Tafa4 (TAFA chemokine like family member 4) - Rat Genome Database
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Gene: Tafa4 (TAFA chemokine like family member 4) Mus musculus
Analyze
Symbol: Tafa4
Name: TAFA chemokine like family member 4
RGD ID: 1616442
MGI Page MGI
Description: Exhibits receptor ligand activity. Involved in several processes, including macrophage chemotaxis; regulation of sensory perception of pain; and superoxide anion generation. Localizes to extracellular space. Is expressed in central nervous system; dorsal root ganglion; inner ear; and tooth. Orthologous to human TAFA4 (TAFA chemokine like family member 4); INTERACTS WITH benzo[a]pyrene; 1-naphthyl isothiocyanate (ortholog); 17beta-hydroxy-5alpha-androstan-3-one (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: C130034I18Rik; chemokine-like protein TAFA-4; Fam19; Fam19a4; Fam19a4 Tafa-4; family with sequence similarity 19 (chemokine (C-C motif)-like), member A4; family with sequence similarity 19, member A4; MGC107151; Taf; Tafa-4
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39696,808,167 - 97,037,452 (-)NCBIGRCm39mm39
GRCm38696,831,206 - 97,060,411 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl696,831,203 - 97,060,413 (-)EnsemblGRCm38mm10GRCm38
MGSCv37696,781,203 - 97,010,405 (-)NCBIGRCm37mm9NCBIm37
MGSCv36696,796,672 - 97,025,874 (-)NCBImm8
Celera698,692,988 - 98,920,973 (-)NCBICelera
Cytogenetic Map6D3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:14610273   PMID:15028294   PMID:15489334   PMID:16141072   PMID:16141073   PMID:16602821  
PMID:18799693   PMID:21267068   PMID:21873635   PMID:24139797   PMID:25109685   PMID:25834056   PMID:29453251   PMID:29539418   PMID:31968239   PMID:32826903  


Genomics

Comparative Map Data
Tafa4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39696,808,167 - 97,037,452 (-)NCBIGRCm39mm39
GRCm38696,831,206 - 97,060,411 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl696,831,203 - 97,060,413 (-)EnsemblGRCm38mm10GRCm38
MGSCv37696,781,203 - 97,010,405 (-)NCBIGRCm37mm9NCBIm37
MGSCv36696,796,672 - 97,025,874 (-)NCBImm8
Celera698,692,988 - 98,920,973 (-)NCBICelera
Cytogenetic Map6D3NCBI
TAFA4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl368,731,766 - 68,953,297 (-)EnsemblGRCh38hg38GRCh38
GRCh38368,731,766 - 68,932,610 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37368,780,917 - 68,981,698 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh37368,780,915 - 68,981,761 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36368,863,607 - 69,064,401 (-)NCBINCBI36hg18NCBI36
Build 34368,863,607 - 69,064,401NCBI
Celera368,709,246 - 68,909,796 (-)NCBI
Cytogenetic Map3p14.1NCBI
HuRef368,782,334 - 68,982,838 (-)NCBIHuRef
CHM1_1368,723,972 - 68,924,498 (-)NCBICHM1_1
Tafa4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24129,437,466 - 129,671,320 (-)NCBI
Rnor_6.0 Ensembl4129,196,659 - 129,430,251 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.04129,196,658 - 129,430,438 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04193,702,284 - 193,933,576 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44131,539,009 - 131,783,777 (-)NCBIRGSC3.4rn4RGSC3.4
Celera4118,319,911 - 118,547,558 (-)NCBICelera
Cytogenetic Map4q34NCBI
Tafa4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542118,920,551 - 19,083,915 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542118,920,551 - 19,083,792 (+)NCBIChiLan1.0ChiLan1.0
TAFA4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1370,034,273 - 70,234,376 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl370,035,940 - 70,186,928 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0368,666,666 - 68,867,917 (-)NCBIMhudiblu_PPA_v0panPan3
TAFA4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2022,837,094 - 22,962,831 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12022,843,151 - 22,963,722 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
TAFA4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1350,142,679 - 50,353,425 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11350,142,679 - 50,353,448 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21355,225,682 - 55,435,345 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TAFA4
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12229,764,294 - 29,957,792 (-)NCBI
Tafa4
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247733,207,277 - 3,495,379 (-)NCBI

Position Markers
MHAa61a3.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38696,988,220 - 96,988,392UniSTSGRCm38
MGSCv37696,938,214 - 96,938,386UniSTSGRCm37
Celera698,847,634 - 98,847,806UniSTS
Cytogenetic Map6D3UniSTS
Whitehead_YAC6 UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25440480Moaq2_mmodifier of alien QTL 2 (mouse)61117500000Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139100000Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645314059128835032Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46935985136423692Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648720000125360000Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648720000148450000Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648726556125356785Mouse
1357683Igf1sl1_mIGF-1 serum levels 1 (mouse)Not determined652161713116155267Mouse
1301369Im4_mimmunoregulatory 4 (mouse)Not determined66348473897484905Mouse
1300650Bw18_mbody weight QTL 18 (mouse)Not determined666713869100714031Mouse
1301876Bits2_mbitterness sensitivity 2 (mouse)Not determined670425898104426034Mouse
1301813Skl3_mskeletal size (tail length) 3 (mouse)Not determined670425898104426034Mouse
1301034Egrm2_mearly growth rate (mouse)Not determined670425898104426034Mouse
1300869Stheal5_msoft tissue heal 5 (mouse)Not determined671575060105575178Mouse
1300954Fcsa1_mfemoral cross-sectional area 1 (mouse)Not determined671981024105981170Mouse
1301521Pas1c_mpulmonary adenoma susceptibility 1c (mouse)Not determined671981024105981170Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673500000134700000Mouse
1301320Ots1_movarian teratoma susceptibility 1 (mouse)Not determined675447583104503555Mouse
10043901Pfat5_mpredicted fat percentage 5 (mouse)Not determined675607306109607450Mouse
10412208Cypr4_mcytokine production 4 (mouse)Not determined675716503109716697Mouse
1357875Pfat2_mpredicted fat percentage 2 (mouse)Not determined676463949110464093Mouse
13824985Alh1_mamplitude of lateral head displacement 1 (mouse)67800000097000000Mouse
4141376Dbm1_mdiabetes modifier 1 (mouse)Not determined678629504121115387Mouse
14696731Pairq1_mP. aeruginosa infection resistance QTL 1 (mouse)681500000102200000Mouse
10043864T2dm4sa_mtype 2 diabetes mellitus 4 in SMXA RI mice (mouse)Not determined683713869147052561Mouse
11251720Ewc4_methanol withdrawal and consumption 4 (mouse)684122513118122513Mouse
1301687Mnic2_mmacronutrient intake (mouse)Not determined686806805113544602Mouse
1301744Hdlq11_mHDL QTL 11 (mouse)Not determined687503360121503555Mouse
1301262Gasa3_mgastritis type A susceptibility locus 3 (mouse)Not determined689005405123005603Mouse
1301244Ichs_mimmediate cutaneous hypersensitivity QTL (mouse)Not determined690795610124795846Mouse
11532719Sluc45_msusceptibility to lung cancer 45 (mouse)69260730698258933Mouse
4141578Obrq1_mobesity resistance QTL 1 (mouse)Not determined92607306112004738Mouse
11353842Bmiq4_mbody mass index QTL 4 (mouse)692607306146429238Mouse
1301292Cfbw2_mcystic fibrosis body weight 2 (mouse)Not determined695004651129004738Mouse
1300704Cia3_mcollagen induced arthritis QTL 3 (mouse)Not determined696347325130347522Mouse
11040599Lmr4b_mleishmaniasis resistance 4b (mouse)696347325130347522Mouse
4141940W6q5_mweight 6 weeks QTL 5 (mouse)Not determined96655951146633626Mouse
4142416Egq11_mearly growth QTL 11 (mouse)Not determined96655951146633626Mouse
1357555Tesq2_mtestis weight QTL 2 (mouse)Not determined696655951146633626Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:425
Count of miRNA genes:300
Interacting mature miRNAs:355
Transcripts:ENSMUST00000089295
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000089295   ⟹   ENSMUSP00000086710
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl696,831,203 - 97,060,413 (-)Ensembl
RefSeq Acc Id: ENSMUST00000203930
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl697,056,628 - 97,060,393 (-)Ensembl
RefSeq Acc Id: NM_177233   ⟹   NP_796207
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39696,808,170 - 97,037,372 (-)NCBI
GRCm38696,831,209 - 97,060,411 (-)NCBI
MGSCv37696,781,203 - 97,010,405 (-)RGD
Celera698,692,988 - 98,920,973 (-)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_017321648   ⟹   XP_017177137
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39696,808,167 - 97,001,875 (-)NCBI
GRCm38696,831,206 - 97,024,919 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030255465   ⟹   XP_030111325
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39696,808,167 - 96,855,099 (-)NCBI
GRCm38696,831,206 - 96,878,138 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036166236   ⟹   XP_036022129
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39696,808,167 - 97,037,452 (-)NCBI
RefSeq Acc Id: XM_036166237   ⟹   XP_036022130
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39696,808,167 - 97,037,452 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_796207   ⟸   NM_177233
- Peptide Label: precursor
- UniProtKB: Q7TPG5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017177137   ⟸   XM_017321648
- Peptide Label: isoform X2
- UniProtKB: Q7TPG5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_030111325   ⟸   XM_030255465
- Peptide Label: isoform X1
RefSeq Acc Id: ENSMUSP00000086710   ⟸   ENSMUST00000089295
RefSeq Acc Id: XP_036022130   ⟸   XM_036166237
- Peptide Label: isoform X2
RefSeq Acc Id: XP_036022129   ⟸   XM_036166236
- Peptide Label: isoform X2

Promoters
RGD ID:6890510
Promoter ID:EPDNEW_M8706
Type:multiple initiation site
Name:Fam19a4_1
Description:Mus musculus family with sequence similarity 19, member A4 ,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38697,060,413 - 97,060,473EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2444563 AgrOrtholog
Ensembl Genes ENSMUSG00000046500 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000086710 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000089295 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Chemokine-like_FAM19A2 UniProtKB/Swiss-Prot
KEGG Report mmu:320701 UniProtKB/Swiss-Prot
MGD MGI:2444563 ENTREZGENE
NCBI Gene 320701 ENTREZGENE
Pfam TAFA UniProtKB/Swiss-Prot
PhenoGen Tafa4 PhenoGen
UniProt Q7TPG5 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q5FWC0 UniProtKB/Swiss-Prot
  Q8BV02 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-02-26 Tafa4  TAFA chemokine like family member 4  Fam19a4  family with sequence similarity 19, member A4  Symbol and/or name change 5135510 APPROVED