Spem2 (SPEM family member 2) - Rat Genome Database
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Gene: Spem2 (SPEM family member 2) Mus musculus
Analyze
Symbol: Spem2
Name: SPEM family member 2
RGD ID: 1616649
MGI Page MGI
Description: Orthologous to human SPEM2 (SPEM family member 2); INTERACTS WITH benzo[a]pyrene; 3-isobutyl-1-methyl-7H-xanthine (ortholog); bisphenol A (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 4933402P03Rik; hypothetical protein LOC108803; RIKEN cDNA 4933402P03 gene; RP23-422L16.21; uncharacterized protein C17orf74 homolog; uncharacterized protein SPEM2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391169,707,386 - 69,709,313 (-)NCBIGRCm39mm39
GRCm39 Ensembl1169,707,392 - 69,709,291 (-)Ensembl
GRCm381169,816,560 - 69,818,487 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1169,816,566 - 69,818,465 (-)EnsemblGRCm38mm10GRCm38
MGSCv371169,630,068 - 69,631,942 (-)NCBIGRCm37mm9NCBIm37
MGSCv361169,632,761 - 69,634,635 (-)NCBImm8
Celera1177,377,527 - 77,379,401 (-)NCBICelera
Cytogenetic Map11B3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:16141072   PMID:16141073   PMID:21267068  


Genomics

Comparative Map Data
Spem2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391169,707,386 - 69,709,313 (-)NCBIGRCm39mm39
GRCm39 Ensembl1169,707,392 - 69,709,291 (-)Ensembl
GRCm381169,816,560 - 69,818,487 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1169,816,566 - 69,818,465 (-)EnsemblGRCm38mm10GRCm38
MGSCv371169,630,068 - 69,631,942 (-)NCBIGRCm37mm9NCBIm37
MGSCv361169,632,761 - 69,634,635 (-)NCBImm8
Celera1177,377,527 - 77,379,401 (-)NCBICelera
Cytogenetic Map11B3NCBI
SPEM2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl177,425,616 - 7,427,568 (+)EnsemblGRCh38hg38GRCh38
GRCh38177,424,874 - 7,427,568 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37177,328,935 - 7,330,887 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36177,269,659 - 7,271,611 (+)NCBINCBI36hg18NCBI36
Celera177,354,821 - 7,356,773 (+)NCBI
Cytogenetic Map17p13.1NCBI
HuRef177,222,961 - 7,224,913 (+)NCBIHuRef
CHM1_1177,338,027 - 7,339,979 (+)NCBICHM1_1
Spem2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21054,537,168 - 54,539,026 (-)NCBI
Rnor_6.0 Ensembl1056,424,164 - 56,426,012 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01056,424,164 - 56,426,012 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01056,169,247 - 56,171,081 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41056,638,639 - 56,640,472 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1053,691,427 - 53,693,278 (-)NCBICelera
Cytogenetic Map10q24NCBI
Spem2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554679,498,541 - 9,500,466 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554679,493,708 - 9,500,466 (-)NCBIChiLan1.0ChiLan1.0
SPEM2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1177,445,958 - 7,447,907 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl177,449,092 - 7,453,041 (+)Ensemblpanpan1.1panPan2
PanPan1.1 Ensembl177,445,958 - 7,447,907 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0177,458,605 - 7,461,545 (+)NCBIMhudiblu_PPA_v0panPan3
SPEM2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl532,357,336 - 32,359,129 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1532,357,302 - 32,359,197 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Spem2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936595708,694 - 710,810 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPEM2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1252,728,927 - 52,730,822 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11252,729,001 - 52,731,131 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21255,021,617 - 55,023,538 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SPEM2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1166,800,970 - 6,803,726 (+)NCBI
ChlSab1.1 Ensembl166,801,835 - 6,803,655 (+)Ensembl


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11330000072800000Mouse
13208559Wght10_mweight 10 (mouse)11400000089000000Mouse
13208558Lgth12_mbody length 12 (mouse)11400000095000000Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11693027789128908Mouse
1357859Lvrq7_mliver weight QTL 7 (mouse)Not determined1112318637118131898Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112318637118131898Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1917420497007000Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112185736495990405Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113600000085000000Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113639175083590530Mouse
1301788Lbw8_mlupus NZB x NZW 8 (mouse)Not determined113661246070618665Mouse
1301896Tria1_mT-cell receptor induced activation 1 (mouse)Not determined113672273870723028Mouse
4141853Skmw17_mskeletal muscle weight 17 (mouse)Not determined113719011571190238Mouse
10766457Nwa3_mNew Zealand White autoimmunity 3 (mouse)113812528972125383Mouse
11532698Sluc36a_msusceptibility to lung cancer 36a (mouse)114236579176365904Mouse
11532699Sluc36b_msusceptibility to lung cancer 36b (mouse)114236579176365904Mouse
4142300Ctrq3_mC. trachomatis resistance QTL 3 (mouse)Not determined114473921176963931Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44739211113167183Mouse
4141000Nidd3_mnon-insulin-dependent diabetes mellitus 3 (mouse)Not determined4515120179151308Mouse
1302021Nidd1n_mnon-insulin-dependent diabetes mellitus 1 in NSY (mouse)Not determined114527504680087498Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114581775489927907Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114629434180294436Mouse
1301988Bmd11_mbone mineral density 11 (mouse)Not determined114642858180428696Mouse
1301830Ssta4_msusceptibility to Salmonella typhimurium antigens 4 (mouse)Not determined115018736584187585Mouse
13524840Ppiq9a_mprepulse inhibition QTL 9a (mouse)115260355986603559Mouse
1300774Pgia7_mproteoglycan induced arthritis 7 (mouse)Not determined115349976287499911Mouse
4141830Pregq1_mpregnancy QTL 1 (mouse)Not determined115423592683842826Mouse
4141875Etax9_methanol induced ataxia 9 (mouse)Not determined5539415972319101Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156973201114267131Mouse
1300664Etohcta9_methanol conditioned taste aversion 9 (mouse)Not determined115786383491863932Mouse
10053682Eae45_mexperimental allergic encephalomyelitis susceptibility 45 (mouse)Not determined115859972974863932Mouse
1300924Ity2_mimmunity to S. typhimurium 2 (mouse)Not determined15861720487804412Mouse
4141982Skts-fp2_mskin tumor susceptibility in FVB and PWK 2 (mouse)Not determined5882844085175703Mouse
1301987Pid3_mprior incubation determinant 3 (mouse)Not determined116179599488808902Mouse
1301319Dautb4_mdopamine uptake transporter binding 4 (mouse)Not determined116226517996265327Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162700000109500000Mouse
1301999Lmr15_mleishmaniasis resistance 15 (mouse)Not determined116342858181939647Mouse
10044004Stzid3_mstreptozotocin induced diabetes susceptibility 3 (mouse)Not determined116342858194173092Mouse
11039501Ltpr6a_mLeishmania tropica response 6a (mouse)116493951098939647Mouse
11039502Ltpr6b_mLeishmania tropica response 6b (mouse)116493951098939647Mouse
11039515Ltpr6_mLeishmania tropica response 6 (mouse)116493951098939647Mouse
1301546Pcir2_mperiosteal circumference 2 (mouse)Not determined1166842594100842826Mouse
1357766Si5lq6_mserum IGFBP-5 level QTL 6 (mouse)Not determined1166842594100842826Mouse
4141012Femwf6_mfemur work to failure 6 (mouse)Not determined66842594100842826Mouse
1301833Tbbmd5_mtotal body bone mineral density 5 (mouse)Not determined1166842594100842826Mouse
1300784Prdt3_mprion disease incubation time 3 (mouse)Not determined1166842594100842826Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166842594100842826Mouse
4142316Ity2b_mimmunity to S. typhimurium 2b (mouse)Not determined116718736579923086Mouse
27226783Tibl5_mtibia length 5, 5 week (mouse)1168300000102000000Mouse
36049778Ars6_mantibody response to SARS-CoV 6, day 15, IgM (mouse)116910000072600000Mouse
36049779Ars7_mantibody response to SARS-CoV 7, day 29, IgG1 (mouse)116910000072600000Mouse
36049784Ars8_mantibody response to SARS-CoV 8, day 29, IgG2a+IgG2c (mouse)116910000072600000Mouse
36049785Ars9_mantibody response to SARS-CoV 9, day 29, IgM (mouse)116910000072600000Mouse
36049786Ars10_mantibody response to SARS-CoV 10, 4 days post-rechallenge, IgG2a+IgG2c (mouse)116910000072600000Mouse
36049787Ars11_mantibody response to SARS-CoV 11, 4 days post-rechallenge, IgM (mouse)116910000072600000Mouse
36049788Ars1_mantibody response to SARS-CoV 1, day 7, IgG1 (mouse)116910000072600000Mouse
36049789Ars2_mantibody response to SARS-CoV 2, day 7, IgG2a+IgG2c (mouse)116910000072600000Mouse
36049790Ars3_mantibody response to SARS-CoV 3, day 7, IgG2b (mouse)116910000072600000Mouse
36049791Ars4_mantibody response to SARS-CoV 4, day 7, IgG3 (mouse)116910000072600000Mouse
36049792Ars5_mantibody response to SARS-CoV 5, day 7, IgM (mouse)116910000072600000Mouse
35673314Ari2_mantibody response to influenza 2, day 10, IgG3 (mouse)116910000072600000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:70
Count of miRNA genes:70
Interacting mature miRNAs:70
Transcripts:ENSMUST00000056941
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000056941   ⟹   ENSMUSP00000051204
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1169,816,566 - 69,818,465 (-)Ensembl
RefSeq Acc Id: NM_175368   ⟹   NP_780577
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391169,707,392 - 69,709,289 (-)NCBI
GRCm381169,816,566 - 69,818,463 (-)NCBI
MGSCv371169,630,068 - 69,631,942 (-)RGD
Celera1177,377,527 - 77,379,401 (-)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006531970   ⟹   XP_006532033
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391169,707,386 - 69,709,313 (-)NCBI
GRCm381169,816,560 - 69,818,487 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_780577   ⟸   NM_175368
- UniProtKB: Q8C5U4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006532033   ⟸   XM_006531970
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000051204   ⟸   ENSMUST00000056941

Promoters
RGD ID:8675224
Promoter ID:EPDNEW_M15643
Type:initiation region
Name:Spem2_1
Description:Mus musculus SPEM family member 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381169,818,463 - 69,818,523EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1918293 AgrOrtholog
Ensembl Genes ENSMUSG00000044084 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000051204 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000056941 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro SPEM1_N UniProtKB/Swiss-Prot
KEGG Report mmu:108803 UniProtKB/Swiss-Prot
MGD MGI:1918293 ENTREZGENE
NCBI Gene 108803 ENTREZGENE
Pfam Spem1 UniProtKB/Swiss-Prot
PhenoGen Spem2 PhenoGen
UniProt Q8C5U4 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-08-22 Spem2  SPEM family member 2  4933402P03Rik  RIKEN cDNA 4933402P03 gene  Symbol and/or name change 5135510 APPROVED