Tgtp1 (T cell specific GTPase 1) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Tgtp1 (T cell specific GTPase 1) Mus musculus
Analyze
No known orthologs.
Symbol: Tgtp1
Name: T cell specific GTPase 1
RGD ID: 1615940
MGI Page MGI
Description: Enables GTPase activity. Involved in defense response to protozoan and response to virus. Acts upstream of or within several processes, including cellular response to interferon-beta; response to interferon-alpha; and response to type II interferon. Predicted to be located in Golgi apparatus; endoplasmic reticulum; and membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including genitourinary system; hemolymphoid system; integumental system; nervous system; and nose.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Gtp; Gtp2; Ifggb6; interferon-gamma-inducible GTPase Ifggb5; Irgb6; Mg21; T-cell specific GTPase; T-cell specific GTPase 1; T-cell-specific guanine nucleotide triphosphate-binding protein 1; T-cell-specific guanine nucleotide triphosphate-binding protein 2; Tgt; Tgtp; Tgtp2
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391148,876,156 - 48,883,073 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1148,876,154 - 48,884,999 (-)EnsemblGRCm39 Ensembl
GRCm381148,985,329 - 48,992,246 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1148,985,327 - 48,994,172 (-)EnsemblGRCm38mm10GRCm38
MGSCv371148,798,831 - 48,805,748 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361148,828,753 - 48,835,671 (-)NCBIMGSCv36mm8
Celera1153,603,995 - 53,610,921 (-)NCBICelera
Cytogenetic Map11B1.2NCBI
cM Map1128.98NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7561525   PMID:7836757   PMID:7884320   PMID:9725230   PMID:10349636   PMID:10438942   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932  
PMID:14681479   PMID:15556938   PMID:15568025   PMID:15733672   PMID:16141072   PMID:16141073   PMID:16277747   PMID:19158679   PMID:20109161   PMID:21267068   PMID:21757726   PMID:21873635  
PMID:23012479   PMID:23070814   PMID:27001747   PMID:31852733  


Genomics

Variants

.
Variants in Tgtp1
6 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:449
Count of miRNA genes:335
Interacting mature miRNAs:359
Transcripts:ENSMUST00000068063, ENSMUST00000132745, ENSMUST00000146439
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357844Si5lq5_mserum IGFBP-5 level QTL 5 (mouse)Not determined112816587362165976Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
1357720Kidpq1_mkidney weight percentage QTL 1 (mouse)Not determined111226863768500330Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114618516780185262Mouse
1357851Scfq3_msubcutaneous fat pad weight QTL 3 (mouse)Not determined111226863768500330Mouse
1301788Lbw8_mlupus NZB x NZW 8 (mouse)Not determined113650328770509492Mouse
12910804Pwbwq16_mpost-weaning body weight QTL 16 (mouse)112719805750636094Mouse
12910806Pwbwq15_mpost-weaning body weight QTL 15 (mouse)112719805750636094Mouse
12910801Pwbwq14_mpost-weaning body weight QTL 14 (mouse)112719805750636094Mouse
27226762Feml21_mfemur length 21, 16 week (mouse)111175000065990826Mouse
1302021Nidd1n_mnon-insulin-dependent diabetes mellitus 1 in NSY (mouse)Not determined114516587379978324Mouse
1301896Tria1_mT-cell receptor induced activation 1 (mouse)Not determined113661356570613855Mouse
4141470Egq4_mearly growth QTL 4 (mouse)Not determined1226863768500330Mouse
1301426Desp2_mdespair 2 (mouse)Not determined112870858162708700Mouse
4142109W10q2_mweight 10 weeks QTL 2 (mouse)Not determined1226863768500330Mouse
4141853Skmw17_mskeletal muscle weight 17 (mouse)Not determined113708094171081064Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114570858189818733Mouse
12910817Pwgrq20_mpost-weaning growth rate QTL 20 (mouse)112719805750636094Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
12910818Ogrq5_moverall growth rate QTL 5 (mouse)112719805750636094Mouse
26884401Huml4_mhumerus length 4, 10 week (mouse)111155000068490826Mouse
10053687Eae6_msusceptibility to experimental allergic encephalomyelitis 6 (mouse)Not determined111778196668500330Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113589082784890826Mouse
27226798Scvln18_msacral vertebrae length 2, 16 week (mouse)11325000060690826Mouse
4141582Lgaq1_mlate growth adjusted QTL 1 (mouse)Not determined1226863768500330Mouse
4141966Tailq1_mtail length QTL 1 (mouse)Not determined1226863768500330Mouse
10053675Eae44b_mexperimental allergic encephalomyelitis susceptibility 44b (mouse)Not determined113995072854094448Mouse
4142475Ity2a_mimmunity to S. typhimurium 2a (mouse)Not determined113776858060402716Mouse
11532699Sluc36b_msusceptibility to lung cancer 36b (mouse)114225661776256730Mouse
11532698Sluc36a_msusceptibility to lung cancer 36a (mouse)114225661776256730Mouse
1558945Orgwq8_morgan weight QTL 8 (mouse)Not determined111705617567078411Mouse
4142216Lgq1_mlate growth QTL 1 (mouse)Not determined1226863768500330Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
14746971Manh70_mmandible shape 70 (mouse)111990589053905890Mouse
13524848Ppiq7_mprepulse inhibition QTL 7 (mouse)112856914762569147Mouse
13452402Hipmt3_mhippocampal morphometry trait 3 (mouse)114797732550277325Mouse
1357782Char8_mP. chabaudi malaria resistance QTL 8 (mouse)Not determined113557861669684987Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
11059563Lmr31_mleishmaniasis resistance 31 (mouse)113210057766100694Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113628257783481356Mouse
26884446Sklq10_mskull length QTL 10, 10 week (mouse)11325000062890826Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
1559002Lmrq4_mLeishmania major resistance QTL 4 (mouse)Not determined111226863769684947Mouse
1300938Bulb3_mbulb size 3 (mouse)Not determined111857861652578716Mouse
4142308W6q3_mweight 6 weeks QTL 3 (mouse)Not determined111226863768500330Mouse
1357640Orq2_movulation rate QTL 2 (mouse)Not determined111226863768500330Mouse
10766457Nwa3_mNew Zealand White autoimmunity 3 (mouse)113801611572016209Mouse
4142300Ctrq3_mC. trachomatis resistance QTL 3 (mouse)Not determined114463003876854757Mouse
1357437Epfq4_mepididymal fat pad weight QTL 4 (mouse)Not determined111226863768500330Mouse
4141398Tgq22_mtriglyceride QTL 22 (mouse)Not determined2116340655163406Mouse
27226738Metcl11_mmetatarsal-calcaneal length 11, 10 week (mouse)11885000061390826Mouse
11522752Cocia18_mcocaine-induced activity, QTL 18 (mouse)113100820965008209Mouse
12801459Leuf1_mleukocyte filtration 1 (mouse)111857861652578716Mouse
1300579Thypr1_mthymocyte proliferative response 1 (mouse)Not determined111928257753282715Mouse
12801457Intmrm2_mintima/media ratio modifier 2 (mouse)111857861652578716Mouse
12801460Intim2_mintima modifier 2 (mouse)111857861652578716Mouse
1301988Bmd11_mbone mineral density 11 (mouse)Not determined114631940780319522Mouse
4141127W3q4_mweight 3 weeks QTL 4 (mouse)Not determined1226863768500330Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
1300713Vmbic10_mventral midbrain iron content 10 (mouse)Not determined114277262654081064Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse
10044006Hbnr13_mHeligmosomoides bakeri nematode resistance 13 (mouse)Not determined112577262659772741Mouse

Markers in Region
Tgtp  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11B1.2UniSTS
cM Map11 UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000068063   ⟹   ENSMUSP00000069914
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1148,876,154 - 48,883,085 (-)Ensembl
GRCm38.p6 Ensembl1148,985,327 - 48,992,258 (-)Ensembl
Ensembl Acc Id: ENSMUST00000132745   ⟹   ENSMUSP00000150328
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1148,878,679 - 48,883,717 (-)Ensembl
GRCm38.p6 Ensembl1148,987,852 - 48,992,890 (-)Ensembl
Ensembl Acc Id: ENSMUST00000146439   ⟹   ENSMUSP00000123089
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1148,878,308 - 48,884,999 (-)Ensembl
GRCm38.p6 Ensembl1148,987,481 - 48,994,172 (-)Ensembl
RefSeq Acc Id: NM_011579   ⟹   NP_035709
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391148,876,156 - 48,883,073 (-)NCBI
GRCm381148,985,329 - 48,992,246 (-)ENTREZGENE
MGSCv371148,798,831 - 48,805,748 (-)RGD
Celera1153,603,995 - 53,610,921 (-)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_035709   ⟸   NM_011579
- UniProtKB: Q60711 (UniProtKB/Swiss-Prot),   Q8BN19 (UniProtKB/Swiss-Prot),   Q3T9E4 (UniProtKB/Swiss-Prot),   Q62293 (UniProtKB/TrEMBL),   A0A1G5SLN0 (UniProtKB/TrEMBL),   U5NJF8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000150328   ⟸   ENSMUST00000132745
Ensembl Acc Id: ENSMUSP00000069914   ⟸   ENSMUST00000068063
Ensembl Acc Id: ENSMUSP00000123089   ⟸   ENSMUST00000146439
Protein Domains
IRG-type G

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q3T9E4-F1-model_v2 AlphaFold Q3T9E4 1-415 view protein structure
AF-Q62293-F1-model_v2 AlphaFold Q62293 1-415 view protein structure

Promoters
RGD ID:6822350
Promoter ID:MM_KWN:7155
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_4Hour
Transcripts:NM_001145164_1_TGTP2,   OTTMUST00000012294,   OTTMUST00000012296,   UC007IPK.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361148,806,086 - 48,806,586 (-)MPROMDB
RGD ID:6822304
Promoter ID:MM_KWN:7156
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:OTTMUST00000012295
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361148,807,286 - 48,807,786 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:98734 AgrOrtholog
Ensembl Genes ENSMUSG00000078921 UniProtKB/Swiss-Prot
  ENSMUSG00000078922 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000046745.7 UniProtKB/Swiss-Prot
  ENSMUST00000068063 ENTREZGENE
  ENSMUST00000068063.4 UniProtKB/Swiss-Prot
  ENSMUST00000132745.2 UniProtKB/TrEMBL
  ENSMUST00000146439.8 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro G_IRG_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Immunity-related_GTPase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IRG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:100039796 UniProtKB/Swiss-Prot
  mmu:21822 UniProtKB/Swiss-Prot
MGD MGI:98734 ENTREZGENE
NCBI Gene 21822 ENTREZGENE
PANTHER INTERFERON-INDUCIBLE GTPASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RIKEN CDNA 9930111J21 GENE 1-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IIGP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tgtp1 PhenoGen
PROSITE G_IRG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1G5SLN0 ENTREZGENE
  A0A1L1STI2_MOUSE UniProtKB/TrEMBL
  Q3T9E4 ENTREZGENE
  Q5SVP4_MOUSE UniProtKB/TrEMBL
  Q60711 ENTREZGENE
  Q62293 ENTREZGENE
  Q8BN19 ENTREZGENE
  TGTP1_MOUSE UniProtKB/Swiss-Prot
  TGTP2_MOUSE UniProtKB/Swiss-Prot
  U5NJF8 ENTREZGENE
UniProt Secondary Q60711 UniProtKB/Swiss-Prot
  Q8BN19 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-02-07 Tgtp1  T cell specific GTPase 1  Tgtp1  T-cell specific GTPase 1  Symbol and/or name change 5135510 APPROVED
2011-07-27 Tgtp1  T-cell specific GTPase 1  Tgtp  T-cell specific GTPase  Symbol and/or name change 5135510 APPROVED