Tusc2 (tumor suppressor 2, mitochondrial calcium regulator)

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Gene: Tusc2 (tumor suppressor 2, mitochondrial calcium regulator) Mus musculus

Analyze

Symbol:

Tusc2

Name:

tumor suppressor 2, mitochondrial calcium regulator

RGD ID:

1615786

MGI Page

MGI

Description:

Is expressed in liver and metanephros. Orthologous to human TUSC2 (tumor suppressor 2, mitochondrial calcium regulator); INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Also known as:

1190001E22Rik; AA407686; Fus; fus-1 protein; Fus1; fusion 1 protein; Lgcc; lung cancer candidiate, FUS; PAP; Pd; Pdap2; PDGFA associated protein 2; PDGFA-associated protein 2; tumor suppressor candidate 2

RGD Orthologs

Human

Rat

Chinchilla

Bonobo

Dog

Squirrel

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

GRCm38 - Mouse Genome Assembly GRCm38

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	107,440,454 - 107,443,307 (+)	NCBI	GRCm39		mm39
GRCm39 Ensembl	9	107,440,454 - 107,443,311 (+)	Ensembl
GRCm38	9	107,563,255 - 107,566,108 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	107,563,255 - 107,566,112 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	107,465,586 - 107,468,439 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	9	107,421,356 - 107,424,209 (+)	NCBI			mm8
Celera	9	107,172,004 - 107,174,857 (+)	NCBI		Celera
Cytogenetic Map	9	F1	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (EXP)

17alpha-ethynylestradiol (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

3,4-methylenedioxymethamphetamine (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

aflatoxin B1 (ISO)

benzo[a]pyrene (ISO)

benzo[b]fluoranthene (EXP)

bisphenol A (ISO)

bisphenol F (ISO)

cadmium atom (ISO)

cisplatin (EXP,ISO)

copper(II) sulfate (ISO)

dexamethasone (ISO)

disodium selenite (ISO)

ethyl methanesulfonate (ISO)

finasteride (ISO)

folic acid (EXP)

indometacin (ISO)

leflunomide (ISO)

malathion (ISO)

methyl methanesulfonate (ISO)

oxaliplatin (ISO)

paracetamol (EXP)

pirinixic acid (EXP)

sulindac (ISO)

sunitinib (ISO)

topotecan (ISO)

valproic acid (EXP,ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell maturation (IGI,IMP)

defense response to Gram-negative bacterium (IMP)

inflammatory response (IBA,IMP)

natural killer cell differentiation (IGI,IMP)

negative regulation of interleukin-17 production (IMP)

neutrophil-mediated killing of gram-negative bacterium (IMP)

phagocytosis (IMP)

positive regulation of interleukin-10 production (IMP)

regulation of mitochondrial membrane potential (IBA,IMP)

regulation of reactive oxygen species metabolic process (IMP)

Cellular Component

mitochondrion (IBA,IDA)

Molecular Function

molecular_function (ND)

protein binding (ISO)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal glomerular capillary thrombosis (IAGP)

abnormal NK cell differentiation (IAGP)

abnormal renal glomerulus morphology (IAGP)

abnormal tumor incidence (IAGP)

adipose tissue necrosis (IAGP)

arteritis (IAGP)

decreased body weight (IAGP)

decreased erythrocyte cell number (IAGP)

decreased interleukin-15 secretion (IAGP)

decreased NK cell number (IAGP)

glomerulonephritis (IAGP)

increased anti-nuclear antigen antibody level (IAGP)

increased hemangioma incidence (IAGP)

increased hemangiosarcoma incidence (IAGP)

increased leukemia incidence (IAGP)

increased leukocyte cell number (IAGP)

increased lymphoma incidence (IAGP)

increased squamous cell carcinoma incidence (IAGP)

increased susceptibility to autoimmune disorder (IAGP)

premature death (IAGP)

renal cast (IAGP)

vascular inflammation (IAGP)

References

References - curated


1.	RGD automated import pipeline
2.	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3.	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:8889548	PMID:10349636	PMID:10922068	PMID:11042159	PMID:11076861	PMID:11085536	PMID:11217851	PMID:12466851	PMID:12477932	PMID:14610273	PMID:15489334	PMID:15782199
PMID:16141072	PMID:16141073	PMID:17318811	PMID:18772348	PMID:21267068	PMID:21873635	PMID:22513871	PMID:24042119	PMID:24328503	PMID:28391779

Genomics

Comparative Map Data

Tusc2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	107,440,454 - 107,443,307 (+)	NCBI	GRCm39		mm39
GRCm39 Ensembl	9	107,440,454 - 107,443,311 (+)	Ensembl
GRCm38	9	107,563,255 - 107,566,108 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	107,563,255 - 107,566,112 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	107,465,586 - 107,468,439 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	9	107,421,356 - 107,424,209 (+)	NCBI			mm8
Celera	9	107,172,004 - 107,174,857 (+)	NCBI		Celera
Cytogenetic Map	9	F1	NCBI

TUSC2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	3	50,320,027 - 50,328,251 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	3	50,324,909 - 50,328,223 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	3	50,362,340 - 50,365,654 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	50,337,345 - 50,340,672 (-)	NCBI	NCBI36		hg18	NCBI36
Build 34	3	50,337,344 - 50,340,672	NCBI
Celera	3	50,335,176 - 50,338,503 (-)	NCBI
Cytogenetic Map	3	p21.31	NCBI
HuRef	3	50,418,054 - 50,421,381 (-)	NCBI		HuRef
CHM1_1	3	50,314,606 - 50,317,935 (-)	NCBI		CHM1_1

Tusc2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	8	108,236,838 - 108,240,056 (+)	NCBI
Rnor_6.0 Ensembl	8	116,318,963 - 116,322,181 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	8	116,318,963 - 116,322,181 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	8	115,675,223 - 115,678,441 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	112,810,678 - 112,813,896 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
Celera	8	107,543,405 - 107,546,623 (+)	NCBI		Celera
Cytogenetic Map	8	q32	NCBI

Tusc2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955532	2,128,430 - 2,131,235 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955532	2,128,430 - 2,131,235 (-)	NCBI	ChiLan1.0	ChiLan1.0

TUSC2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	3	51,486,641 - 51,489,962 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	51,486,641 - 51,489,962 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	3	50,251,034 - 50,254,351 (-)	NCBI	Mhudiblu_PPA_v0		panPan3

TUSC2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	39,024,814 - 39,026,209 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Tusc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936529	1,853,092 - 1,856,027 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TUSC2
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	22	11,711,487 - 11,715,095 (-)	NCBI
ChlSab1.1 Ensembl	22	11,711,386 - 11,715,057 (-)	Ensembl

Tusc2
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624730	4,177,351 - 4,181,036 (-)	NCBI

Position Markers

AU044980

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	9	107,561,906 - 107,562,070	UniSTS	GRCm38
MGSCv37	9	107,464,237 - 107,464,401	UniSTS	GRCm37
Celera	9	107,170,648 - 107,170,812	UniSTS
Cytogenetic Map	9	F1	UniSTS
Whitehead/MRC_RH	9	1108.91	UniSTS

RH124504

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	9	107,562,096 - 107,562,183	UniSTS	GRCm38
MGSCv37	9	107,464,427 - 107,464,514	UniSTS	GRCm37
Cytogenetic Map	9	F1	UniSTS

RH125715

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
Cytogenetic Map	9	F1	UniSTS
Whitehead/MRC_RH	9	1110.78	UniSTS

Tusc2

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	9	107,563,472 - 107,564,970	UniSTS	GRCm38
MGSCv37	9	107,465,803 - 107,467,301	UniSTS	GRCm37
Celera	9	107,172,221 - 107,173,719	UniSTS
Cytogenetic Map	9	F1	UniSTS
cM Map	9		UniSTS

QTLs in Region (GRCm38)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
13207569	Tcq13_m	total cholesterol QTL 13 (mouse)					9	59990000	109260000	Mouse
4141833	W10q13_m	weight 10 weeks QTL 13 (mouse)			Not determined			63332429	120362868	Mouse
4141545	Tailaq2_m	tail length adjusted QTL 2 (mouse)			Not determined			63332429	120362868	Mouse
1357635	Splq4_m	spleen weight QTL 4 (mouse)			Not determined		9	63332429	120362868	Mouse
1301725	Lifespan1_m	life span 1 (mouse)			Not determined		9	74368177	108368325	Mouse
1302065	El1_m	epilepsy 1 (mouse)			Not determined		9	75775364	114474379	Mouse
10054492	El7_m	epilepsy 7 (mouse)			Not determined		9	75775364	114474379	Mouse
1301407	Rapop2_m	radiation-induced apoptosis 2 (mouse)			Not determined		9	76535936	110536130	Mouse
1301192	Skts6_m	skin tumor susceptibility 6 (mouse)			Not determined		9	78640645	112640755	Mouse
10401247	Bglu14_m	blood glucose level 14 (mouse)			Not determined		9	79397810	113397888	Mouse
1301732	Char1_m	P. chabaudi malaria resistance QTL 1 (mouse)			Not determined		9	81798268	115798392	Mouse
1300884	Sluc11_m	susceptibility to lung cancer 11 (mouse)			Not determined		9	82910333	116910428	Mouse
1357461	Idd2_m	insulin dependent diabetes susceptibility 2 (mouse)			Not determined		9	82910333	116910428	Mouse
10766454	Char10_m	P. chabaudi malaria resistance QTL 10 (mouse)					9	82910333	116910428	Mouse
1301487	Nociq1_m	nociceptive sensitivity inflammatory QTL 1 (mouse)			Not determined		9	84528818	118528921	Mouse
10412180	Msam3_m	muscle, skeletal, activity measure 3 (mouse)			Not determined		9	85897510	108641186	Mouse
1300549	Bbaa17_m	B. burgdorferi-associated arthritis 17 (mouse)			Not determined		9	86230401	120230530	Mouse
1302103	Dob2_m	dietary obesity 2 (mouse)			Not determined		9	86239845	120289624	Mouse
11251716	Siim2_m	stress induced immobility 2 (mouse)					9	86748483	120748483	Mouse
12880422	V25Dq6_m	vitamin D inactive form serum level QTL 6 (mouse)					9	87800000	121800000	Mouse
10412242	Alpq8_m	alcohol preference QTL 8 (mouse)			Not determined		9	89284925	123284925	Mouse
1301649	Psl1_m	promotion susceptibility QTL 1 (mouse)			Not determined		9	89412277	123412396	Mouse
18182932	Metl3_m	metabolite locus 3, N-acetylglutamate (mouse)					9	89563342	123563342	Mouse
1357657	Pymr_m	Plasmodium yoelli malaria resistance (mouse)			Not determined		9	89977005	118938021	Mouse
12910770	Splic1_m	spleen iron content 1 (mouse)					9	91413879	124595110	Mouse
12910772	Lvic6_m	liver iron content 6 (mouse)					9	91413879	124595110	Mouse
12910773	Splic3_m	spleen iron content 3 (mouse)					9	91413879	124595110	Mouse
1558767	Skmw11_m	skeletal muscle weight 11 (mouse)			Not determined		9	91641084	124595110	Mouse
13463474	Hbbcq5_m	hemoglobin concentration QTL 5 (mouse)					9	91641084	124595110	Mouse
13463475	Hctq7_m	hematocrit QTL 7 (mouse)					9	91641084	124595110	Mouse
13463477	Rbc9_m	red blood cell count 9 (mouse)					9	91641084	124595110	Mouse
13463478	Mchq18_m	mean corpuscular hemoglobin QTL 18 (mouse)					9	91641084	124595110	Mouse
13463480	Mchcq2_m	mean corpuscular hemoglobin concentration QTL 2 (mouse)					9	91641084	124595110	Mouse
12904937	Edlmmq9_m	extensor digitorum longus muscle mass QTL 9 (mouse)					9	91683173	124595110	Mouse
12904947	Tammq7_m	tibialis anterior muscle mass QTL 7 (mouse)					9	91683173	124595110	Mouse
12904961	Gmmq7_m	gastrocnemius muscle mass QTL 7 (mouse)					9	91683173	124595110	Mouse
1302001	Bdln5_m	body length 5 (mouse)			Not determined		9	93762590	124595110	Mouse
1301484	Bwq6_m	body weight (mouse)			Not determined		9	93762590	124595110	Mouse
14746992	Manh67_m	mandible shape 67 (mouse)					9	94036768	124595110	Mouse
11081166	Psl5_m	promotion susceptibility QTL 5 (mouse)					9	94981301	112872929	Mouse
11537364	Cnes5_m	C. neoformans susceptibility locus 5 (mouse)					9	96917590	124595110	Mouse
1301297	Lcho1_m	liver cholesterol 1 (mouse)			Not determined		9	101060861	124595110	Mouse
1357627	Tgq2_m	triglyceride QTL 2 (mouse)			Not determined		9	102000187	124595110	Mouse
1357648	Obq18_m	obesity QTL 18 (mouse)			Not determined		9	102000187	124595110	Mouse
1301789	Pbwg4_m	postnatal body weight growth 4 (mouse)			Not determined		9	103289445	124595110	Mouse
10412290	Pvacm1l_m	plasma vascular cell adhesion molecule 1 levels (mouse)			Not determined		9	103289445	124595110	Mouse
12879896	Berr3_m	berghei resistance locus 3 (mouse)					9	103289445	124595110	Mouse

miRNA Target Status

Confirmed Target Of

miRNA Gene	Mature miRNA	Method Name	Result Type	Data Type	Support Type	PMID
Mir93	mmu-miR-93-5p	OncomiRDB	external_info	NA	NA	19671678
Mir98	mmu-miR-98-5p	OncomiRDB	external_info	NA	NA	19671678

Predicted Target Of

	Summary Value
Count of predictions:	542
Count of miRNA genes:	356
Interacting mature miRNAs:	416
Transcripts:	ENSMUST00000010198
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_019742	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF123387	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK004430	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK082684	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK198946	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AL672219	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC048477	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH466560	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSMUST00000010198 ⟹ ENSMUSP00000010198

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	9	107,563,255 - 107,566,112 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000193292

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	9	107,563,351 - 107,563,948 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000193418 ⟹ ENSMUSP00000141635

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	9	107,563,370 - 107,564,996 (+)	Ensembl

RefSeq Acc Id:

NM_019742 ⟹ NP_062716

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	9	107,440,454 - 107,443,307 (+)	NCBI
GRCm38	9	107,563,255 - 107,566,108 (+)	ENTREZGENE
MGSCv37	9	107,465,586 - 107,468,439 (+)	RGD
Celera	9	107,172,004 - 107,174,857 (+)	RGD
cM Map	9		ENTREZGENE

Sequence:

show sequence

GGAGACAGCAGAGCCTGCGGAAGGCGGCGGCGGCGGCACCTGCGAGTGGAAGCTGGGGCAGGGC
ATGGTCGCGCCCGCCGCGCTGTGAGAGCGGAGCGGCCGCTGGGTCCGCCATGCGCCCGCGGCGC
TGACATGGGCGCCAGCGGCTCCAAAGCTCGGGGCCTCTGGCCCTTTGCCTCCACTCCGGGGGGC
GGCGGCCCAGAGGCGGCAGGCTCCGAGCAGTCTCTGGTGCGGTCTCGAGCCCGAGCAGTGCCTC
CCTTCGTATTCACGCGCCGCGGCTCCATGTTCTACGATGAAGATGGAGATCTGGCTCACGAATT
CTATGAGGAGACAATCGTCACCAAGAATGGGCAGAAGCGAGCCAAGCTGAGGCGGGTACATAAG
AATCTGATTCCTCAGGGCATCGTGAAGCTGGATCCTCCCCGAATCCACGTGGATTTCCCCGTGA
TCCTCTATGAAGTATGAACCTGTGTGTGGCATGGCAGACACGAGCACCCACTGCCCCAGCAAGA
AACTCCCAGGATCAAGGTGTAGCTTCCATTCAGGAGTCCAGGCTGGTGCCACAACCTTGAATAA
ACTAAACTCCGTTGGCCCAGAACCTTCAGTTGTAAGAGGGGTTGTCCCTCAGTGTTAACTGGTA
TTGGCGGATGTCTGAACAATAAGAGGTTGGTGGCTGGTGAGGGCTAAGGACAGAATTACCAGCC
CGTCTCCCCCAGCCGCTTGTGGGAGAAGCATGACAGGAGACACGTGCCGGTCAGGAATGCCTGG
TTCCTGGTTACCTGCCTGACCTGCTTTCTTCCAAGCTTGCCTAGGGCCCAGCCCTCCTAGAAGC
TACAGCACTTTACAAGCAGAGTCTGCCTTCTTCCAGCCCCTGGGCTGTAGGGGCTCTACCCAAG
TGGGAACTTCCTTTTCCTCACTCCCCTTCCCCCCTAGTCAGAGCATTTCAGCCGTTTGCTACCT
CGATTCCTCCTGTATCGGACAGACTGGAGATACATACCAGCCTCACCCTTCCTGCCTACCTACC
ACATGCTCCCGCTCTTAAGCTGGACACTTTGCTGGCTGTTCAATAAGAATGAGGACCAGTGTGG
GAGGCTTCTCCTTTCACCCAGGGCTGGACTGATCTCTCTTGATTTCAACCAGTTGCCCTCAAGT
TGAGAGGGTACAGGCCGGGGTCAGGACAGGCTACTGACGCCTGTACCTGTGGGGACTTGCCCCA
AACCACATATTCGTCGTCTCCCTTGTCTTTGCACCAGTCCCACAAATCCCCAGTTGTAGGGGAG
AGGCAGTCCACCACCTAGTGGTAAGAAACGACTGGGGCTGGTGCCAGTAGCTATGAGGAGCCCA
TCCCCCCCCTTCTCCTTACAGTATCTTTACCCCTTCAGGGTCTGTTAAGAGAAAGTACTGGAGC
TCCTTGGTAAGGATAGAAAGGAGGGGAAAATACTTAAGAGGCATAATTAAAATGTGAAGGTTTG
TAAATAGTCTAGACTATGATAATGTTGGGGCAGAGTCTGATTTCTATACAGAGATGGCTTTAAA
AAAATACTTCCTTGTGGAAGCTCTGTGCTTCTAGAGTGTGGGAAATGGCTTGGGACGAGTGATC
CCCAGCACAGGAAGGCTGTTGTGTTATTTGTTCAATTTCAATAAAAGTTATTTGTAGACCC

hide sequence

Protein Sequences


Protein RefSeqs	NP_062716	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAD42286	(Get FASTA)	NCBI Sequence Viewer
	AAH48477	(Get FASTA)	NCBI Sequence Viewer
	BAB23300	(Get FASTA)	NCBI Sequence Viewer
	BAC38571	(Get FASTA)	NCBI Sequence Viewer
	EDL21200	(Get FASTA)	NCBI Sequence Viewer
	Q9WVF8	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_062716 ⟸ NM_019742
- UniProtKB:	Q9WVF8 (UniProtKB/Swiss-Prot), Q542N4 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGASGSKARGLWPFASTPGGGGPEAAGSEQSLVRSRARAVPPFVFTRRGSMFYDEDGDLAHEFY EETIVTKNGQKRAKLRRVHKNLIPQGIVKLDPPRIHVDFPVILYEV hide sequence

RefSeq Acc Id:

ENSMUSP00000141635 ⟸ ENSMUST00000193418

RefSeq Acc Id:

ENSMUSP00000010198 ⟸ ENSMUST00000010198

Promoters

RGD ID:

6845289

Promoter ID:

MM_KWN:58722

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

3T3L1_Day0, 3T3L1_Day1, 3T3L1_Day2, 3T3L1_Day3, 3T3L1_Day4, 3T3L1_Day6, BoneMarrow_0Hour, BoneMarrow_2Hour, BoneMarrow_4Hour, Brain, ES_Cell, Kidney, Liver, Lung, MEF_B4, MEF_B6, Spleen

Transcripts:

NM_019742

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	9	107,464,811 - 107,465,582 (+)	MPROMDB

RGD ID:

8670796

Promoter ID:

EPDNEW_M13429

Type:

initiation region

Name:

Tusc2_1

Description:

Mus musculus tumor suppressor candidate 2 , mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	9	107,563,264 - 107,563,324	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:1931086	AgrOrtholog
Ensembl Genes	ENSMUSG00000010054	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein	ENSMUSP00000010198	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSMUSP00000141635	UniProtKB/TrEMBL
Ensembl Transcript	ENSMUST00000010198	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSMUST00000193418	UniProtKB/TrEMBL
InterPro	FUS1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	mmu:80385	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD	MGI:1931086	ENTREZGENE
NCBI Gene	80385	ENTREZGENE
PANTHER	PTHR15453	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	TUSC2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Tusc2	PhenoGen
UniProt	A0A0A6YWP5_MOUSE	UniProtKB/TrEMBL
	Q542N4	ENTREZGENE, UniProtKB/TrEMBL
	Q9WVF8	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-08-14	Tusc2	tumor suppressor 2, mitochondrial calcium regulator		tumor suppressor candidate 2	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)