Gene: Tusc2 (tumor suppressor 2, mitochondrial calcium regulator) Mus musculus
Analyze
Symbol:
Tusc2
Name:
tumor suppressor 2, mitochondrial calcium regulator
Description:
INVOLVED IN cell maturation; chemokine (C-C motif) ligand 5 production; defense response to Gram-negative bacterium; ASSOCIATED WITH abnormal NK cell differentiation; abnormal renal glomerulus morphology; abnormal tumor incidence; FOUND IN mitochondrion; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
1190001E22Rik; AA407686; fus-1 protein; Fus1; fusion 1 protein; Lgcc; lung cancer candidiate, FUS; PAP; Pdap2; PDGFA associated protein 2; PDGFA-associated protein 2; tumor suppressor candidate 2
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
TUSC2 (tumor suppressor 2, mitochondrial calcium regulator) HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):
Tusc2 (tumor suppressor 2, mitochondrial calcium regulator) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Tusc2 (tumor suppressor 2, mitochondrial calcium regulator) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
TUSC2 (tumor suppressor 2, mitochondrial calcium regulator) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
TUSC2 (tumor suppressor 2, mitochondrial calcium regulator) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Tusc2 (tumor suppressor 2, mitochondrial calcium regulator) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
TUSC2 (tumor suppressor 2, mitochondrial calcium regulator)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Rattus norvegicus (Norway rat):
Tusc2 (tumor suppressor 2, mitochondrial calcium regulator)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
tusc2a (tumor suppressor 2, mitochondrial calcium regulator a)
Alliance
DIOPT (Ensembl Compara, Hieranoid, OMA, OrthoFinder, PANTHER, PhylomeDB, TreeFam, ZFIN)
Danio rerio (zebrafish):
tusc2b (tumor suppressor 2, mitochondrial calcium regulator b)
Alliance
DIOPT (Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam, ZFIN)
Caenorhabditis elegans (roundworm):
C09E9.1
Alliance
DIOPT (Hieranoid, InParanoid, OrthoFinder, PANTHER, PhylomeDB, Roundup, TreeFam)
Latest Assembly:
GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm38 9 107,563,255 - 107,566,108 (+) NCBI GRCm38 GRCm38 mm10 GRCm38 MGSCv37 9 107,465,586 - 107,468,439 (+) NCBI GRCm37 mm9 NCBIm37 MGSCv36 9 107,421,356 - 107,424,209 (+) NCBI mm8 Celera 9 107,172,004 - 107,174,857 (+) NCBI Celera Cytogenetic Map 9 F1 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Gene-Chemical Interaction Annotations
(S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE multiple interactions ISO RGD:1561664 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of TUSC2 mRNA CTD PMID:25729387 17alpha-ethynylestradiol multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TUSC2 mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TUSC2 mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of TUSC2 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of TUSC2 mRNA CTD PMID:21354282 3,4-methylenedioxymethamphetamine increases expression EXP 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in increased expression of TUSC2 mRNA CTD PMID:20188158 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:1343391 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TUSC2 mRNA, [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of TUSC2 mRNA CTD PMID:28628672 aflatoxin B1 increases methylation ISO RGD:1343391 6480464 Aflatoxin B1 results in increased methylation of TUSC2 gene CTD PMID:27153756 benzo[b]fluoranthene increases expression EXP 6480464 benzo(b)fluoranthene results in increased expression of TUSC2 mRNA CTD PMID:26377693 bisphenol A increases expression ISO RGD:1561664 6480464 bisphenol A results in increased expression of TUSC2 mRNA CTD PMID:25181051 bisphenol A multiple interactions ISO RGD:1343391 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TUSC2 mRNA CTD PMID:28628672 bisphenol F multiple interactions ISO RGD:1343391 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of TUSC2 mRNA CTD PMID:28628672 cadmium atom decreases expression ISO RGD:1343391 6480464 Cadmium results in decreased expression of TUSC2 mRNA CTD PMID:24284285 cisplatin increases expression ISO RGD:1343391 6480464 Cisplatin results in increased expression of TUSC2 mRNA CTD PMID:24280081 , PMID:27392435 cisplatin increases expression EXP 6480464 Cisplatin results in increased expression of TUSC2 mRNA CTD PMID:24280081 copper(II) sulfate decreases expression ISO RGD:1343391 6480464 Copper Sulfate results in decreased expression of TUSC2 mRNA CTD PMID:19549813 dexamethasone multiple interactions ISO RGD:1343391 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TUSC2 mRNA, [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of TUSC2 mRNA CTD PMID:28628672 disodium selenite increases expression ISO RGD:1343391 6480464 Sodium Selenite results in increased expression of TUSC2 mRNA CTD PMID:18175754 ethyl methanesulfonate increases expression ISO RGD:1343391 6480464 Ethyl Methanesulfonate results in increased expression of TUSC2 mRNA CTD PMID:23649840 finasteride increases expression ISO RGD:1561664 6480464 Finasteride results in increased expression of TUSC2 mRNA CTD PMID:24136188 indometacin multiple interactions ISO RGD:1343391 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TUSC2 mRNA, [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of TUSC2 mRNA CTD PMID:28628672 leflunomide decreases expression ISO RGD:1343391 6480464 leflunomide results in decreased expression of TUSC2 mRNA CTD PMID:28988120 , PMID:29427785 methyl methanesulfonate increases expression ISO RGD:1343391 6480464 Methyl Methanesulfonate results in increased expression of TUSC2 mRNA CTD PMID:23649840 oxaliplatin multiple interactions ISO RGD:1561664 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of TUSC2 mRNA CTD PMID:25729387 paracetamol affects expression EXP 6480464 Acetaminophen affects the expression of TUSC2 mRNA CTD PMID:17562736 pirinixic acid increases expression EXP 6480464 pirinixic acid results in increased expression of TUSC2 mRNA CTD PMID:18301758 , PMID:23811191 sulindac increases expression ISO RGD:1561664 6480464 Sulindac results in increased expression of TUSC2 mRNA CTD PMID:24136188 topotecan multiple interactions ISO RGD:1561664 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of TUSC2 mRNA CTD PMID:25729387 valproic acid affects expression EXP 6480464 Valproic Acid affects the expression of TUSC2 mRNA CTD PMID:17963808 valproic acid affects expression ISO RGD:1343391 6480464 Valproic Acid affects the expression of TUSC2 mRNA CTD PMID:25979313 valproic acid increases expression ISO RGD:1343391 6480464 Valproic Acid results in increased expression of TUSC2 mRNA CTD PMID:23179753 more ... vorinostat increases expression ISO RGD:1343391 6480464 vorinostat results in increased expression of TUSC2 protein CTD PMID:20543569
Gene Ontology Annotations
Biological Process cell maturation IMP MGI:MGI:3706236 2290270 (MGI:MGI:3703651, PMID:17318811) MGI MGI:MGI:3703651 , PMID:17318811 cell maturation IGI MGI:MGI:103014 2290270 (MGI:MGI:3703651, PMID:17318811) MGI MGI:MGI:3703651 , PMID:17318811 chemokine (C-C motif) ligand 5 production IMP MGI:MGI:3706236 2290270 (MGI:MGI:5435130, PMID:22513871) MGI MGI:MGI:5435130 , PMID:22513871 defense response to Gram-negative bacterium IMP MGI:MGI:3706236 2290270 (MGI:MGI:5518492, PMID:24042119) MGI MGI:MGI:5518492 , PMID:24042119 inflammatory response IMP MGI:MGI:3706236 2290270 (MGI:MGI:5435130, PMID:22513871) MGI MGI:MGI:5435130 , PMID:22513871 interleukin-15 production IMP MGI:MGI:3706236 2290270 (MGI:MGI:3703651, PMID:17318811) MGI MGI:MGI:3703651 , PMID:17318811 natural killer cell differentiation IMP MGI:MGI:3706236 2290270 (MGI:MGI:3703651, PMID:17318811) MGI MGI:MGI:3703651 , PMID:17318811 natural killer cell differentiation IGI MGI:MGI:103014 2290270 (MGI:MGI:3703651, PMID:17318811) MGI MGI:MGI:3703651 , PMID:17318811 negative regulation of interleukin-17 production IMP MGI:MGI:3706236 2290270 (MGI:MGI:5518492, PMID:24042119) MGI MGI:MGI:5518492 , PMID:24042119 neutrophil mediated killing of gram-negative bacterium IMP MGI:MGI:3706236 2290270 (MGI:MGI:5518492, PMID:24042119) MGI MGI:MGI:5518492 , PMID:24042119 phagocytosis IMP MGI:MGI:3706236 2290270 (MGI:MGI:5518492, PMID:24042119) MGI MGI:MGI:5518492 , PMID:24042119 positive regulation of interleukin-10 production IMP MGI:MGI:3706236 2290270 (MGI:MGI:5518492, PMID:24042119) MGI MGI:MGI:5518492 , PMID:24042119 regulation of mitochondrial membrane potential IMP MGI:MGI:3706236 2290270 (MGI:MGI:5435130 more ... MGI MGI:MGI:5435130 more ... regulation of reactive oxygen species metabolic process IMP MGI:MGI:3706236 2290270 (MGI:MGI:5435130, PMID:22513871) MGI MGI:MGI:5435130 , PMID:22513871 response to defense-related host reactive oxygen species production IMP MGI:MGI:3706236 2290270 (MGI:MGI:5518492, PMID:24042119) MGI MGI:MGI:5518492 , PMID:24042119 
Gene Ontology Annotations
