Trem3 (triggering receptor expressed on myeloid cells 3) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Trem3 (triggering receptor expressed on myeloid cells 3) Mus musculus
Analyze
No known orthologs.
Symbol: Trem3
Name: triggering receptor expressed on myeloid cells 3
RGD ID: 1615915
MGI Page MGI
Description: Involved in positive regulation of innate immune response. Acts upstream of or within neutrophil chemotaxis; neutrophil extravasation; and neutrophil-mediated killing of gram-negative bacterium. Predicted to be located in plasma membrane. Is expressed in renal vasculature.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: BB134760; TREM-3; triggering receptor expressed on monocytes 3
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391748,554,707 - 48,565,876 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1748,554,805 - 48,565,869 (+)EnsemblGRCm39 Ensembl
GRCm381748,247,677 - 48,258,848 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1748,247,777 - 48,258,841 (+)EnsemblGRCm38mm10GRCm38
MGSCv371748,386,944 - 48,398,207 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361747,713,186 - 47,724,449 (+)NCBIMGSCv36mm8
Celera1751,683,014 - 51,694,337 (+)NCBICelera
Cytogenetic Map17CNCBI
cM Map1723.99NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Mouse MP Annotation Import Pipeline RGD automated import pipeline
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:10799849   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11754004   PMID:12466851   PMID:12477932   PMID:12847223   PMID:14969392   PMID:16141072   PMID:16141073  
PMID:18222421   PMID:18287559   PMID:19079182   PMID:20337897   PMID:21267068   PMID:21873635   PMID:23241959   PMID:24358193   PMID:25860078   PMID:27480124   PMID:34125599  


Genomics

Variants

.
Variants in Trem3
474 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:119
Count of miRNA genes:111
Interacting mature miRNAs:113
Transcripts:ENSMUST00000048065
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300890Bhr3_mbronchial hyperresponsiveness 3 (mouse)Not determined17397489048866091Mouse
4141272Tfv1_mtotal food volume 1 (mouse)Not determined485475265637357Mouse
1301338Lmr1_mleishmaniasis resistance 1 (mouse)Not determined171008134086996400Mouse
4142150Stheal11_msoft tissue heal 11 (mouse)Not determined171228621183361768Mouse
1300995Fembrs4_mfemur breaking strength 4 (mouse)Not determined171506165249061760Mouse
1300914Pcir4_mperiosteal circumference 4 (mouse)Not determined171506165249061760Mouse
1302070Tbbmd7_mtotal body bone mineral density 7 (mouse)Not determined171506165249061760Mouse
1558886Lgth9_mbody length 9 (mouse)Not determined171506165249061760Mouse
1302140Wta4_mweight adult 4 (mouse)Not determined171681972150819843Mouse
1302152Skull25_mskull morphology 25 (mouse)Not determined171681972150819843Mouse
10412083Sm2_msusceptibility to Schistosoma mansoni infection 2 (mouse)Not determined171702994351030078Mouse
13452396Leusq3_mleucocytosis susceptibility QTL 3 (mouse)171746220851462345Mouse
13452399Leusq6_mleucocytosis susceptibility QTL 6 (mouse)171746220851462345Mouse
10412214Sxbq3_mSGC/Knj cross B6 QTL 3 (mouse)Not determined171746220851462345Mouse
1300535Char3_mP. chabaudi malaria resistance QTL 3 (mouse)Not determined171746220851462345Mouse
1301840Ssial4_msusceptibility to sialadenitiss 4 (mouse)Not determined171817541252178214Mouse
1301331Lbw1_mlupus NZB x NZW 1 (mouse)Not determined171841835752420983Mouse
1301056Pas2_mpulmonary adenoma susceptibility 2 (mouse)Not determined171842214152424327Mouse
15039354Nmrs36_mNAFLD-associated magnetic resonance shift 36 (mouse)171914502553145025Mouse
1301454Eae5_msusceptibility to experimental allergic encephalomyelitis 5 (mouse)Not determined172461275058612864Mouse
10412198Sst5_msusceptibility to tuberculosis 5 (mouse)Not determined172507658355712970Mouse
10412204Bbaa29_mB.burgdorferi-associated arthritis 29 (mouse)Not determined172605118560051352Mouse
1558758Kcal2_mkilocalorie 2 (mouse)Not determined172640101252911704Mouse
1302005Loco2_mlocomotor activity 2 (mouse)Not determined172688497260885114Mouse
15039348Nmrs37_mNAFLD-associated magnetic resonance shift 37 (mouse)172781520961815209Mouse
1300703Uvbi2_mUVB induced immunosuppression 2 (mouse)Not determined172862240662622654Mouse
1300589Myaa2_mmodifier of Yaa 2 (mouse)Not determined173013255564132666Mouse
4140955Plgr1_mplague resistance locus 1 (mouse)Not determined3103350065033630Mouse
26884379Skwq5_mskull length QTL 5, 5 week (mouse)173311897454107028Mouse
1300885Mbis4_mMycobacterium bovis-induced systemic lupus erythematosus 4 (mouse)Not determined173517581770165926Mouse
10755514Amzn2_manatomical modifier of Zfp423 2 (mouse)173596629469966424Mouse
12904951Smmq2_msoleus muscle mass QTL 2 (mouse)173678974370789743Mouse
1300592Pcyts5_mplasmacytoma susceptibility 5 (mouse)Not determined173871288772712970Mouse
10755525Lymph2_mlymphocyte differential 2 (mouse)173880562672805626Mouse
10755534Lymph4_mlymphocyte differential 4 (mouse)173880562672805626Mouse
4141319Hmtb8_mhemostasis and thrombosis rebleeding time 8 (mouse)Not determined4053444774534623Mouse
15039324Nmrs48_mNAFLD-associated magnetic resonance shift 48 (mouse)174093918774939187Mouse
4141478Hbnr7_mHeligmosomoides bakeri nematode resistance 7 (mouse)Not determined4305118551739122Mouse
26884386Skwq13_mskull length QTL 13, 16 week (mouse)174371089153107028Mouse
26884390Skwq9_mskull length QTL 9, 10 week (mouse)174371089167806995Mouse
12903997Cfq4_mconditioned fear QTL 4 (mouse)174501655249366402Mouse
26884428Cvht3_mcranial vault height 3, 5 week (mouse)174651092682407429Mouse
35673315Ari1_mantibody response to influenza 1, day 7, IgG2a+IgG2c (mouse)174731092654707028Mouse

Markers in Region
BB134760  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381748,258,684 - 48,258,786UniSTSGRCm38
MGSCv371748,398,050 - 48,398,152UniSTSGRCm37
Celera1751,694,180 - 51,694,282UniSTS
Cytogenetic Map17CUniSTS
Whitehead/MRC_RH17592.35UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000048065   ⟹   ENSMUSP00000044478
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1748,554,805 - 48,565,869 (+)Ensembl
GRCm38.p6 Ensembl1748,247,777 - 48,258,841 (+)Ensembl
RefSeq Acc Id: NM_021407   ⟹   NP_067382
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391748,554,757 - 48,565,875 (+)NCBI
GRCm381748,247,729 - 48,258,847 (+)NCBI
MGSCv371748,386,944 - 48,398,207 (+)RGD
Celera1751,682,966 - 51,694,343 (+)NCBI
cM Map17 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006524731   ⟹   XP_006524794
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391748,554,863 - 48,565,876 (+)NCBI
GRCm381748,247,823 - 48,258,848 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017317592   ⟹   XP_017173081
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391748,554,707 - 48,565,876 (+)NCBI
GRCm381748,247,677 - 48,258,848 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_067382   ⟸   NM_021407
- Peptide Label: precursor
- UniProtKB: Q9JKE1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006524794   ⟸   XM_006524731
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017173081   ⟸   XM_017317592
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000044478   ⟸   ENSMUST00000048065
Protein Domains
Ig-like V-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JKE1-F1-model_v2 AlphaFold Q9JKE1 1-183 view protein structure

Promoters
RGD ID:13676346
Promoter ID:EPDNEW_M22322
Type:initiation region
Name:Trem3_1
Description:Mus musculus triggering receptor expressed on myeloid cells 3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381748,247,729 - 48,247,789EPDNEW
RGD ID:6828820
Promoter ID:MM_KWN:23753
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour
Transcripts:NM_021407
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361748,386,731 - 48,387,231 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1930003 AgrOrtholog
Ensembl Genes ENSMUSG00000041754 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000048065 ENTREZGENE
  ENSMUST00000048065.6 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
InterPro Ig-like_dom_sf UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Ig_V-set UniProtKB/Swiss-Prot
KEGG Report mmu:58218 UniProtKB/Swiss-Prot
MGD MGI:1930003 ENTREZGENE
NCBI Gene 58218 ENTREZGENE
PANTHER TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 1 UniProtKB/Swiss-Prot
  TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 3 UniProtKB/Swiss-Prot
Pfam V-set UniProtKB/Swiss-Prot
PhenoGen Trem3 PhenoGen
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot
UniProt Q9JKE1 ENTREZGENE, UniProtKB/Swiss-Prot