Pip4p2 (phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2) - Rat Genome Database

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Gene: Pip4p2 (phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2) Mus musculus
Analyze
Symbol: Pip4p2
Name: phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2
RGD ID: 1615845
MGI Page MGI
Description: Predicted to enable phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity. Involved in negative regulation of phagocytosis and phosphatidylinositol dephosphorylation. Located in late endosome membrane; phagocytic vesicle membrane; and plasma membrane. Orthologous to human PIP4P2 (phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2610319K07Rik; AI315591; AV001360; ptdIns-4,5-P2 4-Ptase II; Tmem55; Tmem55a; transmembrane protein 55A; type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase; type 2 PtdIns-4,5-P2 4-Ptase; type II phosphatidylinositol 4,5-bisphosphate 4-phosphatase
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39414,864,219 - 14,915,501 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl414,864,076 - 14,915,176 (+)EnsemblGRCm39 Ensembl
GRCm38414,864,219 - 14,915,260 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl414,864,076 - 14,915,176 (+)EnsemblGRCm38mm10GRCm38
MGSCv37414,791,366 - 14,842,407 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36414,791,366 - 14,842,407 (+)NCBIMGSCv36mm8
Celera414,666,242 - 14,716,763 (+)NCBICelera
Cytogenetic Map4A1NCBI
cM Map46.41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11125038   PMID:11217851   PMID:12466851   PMID:12477932   PMID:12520002   PMID:14610273   PMID:15489334   PMID:15782199  
PMID:16141072   PMID:16141073   PMID:17967808   PMID:20463296   PMID:21267068   PMID:21873635   PMID:26496610   PMID:29378918   PMID:32098917  


Genomics

Comparative Map Data
Pip4p2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39414,864,219 - 14,915,501 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl414,864,076 - 14,915,176 (+)EnsemblGRCm39 Ensembl
GRCm38414,864,219 - 14,915,260 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl414,864,076 - 14,915,176 (+)EnsemblGRCm38mm10GRCm38
MGSCv37414,791,366 - 14,842,407 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36414,791,366 - 14,842,407 (+)NCBIMGSCv36mm8
Celera414,666,242 - 14,716,763 (+)NCBICelera
Cytogenetic Map4A1NCBI
cM Map46.41NCBI
PIP4P2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38890,993,802 - 91,040,859 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl890,993,802 - 91,040,872 (-)EnsemblGRCh38hg38GRCh38
GRCh37892,006,030 - 92,053,087 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36892,075,675 - 92,122,227 (-)NCBINCBI36Build 36hg18NCBI36
Celera888,201,253 - 88,248,229 (-)NCBICelera
Cytogenetic Map8q21.3NCBI
HuRef887,216,426 - 87,263,709 (-)NCBIHuRef
CHM1_1892,047,148 - 92,093,868 (-)NCBICHM1_1
T2T-CHM13v2.0892,118,724 - 92,165,782 (-)NCBIT2T-CHM13v2.0
Pip4p2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8533,057,046 - 33,104,448 (+)NCBIGRCr8
mRatBN7.2528,259,821 - 28,307,225 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl528,259,760 - 28,307,225 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx530,414,507 - 30,461,769 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0532,007,188 - 32,054,448 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0531,967,347 - 32,014,607 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0528,395,517 - 28,442,924 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl528,395,296 - 28,442,924 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0533,079,533 - 33,126,623 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4529,329,329 - 29,376,733 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1529,329,328 - 29,376,729 (+)NCBI
Celera527,511,708 - 27,556,541 (+)NCBICelera
Cytogenetic Map5q13NCBI
Pip4p2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554177,771,218 - 7,825,799 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554177,769,365 - 7,825,892 (-)NCBIChiLan1.0ChiLan1.0
PIP4P2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27108,365,016 - 108,411,716 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1883,904,246 - 83,950,250 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0887,657,202 - 87,704,355 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1889,610,315 - 89,640,736 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl889,611,726 - 89,639,419 (-)Ensemblpanpan1.1panPan2
PIP4P2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12936,376,211 - 36,410,680 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2936,377,413 - 36,419,132 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2936,528,349 - 36,584,476 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02936,577,248 - 36,633,018 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12936,597,823 - 36,653,297 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02936,579,206 - 36,635,139 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02937,017,626 - 37,073,778 (-)NCBIUU_Cfam_GSD_1.0
Pip4p2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530343,122,960 - 43,172,916 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365444,618,660 - 4,670,140 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365444,621,222 - 4,669,808 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PIP4P2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl445,826,326 - 45,892,417 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1445,825,415 - 45,891,192 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2449,447,375 - 49,512,725 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PIP4P2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1886,059,522 - 86,111,027 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl886,059,397 - 86,107,014 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603954,723,306 - 54,803,988 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pip4p2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624744924,211 - 978,625 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pip4p2
1983 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:369
Count of miRNA genes:254
Interacting mature miRNAs:291
Transcripts:ENSMUST00000029875
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142047Mvwf3_mmodifier of von Willebrand factor 3 (mouse)Not determined14010457117072206Mouse
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156268235Mouse
11049579Lmr9b_mleishmaniasis resistance 9b (mouse)4120657234Mouse
11049580Lmr9a_mleishmaniasis resistance 9 (mouse)4120657234Mouse
10401115Pgia35_mproteoglycan induced arthritis 35 (mouse)Not determined41256237746562509Mouse
1558992Ses8_msalmonella enteritidis susceptibility 8 (mouse)Not determined4868324042683429Mouse
1301274Lmr9_mleishmaniasis resistance 9 (mouse)Not determined4120657234Mouse
1302010Wta1_mweight adult 1 (mouse)Not determined4868324042683429Mouse
4141302Ssrq5_mstress response QTL 5 (mouse)Not determined868324042683430Mouse
10401905Sicd3_mseizure-induced cell death 3 (mouse)Not determined4939552543760862Mouse
10412079Sm1_msusceptibility to Schistosoma mansoni infection 1 (mouse)Not determined4122955614Mouse
12880405Jcdq1_mjoint cartilage degeneration QTL 1 (mouse)41256237746562509Mouse
4142318Lyr2_mlymphoma resistance 2 (mouse)Not determined1401045763283678Mouse
1301473Triglq1_mtriglyceride QTL 1 (mouse)Not determined4868324042683429Mouse
1301510Bbaa13_mB.burgdorferi-associated arthritis 13 (mouse)Not determined4126395649Mouse
1302125Lxw1_mlupus BXSB x NZW 1 (mouse)Not determined4868324042683429Mouse

Markers in Region
AV001360  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38414,914,983 - 14,915,101UniSTSGRCm38
MGSCv37414,842,130 - 14,842,248UniSTSGRCm37
Celera414,716,486 - 14,716,604UniSTS
Cytogenetic Map4A1-A2UniSTS
Whitehead/MRC_RH4318.15UniSTS
AI315591  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38414,914,954 - 14,915,101UniSTSGRCm38
MGSCv37414,842,101 - 14,842,248UniSTSGRCm37
Celera414,716,457 - 14,716,604UniSTS
Cytogenetic Map4A1-A2UniSTS
Whitehead/MRC_RH4316.53UniSTS
UniSTS:234872  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38414,915,021 - 14,915,237UniSTSGRCm38
MGSCv37414,842,168 - 14,842,384UniSTSGRCm37
Celera414,716,524 - 14,716,740UniSTS
Cytogenetic Map4A1-A2UniSTS
UniSTS:234874  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38414,892,484 - 14,892,805UniSTSGRCm38
MGSCv37414,819,631 - 14,819,952UniSTSGRCm37
Celera414,694,497 - 14,694,818UniSTS
Cytogenetic Map4A1-A2UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001419231 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_028264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_185048 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_185049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_185050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036164462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036164463 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK012054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK033845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK049213 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK165999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK180143 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK185686 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK206695 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL831792 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AX775959 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC021435 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000029875   ⟹   ENSMUSP00000029875
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl414,864,076 - 14,915,176 (+)Ensembl
GRCm38.p6 Ensembl414,864,076 - 14,915,176 (+)Ensembl
RefSeq Acc Id: NM_001419231   ⟹   NP_001406160
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39414,864,219 - 14,903,047 (+)NCBI
RefSeq Acc Id: NM_028264   ⟹   NP_082540
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39414,864,219 - 14,915,265 (+)NCBI
GRCm38414,864,219 - 14,915,260 (+)ENTREZGENE
MGSCv37414,791,366 - 14,842,407 (+)RGD
Celera414,666,242 - 14,716,763 (+)RGD
cM Map4 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_185048
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39414,864,219 - 14,915,265 (+)NCBI
RefSeq Acc Id: NR_185049
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39414,864,219 - 14,915,265 (+)NCBI
RefSeq Acc Id: NR_185050
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39414,864,219 - 14,915,265 (+)NCBI
RefSeq Acc Id: XM_036164462   ⟹   XP_036020355
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39414,864,224 - 14,915,501 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036164463   ⟹   XP_036020356
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39414,864,320 - 14,915,501 (+)NCBI
Sequence:
RefSeq Acc Id: NP_082540   ⟸   NM_028264
- Peptide Label: isoform 1
- UniProtKB: Q9CZX7 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000029875   ⟸   ENSMUST00000029875
RefSeq Acc Id: XP_036020355   ⟸   XM_036164462
- Peptide Label: isoform X1
RefSeq Acc Id: XP_036020356   ⟸   XM_036164463
- Peptide Label: isoform X1
RefSeq Acc Id: NP_001406160   ⟸   NM_001419231
- Peptide Label: isoform 2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9CZX7-F1-model_v2 AlphaFold Q9CZX7 1-257 view protein structure

Promoters
RGD ID:6836538
Promoter ID:MM_KWN:36738
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:OTTMUST00000010310
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36414,791,011 - 14,791,562 (+)MPROMDB
RGD ID:6882866
Promoter ID:EPDNEW_M4884
Type:initiation region
Name:Tmem55a_1
Description:Mus musculus transmembrane protein 55A , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38414,864,260 - 14,864,320EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1919769 AgrOrtholog
Ensembl Genes ENSMUSG00000028221 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000029875 ENTREZGENE
  ENSMUST00000029875.4 UniProtKB/Swiss-Prot
InterPro PtdIns-P2-Ptase UniProtKB/Swiss-Prot
KEGG Report mmu:72519 UniProtKB/Swiss-Prot
MGD MGI:1919769 ENTREZGENE
NCBI Gene 72519 ENTREZGENE
PANTHER PTHR21014 UniProtKB/Swiss-Prot
  TYPE 2 PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 4-PHOSPHATASE UniProtKB/Swiss-Prot
Pfam Tmemb_55A UniProtKB/Swiss-Prot
PhenoGen Pip4p2 PhenoGen
UniProt PP4P2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-06-05 Pip4p2  phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2  Tmem55a  transmembrane protein 55A  Symbol and/or name change 5135510 APPROVED