0
IRGC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22049,874,608 - 49,883,428 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11951,747,306 - 51,766,031 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01940,664,034 - 40,669,120 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11949,270,112 - 49,274,101 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1949,272,639 - 49,274,030 (+)Ensemblpanpan1.1panPan2
LOC476445
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11111,442,243 - 111,447,194 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1111,441,748 - 111,447,042 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1110,922,293 - 110,925,427 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01112,015,589 - 112,020,435 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1112,015,593 - 112,018,727 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11111,640,677 - 111,643,815 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01111,274,631 - 111,277,769 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01112,158,685 - 112,161,819 (-)NCBIUU_Cfam_GSD_1.0
Irgc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934916,548,843 - 16,552,153 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936706896,247 - 900,088 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936706896,247 - 899,492 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IRGC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl650,542,124 - 50,543,636 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1650,540,292 - 50,543,636 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2646,399,945 - 46,403,353 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IRGC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1637,239,527 - 37,241,438 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl637,239,976 - 37,241,367 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607316,784,238 - 16,785,764 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Irgc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249071,229,663 - 1,231,450 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249071,229,630 - 1,231,778 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Irgc
495 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:221
Count of miRNA genes:205
Interacting mature miRNAs:212
Transcripts:ENSMUST00000080594
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300722Sle3_msystemic lupus erythmatosus susceptibility 3 (mouse)Not determined7351172887142720Mouse
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
4141566Femwf8_mfemur work to failure 8 (mouse)Not determined1303248547032621Mouse
1301041Prnr2_mprion resistance 2 (mouse)Not determined71872879439674033Mouse
12904742Litsq2_mlitter size QTL 2 (mouse)72267388756674033Mouse
1301622Eae12_msusceptibility to experimental allergic encephalomyelitis 12 (mouse)Not determined71928001553280104Mouse
11354952Pdcc1_mplasmacytoid dentritic cell compartment 1 (mouse)72306653157066531Mouse
38501068Tip1_mtuberculosis immunophenotype 1, spleen CFU (mouse)7360299972549748Mouse
1301115Lrdm1_mlymphoproliferation (Fas) renal disease modifier 1 (mouse)Not determined7335204824879418Mouse
25314314Sccor1_msynaptonemal complex length to mean MLH1 count ratio 1 (mouse)71333392547349748Mouse
10449139Eosn1_meosinophil differential 1 (mouse)71248087746480877Mouse
1301052Bhr6_mbronchial hyperresponsiveness 6 (mouse)Not determined71984225053842367Mouse
11522751Cocia17_mcocaine-induced activity, QTL 17 (mouse)71313520447135204Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
1301572Sluc30_msusceptibility to lung cancer 30 (mouse)Not determined7243169636431844Mouse
1357699Nhdlq6_mnon-HDL QTL 6 (mouse)Not determined7998886743988984Mouse
10449158Eosn3_meosinophil differential 3 (mouse)71248087746480877Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718728794119485380Mouse
1558893Spir1_mStreptococcus pneumoniae infection resistance 1 (mouse)Not determined71030579844305936Mouse
1301709Bdt4_mbone density traits 4 (mouse)Not determined72288857256888716Mouse
1559016Drsi_mDCC-related Spp1 induction (mouse)Not determined71663729349159331Mouse


Sequence


Ensembl Acc Id: ENSMUST00000080594   ⟹   ENSMUSP00000104072
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl724,131,347 - 24,134,959 (-)Ensembl
GRCm38.p6 Ensembl724,431,922 - 24,435,534 (-)Ensembl
Ensembl Acc Id: ENSMUST00000205385   ⟹   ENSMUSP00000146207
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl724,132,569 - 24,151,596 (-)Ensembl
GRCm38.p6 Ensembl724,433,144 - 24,452,171 (-)Ensembl
Ensembl Acc Id: ENSMUST00000205629
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl724,150,306 - 24,151,712 (-)Ensembl
GRCm38.p6 Ensembl724,450,881 - 24,452,287 (-)Ensembl
Ensembl Acc Id: ENSMUST00000205776   ⟹   ENSMUSP00000145975
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl724,131,347 - 24,145,107 (-)Ensembl
GRCm38.p6 Ensembl724,431,922 - 24,445,682 (-)Ensembl
Ensembl Acc Id: ENSMUST00000206992
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl724,149,901 - 24,151,722 (-)Ensembl
GRCm38.p6 Ensembl724,450,476 - 24,452,297 (-)Ensembl
RefSeq Acc Id: NM_001358033   ⟹   NP_001344962
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39724,131,344 - 24,134,957 (-)NCBI
GRCm38724,431,919 - 24,435,532 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001358034   ⟹   NP_001344963
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39724,131,344 - 24,134,957 (-)NCBI
GRCm38724,431,919 - 24,435,532 (-)NCBI
Sequence:
RefSeq Acc Id: NM_199013   ⟹   NP_950178
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39724,131,351 - 24,145,107 (-)NCBI
GRCm38724,431,926 - 24,445,682 (-)NCBI
MGSCv37725,216,945 - 25,230,701 (-)RGD
Celera719,056,292 - 19,060,313 (-)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_950178   ⟸   NM_199013
- UniProtKB: D3Z720 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001344963   ⟸   NM_001358034
- UniProtKB: D3Z720 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001344962   ⟸   NM_001358033
- UniProtKB: D3Z720 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSMUSP00000145975   ⟸   ENSMUST00000205776
Ensembl Acc Id: ENSMUSP00000146207   ⟸   ENSMUST00000205385
Ensembl Acc Id: ENSMUSP00000104072   ⟸   ENSMUST00000080594
Protein Domains
IRG-type G

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8C262-F1-model_v2 AlphaFold Q8C262 1-412 view protein structure

Promoters
RGD ID:6892180
Promoter ID:EPDNEW_M9541
Type:initiation region
Name:Irgc1_1
Description:Mus musculus immunity-related GTPase family, cinema 1 , transcriptvariant 3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38724,445,604 - 24,445,664EPDNEW
RGD ID:6841357
Promoter ID:MM_KWN:49368
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Spleen
Transcripts:NM_199013
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36725,230,476 - 25,230,976 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2685948 AgrOrtholog
Ensembl Genes ENSMUSG00000062028 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000080594 ENTREZGENE
  ENSMUST00000080594.8 UniProtKB/TrEMBL
  ENSMUST00000205385.2 UniProtKB/TrEMBL
  ENSMUST00000205776 ENTREZGENE
  ENSMUST00000205776.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro G_IRG_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Immunity-related_GTPase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IRG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:2685948 ENTREZGENE
NCBI Gene Irgc ENTREZGENE
PANTHER INTERFERON-INDUCIBLE GTPASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INTERFERON-INDUCIBLE GTPASE 5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IIGP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Irgc PhenoGen
PROSITE G_IRG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0U1RQ16_MOUSE UniProtKB/TrEMBL
  D3Z720 ENTREZGENE, UniProtKB/TrEMBL
  IIGP5_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-25 Irgc  immunity related GTPase cinema  Irgc1  immunity related GTPase cinema 1  Symbol and/or name updated 27372883 PROVISIONAL
2023-06-06 Irgc1  immunity related GTPase cinema 1  Irgc1  immunity-related GTPase family, cinema 1  Symbol and/or name change 5135510 APPROVED