Tgm4 (transglutaminase 4 (prostate)) - Rat Genome Database
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Gene: Tgm4 (transglutaminase 4 (prostate)) Mus musculus
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Symbol: Tgm4
Name: transglutaminase 4 (prostate)
RGD ID: 1617218
MGI Page MGI
Description: Predicted to have protein-glutamine gamma-glutamyltransferase activity. Involved in mating plug formation. Predicted to localize to Golgi apparatus and collagen-containing extracellular matrix. Is expressed in anterior prostate gland and prostate gland dorsolateral lobe. Orthologous to human TGM4 (transglutaminase 4); INTERACTS WITH 1,2-dimethylhydrazine; folic acid; titanium dioxide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 9530008N10Rik; Ea; Eapa1; experimental autoimmune prostatitis antigen 1; protein-glutamine gamma-glutamyltransferase 4; TGase-4; TGP; transglutaminase-4
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399122,863,806 - 122,896,623 (+)NCBIGRCm39mm39
GRCm389123,034,741 - 123,067,558 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9123,034,726 - 123,067,561 (+)EnsemblGRCm38mm10GRCm38
MGSCv379122,943,859 - 122,976,676 (+)NCBIGRCm37mm9NCBIm37
MGSCv369122,883,439 - 122,916,256 (+)NCBImm8
Celera9123,496,347 - 123,518,874 (+)NCBICelera
Cytogenetic Map9F4NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11544199   PMID:12466851   PMID:12477932   PMID:14681479   PMID:16141072   PMID:16141073   PMID:16223778   PMID:18371946  
PMID:19452452   PMID:21267068   PMID:21677750   PMID:21873635   PMID:22307675   PMID:23341775   PMID:26084804   PMID:27488082  


Genomics

Comparative Map Data
Tgm4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399122,863,806 - 122,896,623 (+)NCBIGRCm39mm39
GRCm389123,034,741 - 123,067,558 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9123,034,726 - 123,067,561 (+)EnsemblGRCm38mm10GRCm38
MGSCv379122,943,859 - 122,976,676 (+)NCBIGRCm37mm9NCBIm37
MGSCv369122,883,439 - 122,916,256 (+)NCBImm8
Celera9123,496,347 - 123,518,874 (+)NCBICelera
Cytogenetic Map9F4NCBI
TGM4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl344,874,608 - 44,914,990 (+)EnsemblGRCh38hg38GRCh38
GRCh38344,874,608 - 44,914,990 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37344,916,098 - 44,956,093 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36344,891,102 - 44,931,092 (+)NCBINCBI36hg18NCBI36
Build 34344,891,130 - 44,931,097NCBI
Celera344,854,064 - 44,894,051 (+)NCBI
Cytogenetic Map3p21.31NCBI
HuRef344,959,958 - 44,999,946 (+)NCBIHuRef
CHM1_1344,866,110 - 44,906,068 (+)NCBICHM1_1
Tgm4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.08132,117,279 - 132,157,485 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8132,120,452 - 132,157,485 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08131,272,260 - 131,311,091 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48127,782,460 - 127,819,491 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18127,802,187 - 127,838,603 (+)NCBI
Celera8121,803,208 - 121,839,825 (+)NCBICelera
Cytogenetic Map8q32NCBI
Tgm4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542026,737,533 - 26,766,386 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542026,736,880 - 26,766,386 (-)NCBIChiLan1.0ChiLan1.0
TGM4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1345,830,764 - 45,870,208 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl345,830,764 - 45,870,208 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0344,775,855 - 44,815,691 (+)NCBIMhudiblu_PPA_v0panPan3
TGM4
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1226,362,600 - 6,391,099 (+)NCBI
ChlSab1.1 Ensembl226,362,782 - 6,390,223 (+)Ensembl
Tgm4
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473075,597,903 - 75,619,589 (-)NCBI

Position Markers
AW742220  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389123,064,694 - 123,064,941UniSTSGRCm38
MGSCv379122,973,812 - 122,974,059UniSTSGRCm37
Celera9123,516,010 - 123,516,257UniSTS
Cytogenetic Map9F4UniSTS
Whitehead/MRC_RH91210.79UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989284925123284925Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989412277123412396Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989563342123563342Mouse
12910770Splic1_mspleen iron content 1 (mouse)991413879124595110Mouse
12910772Lvic6_mliver iron content 6 (mouse)991413879124595110Mouse
12910773Splic3_mspleen iron content 3 (mouse)991413879124595110Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991641084124595110Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991641084124595110Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991641084124595110Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991641084124595110Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991641084124595110Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991641084124595110Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991683173124595110Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991683173124595110Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991683173124595110Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993762590124595110Mouse
1301484Bwq6_mbody weight (mouse)Not determined993762590124595110Mouse
14746992Manh67_mmandible shape 67 (mouse)994036768124595110Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996917590124595110Mouse
1301297Lcho1_mliver cholesterol 1 (mouse)Not determined9101060861124595110Mouse
1357627Tgq2_mtriglyceride QTL 2 (mouse)Not determined9102000187124595110Mouse
1357648Obq18_mobesity QTL 18 (mouse)Not determined9102000187124595110Mouse
1301789Pbwg4_mpostnatal body weight growth 4 (mouse)Not determined9103289445124595110Mouse
10412290Pvacm1l_mplasma vascular cell adhesion molecule 1 levels (mouse)Not determined9103289445124595110Mouse
12879896Berr3_mberghei resistance locus 3 (mouse)9103289445124595110Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:600
Count of miRNA genes:431
Interacting mature miRNAs:503
Transcripts:ENSMUST00000026893, ENSMUST00000128572, ENSMUST00000143364, ENSMUST00000171897
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000026893   ⟹   ENSMUSP00000026893
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9123,034,726 - 123,067,561 (+)Ensembl
RefSeq Acc Id: ENSMUST00000128572
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9123,040,432 - 123,049,035 (+)Ensembl
RefSeq Acc Id: ENSMUST00000143364
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9123,034,739 - 123,035,831 (+)Ensembl
RefSeq Acc Id: ENSMUST00000171897
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9123,034,740 - 123,052,699 (+)Ensembl
RefSeq Acc Id: ENSMUST00000214552
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9123,061,855 - 123,065,443 (+)Ensembl
RefSeq Acc Id: ENSMUST00000215247   ⟹   ENSMUSP00000149120
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9123,034,743 - 123,067,016 (+)Ensembl
RefSeq Acc Id: ENSMUST00000217607   ⟹   ENSMUSP00000149061
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9123,034,726 - 123,061,656 (+)Ensembl
RefSeq Acc Id: NM_177911   ⟹   NP_808579
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399122,863,806 - 122,896,623 (+)NCBI
GRCm389123,034,741 - 123,067,558 (+)ENTREZGENE
MGSCv379122,943,859 - 122,976,676 (+)RGD
Celera9123,496,352 - 123,518,874 (+)ENTREZGENE
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_017313442   ⟹   XP_017168931
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399122,863,875 - 122,896,621 (+)NCBI
GRCm389123,034,810 - 123,067,556 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_808579   ⟸   NM_177911
- UniProtKB: Q8BZH1 (UniProtKB/Swiss-Prot),   A0A0R4J071 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017168931   ⟸   XM_017313442
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000026893   ⟸   ENSMUST00000026893
RefSeq Acc Id: ENSMUSP00000149061   ⟸   ENSMUST00000217607
RefSeq Acc Id: ENSMUSP00000149120   ⟸   ENSMUST00000215247
Protein Domains
TGc   Transglut_C   Transglut_N

Promoters
RGD ID:8671324
Promoter ID:EPDNEW_M13692
Type:multiple initiation site
Name:Tgm4_1
Description:Mus musculus transglutaminase 4 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm389123,034,743 - 123,034,803EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3027002 AgrOrtholog
Ensembl Genes ENSMUSG00000025787 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000026893 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000149061 UniProtKB/TrEMBL
  ENSMUSP00000149120 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000026893 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000215247 UniProtKB/TrEMBL
  ENSMUST00000217607 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.260.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_E-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Papain-like_cys_pep_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transglutaminase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transglutaminase-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transglutaminase_animal UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transglutaminase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transglutaminase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transglutaminase_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transglutaminase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:331046 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:3027002 ENTREZGENE
NCBI Gene 331046 ENTREZGENE
Pfam Transglut_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transglut_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transglut_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tgm4 PhenoGen
PIRSF TGM_EBP42 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TRANSGLUTAMINASES UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART TGc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49309 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54001 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF81296 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.195309 ENTREZGENE
UniProt A0A0R4J071 ENTREZGENE, UniProtKB/TrEMBL
  A0A1L1SQH9_MOUSE UniProtKB/TrEMBL
  A0A1L1SQM7_MOUSE UniProtKB/TrEMBL
  Q8BZH1 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary B7ZP44 UniProtKB/Swiss-Prot
  Q8K460 UniProtKB/Swiss-Prot