Nxpe3 (neurexophilin and PC-esterase domain family, member 3) - Rat Genome Database

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Gene: Nxpe3 (neurexophilin and PC-esterase domain family, member 3) Mus musculus
Analyze
Symbol: Nxpe3
Name: neurexophilin and PC-esterase domain family, member 3
RGD ID: 1617184
MGI Page MGI
Description: Orthologous to human NXPE3 (neurexophilin and PC-esterase domain family member 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Fam55; Fam55c; family with sequence similarity 55, member C; Gm1752; Gm611; hypothetical protein LOC385658; MGC15606; NXPE family member 3; uncharacterized protein LOC385658
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391655,660,316 - 55,717,467 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1655,660,316 - 55,715,648 (-)EnsemblGRCm39 Ensembl
GRCm381655,839,953 - 55,897,104 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1655,839,953 - 55,895,285 (-)EnsemblGRCm38mm10GRCm38
MGSCv371655,840,066 - 55,895,398 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361655,768,132 - 55,820,343 (-)NCBIMGSCv36mm8
Celera1656,155,440 - 56,210,680 (-)NCBICelera
Cytogenetic Map16C1.1NCBI
cM Map1633.65NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:16141072   PMID:16141073   PMID:18799693   PMID:21267068  


Genomics

Comparative Map Data
Nxpe3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391655,660,316 - 55,717,467 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1655,660,316 - 55,715,648 (-)EnsemblGRCm39 Ensembl
GRCm381655,839,953 - 55,897,104 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1655,839,953 - 55,895,285 (-)EnsemblGRCm38mm10GRCm38
MGSCv371655,840,066 - 55,895,398 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361655,768,132 - 55,820,343 (-)NCBIMGSCv36mm8
Celera1656,155,440 - 56,210,680 (-)NCBICelera
Cytogenetic Map16C1.1NCBI
cM Map1633.65NCBI
NXPE3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383101,779,211 - 101,828,231 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3101,779,177 - 101,843,743 (+)EnsemblGRCh38hg38GRCh38
GRCh373101,498,055 - 101,547,075 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363102,980,764 - 103,025,150 (+)NCBINCBI36Build 36hg18NCBI36
Build 343102,980,763 - 103,025,141NCBI
Celera399,891,428 - 99,940,459 (+)NCBICelera
Cytogenetic Map3q12.3NCBI
HuRef398,866,721 - 98,915,769 (+)NCBIHuRef
CHM1_13101,461,310 - 101,510,345 (+)NCBICHM1_1
T2T-CHM13v2.03104,492,001 - 104,541,024 (+)NCBIT2T-CHM13v2.0
Nxpe3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81158,195,951 - 58,246,739 (+)NCBIGRCr8
mRatBN7.21144,726,905 - 44,777,694 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1144,727,069 - 44,777,694 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1153,503,293 - 53,554,204 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01146,164,928 - 46,215,850 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01145,289,082 - 45,339,993 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01147,188,332 - 47,238,372 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1147,188,495 - 47,238,372 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01150,366,176 - 50,415,914 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41145,714,387 - 45,770,951 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1144,479,657 - 44,529,454 (+)NCBICelera
Cytogenetic Map11q12NCBI
Nxpe3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554273,256,236 - 3,320,525 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554273,256,305 - 3,320,525 (+)NCBIChiLan1.0ChiLan1.0
NXPE3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2299,717,786 - 99,765,171 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1399,722,564 - 99,769,954 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0398,867,439 - 98,914,807 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13105,547,763 - 105,595,420 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3105,547,811 - 105,590,218 (+)Ensemblpanpan1.1panPan2
NXPE3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1338,073,254 - 8,120,253 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl338,073,840 - 8,154,561 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha338,227,941 - 8,274,816 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0338,212,543 - 8,258,753 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl338,212,452 - 8,261,977 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1338,100,129 - 8,147,297 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0338,146,789 - 8,193,617 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0338,486,972 - 8,534,043 (+)NCBIUU_Cfam_GSD_1.0
Nxpe3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602148,739,299 - 148,784,869 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366301,634,405 - 1,690,387 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366301,637,120 - 1,690,470 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NXPE3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13157,295,745 - 157,337,888 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113157,298,831 - 157,337,904 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213166,780,905 - 166,819,964 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NXPE3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12279,082,196 - 79,122,619 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2279,083,084 - 79,119,772 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604187,430,462 - 87,474,878 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nxpe3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478915,536,250 - 15,586,853 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478915,536,080 - 15,586,853 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nxpe3
2118 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1456
Count of miRNA genes:648
Interacting mature miRNAs:822
Transcripts:ENSMUST00000099705
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300915Lmr12_mleishmaniasis resistance 12 (mouse)Not determined162879281362792952Mouse
26884416Bzwq5_mbi-zygomatic width QTL 5, 5 week (mouse)163732036284696888Mouse
1301070Cypr1_mcytokine production 1 (mouse)Not determined163231279566312933Mouse
14696806Smcl1_msmoke-mediated chord length 1 (mouse)165401530958330871Mouse
26884432Zlq7_mzygomatic length QTL 7, 10 week (mouse)16381786464620363Mouse
1302096Aod1a_mautoimmune ovarian dysgenesis 1a (mouse)Not determined163544664392573008Mouse
11059560Lmr12b_mleishmaniasis resistance 12b (mouse)162879281362792952Mouse
1301394Eae11_msusceptibility to experimental allergic encephalomyelitis 11 (mouse)Not determined165356189187562035Mouse
4141212Imraq3_mimmune response to AAV2 QTL 3 (mouse)Not determined164438335078383506Mouse
1301138Pcd4ts3_mp-glycoprotein positive CD4 T cell subset 3 (mouse)Not determined164059392374594076Mouse
11059559Lmr12a_mleishmaniasis resistance 12a (mouse)162879281362792952Mouse
1301719Remslp3_mrapid eye movement sleep 3 (mouse)Not determined164438335078383506Mouse
1357778Diobq_mdiet-induced obesity QTL (mouse)Not determined164219781782331174Mouse
14928310Manh80_mmandible shape 80 (mouse)164821984182219841Mouse
11049571Lmr12c_mleishmaniasis resistance 12c (mouse)162879281362792952Mouse
1301364Lith14_mlithogenic gene 14 (mouse)Not determined165566184689661961Mouse
4142112Skts-fp3_mskin tumor susceptibility in FVB and PWK 3 (mouse)Not determined164005388172924385Mouse
1558836Dice1b_mdetermination of interleukin 4 commitment 1b (mouse)Not determined164551100072274485Mouse
1357763Lp1_mlymphocyte proliferation 1 (mouse)Not determined16654297965466552Mouse
1357517Bwtn1_mbody weight at necropsy 1 (mouse)Not determined162001932985600826Mouse
4141179Ipng3_mimprinted postnatal growth 3 (mouse)Not determined2277525257594076Mouse
11522747Eae41_mexperimental allergic encephalomyelitis susceptibility 41 (mouse)164039913478015472Mouse
27226785Feml12_mfemur length 12, 5 week (mouse)16331786464620363Mouse
26884376Skwq4_mskull length QTL 4, 5 week (mouse)16841786490896888Mouse
1300534Bmd15_mbone mineral density 15 (mouse)Not determined162193838355938574Mouse
4142187Arrd3_mage-related retinal degeneration 3 (mouse)Not determined3252290965466552Mouse

Markers in Region
RH133833  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381655,881,470 - 55,881,676UniSTSGRCm38
MGSCv371655,881,583 - 55,881,789UniSTSGRCm37
Celera1656,196,783 - 56,196,989UniSTS
Cytogenetic Map16C1.1UniSTS
Chuk  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381944,073,445 - 44,073,580UniSTSGRCm38
GRCm381655,881,482 - 55,881,605UniSTSGRCm38
MGSCv371944,147,935 - 44,148,070UniSTSGRCm37
MGSCv371655,881,595 - 55,881,718UniSTSGRCm37
Celera1656,196,795 - 56,196,918UniSTS
Celera1944,858,921 - 44,859,056UniSTS
Cytogenetic Map19C3UniSTS
Cytogenetic Map16C1.1UniSTS
cM Map1945.0UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000099705   ⟹   ENSMUSP00000097296
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1655,660,316 - 55,715,648 (-)Ensembl
GRCm38.p6 Ensembl1655,839,953 - 55,895,285 (-)Ensembl
RefSeq Acc Id: NM_001134457   ⟹   NP_001127929
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391655,660,316 - 55,715,642 (-)NCBI
GRCm381655,839,953 - 55,895,279 (-)NCBI
MGSCv371655,840,066 - 55,895,398 (-)RGD
Celera1656,155,440 - 56,210,674 (-)NCBI
cM Map16 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006522325   ⟹   XP_006522388
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391655,663,559 - 55,717,467 (-)NCBI
GRCm381655,843,196 - 55,897,104 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011245941   ⟹   XP_011244243
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391655,663,559 - 55,717,467 (-)NCBI
GRCm381655,843,196 - 55,897,104 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011245942   ⟹   XP_011244244
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391655,663,559 - 55,715,644 (-)NCBI
GRCm381655,843,196 - 55,895,281 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011245943   ⟹   XP_011244245
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391655,663,559 - 55,717,467 (-)NCBI
GRCm381655,843,196 - 55,897,104 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011245944   ⟹   XP_011244246
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391655,663,559 - 55,717,467 (-)NCBI
GRCm381655,843,196 - 55,897,104 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030249167   ⟹   XP_030105027
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391655,663,559 - 55,717,467 (-)NCBI
GRCm381655,843,196 - 55,897,104 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001127929   ⟸   NM_001134457
- UniProtKB: B9EKK6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006522388   ⟸   XM_006522325
- Peptide Label: isoform X2
- UniProtKB: B9EKK6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011244245   ⟸   XM_011245943
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_011244243   ⟸   XM_011245941
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_011244246   ⟸   XM_011245944
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_011244244   ⟸   XM_011245942
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_030105027   ⟸   XM_030249167
- Peptide Label: isoform X2
- UniProtKB: B9EKK6 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSMUSP00000097296   ⟸   ENSMUST00000099705

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B9EKK6-F1-model_v2 AlphaFold B9EKK6 1-559 view protein structure

Promoters
RGD ID:6827044
Promoter ID:MM_KWN:21238
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_001134494
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361655,895,349 - 55,895,849 (-)MPROMDB
RGD ID:8686368
Promoter ID:EPDNEW_M21214
Type:initiation region
Name:Nxpe3_1
Description:Mus musculus neurexophilin and PC-esterase domain family, member3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381655,895,363 - 55,895,423EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2686598 AgrOrtholog
Ensembl Genes ENSMUSG00000075033 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000099705 ENTREZGENE
  ENSMUST00000099705.5 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro Ig-like_fold UniProtKB/TrEMBL
  Ig_E-set UniProtKB/TrEMBL
  NXPH/NXPE UniProtKB/TrEMBL
KEGG Report mmu:385658 UniProtKB/TrEMBL
MGD MGI:2686598 ENTREZGENE
NCBI Gene 385658 ENTREZGENE
PANTHER NXPE FAMILY MEMBER UniProtKB/TrEMBL
  NXPE FAMILY MEMBER 3 UniProtKB/TrEMBL
Pfam Neurexophilin UniProtKB/TrEMBL
PhenoGen Nxpe3 PhenoGen
Superfamily-SCOP Ig_E-set UniProtKB/TrEMBL
UniProt B9EKK6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-09-19 Nxpe3  neurexophilin and PC-esterase domain family, member 3  Fam55c  family with sequence similarity 55, member C  Symbol and/or name change 5135510 APPROVED