Prss43 (serine protease 43) - Rat Genome Database

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Gene: Prss43 (serine protease 43) Mus musculus
Analyze
Symbol: Prss43
Name: serine protease 43 (Ensembl:protease, serine 43)
RGD ID: 1616459
MGI Page MGI
Description: Predicted to enable serine-type endopeptidase activity. Acts upstream of or within germ cell development and spermatogenesis. Located in plasma membrane. Is expressed in cerebral cortex mantle layer; diencephalon lateral wall mantle layer; midbrain mantle layer; pretectum; and telencephalon mantle layer. Orthologous to human PRSS43P (serine protease 43, pseudogene).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Gm661; protease, serine 43; protease, serine, 43; putative inactive serine protease 43; Tes; Tessp3; testis serine protease 3
RGD Orthologs
Human
Dog
Squirrel
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399110,655,758 - 110,660,575 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9110,655,758 - 110,660,907 (+)EnsemblGRCm39 Ensembl
GRCm389110,826,690 - 110,831,507 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9110,826,690 - 110,831,839 (+)EnsemblGRCm38mm10GRCm38
MGSCv379110,729,194 - 110,734,011 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369110,671,506 - 110,676,323 (+)NCBIMGSCv36mm8
Celera9110,557,538 - 110,562,236 (+)NCBICelera
Cytogenetic Map9F2NCBI
cM Map960.79NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:21267068   PMID:21873635   PMID:23536369  


Genomics

Comparative Map Data
Prss43
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399110,655,758 - 110,660,575 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9110,655,758 - 110,660,907 (+)EnsemblGRCm39 Ensembl
GRCm389110,826,690 - 110,831,507 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9110,826,690 - 110,831,839 (+)EnsemblGRCm38mm10GRCm38
MGSCv379110,729,194 - 110,734,011 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369110,671,506 - 110,676,323 (+)NCBIMGSCv36mm8
Celera9110,557,538 - 110,562,236 (+)NCBICelera
Cytogenetic Map9F2NCBI
cM Map960.79NCBI
PRSS43P
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38346,753,043 - 46,756,855 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl346,753,691 - 46,756,816 (-)EnsemblGRCh38hg38GRCh38
GRCh37346,794,533 - 46,798,345 (-)NCBIGRCh37GRCh37hg19GRCh37
Celera346,733,721 - 46,736,858 (-)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef346,837,970 - 46,841,151 (-)NCBIHuRef
CHM1_1346,744,668 - 46,804,294 (-)NCBICHM1_1
T2T-CHM13v2.0346,769,128 - 46,772,940 (-)NCBIT2T-CHM13v2.0
LOC100684662
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12041,987,596 - 41,991,752 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2041,903,757 - 41,907,929 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02042,470,070 - 42,474,339 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2042,452,205 - 42,488,050 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12041,711,719 - 41,715,984 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02042,112,692 - 42,116,851 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02042,393,665 - 42,397,934 (+)NCBIUU_Cfam_GSD_1.0
LOC101960405
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118201,063,515 - 201,067,441 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936596613,328 - 616,341 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0

Variants

.
Variants in Prss43
132 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:228
Count of miRNA genes:202
Interacting mature miRNAs:216
Transcripts:ENSMUST00000077549
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63239711120191934Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63239711120191934Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963239711120191934Mouse
1302065El1_mepilepsy 1 (mouse)Not determined975682646114303447Mouse
10054492El7_mepilepsy 7 (mouse)Not determined975682646114303447Mouse
1301192Skts6_mskin tumor susceptibility 6 (mouse)Not determined978522698112522808Mouse
10401247Bglu14_mblood glucose level 14 (mouse)Not determined979279863113279941Mouse
1301732Char1_mP. chabaudi malaria resistance QTL 1 (mouse)Not determined981680321115680445Mouse
10766454Char10_mP. chabaudi malaria resistance QTL 10 (mouse)982792386116792481Mouse
1300884Sluc11_msusceptibility to lung cancer 11 (mouse)Not determined982792386116792481Mouse
1357461Idd2_minsulin dependent diabetes susceptibility 2 (mouse)Not determined982792386116792481Mouse
1301487Nociq1_mnociceptive sensitivity inflammatory QTL 1 (mouse)Not determined984406017118406120Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986107600120107729Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986121898120118690Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986625682120625682Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987677199121677199Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989162124123162124Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989289476123289595Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989440541123440541Mouse
1357657Pymr_mPlasmodium yoelli malaria resistance (mouse)Not determined989859058118767089Mouse
12910770Splic1_mspleen iron content 1 (mouse)991291078124359700Mouse
12910772Lvic6_mliver iron content 6 (mouse)991291078124359700Mouse
12910773Splic3_mspleen iron content 3 (mouse)991291078124359700Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991518283124359700Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991518283124359700Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991518283124359700Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991518283124359700Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991518283124359700Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991518283124359700Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991560372124359700Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991560372124359700Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991560372124359700Mouse
1301484Bwq6_mbody weight (mouse)Not determined993591658124359700Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993591658124359700Mouse
14746992Manh67_mmandible shape 67 (mouse)993865836124359700Mouse
11081166Psl5_mpromotion susceptibility QTL 5 (mouse)994863354112701997Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996746658124359700Mouse
1301297Lcho1_mliver cholesterol 1 (mouse)Not determined9100889929124359700Mouse
1357648Obq18_mobesity QTL 18 (mouse)Not determined9101829255124359700Mouse
1357627Tgq2_mtriglyceride QTL 2 (mouse)Not determined9101829255124359700Mouse
10412290Pvacm1l_mplasma vascular cell adhesion molecule 1 levels (mouse)Not determined9103118511124359700Mouse
12879896Berr3_mberghei resistance locus 3 (mouse)9103118511124359700Mouse
1301789Pbwg4_mpostnatal body weight growth 4 (mouse)Not determined9103118511124359700Mouse
13515058Adip20d_madiposity 20d (mouse)9108744078118744078Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000077549   ⟹   ENSMUSP00000076752
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9110,655,758 - 110,660,907 (+)Ensembl
GRCm38.p6 Ensembl9110,826,690 - 110,831,839 (+)Ensembl
RefSeq Acc Id: NM_199471   ⟹   NP_955765
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399110,655,758 - 110,660,575 (+)NCBI
GRCm389110,826,690 - 110,831,507 (+)ENTREZGENE
MGSCv379110,729,194 - 110,734,011 (+)RGD
Celera9110,557,538 - 110,562,236 (+)RGD
cM Map9 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_955765 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAD06396 (Get FASTA)   NCBI Sequence Viewer  
  EDL08995 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000076752
  ENSMUSP00000076752.6
GenBank Protein Q76HL1 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_955765   ⟸   NM_199471
- Peptide Label: precursor
- UniProtKB: Q76HL1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000076752   ⟸   ENSMUST00000077549
Protein Domains
Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q76HL1-F1-model_v2 AlphaFold Q76HL1 1-382 view protein structure

Promoters
RGD ID:6844987
Promoter ID:MM_KWN:58939
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour
Transcripts:NM_199471
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv369110,728,281 - 110,728,781 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2684822 AgrOrtholog
Ensembl Genes ENSMUSG00000058398 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000077549 ENTREZGENE
  ENSMUST00000077549.7 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot
InterPro Peptidase_S1_PA UniProtKB/Swiss-Prot
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot
  Peptidase_S1A UniProtKB/Swiss-Prot
  Trypsin_dom UniProtKB/Swiss-Prot
  TRYPSIN_HIS UniProtKB/Swiss-Prot
KEGG Report mmu:272643 UniProtKB/Swiss-Prot
MGD MGI:2684822 ENTREZGENE
NCBI Gene 272643 ENTREZGENE
PANTHER PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot
  TRANSMEMBRANE PROTEASE SERINE UniProtKB/Swiss-Prot
Pfam Trypsin UniProtKB/Swiss-Prot
PhenoGen Prss43 PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot
PROSITE TRYPSIN_DOM UniProtKB/Swiss-Prot
  TRYPSIN_HIS UniProtKB/Swiss-Prot
SMART Tryp_SPc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot
UniProt PRS43_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-08-29 Prss43  serine protease 43  Prss43  protease, serine 43  Symbol and/or name change 5135510 APPROVED
2013-11-26 Prss43  protease, serine 43    protease, serine, 43  Symbol and/or name change 5135510 APPROVED
2011-07-27 Prss43  protease, serine, 43  Tessp3  testis serine protease 3  Symbol and/or name change 5135510 APPROVED