Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dimethylhydrazine | decreases expression | EXP | | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of SPECC1 mRNA | CTD | PMID:22206623 | 1-naphthyl isothiocyanate | increases expression | ISO | Specc1 (Rattus norvegicus) | 6480464 | 1-Naphthylisothiocyanate results in increased expression of SPECC1 mRNA | CTD | PMID:30723492 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Specc1 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of SPECC1 mRNA | CTD | PMID:32109520 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Specc1 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of SPECC1 mRNA | CTD | PMID:34747641 | 2,3,7,8-Tetrachlorodibenzofuran | decreases expression | ISO | Specc1 (Rattus norvegicus) | 6480464 | 2 more ... | CTD | PMID:32109520 | 6-propyl-2-thiouracil | decreases expression | ISO | Specc1 (Rattus norvegicus) | 6480464 | Propylthiouracil results in decreased expression of SPECC1 mRNA | CTD | PMID:24780913 | aflatoxin B1 | increases methylation | ISO | SPECC1 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of SPECC1 gene | CTD | PMID:27153756 | Aflatoxin B2 alpha | increases methylation | ISO | SPECC1 (Homo sapiens) | 6480464 | aflatoxin B2 results in increased methylation of SPECC1 intron | CTD | PMID:30157460 | all-trans-retinoic acid | increases expression | ISO | SPECC1 (Homo sapiens) | 6480464 | Tretinoin results in increased expression of SPECC1 mRNA | CTD | PMID:33167477 | arsenite(3-) | multiple interactions | ISO | SPECC1 (Homo sapiens) | 6480464 | arsenite inhibits the reaction [G3BP1 protein binds to SPECC1 mRNA] | CTD | PMID:32406909 | atrazine | decreases expression | EXP | | 6480464 | Atrazine results in decreased expression of SPECC1 mRNA | CTD | PMID:27655631 | benzo[a]pyrene | decreases expression | ISO | SPECC1 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of SPECC1 mRNA | CTD | PMID:20064835 | benzo[a]pyrene | decreases methylation | ISO | SPECC1 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of SPECC1 5' UTR and Benzo(a)pyrene results in decreased methylation of SPECC1 promoter | CTD | PMID:27901495 | benzo[a]pyrene | increases expression | ISO | SPECC1 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of SPECC1 mRNA | CTD | PMID:26238291 | benzo[a]pyrene | decreases expression | EXP | | 6480464 | Benzo(a)pyrene results in decreased expression of SPECC1 mRNA | CTD | PMID:19770486 | bis(2-ethylhexyl) phthalate | increases expression | ISO | SPECC1 (Homo sapiens) | 6480464 | Diethylhexyl Phthalate results in increased expression of SPECC1 mRNA | CTD | PMID:31163220 | bisphenol A | increases expression | ISO | SPECC1 (Homo sapiens) | 6480464 | bisphenol A results in increased expression of SPECC1 mRNA | CTD | PMID:25047013 and PMID:29275510 | bisphenol A | decreases methylation | ISO | SPECC1 (Homo sapiens) | 6480464 | bisphenol A results in decreased methylation of SPECC1 gene | CTD | PMID:31601247 | bisphenol A | multiple interactions | ISO | SPECC1 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in decreased methylation of SPECC1 gene | CTD | PMID:31601247 | bisphenol A | decreases expression | ISO | Specc1 (Rattus norvegicus) | 6480464 | bisphenol A results in decreased expression of SPECC1 mRNA | CTD | PMID:25181051 | Brodifacoum | decreases expression | ISO | Specc1 (Rattus norvegicus) | 6480464 | bromfenacoum results in decreased expression of SPECC1 protein | CTD | PMID:28903499 | caffeine | decreases phosphorylation | ISO | SPECC1 (Homo sapiens) | 6480464 | Caffeine results in decreased phosphorylation of SPECC1 protein | CTD | PMID:35688186 | calcitriol | increases expression | ISO | SPECC1 (Homo sapiens) | 6480464 | Calcitriol results in increased expression of SPECC1 mRNA | CTD | PMID:21592394 | calcitriol | multiple interactions | ISO | SPECC1 (Homo sapiens) | 6480464 | [Testosterone co-treated with Calcitriol] results in increased expression of SPECC1 mRNA | CTD | PMID:21592394 | chlordecone | decreases expression | EXP | | 6480464 | Chlordecone results in decreased expression of SPECC1 mRNA | CTD | PMID:29980752 | chlorpyrifos | decreases expression | EXP | | 6480464 | Chlorpyrifos results in decreased expression of SPECC1 mRNA | CTD | PMID:37019170 | chromium(6+) | affects expression | EXP | | 6480464 | chromium hexavalent ion affects the expression of SPECC1 mRNA | CTD | PMID:28472532 | clobetasol | decreases expression | EXP | | 6480464 | Clobetasol results in decreased expression of SPECC1 mRNA | CTD | PMID:27462272 | copper(II) sulfate | increases expression | ISO | SPECC1 (Homo sapiens) | 6480464 | Copper Sulfate results in increased expression of SPECC1 mRNA | CTD | PMID:19549813 | coumarin | affects phosphorylation | ISO | SPECC1 (Homo sapiens) | 6480464 | coumarin affects the phosphorylation of SPECC1 protein | CTD | PMID:35688186 | cyclosporin A | decreases expression | ISO | SPECC1 (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of SPECC1 mRNA | CTD | PMID:27989131 | dorsomorphin | multiple interactions | ISO | SPECC1 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SPECC1 mRNA | CTD | PMID:27188386 | endosulfan | decreases expression | ISO | Specc1 (Rattus norvegicus) | 6480464 | Endosulfan results in decreased expression of SPECC1 mRNA | CTD | PMID:29391264 | ethanol | affects expression | EXP | | 6480464 | Ethanol affects the expression of SPECC1 mRNA | CTD | PMID:30319688 | FR900359 | affects phosphorylation | ISO | SPECC1 (Homo sapiens) | 6480464 | FR900359 affects the phosphorylation of SPECC1 protein | CTD | PMID:37730182 | fulvestrant | multiple interactions | ISO | SPECC1 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in decreased methylation of SPECC1 gene | CTD | PMID:31601247 | furan | decreases expression | ISO | Specc1 (Rattus norvegicus) | 6480464 | furan results in decreased expression of SPECC1 mRNA | CTD | PMID:25539665 | glyphosate | affects methylation | ISO | Specc1 (Rattus norvegicus) | 6480464 | Glyphosate affects the methylation of SPECC1 gene | CTD | PMID:35440735 | hexadecanoic acid | decreases phosphorylation | ISO | SPECC1 (Homo sapiens) | 6480464 | Palmitic Acid results in decreased phosphorylation of SPECC1 protein | CTD | PMID:28073184 | hexamethylene diisocyanate | increases methylation | ISO | SPECC1 (Homo sapiens) | 6480464 | 1 and 6-hexamethylene diisocyanate results in increased methylation of SPECC1 gene | CTD | PMID:25445006 | lipopolysaccharide | multiple interactions | ISO | SPECC1 (Homo sapiens) | 6480464 | [S-(1 more ... | CTD | PMID:35811015 | lipopolysaccharide | decreases expression | ISO | SPECC1 (Homo sapiens) | 6480464 | Lipopolysaccharides results in decreased expression of SPECC1 mRNA | CTD | PMID:35811015 | miconazole | decreases expression | EXP | | 6480464 | Miconazole results in decreased expression of SPECC1 mRNA | CTD | PMID:27462272 | mono(2-ethylhexyl) phthalate | affects expression | EXP | | 6480464 | mono-(2-ethylhexyl)phthalate affects the expression of SPECC1 mRNA | CTD | PMID:21195148 | Monobutylphthalate | affects expression | EXP | | 6480464 | monobutyl phthalate affects the expression of SPECC1 mRNA | CTD | PMID:21195148 | N-nitrosodiethylamine | increases expression | EXP | | 6480464 | Diethylnitrosamine results in increased expression of SPECC1 mRNA | CTD | PMID:24535843 | paracetamol | affects expression | EXP | | 6480464 | Acetaminophen affects the expression of SPECC1 mRNA | CTD | PMID:17562736 | paracetamol | increases expression | ISO | SPECC1 (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of SPECC1 mRNA | CTD | PMID:29067470 | potassium chromate | decreases expression | ISO | SPECC1 (Homo sapiens) | 6480464 | potassium chromate(VI) results in decreased expression of SPECC1 mRNA | CTD | PMID:22714537 | S-(1,2-dichlorovinyl)-L-cysteine | multiple interactions | ISO | SPECC1 (Homo sapiens) | 6480464 | [S-(1 more ... | CTD | PMID:35811015 | SB 431542 | multiple interactions | ISO | SPECC1 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SPECC1 mRNA | CTD | PMID:27188386 | sodium arsenite | decreases expression | ISO | SPECC1 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of SPECC1 mRNA | CTD | PMID:34032870 | testosterone | multiple interactions | ISO | SPECC1 (Homo sapiens) | 6480464 | [Testosterone co-treated with Calcitriol] results in increased expression of SPECC1 mRNA | CTD | PMID:21592394 | testosterone | increases expression | ISO | SPECC1 (Homo sapiens) | 6480464 | Testosterone results in increased expression of SPECC1 mRNA | CTD | PMID:21592394 | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of SPECC1 mRNA | CTD | PMID:27339419 | thimerosal | increases expression | ISO | SPECC1 (Homo sapiens) | 6480464 | Thimerosal results in increased expression of SPECC1 mRNA | CTD | PMID:27188386 | thioacetamide | increases expression | ISO | Specc1 (Rattus norvegicus) | 6480464 | Thioacetamide results in increased expression of SPECC1 mRNA | CTD | PMID:34492290 | trimellitic anhydride | increases expression | EXP | | 6480464 | trimellitic anhydride results in increased expression of SPECC1 mRNA | CTD | PMID:19042947 | triptonide | increases expression | EXP | | 6480464 | triptonide results in increased expression of SPECC1 mRNA | CTD | PMID:33045310 | valproic acid | increases expression | ISO | SPECC1 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of SPECC1 mRNA | CTD | PMID:23179753 and PMID:26272509 | valproic acid | multiple interactions | ISO | SPECC1 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SPECC1 mRNA | CTD | PMID:27188386 | |