Trir (telomerase RNA component interacting RNase) - Rat Genome Database
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Gene: Trir (telomerase RNA component interacting RNase) Mus musculus
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Symbol: Trir
Name: telomerase RNA component interacting RNase
RGD ID: 1616776
MGI Page MGI
Description: Predicted to have 3'-5' exonuclease activity and 5'-3' exonuclease activity. Predicted to be involved in RNA phosphodiester bond hydrolysis, exonucleolytic and rRNA catabolic process. Orthologous to human TRIR (telomerase RNA component interacting RNase); INTERACTS WITH 1,2-dimethylhydrazine; folic acid; tetrachloroethene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1110002H14Rik; 2310036O22Rik; AI854688; exoribonuclease Trir; exoribonuclease TrirR; hypothetical protein LOC68544; RIKEN cDNA 2310036O22 gene; uncharacterized protein C19orf43 homolog
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39885,753,440 - 85,756,920 (+)NCBIGRCm39mm39
GRCm38885,026,811 - 85,030,291 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl885,026,823 - 85,030,286 (+)EnsemblGRCm38mm10GRCm38
MGSCv37887,550,732 - 87,554,185 (+)NCBIGRCm37mm9NCBIm37
MGSCv36887,916,938 - 87,920,391 (+)NCBImm8
Celera889,321,614 - 89,325,063 (+)NCBICelera
Cytogenetic Map8C3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
1. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:14610273   PMID:15489334   PMID:16141072   PMID:16141073   PMID:19409822  
PMID:21267068   PMID:21873635   PMID:32325033  


Genomics

Comparative Map Data
Trir
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39885,753,440 - 85,756,920 (+)NCBIGRCm39mm39
GRCm38885,026,811 - 85,030,291 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl885,026,823 - 85,030,286 (+)EnsemblGRCm38mm10GRCm38
MGSCv37887,550,732 - 87,554,185 (+)NCBIGRCm37mm9NCBIm37
MGSCv36887,916,938 - 87,920,391 (+)NCBImm8
Celera889,321,614 - 89,325,063 (+)NCBICelera
Cytogenetic Map8C3NCBI
TRIR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1912,730,640 - 12,734,684 (-)EnsemblGRCh38hg38GRCh38
GRCh381912,730,640 - 12,734,684 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371912,841,454 - 12,845,529 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361912,702,454 - 12,706,529 (-)NCBINCBI36hg18NCBI36
Celera1912,731,165 - 12,735,240 (-)NCBI
Cytogenetic Map19p13.13NCBI
HuRef1912,414,575 - 12,418,651 (-)NCBIHuRef
CHM1_11912,841,916 - 12,845,991 (-)NCBICHM1_1
Trir
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01926,142,720 - 26,146,136 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1926,142,720 - 26,146,136 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01937,118,343 - 37,121,759 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41924,781,364 - 24,784,781 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1922,683,041 - 22,686,457 (-)NCBICelera
Cytogenetic Map19q11NCBI
Trir
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541531,831,093 - 31,834,796 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541531,831,093 - 31,834,796 (-)NCBIChiLan1.0ChiLan1.0
TRIR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11913,038,516 - 13,045,720 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1913,038,837 - 13,046,866 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01912,293,236 - 12,297,338 (-)NCBIMhudiblu_PPA_v0panPan3
TRIR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2049,400,179 - 49,403,530 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12049,400,082 - 49,403,533 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Trir
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366591,847,065 - 1,850,557 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TRIR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl266,262,424 - 66,265,426 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1266,262,377 - 66,265,427 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2266,642,986 - 66,646,027 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TRIR
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl611,419,938 - 11,424,062 (-)Ensembl
ChlSab1.1611,419,982 - 11,424,075 (-)NCBI
Trir
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624901356,151 - 360,001 (-)NCBI

Position Markers
AI854688  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38885,029,945 - 85,030,071UniSTSGRCm38
MGSCv37887,553,844 - 87,553,970UniSTSGRCm37
Celera889,324,722 - 89,324,848UniSTS
Cytogenetic Map8C3UniSTS
Whitehead/MRC_RH81007.48UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)83970925694689598Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85188219185882191Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85428781788287993Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85470661488706763Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85554502889545028Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85820147992201479Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85840977692409776Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86078685094786976Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6346010797460107Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86393954797939696Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined86535776899357920Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined86560020799600347Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined870305375104305495Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined870305375104305495Mouse
1558780Idd22_minsulin dependent diabetes susceptibility 22 (mouse)Not determined871102903105103009Mouse
4141395Char2a_mP. chabaudi malaria resistance QTL 2a (mouse)Not determined7113678390202598Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71287817123895615Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871287817123895615Mouse
1301872Cd4ts3_mCD4 T cell subset 3 (mouse)Not determined871396181105396393Mouse
1300920Pitm3_mprion incubation time 3 (mouse)Not determined873202495107202598Mouse
27095912Pglq14_mpelvic girdle length QTL 14, 16 week (mouse)873400000126100000Mouse
1558890Lith18_mlithogenic gene 18 (mouse)Not determined875675517109675623Mouse
1357470Obq16_mobesity QTL 16 (mouse)Not determined875685348109685497Mouse
1301808Nhdlq1_mnon-HDL QTL 1 (mouse)Not determined875685348109685497Mouse
1301874Hdlq16_mHDL QTL 16 (mouse)Not determined875685348109685497Mouse
10412234Nhdlq14_mnon-HDL QTL 14 (mouse)Not determined875685348109685497Mouse
1301099Cbm2_mcerebellum weight 2 (mouse)Not determined878518613112518703Mouse
1301581Char2_mP. chabaudi malaria resistance QTL 2 (mouse)Not determined879082178113082403Mouse
12904012Cfq10_mconditioned fear QTL 10 (mouse)88006677589014359Mouse
10755530Wbc2_mwhite blood cell count 2 (mouse)881092664115092664Mouse
10755519Wbc1_mwhite blood cell count 1 (mouse)881619151115619151Mouse
1301766Desp1_mdespair 1 (mouse)Not determined884759576118759741Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:142
Count of miRNA genes:126
Interacting mature miRNAs:135
Transcripts:ENSMUST00000047281
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000047281   ⟹   ENSMUSP00000044129
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl885,026,823 - 85,030,286 (+)Ensembl
RefSeq Acc Id: NM_026760   ⟹   NP_081036
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39885,753,462 - 85,756,920 (+)NCBI
GRCm38885,026,833 - 85,030,291 (+)NCBI
MGSCv37887,550,732 - 87,554,185 (+)RGD
Celera889,321,614 - 89,325,063 (+)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_160793
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39885,753,462 - 85,756,920 (+)NCBI
GRCm38885,026,833 - 85,030,291 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030243747   ⟹   XP_030099607
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39885,753,443 - 85,756,247 (+)NCBI
GRCm38885,026,813 - 85,029,618 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030243748   ⟹   XP_030099608
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39885,753,440 - 85,756,247 (+)NCBI
GRCm38885,026,811 - 85,029,618 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_081036   ⟸   NM_026760
- UniProtKB: Q9D735 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_030099608   ⟸   XM_030243748
- Peptide Label: isoform X2
RefSeq Acc Id: XP_030099607   ⟸   XM_030243747
- Peptide Label: isoform X1
RefSeq Acc Id: ENSMUSP00000044129   ⟸   ENSMUST00000047281

Promoters
RGD ID:8667731
Promoter ID:EPDNEW_M11897
Type:initiation region
Name:Trir_1
Description:Mus musculus telomerase RNA component interacting RNase , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38885,026,872 - 85,026,932EPDNEW
RGD ID:6842494
Promoter ID:MM_KWN:55128
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_026760
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36887,550,489 - 87,550,989 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1922833 AgrOrtholog
Ensembl Genes ENSMUSG00000041203 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000044129 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000047281 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro TRIR UniProtKB/Swiss-Prot
KEGG Report mmu:68544 UniProtKB/Swiss-Prot
MGD MGI:1922833 ENTREZGENE
NCBI Gene 68544 ENTREZGENE
PANTHER PTHR34753 UniProtKB/Swiss-Prot
PhenoGen Trir PhenoGen
UniGene Mm.196005 ENTREZGENE
UniProt Q9D735 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q9D1N3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-06-20 Trir  telomerase RNA component interacting RNase  2310036O22Rik  RIKEN cDNA 2310036O22 gene  Symbol and/or name change 5135510 APPROVED