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Gene: Igh (immunoglobulin heavy chain complex) Mus musculus
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Symbol: Igh
Name: immunoglobulin heavy chain complex
Description: Summary:Immunoglobulins recognize foreign antigens and initiate immune responses such as phagocytosis and the complement system. Each immunoglobulin molecule consists of two identical heavy chains and two identical light chains. This region represents the germline organization of the heavy chain locus. The locus includes V (variable), D (diversity), J (joining), and C (constant) segments. During B cell development, a recombination event at the DNA level joins a single D segment with a J segment; this partially rearranged D-J gene is then joined to a V segment. The rearranged V-D-J is then transcribed with the IGHM constant region; this transcript encodes a mu heavy chain. Later in development B cells generate V-D-J-Cmu-Cdelta pre-messenger RNA, which is alternatively spliced to encode either a mu or a delta heavy chain. Mature B cells in the lymph nodes undergo switch recombination, so that the V-D-J gene is brought in proximity to one of the IGHG, IGHA, or IGHE genes and each cell expresses either the gamma, alpha, or epsilon heavy chain. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase, and by somatic hypermutation, which occurs during B cell maturation in the spleen and lymph nodes. The RefSeq represents the IGH locus from C57BL/6. Several V and D segments in C57BL/6 are known to be incapable of encoding a protein and are considered pseudogenes. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: MGC102661; MGC102662; MGC103226; MGC118125; MGC28019; MGC36307; MGC6486; MGC6522; MGC6529; MGC6628; MGC6740; MGC68276; MGC68378
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3812113,258,768 - 116,009,954 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3712114,496,979 - 117,248,165 (-)NCBIGRCm37mm9NCBIm37
MGSCv3612108,946,391 - 108,949,024 (-)NCBImm8
MGSCv3612115,119,707 - 115,122,340 (-)NCBImm8
Cytogenetic Map12F1-F2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Position Markers
QTLs in Region (GRCm38)

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Igh
Alliance Gene
NCBI Gene
Ensembl Gene
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MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1615753
Created: 2007-04-30
Species: Mus musculus
Last Modified: 2020-02-11
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.