Tusc2 (tumor suppressor 2, mitochondrial calcium regulator) - Rat Genome Database
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Gene: Tusc2 (tumor suppressor 2, mitochondrial calcium regulator) Mus musculus
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Symbol: Tusc2
Name: tumor suppressor 2, mitochondrial calcium regulator
RGD ID: 1615786
MGI Page MGI
Description: Is expressed in liver and metanephros. Orthologous to human TUSC2 (tumor suppressor 2, mitochondrial calcium regulator); INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 1190001E22Rik; AA407686; Fus; fus-1 protein; Fus1; fusion 1 protein; Lgcc; lung cancer candidiate, FUS; PAP; Pd; Pdap2; PDGFA associated protein 2; PDGFA-associated protein 2; tumor suppressor candidate 2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399107,440,454 - 107,443,307 (+)NCBIGRCm39mm39
GRCm39 Ensembl9107,440,454 - 107,443,311 (+)Ensembl
GRCm389107,563,255 - 107,566,108 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9107,563,255 - 107,566,112 (+)EnsemblGRCm38mm10GRCm38
MGSCv379107,465,586 - 107,468,439 (+)NCBIGRCm37mm9NCBIm37
MGSCv369107,421,356 - 107,424,209 (+)NCBImm8
Celera9107,172,004 - 107,174,857 (+)NCBICelera
Cytogenetic Map9F1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
mitochondrion  (IBA,IDA)

Molecular Function

References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11085536   PMID:11217851   PMID:12466851   PMID:12477932   PMID:14610273   PMID:15489334   PMID:15782199  
PMID:16141072   PMID:16141073   PMID:17318811   PMID:18772348   PMID:21267068   PMID:21873635   PMID:22513871   PMID:24042119   PMID:24328503   PMID:28391779  


Genomics

Comparative Map Data
Tusc2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399107,440,454 - 107,443,307 (+)NCBIGRCm39mm39
GRCm39 Ensembl9107,440,454 - 107,443,311 (+)Ensembl
GRCm389107,563,255 - 107,566,108 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9107,563,255 - 107,566,112 (+)EnsemblGRCm38mm10GRCm38
MGSCv379107,465,586 - 107,468,439 (+)NCBIGRCm37mm9NCBIm37
MGSCv369107,421,356 - 107,424,209 (+)NCBImm8
Celera9107,172,004 - 107,174,857 (+)NCBICelera
Cytogenetic Map9F1NCBI
TUSC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl350,320,027 - 50,328,251 (-)EnsemblGRCh38hg38GRCh38
GRCh38350,324,909 - 50,328,223 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37350,362,340 - 50,365,654 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36350,337,345 - 50,340,672 (-)NCBINCBI36hg18NCBI36
Build 34350,337,344 - 50,340,672NCBI
Celera350,335,176 - 50,338,503 (-)NCBI
Cytogenetic Map3p21.31NCBI
HuRef350,418,054 - 50,421,381 (-)NCBIHuRef
CHM1_1350,314,606 - 50,317,935 (-)NCBICHM1_1
Tusc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.28108,236,838 - 108,240,056 (+)NCBI
Rnor_6.0 Ensembl8116,318,963 - 116,322,181 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.08116,318,963 - 116,322,181 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.08115,675,223 - 115,678,441 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48112,810,678 - 112,813,896 (+)NCBIRGSC3.4rn4RGSC3.4
Celera8107,543,405 - 107,546,623 (+)NCBICelera
Cytogenetic Map8q32NCBI
Tusc2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555322,128,430 - 2,131,235 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555322,128,430 - 2,131,235 (-)NCBIChiLan1.0ChiLan1.0
TUSC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1351,486,641 - 51,489,962 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl351,486,641 - 51,489,962 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0350,251,034 - 50,254,351 (-)NCBIMhudiblu_PPA_v0panPan3
TUSC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12039,024,814 - 39,026,209 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Tusc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365291,853,092 - 1,856,027 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TUSC2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12211,711,487 - 11,715,095 (-)NCBI
ChlSab1.1 Ensembl2211,711,386 - 11,715,057 (-)Ensembl
Tusc2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247304,177,351 - 4,181,036 (-)NCBI

Position Markers
AU044980  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389107,561,906 - 107,562,070UniSTSGRCm38
MGSCv379107,464,237 - 107,464,401UniSTSGRCm37
Celera9107,170,648 - 107,170,812UniSTS
Cytogenetic Map9F1UniSTS
Whitehead/MRC_RH91108.91UniSTS
RH124504  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389107,562,096 - 107,562,183UniSTSGRCm38
MGSCv379107,464,427 - 107,464,514UniSTSGRCm37
Cytogenetic Map9F1UniSTS
RH125715  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9F1UniSTS
Whitehead/MRC_RH91110.78UniSTS
Tusc2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389107,563,472 - 107,564,970UniSTSGRCm38
MGSCv379107,465,803 - 107,467,301UniSTSGRCm37
Celera9107,172,221 - 107,173,719UniSTS
Cytogenetic Map9F1UniSTS
cM Map9 UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13207569Tcq13_mtotal cholesterol QTL 13 (mouse)959990000109260000Mouse
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63332429120362868Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63332429120362868Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963332429120362868Mouse
1301725Lifespan1_mlife span 1 (mouse)Not determined974368177108368325Mouse
1302065El1_mepilepsy 1 (mouse)Not determined975775364114474379Mouse
10054492El7_mepilepsy 7 (mouse)Not determined975775364114474379Mouse
1301407Rapop2_mradiation-induced apoptosis 2 (mouse)Not determined976535936110536130Mouse
1301192Skts6_mskin tumor susceptibility 6 (mouse)Not determined978640645112640755Mouse
10401247Bglu14_mblood glucose level 14 (mouse)Not determined979397810113397888Mouse
1301732Char1_mP. chabaudi malaria resistance QTL 1 (mouse)Not determined981798268115798392Mouse
1300884Sluc11_msusceptibility to lung cancer 11 (mouse)Not determined982910333116910428Mouse
1357461Idd2_minsulin dependent diabetes susceptibility 2 (mouse)Not determined982910333116910428Mouse
10766454Char10_mP. chabaudi malaria resistance QTL 10 (mouse)982910333116910428Mouse
1301487Nociq1_mnociceptive sensitivity inflammatory QTL 1 (mouse)Not determined984528818118528921Mouse
10412180Msam3_mmuscle, skeletal, activity measure 3 (mouse)Not determined985897510108641186Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986230401120230530Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986239845120289624Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986748483120748483Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987800000121800000Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989284925123284925Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989412277123412396Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989563342123563342Mouse
1357657Pymr_mPlasmodium yoelli malaria resistance (mouse)Not determined989977005118938021Mouse
12910770Splic1_mspleen iron content 1 (mouse)991413879124595110Mouse
12910772Lvic6_mliver iron content 6 (mouse)991413879124595110Mouse
12910773Splic3_mspleen iron content 3 (mouse)991413879124595110Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991641084124595110Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991641084124595110Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991641084124595110Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991641084124595110Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991641084124595110Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991641084124595110Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991683173124595110Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991683173124595110Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991683173124595110Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993762590124595110Mouse
1301484Bwq6_mbody weight (mouse)Not determined993762590124595110Mouse
14746992Manh67_mmandible shape 67 (mouse)994036768124595110Mouse
11081166Psl5_mpromotion susceptibility QTL 5 (mouse)994981301112872929Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996917590124595110Mouse
1301297Lcho1_mliver cholesterol 1 (mouse)Not determined9101060861124595110Mouse
1357627Tgq2_mtriglyceride QTL 2 (mouse)Not determined9102000187124595110Mouse
1357648Obq18_mobesity QTL 18 (mouse)Not determined9102000187124595110Mouse
1301789Pbwg4_mpostnatal body weight growth 4 (mouse)Not determined9103289445124595110Mouse
10412290Pvacm1l_mplasma vascular cell adhesion molecule 1 levels (mouse)Not determined9103289445124595110Mouse
12879896Berr3_mberghei resistance locus 3 (mouse)9103289445124595110Mouse

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir93mmu-miR-93-5pOncomiRDBexternal_infoNANA19671678
Mir98mmu-miR-98-5pOncomiRDBexternal_infoNANA19671678

Predicted Target Of
Summary Value
Count of predictions:542
Count of miRNA genes:356
Interacting mature miRNAs:416
Transcripts:ENSMUST00000010198
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000010198   ⟹   ENSMUSP00000010198
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9107,563,255 - 107,566,112 (+)Ensembl
RefSeq Acc Id: ENSMUST00000193292
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9107,563,351 - 107,563,948 (+)Ensembl
RefSeq Acc Id: ENSMUST00000193418   ⟹   ENSMUSP00000141635
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9107,563,370 - 107,564,996 (+)Ensembl
RefSeq Acc Id: NM_019742   ⟹   NP_062716
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399107,440,454 - 107,443,307 (+)NCBI
GRCm389107,563,255 - 107,566,108 (+)ENTREZGENE
MGSCv379107,465,586 - 107,468,439 (+)RGD
Celera9107,172,004 - 107,174,857 (+)RGD
cM Map9 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_062716   ⟸   NM_019742
- UniProtKB: Q9WVF8 (UniProtKB/Swiss-Prot),   Q542N4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000141635   ⟸   ENSMUST00000193418
RefSeq Acc Id: ENSMUSP00000010198   ⟸   ENSMUST00000010198

Promoters
RGD ID:6845289
Promoter ID:MM_KWN:58722
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_019742
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv369107,464,811 - 107,465,582 (+)MPROMDB
RGD ID:8670796
Promoter ID:EPDNEW_M13429
Type:initiation region
Name:Tusc2_1
Description:Mus musculus tumor suppressor candidate 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm389107,563,264 - 107,563,324EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1931086 AgrOrtholog
Ensembl Genes ENSMUSG00000010054 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000010198 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000141635 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000010198 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000193418 UniProtKB/TrEMBL
InterPro FUS1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:80385 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1931086 ENTREZGENE
NCBI Gene 80385 ENTREZGENE
PANTHER PTHR15453 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TUSC2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tusc2 PhenoGen
UniProt A0A0A6YWP5_MOUSE UniProtKB/TrEMBL
  Q542N4 ENTREZGENE, UniProtKB/TrEMBL
  Q9WVF8 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-08-14 Tusc2  tumor suppressor 2, mitochondrial calcium regulator    tumor suppressor candidate 2  Symbol and/or name change 5135510 APPROVED