Bcr (BCR activator of RhoGEF and GTPase) - Rat Genome Database

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Gene: Bcr (BCR activator of RhoGEF and GTPase) Mus musculus
Analyze
Symbol: Bcr
Name: BCR activator of RhoGEF and GTPase
RGD ID: 1615754
MGI Page MGI
Description: Enables GTPase activator activity. Involved in several processes, including negative regulation of blood vessel remodeling; negative regulation of cellular extravasation; and regulation of vascular permeability. Acts upstream of or within several processes, including cellular response to lipopolysaccharide; negative regulation of macrophage migration; and regulation of vesicle-mediated transport. Located in cytosol; plasma membrane; and postsynaptic density. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is expressed in several structures, including cardiovascular system; central nervous system; forelimb bud; genitourinary system; and spleen. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; chronic myeloid leukemia; and leukemia. Orthologous to human BCR (BCR activator of RhoGEF and GTPase).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 5133400C09Rik; AI561783; AI853148; breakpoint cluster region; breakpoint cluster region homolog; breakpoint cluster region protein; mKIAA3017
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Gm18373  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391074,896,384 - 75,020,753 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1074,896,424 - 75,020,753 (+)EnsemblGRCm39 Ensembl
GRCm381075,060,560 - 75,184,923 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1075,060,592 - 75,184,921 (+)EnsemblGRCm38mm10GRCm38
MGSCv371074,523,641 - 74,647,668 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361074,504,612 - 74,628,764 (+)NCBIMGSCv36mm8
MGSCv361075,455,937 - 75,580,316 (+)NCBIMGSCv36mm8
Celera1076,108,779 - 76,233,250 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1038.49NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-butoxyethanol  (EXP)
2-palmitoylglycerol  (ISO)
4,4'-sulfonyldiphenol  (EXP)
6-propyl-2-thiouracil  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (ISO)
antirheumatic drug  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
ATP  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-hexachlorocyclohexane  (EXP)
bisphenol A  (ISO)
bortezomib  (ISO)
caffeine  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
clobetasol  (EXP)
clothianidin  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
cyfluthrin  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
ethanol  (EXP)
fenofibrate  (ISO)
flavonoids  (ISO)
folic acid  (EXP,ISO)
FR900359  (ISO)
gallic acid  (ISO)
histamine  (ISO)
hydrogen cyanide  (EXP)
irinotecan  (ISO)
LY294002  (ISO)
methimazole  (ISO)
methoxychlor  (ISO)
N-nitrosodiethylamine  (ISO)
nilotinib  (ISO)
Nor-9-carboxy-delta9-THC  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenobarbital  (EXP)
ponatinib  (ISO)
potassium cyanide  (EXP)
purmorphamine  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
serpentine asbestos  (ISO)
sorafenib  (ISO)
sulfadimethoxine  (ISO)
testosterone  (ISO)
theophylline  (ISO)
titanium dioxide  (EXP)
trichostatin A  (ISO)
tungsten  (EXP)
valproic acid  (ISO)
vinclozolin  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal astrocyte morphology  (IAGP)
abnormal astrocyte physiology  (IAGP)
abnormal bone marrow cell physiology  (IAGP)
abnormal cerebellar foliation  (IAGP)
abnormal cerebellum morphology  (IAGP)
abnormal CNS glial cell morphology  (IAGP)
abnormal definitive hematopoiesis  (IAGP)
abnormal ileum morphology  (IAGP)
abnormal inner ear development  (IAGP)
abnormal inner ear vestibule morphology  (IAGP)
abnormal liver parenchyma morphology  (IAGP)
abnormal neutrophil physiology  (IAGP)
abnormal proximal convoluted tubule morphology  (IAGP)
abnormal radial glial cell morphology  (IAGP)
abnormal renal glomerulus morphology  (IAGP)
abnormal utricle morphology  (IAGP)
abnormal vestibular saccule morphology  (IAGP)
absent otoliths  (IAGP)
circling  (IAGP)
decreased hematopoietic stem cell number  (IAGP)
decreased lymphocyte cell number  (IAGP)
decreased otolith number  (IAGP)
ectopic cerebellar granule cells  (IAGP)
enlarged otoliths  (IAGP)
gliosis  (IAGP)
hyperactivity  (IAGP)
impaired balance  (IAGP)
impaired coordination  (IAGP)
impaired swimming  (IAGP)
increased blood urea nitrogen level  (IAGP)
increased circulating alanine transaminase level  (IAGP)
increased circulating aspartate transaminase level  (IAGP)
increased circulating lactate dehydrogenase level  (IAGP)
increased leukocyte cell number  (IAGP)
increased monocyte cell number  (IAGP)
increased neutrophil cell number  (IAGP)
increased susceptibility to endotoxin shock  (IAGP)
intestinal edema  (IAGP)
neonatal lethality, incomplete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
premature death  (IAGP)
renal necrosis  (IAGP)
sepsis  (IAGP)
thrombocytopenia  (IAGP)
weight loss  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. BCR/ABL p210, p190 and p230 fusion genes in 250 Mexican patients with chronic myeloid leukaemia (CML). Arana-Trejo RM, etal., Clin Lab Haematol. 2002 Jun;24(3):145-50.
2. Transferred BCR/ABL DNA from K562 extracellular vesicles causes chronic myeloid leukemia in immunodeficient mice. Cai J, etal., PLoS One. 2014 Aug 18;9(8):e105200. doi: 10.1371/journal.pone.0105200. eCollection 2014.
3. A BCR-ABL(p190) fusion gene made by homologous recombination causes B-cell acute lymphoblastic leukemias in chimeric mice with independence of the endogenous bcr product. Castellanos A, etal., Blood. 1997 Sep 15;90(6):2168-74.
4. Fine mapping of chromosome 22 breakpoints within the breakpoint cluster region (bcr) implies a role for bcr exon 3 in determining disease duration in chronic myeloid leukemia. Grossman A, etal., Am J Hum Genet. 1989 Nov;45(5):729-38.
5. Minor BCR (m-bcr) rearrangements may appear in major BCR (M-bcr)-positive CML cases. Karlic H, etal., Hematol Pathol. 1992;6(4):203-7.
6. BCR gene expression blocks Bcr-Abl induced pathogenicity in a mouse model. Lin F, etal., Oncogene. 2001 Apr 5;20(15):1873-81.
7. Does a rise in the BCR-ABL1 transcript level identify chronic phase CML patients responding to imatinib who have a high risk of cytogenetic relapse? Marin D, etal., Br J Haematol. 2009 May;145(3):373-5. doi: 10.1111/j.1365-2141.2009.07646.x. Epub 2009 Mar 12.
8. Methylation of the major breakpoint cluster region (M-bcr) in Philadelphia-positive CML. Mills KI, etal., Leukemia. 1993 May;7(5):707-11.
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. Mouse MP Annotation Import Pipeline RGD automated import pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Outcomes of children with BCR-ABL1-like acute lymphoblastic leukemia treated with risk-directed therapy based on the levels of minimal residual disease. Roberts KG, etal., J Clin Oncol. 2014 Sep 20;32(27):3012-20.
15. Quantitative monitoring of BCR/ABL transcript during STI-571 therapy. Wu CJ, etal., Leuk Lymphoma. 2002 Dec;43(12):2281-9. doi: 10.1080/1042819021000039992.
Additional References at PubMed
PMID:1302014   PMID:1370487   PMID:1975791   PMID:2263470   PMID:2901712   PMID:7558021   PMID:7665168   PMID:7806275   PMID:7851892   PMID:7889565   PMID:7916324   PMID:8297798  
PMID:8581068   PMID:8812475   PMID:8889548   PMID:9108392   PMID:9531535   PMID:9591787   PMID:9653653   PMID:9808572   PMID:9858655   PMID:9892622   PMID:10349636   PMID:10430593  
PMID:10450747   PMID:10477548   PMID:10674025   PMID:11042159   PMID:11076861   PMID:11123309   PMID:11217851   PMID:11358387   PMID:11368444   PMID:11684658   PMID:11809706   PMID:11921339  
PMID:12032333   PMID:12466851   PMID:12477932   PMID:12520002   PMID:14610273   PMID:14614146   PMID:14621295   PMID:15226421   PMID:15489334   PMID:15735695   PMID:15761153   PMID:15782199  
PMID:15851034   PMID:16141072   PMID:16141073   PMID:16188879   PMID:16297667   PMID:16377569   PMID:16959763   PMID:16998483   PMID:17000758   PMID:17008533   PMID:17116687   PMID:17160016  
PMID:17705137   PMID:17967808   PMID:18071309   PMID:18216868   PMID:18287094   PMID:18313694   PMID:18429956   PMID:18538733   PMID:18704194   PMID:18725623   PMID:18791164   PMID:18813851  
PMID:19023129   PMID:19026994   PMID:19541367   PMID:19553523   PMID:19571320   PMID:19648281   PMID:19703997   PMID:19823681   PMID:19843948   PMID:20096683   PMID:20697350   PMID:20709952  
PMID:20962234   PMID:21263154   PMID:21267068   PMID:21625221   PMID:21677750   PMID:21764785   PMID:21873635   PMID:21900237   PMID:22000011   PMID:22234689   PMID:22384256   PMID:22408137  
PMID:22451666   PMID:22696202   PMID:22728826   PMID:22767509   PMID:22786773   PMID:23152932   PMID:23160449   PMID:23287417   PMID:23382219   PMID:24095735   PMID:24152735   PMID:24242069  
PMID:24249581   PMID:24319055   PMID:24657654   PMID:24960694   PMID:25249015   PMID:25331951   PMID:25671650   PMID:25886360   PMID:26184912   PMID:26251899   PMID:27889896   PMID:28192788  
PMID:28634551   PMID:28671696   PMID:29186687   PMID:29293918   PMID:30413411   PMID:31433296   PMID:31461398   PMID:31525277   PMID:32276588   PMID:33149299   PMID:34190380   PMID:34941574  
PMID:36265442   PMID:36417873   PMID:37142655  


Genomics

Comparative Map Data
Bcr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391074,896,384 - 75,020,753 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1074,896,424 - 75,020,753 (+)EnsemblGRCm39 Ensembl
GRCm381075,060,560 - 75,184,923 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1075,060,592 - 75,184,921 (+)EnsemblGRCm38mm10GRCm38
MGSCv371074,523,641 - 74,647,668 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361074,504,612 - 74,628,764 (+)NCBIMGSCv36mm8
MGSCv361075,455,937 - 75,580,316 (+)NCBIMGSCv36mm8
Celera1076,108,779 - 76,233,250 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1038.49NCBI
BCR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382223,180,509 - 23,318,037 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2223,179,704 - 23,318,037 (+)EnsemblGRCh38hg38GRCh38
GRCh372223,522,696 - 23,660,224 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362221,852,552 - 21,990,224 (+)NCBINCBI36Build 36hg18NCBI36
Build 342221,847,105 - 21,982,690NCBI
Celera227,337,083 - 7,474,738 (+)NCBICelera
Cytogenetic Map22q11.23ENTREZGENE
HuRef226,461,675 - 6,627,574 (+)NCBIHuRef
CHM1_12223,534,806 - 23,672,427 (+)NCBICHM1_1
T2T-CHM13v2.02223,603,367 - 23,740,899 (+)NCBIT2T-CHM13v2.0
Bcr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82013,468,732 - 13,596,333 (-)NCBIGRCr8
mRatBN7.22013,469,325 - 13,596,942 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2013,471,668 - 13,597,016 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.02014,421,250 - 14,546,406 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2014,421,141 - 14,545,772 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02016,604,476 - 16,729,388 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42013,972,773 - 14,097,816 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12013,973,364 - 14,098,043 (-)NCBI
Celera2014,955,473 - 15,079,934 (-)NCBICelera
Cytogenetic Map20p12NCBI
Bcr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554557,598,794 - 7,727,386 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554557,598,794 - 7,727,386 (+)NCBIChiLan1.0ChiLan1.0
BCR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22333,011,678 - 33,149,165 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12234,933,439 - 35,070,914 (-)NCBINHGRI_mPanPan1
PanPan1.12221,803,806 - 21,922,123 (+)NCBIpanpan1.1PanPan1.1panPan2
BCR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12627,856,280 - 27,980,923 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2627,856,082 - 27,978,318 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2626,931,961 - 27,056,311 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02629,260,365 - 29,385,328 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2629,260,365 - 29,385,294 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12627,343,693 - 27,468,548 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02626,961,155 - 27,085,857 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02627,950,465 - 28,075,113 (+)NCBIUU_Cfam_GSD_1.0
Bcr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118142,324,235 - 142,465,697 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936619288,340 - 432,315 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936619288,377 - 432,297 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BCR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1449,208,762 - 49,322,103 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11449,208,662 - 49,322,109 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21452,727,404 - 52,771,825 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BCR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1192,569,841 - 2,703,703 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl192,566,190 - 2,702,920 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660854,423,712 - 4,553,443 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bcr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247479,528,996 - 9,662,131 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247479,528,968 - 9,664,055 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Bcr
4040 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1046
Count of miRNA genes:547
Interacting mature miRNAs:658
Transcripts:ENSMUST00000164107
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302035Lmb4_mlupus in MRL and B6 F2 cross (mouse)Not determined106684818792258673Mouse
1300882Ath17_matherosclerosis 17 (mouse)Not determined105109149085091639Mouse
39128215Lwq17_mliver weight QTL 17 (mouse)101270405184079784Mouse
26884447Sklq9_mskull length QTL 9, 10 week (mouse)1067335830111735905Mouse
11353832Pcholq4_mplasma cholesterol QTL 4 (mouse)1073987216125515907Mouse
4141943W6q6_mweight 6 weeks QTL 6 (mouse)Not determined1270405184079784Mouse
1301787Bsc1_mbrain size control 1 (mouse)Not determined105851696992517096Mouse
27226772Tibl13_mtibia length 13, 10 week (mouse)1018875748129635869Mouse
1357656Hrtq3_mheart weight QTL 3 (mouse)Not determined101270405184079784Mouse
14746991Manh68_mmandible shape 68 (mouse)105228049786280497Mouse
26884426Cvht1_mcranial vault height 1, 5 week (mouse)1024675898121035905Mouse
10045641Jckm3_mjuvenile cystic kidney modifier 3 (mouse)Not determined104984818783848412Mouse
26884424Zlq9_mzygomatic length QTL 9, 16 week (mouse)1063935779115935905Mouse
4142380W3q11_mweight 3 weeks QTL 11 (mouse)Not determined1270405184079784Mouse
27226764Tibl19_mtibia length 19, 16 week (mouse)1039175996129635869Mouse
26884430Zlq5_mzygomatic length QTL 5, 10 week (mouse)1067835830124835905Mouse
1357825Kidpq2_mkidney weight percentage QTL 2 (mouse)Not determined101270405184079784Mouse
1302150Bbaa18_mB.burgdorferi-associated arthritis 18 (mouse)Not determined104933801283338157Mouse
4142313Angvq1_mangiogenesis by VEGF QTL 1 (mouse)Not determined4672040382491121Mouse
1301380Cia8_mcollagen induced arthritis QTL 8 (mouse)Not determined105149340082491121Mouse
1301386Sysbp1_msystolic blood pressure 1 (mouse)Not determined101010826587401095Mouse
1301966Lifespan2_mlife span 2 (mouse)Not determined104984822283848397Mouse
11353843Gluq1_mblood glucose QTL 1 (mouse)1073987216125515907Mouse
1302067Scc9_mcolon tumor susceptibility 9 (mouse)Not determined1018259333125575232Mouse
26884411Bzwq8_mbi-zygomatic width QTL 8, 10 week (mouse)1044876096115935905Mouse
11039497Ltpr5a_mLeishmania tropica response 5a (mouse)1073506901107507047Mouse
4142107Obrq12_mobesity resistance QTL 12 (mouse)Not determined7398721682491121Mouse
1300597Skull14_mskull morphology 14 (mouse)Not determined104984818783848412Mouse
4142169Pbwg16_mpostnatal body weight growth 16 (mouse)Not determined104984818783848412Mouse
1300533Aem3_manti-erythrocyte autoantibody modifier 3 (mouse)Not determined106549093899491121Mouse
26884403Cvht8_mcranial vault height 8, 16 week (mouse)102287589991035862Mouse
26884407Bzwq14_mbi-zygomatic width QTL 14, 16 wee (mouse)1045476096120635905Mouse
1301502Eae17_msusceptibility to experimental allergic encephalomyelitis 17 (mouse)Not determined105109149085091639Mouse
26884405Huml2_mhumerus length 2, 5 week (mouse)1069735830130430862Mouse
4141070Ltgq1_mliver triglyceride QTL 1 (mouse)Not determined4123732675237326Mouse
1558757Eae34_mexperimental allergic encephalomyelitis susceptibility 34 (mouse)Not determined1021408154114217230Mouse
1357740Obsty3_mobesity 3 (mouse)Not determined108235478116190980Mouse
26884450Sklq15_mskull length QTL 15, 16 week (mouse)1059335822122335905Mouse
13208560Wght9_mweight 9 (mouse)1059835822120835905Mouse
27095911Pglq15_mpelvic girdle length QTL 15, 16 week (mouse)1039175996129635869Mouse
1301737Insq9_minsulin QTL 9 (mouse)Not determined106549093899491121Mouse
4141956Egq7_mearly growth QTL 7 (mouse)Not determined1270405184079784Mouse
1357864Scfpq1_msubcutaneous fat pad percentage QTL 1 (mouse)Not determined101270405184079784Mouse
1357737Hpcr2_mhepatocarcinogen resistance 2 (mouse)Not determined104984822283848397Mouse
4142272W10q5_mweight 10 weeks QTL 5 (mouse)Not determined1270405184079784Mouse
1302060El3_mepilepsy 3 (mouse)Not determined106549093899491121Mouse

Markers in Region
AI853148  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381075,182,351 - 75,182,455UniSTSGRCm38
MGSCv371074,645,096 - 74,645,200UniSTSGRCm37
Celera1076,230,678 - 76,230,782UniSTS
Cytogenetic Map10B5.3-C1UniSTS
Whitehead/MRC_RH10855.48UniSTS
AI561783  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381075,184,616 - 75,184,762UniSTSGRCm38
MGSCv371074,647,361 - 74,647,507UniSTSGRCm37
Celera1076,232,943 - 76,233,089UniSTS
Cytogenetic Map10B5.3-C1UniSTS
Whitehead/MRC_RH10857.79UniSTS
Bcr  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381075,062,038 - 75,062,125UniSTSGRCm38
MGSCv371074,524,783 - 74,524,870UniSTSGRCm37
Celera1076,109,905 - 76,109,992UniSTS
Cytogenetic Map10B5.3-C1UniSTS
cM Map1040.5UniSTS
Bcr  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10B5.3-C1UniSTS
cM Map1040.5UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000164107   ⟹   ENSMUSP00000126377
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1074,896,424 - 75,020,753 (+)Ensembl
GRCm38.p6 Ensembl1075,060,592 - 75,184,921 (+)Ensembl
Ensembl Acc Id: ENSMUST00000218057   ⟹   ENSMUSP00000151277
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1075,010,803 - 75,017,050 (+)Ensembl
GRCm38.p6 Ensembl1075,174,971 - 75,181,218 (+)Ensembl
Ensembl Acc Id: ENSMUST00000218465   ⟹   ENSMUSP00000158833
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1075,009,797 - 75,018,614 (+)Ensembl
GRCm38.p6 Ensembl1075,173,965 - 75,182,782 (+)Ensembl
Ensembl Acc Id: ENSMUST00000218591   ⟹   ENSMUSP00000151282
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1074,996,192 - 75,007,380 (+)Ensembl
GRCm38.p6 Ensembl1075,160,360 - 75,171,548 (+)Ensembl
Ensembl Acc Id: ENSMUST00000219807
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1075,012,208 - 75,014,484 (+)Ensembl
GRCm38.p6 Ensembl1075,176,376 - 75,178,652 (+)Ensembl
RefSeq Acc Id: NM_001081412   ⟹   NP_001074881
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391074,896,406 - 75,020,753 (+)NCBI
GRCm381075,060,896 - 75,184,923 (+)NCBI
MGSCv371074,523,641 - 74,647,668 (+)RGD
Celera1076,108,779 - 76,233,250 (+)RGD
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006513060   ⟹   XP_006513123
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391074,896,384 - 75,007,380 (+)NCBI
GRCm381075,060,560 - 75,171,548 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006513061   ⟹   XP_006513124
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391074,966,471 - 75,020,274 (+)NCBI
GRCm381075,129,923 - 75,182,801 (+)NCBI
Sequence:
RefSeq Acc Id: NP_001074881   ⟸   NM_001081412
- UniProtKB: Q99LW5 (UniProtKB/Swiss-Prot),   Q6ZPE5 (UniProtKB/Swiss-Prot),   Q6PAJ1 (UniProtKB/Swiss-Prot),   Q61339 (UniProtKB/Swiss-Prot),   E9PZL3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006513123   ⟸   XM_006513060
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006513124   ⟸   XM_006513061
- Peptide Label: isoform X2
- UniProtKB: A2RRK7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000151277   ⟸   ENSMUST00000218057
Ensembl Acc Id: ENSMUSP00000151282   ⟸   ENSMUST00000218591
Ensembl Acc Id: ENSMUSP00000158833   ⟸   ENSMUST00000218465
Ensembl Acc Id: ENSMUSP00000126377   ⟸   ENSMUST00000164107
Protein Domains
C2   DH   PH   Rho-GAP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6PAJ1-F1-model_v2 AlphaFold Q6PAJ1 1-1270 view protein structure

Promoters
RGD ID:6819051
Promoter ID:MM_KWN:4534
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Liver,   Lung
Transcripts:NM_001081412
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361074,523,306 - 74,524,902 (+)MPROMDB
RGD ID:6846699
Promoter ID:MM_ACW:5125
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:BCR.CSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361074,594,301 - 74,594,801 (+)MPROMDB
RGD ID:6819617
Promoter ID:MM_KWN:4535
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Kidney,   Lung,   Spleen
Transcripts:UC007FQC.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361074,636,156 - 74,636,892 (+)MPROMDB
RGD ID:8672294
Promoter ID:EPDNEW_M14177
Type:single initiation site
Name:Bcr_1
Description:Mus musculus breakpoint cluster region , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381075,173,974 - 75,174,034EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:88141 AgrOrtholog
Ensembl Genes ENSMUSG00000009681 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000164107 ENTREZGENE
  ENSMUST00000164107.3 UniProtKB/Swiss-Prot
  ENSMUST00000218057.2 UniProtKB/TrEMBL
  ENSMUST00000218465.2 UniProtKB/TrEMBL
  ENSMUST00000218591.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.555.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.900.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.280.30 UniProtKB/Swiss-Prot
InterPro Abr/Bcr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Bcr-Abl_oncoprot_oligo UniProtKB/Swiss-Prot
  Bcr-Abl_oncoprot_oligo_sf UniProtKB/Swiss-Prot
  C2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DBL_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DH-domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GDS_CDC24_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rho_GTPase_activation_prot UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhoGAP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:110279 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:88141 ENTREZGENE
NCBI Gene Bcr ENTREZGENE
PANTHER BREAKPOINT CLUSTER REGION PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23182 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Bcr-Abl_Oligo UniProtKB/Swiss-Prot
  PF00168 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_19 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhoGAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhoGEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Bcr PhenoGen
PROSITE DH_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DH_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50004 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHOGAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RhoGAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhoGEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00233 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00239 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48065 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48350 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49562 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF69036 UniProtKB/Swiss-Prot
UniProt A0A1W2P6I7_MOUSE UniProtKB/TrEMBL
  A0A1W2P6J3_MOUSE UniProtKB/TrEMBL
  A0A571BEM4_MOUSE UniProtKB/TrEMBL
  A2RRK7 ENTREZGENE, UniProtKB/TrEMBL
  BCR_MOUSE UniProtKB/Swiss-Prot
  E9PZL3 ENTREZGENE
  Q61339 ENTREZGENE
  Q6PAJ1 ENTREZGENE
  Q6ZPE5 ENTREZGENE
  Q80UP7_MOUSE UniProtKB/TrEMBL
  Q99LW5 ENTREZGENE
UniProt Secondary E9PZL3 UniProtKB/Swiss-Prot
  Q61339 UniProtKB/Swiss-Prot
  Q6ZPE5 UniProtKB/Swiss-Prot
  Q99LW5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-09-10 Bcr  BCR activator of RhoGEF and GTPase  Bcr  breakpoint cluster region homolog  Symbol and/or name change 5135510 APPROVED
2024-08-21 Bcr  breakpoint cluster region homolog  Bcr  BCR activator of RhoGEF and GTPase  Symbol and/or name change 5135510 APPROVED
2019-10-01 Bcr  BCR activator of RhoGEF and GTPase  Bcr  breakpoint cluster region  Symbol and/or name change 5135510 APPROVED