Esyt3 (extended synaptotagmin-like protein 3) - Rat Genome Database
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Gene: Esyt3 (extended synaptotagmin-like protein 3) Mus musculus
Analyze
Symbol: Esyt3
Name: extended synaptotagmin-like protein 3
RGD ID: 1616460
MGI Page MGI
Description: Predicted to have calcium ion binding activity and phospholipid binding activity. Predicted to be involved in endoplasmic reticulum-plasma membrane tethering and lipid transport. Predicted to localize to several cellular components, including endoplasmic reticulum-plasma membrane contact site; extrinsic component of cytoplasmic side of plasma membrane; and intrinsic component of endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; embryo ectoderm; genitourinary system; lymph node; and nervous system. Orthologous to human ESYT3 (extended synaptotagmin 3); INTERACTS WITH 1,2-dimethylhydrazine; 2,2',4,4',5,5'-hexachlorobiphenyl; 2,2',5,5'-tetrachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: D930024E11; D9Ertd280; D9Ertd280e; E-Syt3; extended synaptotagmin-3; Fam62; Fam62c; family with sequence similarity 62 (C2 domain containing), member C; family with sequence similarity 62, member C; KIAA4186; mKIAA4186
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39999,192,016 - 99,242,210 (-)NCBIGRCm39mm39
GRCm38999,309,963 - 99,360,159 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl999,309,963 - 99,358,557 (-)EnsemblGRCm38mm10GRCm38
MGSCv37999,210,386 - 99,258,949 (-)NCBIGRCm37mm9NCBIm37
MGSCv36999,119,495 - 99,167,882 (-)NCBImm8
Celera998,843,495 - 98,893,869 (-)NCBICelera
Cytogenetic Map9E3.3NCBI
cM Map951.54NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
1. RGD automated import pipeline
2. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:10725249   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:16141072   PMID:16141073   PMID:21267068   PMID:21677750   PMID:21873635  
PMID:24194600   PMID:25486202   PMID:27348751   PMID:27399837   PMID:27626380   PMID:32747560  


Genomics

Comparative Map Data
Esyt3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39999,192,016 - 99,242,210 (-)NCBIGRCm39mm39
GRCm38999,309,963 - 99,360,159 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl999,309,963 - 99,358,557 (-)EnsemblGRCm38mm10GRCm38
MGSCv37999,210,386 - 99,258,949 (-)NCBIGRCm37mm9NCBIm37
MGSCv36999,119,495 - 99,167,882 (-)NCBImm8
Celera998,843,495 - 98,893,869 (-)NCBICelera
Cytogenetic Map9E3.3NCBI
cM Map951.54NCBI
ESYT3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3138,434,586 - 138,481,686 (+)EnsemblGRCh38hg38GRCh38
GRCh383138,434,577 - 138,481,686 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh373138,153,415 - 138,197,910 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363139,636,109 - 139,678,399 (+)NCBINCBI36hg18NCBI36
Celera3136,578,324 - 136,622,170 (+)NCBI
Cytogenetic Map3q22.3NCBI
HuRef3135,528,375 - 135,572,226 (+)NCBIHuRef
CHM1_13138,117,188 - 138,162,562 (+)NCBICHM1_1
Esyt3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.08107,555,417 - 107,602,414 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8107,555,277 - 107,602,263 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08106,981,121 - 107,027,963 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48104,171,726 - 104,216,761 (-)NCBIRGSC3.4rn4RGSC3.4
Celera899,272,485 - 99,319,481 (-)NCBICelera
Cytogenetic Map8q31NCBI
Esyt3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955501538,538 - 585,505 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955501537,195 - 585,640 (-)NCBIChiLan1.0ChiLan1.0
ESYT3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13142,913,450 - 142,958,684 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3142,913,450 - 142,958,684 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03135,463,698 - 135,509,417 (+)NCBIMhudiblu_PPA_v0panPan3
ESYT3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2334,645,087 - 34,691,939 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12334,645,248 - 34,692,178 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Esyt3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936540744,980 - 786,303 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ESYT3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1379,245,791 - 79,297,335 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11379,245,818 - 79,295,471 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21386,861,629 - 86,898,873 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ESYT3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11552,062,156 - 52,130,942 (-)NCBI
ChlSab1.1 Ensembl1552,062,357 - 52,104,852 (-)Ensembl
Esyt3
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473014,986,583 - 15,035,163 (+)NCBI

Position Markers
RH126735  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38999,310,077 - 99,310,322UniSTSGRCm38
MGSCv37999,210,496 - 99,210,741UniSTSGRCm37
Celera998,843,605 - 98,843,850UniSTS
Cytogenetic Map9E3.3UniSTS
cM Map952.0UniSTS
Whitehead/MRC_RH91010.86UniSTS
BM386519  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38999,316,681 - 99,317,263UniSTSGRCm38
MGSCv37999,217,100 - 99,217,682UniSTSGRCm37
Celera998,850,211 - 98,850,793UniSTS
Cytogenetic Map9E3.3UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141224Dxmod_mdoxorubicin nephropathy modifier (mouse)Not determined49541121101528921Mouse
1301241Renf1_mrenal failure 1 (mouse)Not determined95212317899910428Mouse
13207569Tcq13_mtotal cholesterol QTL 13 (mouse)959990000109260000Mouse
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63332429120362868Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63332429120362868Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963332429120362868Mouse
1301636Lith5_mlithogenic gene 5 (mouse)Not determined966207024100207122Mouse
10045638Heal29_mwound healing/regeneration 29 (mouse)Not determined967124167101124167Mouse
1357610Vtbt8_mvertebral trabecular bone trait 8 (mouse)Not determined968897510102897652Mouse
1301924Bmd10_mbone mineral density 10 (mouse)Not determined968897510102897652Mouse
1301302Pas4_mpulmonary adenoma susceptibility 4 (mouse)Not determined969239845103239920Mouse
1301621Hpic1_mhaloperidol-induced catalepsy 1 (mouse)Not determined969546513103546645Mouse
1301573Etohcta8_methanol conditioned taste aversion 8 (mouse)Not determined972977005106977152Mouse
10054068El8_mepilepsy 8 (mouse)Not determined972977005106977152Mouse
1301725Lifespan1_mlife span 1 (mouse)Not determined974368177108368325Mouse
1302065El1_mepilepsy 1 (mouse)Not determined975775364114474379Mouse
10054492El7_mepilepsy 7 (mouse)Not determined975775364114474379Mouse
1301869Tbbmd4_mtotal body bone mineral density 4 (mouse)Not determined976117105101528921Mouse
1301407Rapop2_mradiation-induced apoptosis 2 (mouse)Not determined976535936110536130Mouse
1301192Skts6_mskin tumor susceptibility 6 (mouse)Not determined978640645112640755Mouse
10401247Bglu14_mblood glucose level 14 (mouse)Not determined979397810113397888Mouse
1301732Char1_mP. chabaudi malaria resistance QTL 1 (mouse)Not determined981798268115798392Mouse
1300884Sluc11_msusceptibility to lung cancer 11 (mouse)Not determined982910333116910428Mouse
1357461Idd2_minsulin dependent diabetes susceptibility 2 (mouse)Not determined982910333116910428Mouse
10766454Char10_mP. chabaudi malaria resistance QTL 10 (mouse)982910333116910428Mouse
1301487Nociq1_mnociceptive sensitivity inflammatory QTL 1 (mouse)Not determined984528818118528921Mouse
10412180Msam3_mmuscle, skeletal, activity measure 3 (mouse)Not determined985897510108641186Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986230401120230530Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986239845120289624Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986748483120748483Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987800000121800000Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989284925123284925Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989412277123412396Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989563342123563342Mouse
1357657Pymr_mPlasmodium yoelli malaria resistance (mouse)Not determined989977005118938021Mouse
12910770Splic1_mspleen iron content 1 (mouse)991413879124595110Mouse
12910772Lvic6_mliver iron content 6 (mouse)991413879124595110Mouse
12910773Splic3_mspleen iron content 3 (mouse)991413879124595110Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991641084124595110Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991641084124595110Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991641084124595110Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991641084124595110Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991641084124595110Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991641084124595110Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991683173124595110Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991683173124595110Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991683173124595110Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993762590124595110Mouse
1301484Bwq6_mbody weight (mouse)Not determined993762590124595110Mouse
14746992Manh67_mmandible shape 67 (mouse)994036768124595110Mouse
11081166Psl5_mpromotion susceptibility QTL 5 (mouse)994981301112872929Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996917590124595110Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:662
Count of miRNA genes:411
Interacting mature miRNAs:491
Transcripts:ENSMUST00000042158
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000042158   ⟹   ENSMUSP00000038757
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl999,309,963 - 99,358,518 (-)Ensembl
RefSeq Acc Id: ENSMUST00000186626
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl999,319,569 - 99,322,703 (-)Ensembl
RefSeq Acc Id: ENSMUST00000187365
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl999,332,814 - 99,338,915 (-)Ensembl
RefSeq Acc Id: ENSMUST00000187520   ⟹   ENSMUSP00000140567
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl999,319,613 - 99,325,010 (-)Ensembl
RefSeq Acc Id: ENSMUST00000190002
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl999,355,599 - 99,358,557 (-)Ensembl
RefSeq Acc Id: NM_177775   ⟹   NP_808443
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39999,192,020 - 99,240,583 (-)NCBI
GRCm38999,309,967 - 99,358,530 (-)NCBI
MGSCv37999,210,386 - 99,258,949 (-)RGD
Celera998,843,495 - 98,893,869 (-)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006511221   ⟹   XP_006511284
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39999,192,016 - 99,242,210 (-)NCBI
GRCm38999,309,963 - 99,360,159 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011242752   ⟹   XP_011241054
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39999,192,016 - 99,213,197 (-)NCBI
GRCm38999,309,963 - 99,331,145 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_808443   ⟸   NM_177775
- UniProtKB: Q5DTI8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006511284   ⟸   XM_006511221
- Peptide Label: isoform X1
- UniProtKB: Q5DTI8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011241054   ⟸   XM_011242752
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSMUSP00000038757   ⟸   ENSMUST00000042158
RefSeq Acc Id: ENSMUSP00000140567   ⟸   ENSMUST00000187520
Protein Domains
C2   SMP-LTD

Promoters
RGD ID:6844506
Promoter ID:MM_KWN:58486
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell
Transcripts:ENSMUST00000112906,   NM_177775
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36999,258,756 - 99,259,256 (-)MPROMDB
RGD ID:8670562
Promoter ID:EPDNEW_M13311
Type:multiple initiation site
Name:Esyt3_1
Description:Mus musculus extended synaptotagmin-like protein 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38999,358,530 - 99,358,590EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1098699 AgrOrtholog
Ensembl Genes ENSMUSG00000037681 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000038757 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000140567 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000042158 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000187520 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro C2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C2C_KIAA1228 UniProtKB/Swiss-Prot
  Ext_Synaptotagmin_C2A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ext_Synaptotagmin_C2B UniProtKB/Swiss-Prot
  SMP_LBD UniProtKB/Swiss-Prot
  Synaptotagmin_SMP UniProtKB/Swiss-Prot
KEGG Report mmu:272636 UniProtKB/Swiss-Prot
MGD MGI:1098699 ENTREZGENE
NCBI Gene 272636 ENTREZGENE
Pfam PF00168 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMP_LBD UniProtKB/Swiss-Prot
PhenoGen Esyt3 PhenoGen
PRINTS C2DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PS50004 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMP UniProtKB/Swiss-Prot
SMART SM00239 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.490440 ENTREZGENE
UniProt A0A087WRC5_MOUSE UniProtKB/TrEMBL
  ESYT3_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q0VF61 UniProtKB/Swiss-Prot
  Q8C3B9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-27 Esyt3  extended synaptotagmin-like protein 3  D9Ertd280e  DNA segment, Chr 9, ERATO Doi 280, expressed  Symbol and/or name change 5135510 APPROVED