Znrf3 (zinc and ring finger 3) - Rat Genome Database

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Gene: Znrf3 (zinc and ring finger 3) Mus musculus
Analyze
Symbol: Znrf3
Name: zinc and ring finger 3
RGD ID: 1616373
MGI Page MGI
Description: Predicted to enable frizzled binding activity and ubiquitin protein ligase activity. Involved in regulation of Wnt signaling pathway and stem cell proliferation. Predicted to be located in plasma membrane. Is expressed in vibrissa. Orthologous to human ZNRF3 (zinc and ring finger 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AA591877; BC019575; E3 ubiquitin-protein ligase ZNRF3; Gm1167; RING-type E3 ubiquitin transferase ZNRF3; zinc/RING finger protein 3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39115,226,329 - 5,394,847 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl115,226,324 - 5,394,847 (-)EnsemblGRCm39 Ensembl
GRCm38115,276,329 - 5,444,847 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl115,276,324 - 5,444,847 (-)EnsemblGRCm38mm10GRCm38
MGSCv37115,176,332 - 5,344,850 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36115,142,505 - 5,247,835 (-)NCBIMGSCv36mm8
MGSCv36115,176,332 - 5,281,743 (-)NCBIMGSCv36mm8
Celera115,776,042 - 5,838,491 (-)NCBICelera
Cytogenetic Map11A1NCBI
cM Map113.46NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The complex world of WNT receptor signalling. Niehrs C Nat Rev Mol Cell Biol. 2012 Dec;13(12):767-79. doi: 10.1038/nrm3470. Epub 2012 Nov 15.
2. Mouse MP Annotation Import Pipeline RGD automated import pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:12520002   PMID:14610273   PMID:16141072   PMID:16141073   PMID:18287559  
PMID:19501082   PMID:21267068   PMID:21677750   PMID:21873635   PMID:22575959   PMID:22895187   PMID:24225776   PMID:24349440   PMID:26023187   PMID:26123262   PMID:27088858   PMID:27510977  
PMID:29735715   PMID:29769720   PMID:30692207   PMID:30783098   PMID:31073040   PMID:32125593   PMID:32324134   PMID:32468660   PMID:34079124   PMID:34129813   PMID:34301885   PMID:34995498  
PMID:36240276  


Genomics

Comparative Map Data
Znrf3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39115,226,329 - 5,394,847 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl115,226,324 - 5,394,847 (-)EnsemblGRCm39 Ensembl
GRCm38115,276,329 - 5,444,847 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl115,276,324 - 5,444,847 (-)EnsemblGRCm38mm10GRCm38
MGSCv37115,176,332 - 5,344,850 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36115,142,505 - 5,247,835 (-)NCBIMGSCv36mm8
MGSCv36115,176,332 - 5,281,743 (-)NCBIMGSCv36mm8
Celera115,776,042 - 5,838,491 (-)NCBICelera
Cytogenetic Map11A1NCBI
cM Map113.46NCBI
ZNRF3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382228,883,572 - 29,057,488 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2228,883,572 - 29,057,488 (+)EnsemblGRCh38hg38GRCh38
GRCh372229,279,560 - 29,453,476 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362227,609,890 - 27,783,475 (+)NCBINCBI36Build 36hg18NCBI36
Celera2213,079,876 - 13,253,406 (+)NCBICelera
Cytogenetic Map22q12.1NCBI
HuRef2212,244,792 - 12,417,810 (+)NCBIHuRef
CHM1_12229,238,688 - 29,412,672 (+)NCBICHM1_1
T2T-CHM13v2.02229,344,932 - 29,518,764 (+)NCBIT2T-CHM13v2.0
Znrf3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81484,375,668 - 84,527,465 (-)NCBIGRCr8
mRatBN7.21480,157,854 - 80,313,456 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1480,160,278 - 80,313,485 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01485,527,099 - 85,586,294 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01486,200,958 - 86,256,716 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41485,927,245 - 85,982,249 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1479,049,064 - 79,109,279 (-)NCBICelera
Cytogenetic Map14q21NCBI
Znrf3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554553,228,603 - 3,286,290 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554553,066,957 - 3,289,836 (+)NCBIChiLan1.0ChiLan1.0
ZNRF3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22338,820,444 - 39,041,648 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12241,519,189 - 41,741,134 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0229,891,021 - 10,109,147 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12227,593,268 - 27,810,427 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2227,742,301 - 27,810,427 (+)Ensemblpanpan1.1panPan2
ZNRF3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12622,315,947 - 22,397,568 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2622,334,998 - 22,394,228 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2622,111,976 - 22,269,642 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02622,614,295 - 22,772,224 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2622,614,295 - 22,768,758 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12622,323,930 - 22,481,293 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02622,587,839 - 22,745,375 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02622,650,757 - 22,808,880 (+)NCBIUU_Cfam_GSD_1.0
Znrf3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118112,747,443 - 112,806,527 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366573,064,201 - 3,119,684 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366573,064,199 - 3,119,903 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZNRF3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1446,092,062 - 46,241,321 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11446,092,000 - 46,241,327 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21449,144,230 - 49,201,925 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ZNRF3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11911,754,263 - 11,928,158 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1911,754,685 - 11,928,808 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045114,223,727 - 114,397,500 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Znrf3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247475,211,882 - 5,363,172 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247475,211,894 - 5,366,794 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Znrf3
3948 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1855
Count of miRNA genes:723
Interacting mature miRNAs:920
Transcripts:ENSMUST00000109867, ENSMUST00000143746, ENSMUST00000172492
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357722Vtbt11_mvertebral trabecular bone trait 11 (mouse)Not determined11123880487Mouse
1300768Tshp9_mtooth shape 9 (mouse)Not determined11125976374Mouse
1301765Skull15_mskull morphology 15 (mouse)Not determined11125976374Mouse
1300661Lmr6_mleishmaniasis resistance 6 (mouse)Not determined11125976374Mouse
10044008Hbnr15_mHeligmosomoides bakeri nematode resistance 15 (mouse)Not determined1122705234227232Mouse
1300599Cocrb11_mcocaine related behavior 11 (mouse)Not determined11267035536671472Mouse
27095914Pglq16_mpelvic girdle length QTL 16, 16 week (mouse)11325000018150000Mouse
27095919Pglq10_mpelvic girdle length QTL 10, 10 week (mouse)11325000018450000Mouse
27095925Pglq5_mpelvic girdle length QTL 5, 5 week (mouse)11325000019750000Mouse
27095904Scvln12_msacral vertebrae length 2, 10 week (mouse)11325000034495048Mouse
27095909Scvln6_msacral vertebrae length 2, 5 week (mouse)11325000044090827Mouse
27226798Scvln18_msacral vertebrae length 2, 16 week (mouse)11325000060690826Mouse
26884446Sklq10_mskull length QTL 10, 10 week (mouse)11325000062890826Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
10053676Eae44a_mexperimental allergic encephalomyelitis susceptibility 44a (mouse)Not determined11450789621379532Mouse
27226741Metcl5_mmetatarsal-calcaneal length 5, 5 week (mouse)11465000046290827Mouse
27226735Metcl16_mmetatarsal-calcaneal length 16, 16 week (mouse)11525000035090827Mouse

Markers in Region
UniSTS:492585  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv37927,605,414 - 27,605,786UniSTSGRCm37
MGSCv37115,261,889 - 5,262,276UniSTSGRCm37
Celera1614,643,672 - 14,643,787UniSTS
Celera1552,198,470 - 52,198,733UniSTS
Celera1389,299,883 - 89,300,391UniSTS
Celera645,012,874 - 45,013,116UniSTS
Celera177,311,484 - 77,311,943UniSTS
Celera939,964,108 - 39,964,405UniSTS
Celera3113,679,837 - 113,680,056UniSTS
Celera925,055,303 - 25,055,675UniSTS
Celera484,650,380 - 84,650,804UniSTS
Celera1321,353,471 - 21,353,996UniSTS
Cytogenetic Map9A4UniSTS
cM Map910.0UniSTS
D11Mit74  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38115,326,905 - 5,327,122UniSTSGRCm38
MGSCv37115,226,908 - 5,227,125UniSTSGRCm37
Celera115,826,273 - 5,826,490UniSTS
Cytogenetic Map11A1UniSTS
cM Map11 UniSTS
Whitehead Genetic112.2UniSTS
Whitehead_YAC11 UniSTS
UniSTS:236503  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38115,280,162 - 5,280,540UniSTSGRCm38
MGSCv37115,180,165 - 5,180,543UniSTSGRCm37
Celera115,779,884 - 5,780,262UniSTS
Cytogenetic Map11A1UniSTS
UniSTS:236512  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38115,406,309 - 5,406,511UniSTSGRCm38
MGSCv37115,306,312 - 5,306,514UniSTSGRCm37
Celera115,904,930 - 5,905,132UniSTS
Cytogenetic Map11A1UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000109867   ⟹   ENSMUSP00000105493
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl115,226,324 - 5,394,847 (-)Ensembl
GRCm38.p6 Ensembl115,276,324 - 5,444,847 (-)Ensembl
RefSeq Acc Id: ENSMUST00000143746   ⟹   ENSMUSP00000122475
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl115,238,797 - 5,394,847 (-)Ensembl
GRCm38.p6 Ensembl115,288,797 - 5,444,847 (-)Ensembl
RefSeq Acc Id: ENSMUST00000172492   ⟹   ENSMUSP00000134698
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl115,228,602 - 5,331,740 (-)Ensembl
GRCm38.p6 Ensembl115,278,602 - 5,381,740 (-)Ensembl
RefSeq Acc Id: NM_001080924   ⟹   NP_001074393
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39115,226,329 - 5,394,847 (-)NCBI
GRCm38115,276,329 - 5,444,847 (-)ENTREZGENE
MGSCv37115,176,332 - 5,344,850 (-)RGD
Celera115,776,042 - 5,877,329 (-)NCBI
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001290501   ⟹   NP_001277430
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39115,226,329 - 5,331,740 (-)NCBI
GRCm38115,276,329 - 5,381,740 (-)NCBI
Celera115,776,042 - 5,877,329 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001074393   ⟸   NM_001080924
- Peptide Label: isoform 1 precursor
- UniProtKB: B2RXA5 (UniProtKB/Swiss-Prot),   Q3V095 (UniProtKB/Swiss-Prot),   Q5SSZ7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001277430   ⟸   NM_001290501
- Peptide Label: isoform 2
- UniProtKB: Q5SSZ7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000122475   ⟸   ENSMUST00000143746
RefSeq Acc Id: ENSMUSP00000134698   ⟸   ENSMUST00000172492
RefSeq Acc Id: ENSMUSP00000105493   ⟸   ENSMUST00000109867
Protein Domains
ZNRF-3 ectodomain

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5SSZ7-F1-model_v2 AlphaFold Q5SSZ7 1-913 view protein structure

Promoters
RGD ID:6822518
Promoter ID:MM_KWN:6291
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung
Transcripts:ENSMUST00000109867,   UC007HWL.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36115,344,891 - 5,345,391 (-)MPROMDB
RGD ID:8673838
Promoter ID:EPDNEW_M14950
Type:initiation region
Name:Znrf3_1
Description:Mus musculus zinc and ring finger 3 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38115,444,847 - 5,444,907EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3039616 AgrOrtholog
Ensembl Genes ENSMUSG00000041961 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000109867 ENTREZGENE
  ENSMUST00000109867.8 UniProtKB/Swiss-Prot
  ENSMUST00000143746.3 UniProtKB/TrEMBL
  ENSMUST00000172492 ENTREZGENE
  ENSMUST00000172492.8 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.40.10 UniProtKB/Swiss-Prot
  3.50.30.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Znf_RING UniProtKB/Swiss-Prot
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot
  ZNRF-3_ecto UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZNRF3_Znf_RING UniProtKB/Swiss-Prot
MGD MGI:3039616 ENTREZGENE
NCBI Gene 407821 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE ZNRF3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RING ZINC FINGER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam zf-RING_2 UniProtKB/Swiss-Prot
  ZNRF_3_ecto UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Znrf3 PhenoGen
PROSITE ZF_RING_2 UniProtKB/Swiss-Prot
SMART RING UniProtKB/Swiss-Prot
Superfamily-SCOP RING/U-box UniProtKB/Swiss-Prot
UniProt B2RXA5 ENTREZGENE
  F7D553_MOUSE UniProtKB/TrEMBL
  Q3V095 ENTREZGENE
  Q5SSZ7 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary B2RXA5 UniProtKB/Swiss-Prot
  Q3V095 UniProtKB/Swiss-Prot