Gene: Mrps22 (mitochondrial ribosomal protein S22) Mus musculus
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Symbol:
Mrps22
Name:
mitochondrial ribosomal protein S22
Description:
ENCODES a protein that exhibits structural constituent of ribosome (ortholog); ASSOCIATED WITH prenatal lethality, complete penetrance; ASSOCIATED WITH 46 XX gonadal dysgenesis (ortholog); 46,XX Sex Reversal with Dysgenesis of Kidneys, Adrenals, and Lungs (ortholog); blepharophimosis, ptosis, and epicanthus inversus syndrome (ortholog); FOUND IN mitochondrial small ribosomal subunit (ortholog); mitochondrion (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; carbon nanotube; chromium(6+)
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
28S ribosomal protein S22, mitochondrial; 3100002P07Rik; MRP-S22; ribosomal protein, mitochondrial, S22; Rpms22; S22mt
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
MRPS22 (mitochondrial ribosomal protein S22) HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):
Mrps22 (mitochondrial ribosomal protein S22) HGNC
EggNOG, NCBI, OMA, HomoloGene, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Mrps22 (mitochondrial ribosomal protein S22) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
MRPS22 (mitochondrial ribosomal protein S22) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
MRPS22 (mitochondrial ribosomal protein S22) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Mrps22 (mitochondrial ribosomal protein S22) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
MRPS22 (mitochondrial ribosomal protein S22) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
MRPS22 (mitochondrial ribosomal protein S22)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Rattus norvegicus (Norway rat):
Mrps22 (mitochondrial ribosomal protein S22)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, PANTHER, PhylomeDB)
Danio rerio (zebrafish):
mrps22 (mitochondrial ribosomal protein S22)
Alliance
DIOPT (Ensembl Compara, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, Roundup, TreeFam, ZFIN)
Caenorhabditis elegans (roundworm):
mrps-22
Alliance
DIOPT (Ensembl Compara, InParanoid, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup)
Drosophila melanogaster (fruit fly):
mRpS22
Alliance
DIOPT (Ensembl Compara, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Latest Assembly:
GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm38 9 98,588,730 - 98,601,679 (-) NCBI GRCm38 GRCm38 mm10 GRCm38 MGSCv37 9 98,489,149 - 98,502,098 (-) NCBI GRCm37 mm9 NCBIm37 MGSCv36 9 98,398,089 - 98,411,011 (-) NCBI mm8 Celera 9 98,134,359 - 98,147,288 (-) NCBI Celera Cytogenetic Map 9 E3.3 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - CTD
Breast Neoplasms ISO RGD:1353996 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:21466612
Imported Annotations - MGI
combined oxidative phosphorylation deficiency ISS RGD:1353996 13592920 OMIM:300816 more ... MouseDO Imported Annotations - OMIM
Combined Oxidative Phosphorylation Deficiency 5 ISO RGD:1353996 7240710 OMIM ovarian dysgenesis 7 ISO RGD:1353996 7240710 OMIM
Gene-Chemical Interaction Annotations
2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of MRPS22 mRNA CTD PMID:19770486 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of MRPS22 mRNA CTD PMID:21570461 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:1353996 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of MRPS22 mRNA, [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MRPS22 mRNA CTD PMID:28628672 4,4'-sulfonyldiphenol multiple interactions ISO RGD:1353996 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of MRPS22 mRNA CTD PMID:28628672 4-phenylbutyric acid decreases expression ISO RGD:1353996 6480464 4-phenylbutyric acid results in decreased expression of MRPS22 mRNA CTD PMID:14583596 aflatoxin B1 decreases methylation ISO RGD:1353996 6480464 Aflatoxin B1 results in decreased methylation of MRPS22 gene CTD PMID:27153756 atrazine increases expression ISO RGD:1353996 6480464 Atrazine results in increased expression of MRPS22 mRNA CTD PMID:22378314 bisphenol F multiple interactions ISO RGD:1353996 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MRPS22 mRNA CTD PMID:28628672 buspirone decreases expression ISO RGD:1585674 6480464 Buspirone results in decreased expression of MRPS22 mRNA CTD PMID:24136188 carbamazepine affects expression ISO RGD:1353996 6480464 Carbamazepine affects the expression of MRPS22 mRNA CTD PMID:25979313 carbon nanotube increases expression EXP 6480464 Nanotubes, Carbon analog results in increased expression of MRPS22 mRNA, Nanotubes, Carbon results in increased expression of MRPS22 mRNA CTD PMID:25554681 chromium(6+) affects expression EXP 6480464 chromium hexavalent ion affects the expression of MRPS22 mRNA CTD PMID:28472532 cyclosporin A increases expression EXP 6480464 Cyclosporine results in increased expression of MRPS22 mRNA CTD PMID:19770486 cylindrospermopsin increases expression ISO RGD:1353996 6480464 cylindrospermopsin results in increased expression of MRPS22 mRNA CTD PMID:24921660 dexamethasone multiple interactions ISO RGD:1353996 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of MRPS22 mRNA, [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MRPS22 mRNA CTD PMID:28628672 dicrotophos decreases expression ISO RGD:1353996 6480464 dicrotophos results in decreased expression of MRPS22 mRNA CTD PMID:28302478 dioxygen multiple interactions EXP 6480464 [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of MRPS22 mRNA CTD PMID:30529165 ethanol increases expression EXP 6480464 Ethanol results in increased expression of MRPS22 mRNA CTD PMID:30319688 finasteride increases expression ISO RGD:1585674 6480464 Finasteride results in increased expression of MRPS22 mRNA CTD PMID:24136188 flutamide increases expression ISO RGD:1585674 6480464 Flutamide results in increased expression of MRPS22 mRNA CTD PMID:24136188 indometacin multiple interactions ISO RGD:1353996 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of MRPS22 mRNA, [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MRPS22 mRNA CTD PMID:28628672 lipopolysaccharide multiple interactions ISO RGD:1353996 6480464 [Acetaminophen co-treated with Lipopolysaccharides] results in decreased expression of MRPS22 mRNA CTD PMID:31059760 microcystin RR decreases expression ISO RGD:1353996 6480464 microcystin RR results in decreased expression of MRPS22 protein CTD PMID:19111056 paracetamol affects expression EXP 6480464 Acetaminophen affects the expression of MRPS22 mRNA CTD PMID:17562736 paracetamol multiple interactions ISO RGD:1353996 6480464 [Acetaminophen co-treated with Lipopolysaccharides] results in decreased expression of MRPS22 mRNA CTD PMID:31059760 paracetamol decreases expression ISO RGD:1353996 6480464 Acetaminophen results in decreased expression of MRPS22 mRNA CTD PMID:31059760 pirinixic acid decreases expression EXP 6480464 pirinixic acid results in decreased expression of MRPS22 mRNA CTD PMID:18445702 quercetin affects expression ISO RGD:1353996 6480464 Quercetin affects the expression of MRPS22 protein CTD PMID:15221776 tetrachloromethane affects expression EXP 6480464 Carbon Tetrachloride affects the expression of MRPS22 mRNA CTD PMID:17484886 trichostatin A affects expression ISO RGD:1353996 6480464 trichostatin A affects the expression of MRPS22 mRNA CTD PMID:28542535 trimellitic anhydride increases expression EXP 6480464 trimellitic anhydride results in increased expression of MRPS22 mRNA CTD PMID:19042947 tungsten increases expression EXP 6480464 Tungsten results in increased expression of MRPS22 mRNA CTD PMID:30912803 tungsten(4+) increases expression EXP 6480464 Tungsten results in increased expression of MRPS22 mRNA CTD PMID:30912803 tunicamycin increases expression ISO RGD:1353996 6480464 Tunicamycin results in increased expression of MRPS22 mRNA CTD PMID:22378314 valproic acid affects expression ISO RGD:1353996 6480464 Valproic Acid affects the expression of MRPS22 mRNA CTD PMID:25979313
Gene Ontology Annotations
Phenotype Annotations
4142042 Alpq3_m alcohol preference QTL 3 (mouse) Not determined 9 37394901 98819654 Mouse 4141224 Dxmod_m doxorubicin nephropathy modifier (mouse) Not determined 49541121 101528921 Mouse 1301241 Renf1_m renal failure 1 (mouse) Not determined 9 52123178 99910428 Mouse 13207569 Tcq13_m total cholesterol QTL 13 (mouse) 9 59990000 109260000 Mouse 4141833 W10q13_m weight 10 weeks QTL 13 (mouse) Not determined 63332429 120362868 Mouse 4141545 Tailaq2_m tail length adjusted QTL 2 (mouse) Not determined 63332429 120362868 Mouse 1357635 Splq4_m spleen weight QTL 4 (mouse) Not determined 9 63332429 120362868 Mouse 1301636 Lith5_m lithogenic gene 5 (mouse) Not determined 9 66207024 100207122 Mouse 10045638 Heal29_m wound healing/regeneration 29 (mouse) Not determined 9 67124167 101124167 Mouse 1357610 Vtbt8_m vertebral trabecular bone trait 8 (mouse) Not determined 9 68897510 102897652 Mouse 1301924 Bmd10_m bone mineral density 10 (mouse) Not determined 9 68897510 102897652 Mouse 1301302 Pas4_m pulmonary adenoma susceptibility 4 (mouse) Not determined 9 69239845 103239920 Mouse 10412174 Habiir4_m hyperoxic acute lung injury imprinted region 4 (mouse) Not determined 9 69360465 98819654 Mouse 1301621 Hpic1_m haloperidol-induced catalepsy 1 (mouse) Not determined 9 69546513 103546645 Mouse 1301573 Etohcta8_m ethanol conditioned taste aversion 8 (mouse) Not determined 9 72977005 106977152 Mouse 10054068 El8_m epilepsy 8 (mouse) Not determined 9 72977005 106977152 Mouse 1301725 Lifespan1_m life span 1 (mouse) Not determined 9 74368177 108368325 Mouse 1302065 El1_m epilepsy 1 (mouse) Not determined 9 75775364 114474379 Mouse 10054492 El7_m epilepsy 7 (mouse) Not determined 9 75775364 114474379 Mouse 1301869 Tbbmd4_m total body bone mineral density 4 (mouse) Not determined 9 76117105 101528921 Mouse 1301407 Rapop2_m radiation-induced apoptosis 2 (mouse) Not determined 9 76535936 110536130 Mouse 1301192 Skts6_m skin tumor susceptibility 6 (mouse) Not determined 9 78640645 112640755 Mouse 10401247 Bglu14_m blood glucose level 14 (mouse) Not determined 9 79397810 113397888 Mouse 1301732 Char1_m P. chabaudi malaria resistance QTL 1 (mouse) Not determined 9 81798268 115798392 Mouse 1300884 Sluc11_m susceptibility to lung cancer 11 (mouse) Not determined 9 82910333 116910428 Mouse 1357461 Idd2_m insulin dependent diabetes susceptibility 2 (mouse) Not determined 9 82910333 116910428 Mouse 10766454 Char10_m P. chabaudi malaria resistance QTL 10 (mouse) 9 82910333 116910428 Mouse 1301487 Nociq1_m nociceptive sensitivity inflammatory QTL 1 (mouse) Not determined 9 84528818 118528921 Mouse 10412180 Msam3_m muscle, skeletal, activity measure 3 (mouse) Not determined 9 85897510 108641186 Mouse 1300549 Bbaa17_m B. burgdorferi-associated arthritis 17 (mouse) Not determined 9 86230401 120230530 Mouse 1302103 Dob2_m dietary obesity 2 (mouse) Not determined 9 86239845 120289624 Mouse 11251716 Siim2_m stress induced immobility 2 (mouse) 9 86748483 120748483 Mouse 12880422 V25Dq6_m vitamin D inactive form serum level QTL 6 (mouse) 9 87800000 121800000 Mouse 10412242 Alpq8_m alcohol preference QTL 8 (mouse) Not determined 9 89284925 123284925 Mouse 1301649 Psl1_m promotion susceptibility QTL 1 (mouse) Not determined 9 89412277 123412396 Mouse 1357657 Pymr_m Plasmodium yoelli malaria resistance (mouse) Not determined 9 89977005 118938021 Mouse 12910770 Splic1_m spleen iron content 1 (mouse) 9 91413879 124595110 Mouse 12910772 Lvic6_m liver iron content 6 (mouse) 9 91413879 124595110 Mouse 12910773 Splic3_m spleen iron content 3 (mouse) 9 91413879 124595110 Mouse 1558767 Skmw11_m skeletal muscle weight 11 (mouse) Not determined 9 91641084 124595110 Mouse 13463474 Hbbcq5_m hemoglobin concentration QTL 5 (mouse) 9 91641084 124595110 Mouse 13463475 Hctq7_m hematocrit QTL 7 (mouse) 9 91641084 124595110 Mouse 13463477 Rbc9_m red blood cell count 9 (mouse) 9 91641084 124595110 Mouse 13463478 Mchq18_m mean corpuscular hemoglobin QTL 18 (mouse) 9 91641084 124595110 Mouse 13463480 Mchcq2_m mean corpuscular hemoglobin concentration QTL 2 (mouse) 9 91641084 124595110 Mouse 12904937 Edlmmq9_m extensor digitorum longus muscle mass QTL 9 (mouse) 9 91683173 124595110 Mouse 12904947 Tammq7_m tibialis anterior muscle mass QTL 7 (mouse) 9 91683173 124595110 Mouse 12904961 Gmmq7_m gastrocnemius muscle mass QTL 7 (mouse) 9 91683173 124595110 Mouse 1302001 Bdln5_m body length 5 (mouse) Not determined 9 93762590 124595110 Mouse 1301484 Bwq6_m body weight (mouse) Not determined 9 93762590 124595110 Mouse 14746992 Manh67_m mandible shape 67 (mouse) 9 94036768 124595110 Mouse 11081166 Psl5_m promotion susceptibility QTL 5 (mouse) 9 94981301 112872929 Mouse 11537364 Cnes5_m C. neoformans susceptibility locus 5 (mouse) 9 96917590 124595110 Mouse
Predicted Target Of
Count of predictions: 50 Count of miRNA genes: 48 Interacting mature miRNAs: 50 Transcripts: ENSMUST00000035034 Prediction methods: Miranda, Rnahybrid, Targetscan Result types: miRGate_prediction
Gene-Chemical Interaction Annotations
