Plppr4 (phospholipid phosphatase related 4) - Rat Genome Database

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Gene: Plppr4 (phospholipid phosphatase related 4) Mus musculus
Analyze
Symbol: Plppr4
Name: phospholipid phosphatase related 4
RGD ID: 1616551
MGI Page MGI
Description: Predicted to enable lysophosphatidic acid phosphatase activity and phosphatidate phosphatase activity. Involved in lipid import into cell and regulation of glutamatergic synaptic transmission. Acts upstream of or within inner ear development. Is active in glutamatergic synapse and postsynaptic density membrane. Is expressed in genitourinary system and retina. Orthologous to human PLPPR4 (phospholipid phosphatase related 4).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2-lysophosphatidate phosphatase PLPPR4; A330086D10; brain-specific phosphatidic acid phosphatase-like protein 1; D3Bwg0562e; inactive 2-lysophosphatidate phosphatase PLPPR4; L; lipid phosphate phosphatase-related protein type 4; Lppr4; mKIAA0455; phospholipid phosphatase-related protein type 4; plasticity related gene 1; plasticity-related gene 1 protein; PRG; PRG-1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393117,112,794 - 117,154,525 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3117,112,788 - 117,154,525 (-)EnsemblGRCm39 Ensembl
GRCm383117,319,145 - 117,360,876 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3117,319,139 - 117,360,876 (-)EnsemblGRCm38mm10GRCm38
MGSCv373117,022,063 - 117,063,794 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363117,311,149 - 117,352,880 (-)NCBIMGSCv36mm8
Celera3123,722,032 - 123,763,668 (-)NCBICelera
Cytogenetic Map3G1NCBI
cM Map350.57NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mouse MP Annotation Import Pipeline RGD automated import pipeline
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:9371744   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:12730698   PMID:14621295   PMID:16141072   PMID:16141073  
PMID:18287559   PMID:19302145   PMID:19766573   PMID:21267068   PMID:21677750   PMID:21795542   PMID:21873635   PMID:22337885   PMID:23341629   PMID:23506325   PMID:26671989   PMID:26980613  
PMID:27453502   PMID:27641493   PMID:27909001   PMID:28671696   PMID:28843862   PMID:33378226   PMID:33798452   PMID:34622503   PMID:36417873   PMID:36604605   PMID:36977636   PMID:38187761  


Genomics

Comparative Map Data
Plppr4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393117,112,794 - 117,154,525 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3117,112,788 - 117,154,525 (-)EnsemblGRCm39 Ensembl
GRCm383117,319,145 - 117,360,876 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3117,319,139 - 117,360,876 (-)EnsemblGRCm38mm10GRCm38
MGSCv373117,022,063 - 117,063,794 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363117,311,149 - 117,352,880 (-)NCBIMGSCv36mm8
Celera3123,722,032 - 123,763,668 (-)NCBICelera
Cytogenetic Map3G1NCBI
cM Map350.57NCBI
PLPPR4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38199,262,924 - 99,309,584 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl199,264,292 - 99,309,590 (+)EnsemblGRCh38hg38GRCh38
GRCh37199,730,048 - 99,775,140 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36199,502,488 - 99,547,728 (+)NCBINCBI36Build 36hg18NCBI36
Celera197,983,902 - 98,029,193 (+)NCBICelera
Cytogenetic Map1p21.3-p21.2NCBI
HuRef197,852,810 - 97,898,096 (+)NCBIHuRef
CHM1_1199,846,184 - 99,891,476 (+)NCBICHM1_1
T2T-CHM13v2.0199,111,296 - 99,157,921 (+)NCBIT2T-CHM13v2.0
Plppr4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82208,056,206 - 208,097,191 (-)NCBIGRCr8
mRatBN7.22205,371,317 - 205,412,302 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2205,371,322 - 205,412,302 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2213,018,609 - 213,059,602 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02210,933,198 - 210,974,196 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02205,751,648 - 205,792,638 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02220,298,239 - 220,341,863 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2220,298,245 - 220,341,866 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02238,365,252 - 238,405,892 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42213,686,578 - 213,727,831 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12213,649,335 - 213,690,585 (-)NCBI
Celera2197,848,561 - 197,889,304 (-)NCBICelera
Cytogenetic Map2q42NCBI
Plppr4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554354,091,165 - 4,114,376 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554354,085,918 - 4,112,207 (+)NCBIChiLan1.0ChiLan1.0
PLPPR4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21127,720,740 - 127,766,341 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11126,875,286 - 126,920,897 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01101,919,714 - 101,965,146 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11100,640,187 - 100,685,483 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1100,640,187 - 100,685,483 (+)Ensemblpanpan1.1panPan2
PLPPR4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1650,553,769 - 50,594,298 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl650,554,949 - 50,594,383 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha653,237,104 - 53,277,408 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0650,906,076 - 50,946,382 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl650,906,113 - 50,946,341 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1650,599,385 - 50,639,586 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0650,578,764 - 50,619,057 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0651,011,414 - 51,051,742 (-)NCBIUU_Cfam_GSD_1.0
Plppr4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405058108,444,124 - 108,485,378 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936537462,583 - 503,874 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936537462,595 - 503,770 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLPPR4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4118,713,994 - 118,752,224 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14118,713,987 - 118,752,499 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24130,278,777 - 130,316,328 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PLPPR4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12033,996,027 - 34,042,145 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2033,996,021 - 34,042,004 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603824,010,104 - 24,055,697 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Plppr4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248571,907,932 - 1,956,093 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248571,761,972 - 1,955,112 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Plppr4
1880 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:963
Count of miRNA genes:501
Interacting mature miRNAs:622
Transcripts:ENSMUST00000061071, ENSMUST00000125664
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33265060142405761Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316504164130163649Mouse
26884422Cvht7_mcranial vault height 7, 16 week (mouse)328954149118893649Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330067588147304689Mouse
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337174862143353183Mouse
26884382Bzwq1_mbi-zygomatic width QTL 1, 5 week (mouse)352207421137205761Mouse
25314313Syncl1_msynaptonemal complex length 1 (mouse)367907333128393649Mouse
11041900Lmr11a_mleishmaniasis resistance 11a (mouse)383463991117464137Mouse
11039510Ltpr3d_mLeishmania tropica response 3d (mouse)383463991117464137Mouse
11039511Ltpr3c_mLeishmania tropica response 3c (mouse)383463991117464137Mouse
11039507Ltpr3g_mLeishmania tropica response 3g (mouse)383463991117464137Mouse
11039508Ltpr3f_mLeishmania tropica response 3f (mouse)383463991117464137Mouse
11039509Ltpr3e_mLeishmania tropica response 3e (mouse)383463991117464137Mouse
11039512Ltpr3b_mLeishmania tropica response 3b (mouse)383463991117464137Mouse
1301272Cfsw1_mcystic fibrosis survival to weaning 1 (mouse)Not determined383882912117883044Mouse
4142099Cq3_mcholesterol QTL 3 (mouse)Not determined384888918118889067Mouse
14746984Manh54_mmandible shape 54 (mouse)385289152119289152Mouse
1357583Sle18_msystematic lupus erythematosus susceptibility 18 (mouse)Not determined387208904125316236Mouse
12738440Twq3_mtestis weight QTL 3 (mouse)387228015121228015Mouse
4142178Ctrq2_mC. trachomatis resistance QTL 2 (mouse)Not determined389139967137453008Mouse
10766455Sle22_msystematic lupus erythematosus susceptibility 22 (mouse)390376936124377072Mouse
14747001Mancz4_mmandible centroid size 4 (mouse)390378017124378017Mouse
1302052Etohcta4_methanol conditioned taste aversion 4 (mouse)Not determined391000105125008748Mouse
1301349Pgia26_mproteoglycan induced arthritis 26 (mouse)Not determined392251533126251650Mouse
27226732Tibmd3_mtibia midshaft diameter 3, 10 week (mouse)396607316147805636Mouse
10043955Wt10q4_mbody weight, 10 weeks, QTL 4 (mouse)Not determined398624041132624197Mouse
11533920Mvb3_mmodifier of vibrator 3 (mouse)398635284132635383Mouse
12792984Modn1_mmodifier of Dstn neovascularization 1 (mouse)398635284132635383Mouse
1302114Tbs1_mtuberculosis severity 1 (mouse)Not determined398924105132924250Mouse
1300752Ap6q_malcohol preference 6 QTL (mouse)Not determined3100372912147045722Mouse
26884419Bzwq6_mbi-zygomatic width QTL 6, 10 week (mouse)3100607316137205761Mouse
27226733Tibmd6_mtibia midshaft diameter 6, 16 week (mouse)3101307316149805637Mouse
1301805Mors2_mmodifier of obesity related sterility 2 (mouse)Not determined3103482659137482783Mouse
8655599Cia5c_mcollagen induced arthritis QTL 5c (mouse)Not determined3107376936125316237Mouse
1302093Orgwq5_morgan weight QTL 5 (mouse)Not determined3107376936147304689Mouse
1300619Cdcs1_mcytokine deficiency colitis susceptibility 1 (mouse)Not determined3109834882143835005Mouse
12910793Pwbwq7_mpost-weaning body weight QTL 7 (mouse)3110084357135715812Mouse
12910796Pwbwq6_mpost-weaning body weight QTL 6 (mouse)3110084357135715812Mouse
12910815Ogrq1_moverall growth rate QTL 1 (mouse)3110084357135715812Mouse
1301381Bomb1_mbone marrow pre-B 1 (mouse)Not determined3111133243145133417Mouse
1301100Bdt2_mbone density traits 2 (mouse)Not determined3114736617148736784Mouse

Markers in Region
BB256253  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383117,356,350 - 117,356,455UniSTSGRCm38
MGSCv373117,059,268 - 117,059,373UniSTSGRCm37
Celera3123,759,141 - 123,759,246UniSTS
Cytogenetic Map3G1UniSTS
cM Map355.0UniSTS
Whitehead/MRC_RH31347.58UniSTS
27.MMHAP63FLA6.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383117,348,571 - 117,348,731UniSTSGRCm38
MGSCv373117,051,489 - 117,051,649UniSTSGRCm37
Celera3123,751,512 - 123,751,672UniSTS
Cytogenetic Map3G1UniSTS
cM Map355.0UniSTS
Whitehead_YAC3 UniSTS
MDB0562  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383117,322,896 - 117,323,046UniSTSGRCm38
MGSCv373117,025,814 - 117,025,964UniSTSGRCm37
Celera3123,725,577 - 123,725,727UniSTS
Cytogenetic Map3G1UniSTS
cM Map355.0UniSTS
Whitehead_YAC3 UniSTS
D3Bwg0562e  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383117,322,752 - 117,322,927UniSTSGRCm38
MGSCv373117,025,670 - 117,025,845UniSTSGRCm37
Celera3123,725,433 - 123,725,608UniSTS
Cytogenetic Map3G1UniSTS
cM Map355.0UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000061071   ⟹   ENSMUSP00000052306
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3117,112,788 - 117,154,525 (-)Ensembl
GRCm38.p6 Ensembl3117,319,139 - 117,360,876 (-)Ensembl
RefSeq Acc Id: ENSMUST00000125664
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3117,114,758 - 117,154,525 (-)Ensembl
GRCm38.p6 Ensembl3117,321,109 - 117,360,876 (-)Ensembl
RefSeq Acc Id: ENSMUST00000197743   ⟹   ENSMUSP00000143753
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3117,115,560 - 117,153,897 (-)Ensembl
GRCm38.p6 Ensembl3117,321,911 - 117,360,248 (-)Ensembl
RefSeq Acc Id: NM_177664   ⟹   NP_808332
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393117,112,794 - 117,154,525 (-)NCBI
GRCm383117,319,145 - 117,360,876 (-)ENTREZGENE
MGSCv373117,022,063 - 117,063,794 (-)RGD
Celera3123,722,032 - 123,763,668 (-)RGD
cM Map3 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_808332   ⟸   NM_177664
- UniProtKB: Q8BXK2 (UniProtKB/Swiss-Prot),   Q8BV73 (UniProtKB/Swiss-Prot),   Q6ZQA8 (UniProtKB/Swiss-Prot),   B2RQ15 (UniProtKB/Swiss-Prot),   Q8R3R6 (UniProtKB/Swiss-Prot),   Q7TME0 (UniProtKB/Swiss-Prot),   A0A0G2JGY9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000143753   ⟸   ENSMUST00000197743
RefSeq Acc Id: ENSMUSP00000052306   ⟸   ENSMUST00000061071

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q7TME0-F1-model_v2 AlphaFold Q7TME0 1-766 view protein structure

Promoters
RGD ID:6833327
Promoter ID:MM_KWN:35915
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Kidney
Transcripts:NM_177664,   OTTMUST00000058426
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv363117,062,886 - 117,063,386 (-)MPROMDB
RGD ID:6882252
Promoter ID:EPDNEW_M4551
Type:initiation region
Name:Plppr4_1
Description:Mus musculus phospholipid phosphatase related 4 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm383117,360,206 - 117,360,266EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:106530 AgrOrtholog
Ensembl Genes ENSMUSG00000044667 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000061071 ENTREZGENE
  ENSMUST00000061071.13 UniProtKB/Swiss-Prot
  ENSMUST00000197743.2 UniProtKB/TrEMBL
Gene3D-CATH Phosphatidic acid phosphatase type 2/haloperoxidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro P_Acid_Pase_2/haloperoxi_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P_Acid_Pase_2/haloperoxidase UniProtKB/Swiss-Prot
  PLPP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:229791 UniProtKB/Swiss-Prot
MGD MGI:106530 ENTREZGENE
NCBI Gene 229791 ENTREZGENE
PANTHER PTHR10165 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10165:SF13 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PAP2 UniProtKB/Swiss-Prot
PhenoGen Plppr4 PhenoGen
SMART acidPPc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48317 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JGY9 ENTREZGENE, UniProtKB/TrEMBL
  B2RQ15 ENTREZGENE
  PLPR4_MOUSE UniProtKB/Swiss-Prot
  Q6ZQA8 ENTREZGENE
  Q7TME0 ENTREZGENE
  Q8BV73 ENTREZGENE
  Q8BXK2 ENTREZGENE
  Q8R3R6 ENTREZGENE
UniProt Secondary B2RQ15 UniProtKB/Swiss-Prot
  Q6ZQA8 UniProtKB/Swiss-Prot
  Q8BV73 UniProtKB/Swiss-Prot
  Q8BXK2 UniProtKB/Swiss-Prot
  Q8R3R6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-17 Plppr4  phospholipid phosphatase related 4  Lppr4  lipid phosphate phosphatase-related protein type 4  Symbol and/or name change 5135510 APPROVED
2014-08-05 Lppr4  lipid phosphate phosphatase-related protein type 4  D3Bwg0562e  DNA segment, Chr 3, Brigham & Women's Genetics 0562 expressed  Symbol and/or name change 5135510 APPROVED