Fem1al (fem-1 homolog A like) - Rat Genome Database

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Gene: Fem1al (fem-1 homolog A like) Mus musculus
Analyze
No known orthologs.
Symbol: Fem1al
Name: fem-1 homolog A like
RGD ID: 1617382
MGI Page MGI
Description: Predicted to enable EP4 subtype prostaglandin E2 receptor binding activity and ubiquitin ligase-substrate adaptor activity. Predicted to be involved in negative regulation of inflammatory response and ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Predicted to be located in cytoplasm. Predicted to be part of Cul2-RING ubiquitin ligase complex. Predicted to be active in mitochondrion. Orthologous to human FEM1A (fem-1 homolog A).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 4931440F15Rik; FEM1-alpha-B; FEM1a-B; Fem1a-like; Fem1ab; protein fem-1 homolog A-B; RIKEN cDNA 4931440F15 gene; RP23-76P22.2
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391129,772,395 - 29,775,668 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1129,772,395 - 29,775,668 (-)EnsemblGRCm39 Ensembl
GRCm381129,822,395 - 29,825,668 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1129,822,395 - 29,825,668 (-)EnsemblGRCm38mm10GRCm38
MGSCv371129,722,395 - 29,725,668 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361129,722,395 - 29,725,668 (-)NCBIMGSCv36mm8
Celera1132,190,430 - 32,193,703 (-)NCBICelera
Cytogenetic Map11A3.3NCBI
cM Map1116.96NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:16141072   PMID:16141073   PMID:21267068   PMID:21873635  


Genomics

Variants

.
Variants in Fem1al
96 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:364
Count of miRNA genes:295
Interacting mature miRNAs:316
Transcripts:ENSMUST00000104962
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10044008Hbnr15_mHeligmosomoides bakeri nematode resistance 15 (mouse)Not determined1122705234227232Mouse
4141582Lgaq1_mlate growth adjusted QTL 1 (mouse)Not determined1226863768500330Mouse
12801457Intmrm2_mintima/media ratio modifier 2 (mouse)111857861652578716Mouse
27226735Metcl16_mmetatarsal-calcaneal length 16, 16 week (mouse)11525000035090827Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
10412216Eae44_mexperimental allergic encephalomyelitis susceptibility 44 (mouse)Not determined111226863739950840Mouse
1559002Lmrq4_mLeishmania major resistance QTL 4 (mouse)Not determined111226863769684947Mouse
12910817Pwgrq20_mpost-weaning growth rate QTL 20 (mouse)112719805750636094Mouse
25394552Skmw69_mskeletal muscle weight 69, TA (mouse)112969902932329535Mouse
13524844Ppiq9_mprepulse inhibition QTL 9 (mouse)11904999735077325Mouse
4141966Tailq1_mtail length QTL 1 (mouse)Not determined1226863768500330Mouse
4142109W10q2_mweight 10 weeks QTL 2 (mouse)Not determined1226863768500330Mouse
1357851Scfq3_msubcutaneous fat pad weight QTL 3 (mouse)Not determined111226863768500330Mouse
12910801Pwbwq14_mpost-weaning body weight QTL 14 (mouse)112719805750636094Mouse
1300990Bits3_mbitterness sensitivity 3 (mouse)Not determined11837212142372260Mouse
12801460Intim2_mintima modifier 2 (mouse)111857861652578716Mouse
1301426Desp2_mdespair 2 (mouse)Not determined112870858162708700Mouse
1357844Si5lq5_mserum IGFBP-5 level QTL 5 (mouse)Not determined112816587362165976Mouse
27226798Scvln18_msacral vertebrae length 2, 16 week (mouse)11325000060690826Mouse
26884446Sklq10_mskull length QTL 10, 10 week (mouse)11325000062890826Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse
26884401Huml4_mhumerus length 4, 10 week (mouse)111155000068490826Mouse
27226762Feml21_mfemur length 21, 16 week (mouse)111175000065990826Mouse
1300938Bulb3_mbulb size 3 (mouse)Not determined111857861652578716Mouse
13524848Ppiq7_mprepulse inhibition QTL 7 (mouse)112856914762569147Mouse
27095909Scvln6_msacral vertebrae length 2, 5 week (mouse)11325000044090827Mouse
27095904Scvln12_msacral vertebrae length 2, 10 week (mouse)11325000034495048Mouse
27226738Metcl11_mmetatarsal-calcaneal length 11, 10 week (mouse)11885000061390826Mouse
1357437Epfq4_mepididymal fat pad weight QTL 4 (mouse)Not determined111226863768500330Mouse
10044006Hbnr13_mHeligmosomoides bakeri nematode resistance 13 (mouse)Not determined112577262659772741Mouse
12910806Pwbwq15_mpost-weaning body weight QTL 15 (mouse)112719805750636094Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
1357518Tgyl1_mtriglyceride level 1 (mouse)Not determined11688027733916219Mouse
13463479Mchq19_mmean corpuscular hemoglobin QTL 19 (mouse)111095123244951464Mouse
4142216Lgq1_mlate growth QTL 1 (mouse)Not determined1226863768500330Mouse
1357720Kidpq1_mkidney weight percentage QTL 1 (mouse)Not determined111226863768500330Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
14746971Manh70_mmandible shape 70 (mouse)111990589053905890Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
10053687Eae6_msusceptibility to experimental allergic encephalomyelitis 6 (mouse)Not determined111778196668500330Mouse
1300579Thypr1_mthymocyte proliferative response 1 (mouse)Not determined111928257753282715Mouse
4141127W3q4_mweight 3 weeks QTL 4 (mouse)Not determined1226863768500330Mouse
4142308W6q3_mweight 6 weeks QTL 3 (mouse)Not determined111226863768500330Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
1301814Bbaa7_mB.burgdorferi-associated arthritis 7 (mouse)Not determined112601178044264695Mouse
1300599Cocrb11_mcocaine related behavior 11 (mouse)Not determined11267035536671472Mouse
27226741Metcl5_mmetatarsal-calcaneal length 5, 5 week (mouse)11465000046290827Mouse
1357640Orq2_movulation rate QTL 2 (mouse)Not determined111226863768500330Mouse
1558945Orgwq8_morgan weight QTL 8 (mouse)Not determined111705617567078411Mouse
1302171Pgia28_mproteoglycan induced arthritis 28 (mouse)Not determined11890609742906218Mouse
13463472Mcvq15_mmean corpuscular volume QTL 15 (mouse)111095123244951464Mouse
4141470Egq4_mearly growth QTL 4 (mouse)Not determined1226863768500330Mouse
12801459Leuf1_mleukocyte filtration 1 (mouse)111857861652578716Mouse
4141398Tgq22_mtriglyceride QTL 22 (mouse)Not determined2116340655163406Mouse
4141047Nilac1_mnicotine induced locomotor activity 1 (mouse)Not determined11901178043011942Mouse
1300607Tnbs2_mtri-nitrobenzene sulfonic acid susceptible 2 (mouse)Not determined112489805235126680Mouse
12910804Pwbwq16_mpost-weaning body weight QTL 16 (mouse)112719805750636094Mouse
12910818Ogrq5_moverall growth rate QTL 5 (mouse)112719805750636094Mouse


Expression


Sequence


RefSeq Acc Id: ENSMUST00000104962   ⟹   ENSMUSP00000100568
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1129,772,395 - 29,775,668 (-)Ensembl
GRCm38.p6 Ensembl1129,822,395 - 29,825,668 (-)Ensembl
RefSeq Acc Id: NM_176829   ⟹   NP_789799
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391129,772,395 - 29,775,668 (-)NCBI
GRCm381129,822,395 - 29,825,668 (-)ENTREZGENE
MGSCv371129,722,395 - 29,725,668 (-)RGD
Celera1132,190,430 - 32,193,703 (-)RGD
cM Map11 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_789799 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI39108 (Get FASTA)   NCBI Sequence Viewer  
  AAI39124 (Get FASTA)   NCBI Sequence Viewer  
  BAC26676 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000100568
  ENSMUSP00000100568.3
GenBank Protein Q8C0T1 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_789799   ⟸   NM_176829
- UniProtKB: B2RT26 (UniProtKB/Swiss-Prot),   Q5RJ26 (UniProtKB/Swiss-Prot),   Q8C0T1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000100568   ⟸   ENSMUST00000104962

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8C0T1-F1-model_v2 AlphaFold Q8C0T1 1-654 view protein structure

Promoters
RGD ID:8674182
Promoter ID:EPDNEW_M15122
Type:multiple initiation site
Name:4931440F15Rik_1
Description:Mus musculus RIKEN cDNA 4931440F15 gene , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381129,825,667 - 29,825,727EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2441689 AgrOrtholog
Ensembl Genes ENSMUSG00000078157 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000104962 ENTREZGENE
  ENSMUST00000104962.2 UniProtKB/Swiss-Prot
Gene3D-CATH 1.25.40.10 UniProtKB/Swiss-Prot
  1.25.40.20 UniProtKB/Swiss-Prot
InterPro Ankyrin_rpt UniProtKB/Swiss-Prot
  Ankyrin_rpt-contain_sf UniProtKB/Swiss-Prot
  TPR-like_helical_dom_sf UniProtKB/Swiss-Prot
KEGG Report mmu:216622 UniProtKB/Swiss-Prot
MGD MGI:2441689 ENTREZGENE
NCBI Gene 216622 ENTREZGENE
PANTHER ANKYRIN REPEAT CONTAINING UniProtKB/Swiss-Prot
  ANKYRIN REPEAT DOMAIN 16 UniProtKB/Swiss-Prot
Pfam Ank UniProtKB/Swiss-Prot
  Ank_2 UniProtKB/Swiss-Prot
PhenoGen Fem1al PhenoGen
PRINTS ANKYRIN UniProtKB/Swiss-Prot
PROSITE ANK_REP_REGION UniProtKB/Swiss-Prot
  ANK_REPEAT UniProtKB/Swiss-Prot
SMART ANK UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48403 UniProtKB/Swiss-Prot
UniProt B2RT26 ENTREZGENE
  FM1AB_MOUSE UniProtKB/Swiss-Prot
  Q5RJ26 ENTREZGENE
  Q8C0T1 ENTREZGENE
UniProt Secondary B2RT26 UniProtKB/Swiss-Prot
  Q5RJ26 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-01-21 Fem1al  fem-1 homolog A like  4931440F15Rik  RIKEN cDNA 4931440F15 gene  Symbol and/or name change 5135510 APPROVED