Hs3st5 (heparan sulfate (glucosamine) 3-O-sulfotransferase 5) - Rat Genome Database

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Gene: Hs3st5 (heparan sulfate (glucosamine) 3-O-sulfotransferase 5) Mus musculus
Analyze
Symbol: Hs3st5
Name: heparan sulfate (glucosamine) 3-O-sulfotransferase 5
RGD ID: 1616451
MGI Page MGI
Description: Predicted to have [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity. Predicted to be involved in several processes, including heparan sulfate proteoglycan biosynthetic process, enzymatic modification; protein sulfation; and regulation of viral entry into host cell. Predicted to localize to Golgi apparatus and integral component of membrane. Orthologous to human HS3ST5 (heparan sulfate-glucosamine 3-sulfotransferase 5); PARTICIPATES IN heparan sulfate biosynthetic pathway; INTERACTS WITH 1,2-dichloroethane; 3,4-methylenedioxymethamphetamine; pirinixic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: D930005L05Rik; Gm1151; heparan sulfate 3-O-sulfotransferase 5; heparan sulfate D-glucosaminyl 3-O-sulfotransferase 5; heparan sulfate glucosamine 3-O-sulfotransferase 5; Hs3ost5
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391036,382,794 - 36,710,393 (+)NCBIGRCm39mm39
GRCm39 Ensembl1036,382,810 - 36,710,393 (+)Ensembl
GRCm381036,506,590 - 36,834,397 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1036,506,814 - 36,834,397 (+)EnsemblGRCm38mm10GRCm38
MGSCv371036,226,613 - 36,554,203 (+)NCBIGRCm37mm9NCBIm37
MGSCv361036,196,223 - 36,523,813 (+)NCBImm8
Celera1037,409,543 - 37,736,930 (+)NCBICelera
Cytogenetic Map10B1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:16141072   PMID:16141073   PMID:21677750   PMID:21873635  


Genomics

Comparative Map Data
Hs3st5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391036,382,794 - 36,710,393 (+)NCBIGRCm39mm39
GRCm39 Ensembl1036,382,810 - 36,710,393 (+)Ensembl
GRCm381036,506,590 - 36,834,397 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1036,506,814 - 36,834,397 (+)EnsemblGRCm38mm10GRCm38
MGSCv371036,226,613 - 36,554,203 (+)NCBIGRCm37mm9NCBIm37
MGSCv361036,196,223 - 36,523,813 (+)NCBImm8
Celera1037,409,543 - 37,736,930 (+)NCBICelera
Cytogenetic Map10B1NCBI
HS3ST5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl6114,055,596 - 114,343,023 (-)EnsemblGRCh38hg38GRCh38
GRCh386114,055,586 - 114,343,023 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh376114,376,760 - 114,664,187 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366114,485,114 - 114,490,702 (-)NCBINCBI36hg18NCBI36
Build 346114,485,113 - 114,490,702NCBI
Celera6115,118,158 - 115,125,449 (-)NCBI
Cytogenetic Map6q21-q22.1NCBI
HuRef6111,953,620 - 111,960,911 (-)NCBIHuRef
CHM1_16114,639,638 - 114,646,928 (-)NCBICHM1_1
Hs3st5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22040,106,876 - 40,417,661 (+)NCBI
Rnor_6.0 Ensembl2040,236,437 - 40,545,494 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02040,236,437 - 40,545,502 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02041,969,878 - 42,279,758 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42040,711,763 - 41,022,773 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12041,039,793 - 41,044,941 (+)NCBI
Celera2040,863,898 - 41,173,368 (+)NCBICelera
Cytogenetic Map20q12NCBI
Hs3st5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555262,636,579 - 2,652,405 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555262,418,217 - 2,652,025 (+)NCBIChiLan1.0ChiLan1.0
HS3ST5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.16115,917,004 - 116,202,924 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6115,917,004 - 116,089,942 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v06111,846,143 - 112,132,706 (-)NCBIMhudiblu_PPA_v0panPan3
HS3ST5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11270,137,232 - 70,387,797 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1270,140,802 - 70,388,174 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1269,884,392 - 70,134,790 (-)NCBI
ROS_Cfam_1.01271,019,134 - 71,268,571 (-)NCBI
UMICH_Zoey_3.11270,370,842 - 70,620,669 (-)NCBI
UNSW_CanFamBas_1.01270,209,266 - 70,461,102 (-)NCBI
UU_Cfam_GSD_1.01270,540,322 - 70,791,458 (-)NCBI
Hs3st5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946105,308,246 - 105,505,241 (-)NCBI
SpeTri2.0NW_0049366792,540,894 - 2,737,462 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HS3ST5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl179,955,657 - 80,243,797 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1179,956,485 - 80,140,140 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2190,017,049 - 90,306,175 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HS3ST5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11359,486,748 - 59,774,673 (+)NCBI
ChlSab1.1 Ensembl1359,598,298 - 59,774,953 (+)Ensembl
Vero_WHO_p1.0NW_02366604031,859,012 - 32,137,822 (+)NCBI
Hs3st5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248564,403,071 - 4,689,535 (+)NCBI

Position Markers
UniSTS:224447  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381036,570,044 - 36,570,197UniSTSGRCm38
MGSCv371036,289,850 - 36,290,003UniSTSGRCm37
Celera1037,472,812 - 37,472,965UniSTS
Cytogenetic Map10B1UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357813Ath20_matherosclerosis 20 (mouse)Not determined10340743937407588Mouse
1300790Pgia6_mproteoglycan induced arthritis 6 (mouse)Not determined10393427237934396Mouse
1300997Eae15_msusceptibility to experimental allergic encephalomyelitis 15 (mouse)Not determined10453225538532377Mouse
13208561Wght8_mweight 8 (mouse)10500000044000000Mouse
1302092Ath11_matherosclerosis 11 (mouse)Not determined10620194558857699Mouse
1357740Obsty3_mobesity 3 (mouse)Not determined108359714116355075Mouse
1558865Lith21_mlithogenic gene 21 (mouse)Not determined10864910542649228Mouse
1302133Alcp16_malcohol preference locus 16 (mouse)Not determined101001426844014395Mouse
1301129Alcp15_malcohol preference locus 15 (mouse)Not determined101001426844014395Mouse
1301448Pas11_mpulmonary adenoma susceptibility 11 (mouse)Not determined101001426844014395Mouse
1301386Sysbp1_msystolic blood pressure 1 (mouse)Not determined101023252187565233Mouse
1357825Kidpq2_mkidney weight percentage QTL 2 (mouse)Not determined101282830784243920Mouse
1357656Hrtq3_mheart weight QTL 3 (mouse)Not determined101282830784243920Mouse
1357864Scfpq1_msubcutaneous fat pad percentage QTL 1 (mouse)Not determined101282830784243920Mouse
1357893Lvrq4_mliver weight QTL 4 (mouse)Not determined101282830784243920Mouse
4142380W3q11_mweight 3 weeks QTL 11 (mouse)Not determined1282830784243920Mouse
4141943W6q6_mweight 6 weeks QTL 6 (mouse)Not determined1282830784243920Mouse
4141956Egq7_mearly growth QTL 7 (mouse)Not determined1282830784243920Mouse
4142272W10q5_mweight 10 weeks QTL 5 (mouse)Not determined1282830784243920Mouse
39128215Lwq17_mliver weight QTL 17 (mouse)101282830784243920Mouse
1302067Scc9_mcolon tumor susceptibility 9 (mouse)Not determined1018383585125739363Mouse
27226772Tibl13_mtibia length 13, 10 week (mouse)1019000000129800000Mouse
10755518Chol16_mcholesterol 16 (mouse)101903904753039047Mouse
1302160Mbis2_mMycobacterium bovis-induced systemic lupus erythematosus 2 (mouse)Not determined102040743956155127Mouse
1558757Eae34_mexperimental allergic encephalomyelitis susceptibility 34 (mouse)Not determined1021532255114381325Mouse
1301003Lmblgq4_mlimb length QTL 4 (mouse)Not determined102171529368255809Mouse
26884394Humsd3_mhumerus midshaft diameter 3, 10 week (mouse)102250000051200000Mouse
26884403Cvht8_mcranial vault height 8, 16 week (mouse)102300000091200000Mouse
26884426Cvht1_mcranial vault height 1, 5 week (mouse)1024800000121200000Mouse
4142209Psrs1_mpsoriasis susceptibility 1 (mouse)Not determined102701426846844387Mouse
1300898Cfid_mcystic fibrosis intestinal distress (mouse)Not determined102984430763844387Mouse
10045632Heal16_mwound healing/regeneration 16 (mouse)Not determined103109840365098534Mouse
1357558Bmch4_mbone mechanical trait 4 (mouse)Not determined103170104065701188Mouse
27095920Pglq9_mpelvic girdle length QTL 9, 10 week (mouse)103390000071000000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:730
Count of miRNA genes:341
Interacting mature miRNAs:379
Transcripts:ENSMUST00000058738, ENSMUST00000167191, ENSMUST00000168572, ENSMUST00000171521, ENSMUST00000172357
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001081208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001253355 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001253356 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006512761 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030245115 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036155808 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC124435 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC131667 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC159292 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK031910 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK086098 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC079867 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC147490 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC147493 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC150973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC158004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ113442 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000058738   ⟹   ENSMUSP00000060229
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1036,506,819 - 36,834,389 (+)Ensembl
RefSeq Acc Id: ENSMUST00000167191   ⟹   ENSMUSP00000130778
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1036,506,814 - 36,833,773 (+)Ensembl
RefSeq Acc Id: ENSMUST00000168572   ⟹   ENSMUSP00000129434
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1036,507,026 - 36,834,397 (+)Ensembl
RefSeq Acc Id: ENSMUST00000171521
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1036,507,407 - 36,810,038 (+)Ensembl
RefSeq Acc Id: ENSMUST00000172357
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1036,506,889 - 36,702,949 (+)Ensembl
RefSeq Acc Id: NM_001081208   ⟹   NP_001074677
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391036,382,803 - 36,710,393 (+)NCBI
GRCm381036,506,807 - 36,834,397 (+)NCBI
MGSCv371036,226,613 - 36,554,203 (+)RGD
Celera1037,409,543 - 37,736,930 (+)RGD
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001253355   ⟹   NP_001240284
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391036,382,803 - 36,710,393 (+)NCBI
GRCm381036,506,807 - 36,834,397 (+)NCBI
Celera1037,409,543 - 37,736,930 (+)ENTREZGENE
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001253356   ⟹   NP_001240285
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391036,382,803 - 36,710,393 (+)NCBI
GRCm381036,506,807 - 36,834,397 (+)NCBI
Celera1037,409,543 - 37,736,930 (+)ENTREZGENE
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006512761   ⟹   XP_006512824
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391036,382,794 - 36,710,393 (+)NCBI
GRCm381036,506,590 - 36,834,397 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030245115   ⟹   XP_030100975
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391036,382,800 - 36,710,393 (+)NCBI
GRCm381036,506,590 - 36,834,397 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036155808   ⟹   XP_036011701
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391036,382,800 - 36,710,393 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_001074677   ⟸   NM_001081208
- UniProtKB: Q8BSL4 (UniProtKB/Swiss-Prot),   B2RXW6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001240284   ⟸   NM_001253355
- UniProtKB: Q8BSL4 (UniProtKB/Swiss-Prot),   B2RXW6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001240285   ⟸   NM_001253356
- UniProtKB: Q8BSL4 (UniProtKB/Swiss-Prot),   B2RXW6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006512824   ⟸   XM_006512761
- Peptide Label: isoform X1
- UniProtKB: Q8BSL4 (UniProtKB/Swiss-Prot),   B2RXW6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_030100975   ⟸   XM_030245115
- Peptide Label: isoform X1
RefSeq Acc Id: ENSMUSP00000129434   ⟸   ENSMUST00000168572
RefSeq Acc Id: ENSMUSP00000130778   ⟸   ENSMUST00000167191
RefSeq Acc Id: ENSMUSP00000060229   ⟸   ENSMUST00000058738
RefSeq Acc Id: XP_036011701   ⟸   XM_036155808
- Peptide Label: isoform X1
Protein Domains
Sulfotransfer_1

Promoters
RGD ID:6819448
Promoter ID:MM_KWN:3900
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:NM_001081208,   UC007EVD.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361036,226,831 - 36,227,331 (+)MPROMDB
RGD ID:8671792
Promoter ID:EPDNEW_M13927
Type:multiple initiation site
Name:Hs3st5_2
Description:Mus musculus heparan sulfate 3-O-sulfotransferase 5 , transcriptvariant 3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M13928  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381036,506,841 - 36,506,901EPDNEW
RGD ID:8671794
Promoter ID:EPDNEW_M13928
Type:single initiation site
Name:Hs3st5_1
Description:Mus musculus heparan sulfate 3-O-sulfotransferase 5 , transcriptvariant 3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M13927  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381036,653,657 - 36,653,717EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2441996 AgrOrtholog
Ensembl Genes ENSMUSG00000044499 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000060229 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000129434 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000130778 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000058738 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000167191 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000168572 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro NST/OST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sulfotransferase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:319415 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:2441996 ENTREZGENE
NCBI Gene 319415 ENTREZGENE
PANTHER PTHR10605 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Sulfotransfer_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hs3st5 PhenoGen
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B2RXW6 ENTREZGENE, UniProtKB/TrEMBL
  HS3S5_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE