Mgl2 (macrophage galactose N-acetyl-galactosamine specific lectin 2) - Rat Genome Database

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Gene: Mgl2 (macrophage galactose N-acetyl-galactosamine specific lectin 2) Mus musculus
Analyze
No known orthologs.
Symbol: Mgl2
Name: macrophage galactose N-acetyl-galactosamine specific lectin 2
RGD ID: 1615709
MGI Page MGI
Description: Enables carbohydrate binding activity. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including hemolymphoid system gland; ileum; liver; lung; and male reproductive gland or organ. Orthologous to human CLEC10A (C-type lectin domain containing 10A).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CD301b; macrophage galactose-type C-type lectin 2; MGC123660; MGC123939; MGC124077
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391170,020,953 - 70,028,368 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1170,021,155 - 70,028,376 (+)EnsemblGRCm39 Ensembl
GRCm381170,130,125 - 70,137,542 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1170,130,329 - 70,137,550 (+)EnsemblGRCm38mm10GRCm38
MGSCv371169,943,859 - 69,951,044 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361169,946,615 - 69,953,745 (+)NCBIMGSCv36mm8
Celera1177,679,287 - 77,686,471 (+)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1142.99NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Mouse MP Annotation Import Pipeline RGD automated import pipeline
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12016228   PMID:12466851   PMID:12477932   PMID:14610273   PMID:15591125   PMID:16141072   PMID:16141073   PMID:18053814  
PMID:19162326   PMID:19440334   PMID:20304916   PMID:21267068   PMID:21677750   PMID:21873635   PMID:24076051   PMID:24194600   PMID:25680275   PMID:26377898   PMID:26999763   PMID:27287183  
PMID:27287257   PMID:27566941   PMID:27626380   PMID:27657168   PMID:27732846   PMID:28132857   PMID:28611041   PMID:29038008   PMID:29138056   PMID:29386201   PMID:32424366   PMID:33098765  
PMID:34144098   PMID:34375000   PMID:34890253   PMID:35069539   PMID:36271272   PMID:37198150  


Genomics

Variants

.
Variants in Mgl2
5 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:660
Count of miRNA genes:355
Interacting mature miRNAs:387
Transcripts:ENSMUST00000041550, ENSMUST00000108584, ENSMUST00000132645, ENSMUST00000147502, ENSMUST00000165951
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113589082784890826Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113628257783481356Mouse
1301788Lbw8_mlupus NZB x NZW 8 (mouse)Not determined113650328770509492Mouse
1301896Tria1_mT-cell receptor induced activation 1 (mouse)Not determined113661356570613855Mouse
4141853Skmw17_mskeletal muscle weight 17 (mouse)Not determined113708094171081064Mouse
10766457Nwa3_mNew Zealand White autoimmunity 3 (mouse)113801611572016209Mouse
11532698Sluc36a_msusceptibility to lung cancer 36a (mouse)114225661776256730Mouse
11532699Sluc36b_msusceptibility to lung cancer 36b (mouse)114225661776256730Mouse
4142300Ctrq3_mC. trachomatis resistance QTL 3 (mouse)Not determined114463003876854757Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
1302021Nidd1n_mnon-insulin-dependent diabetes mellitus 1 in NSY (mouse)Not determined114516587379978324Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114570858189818733Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114618516780185262Mouse
1301988Bmd11_mbone mineral density 11 (mouse)Not determined114631940780319522Mouse
1301830Ssta4_msusceptibility to Salmonella typhimurium antigens 4 (mouse)Not determined115007819184078411Mouse
13524840Ppiq9a_mprepulse inhibition QTL 9a (mouse)115249438586494385Mouse
1300774Pgia7_mproteoglycan induced arthritis 7 (mouse)Not determined115339058887390737Mouse
4141830Pregq1_mpregnancy QTL 1 (mouse)Not determined115412675283733652Mouse
4141875Etax9_methanol induced ataxia 9 (mouse)Not determined5528498572209927Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
1300664Etohcta9_methanol conditioned taste aversion 9 (mouse)Not determined115775466091754758Mouse
10053682Eae45_mexperimental allergic encephalomyelitis susceptibility 45 (mouse)Not determined115849055574754758Mouse
1300924Ity2_mimmunity to S. typhimurium 2 (mouse)Not determined15850803087695238Mouse
4141982Skts-fp2_mskin tumor susceptibility in FVB and PWK 2 (mouse)Not determined5871926685066529Mouse
1301987Pid3_mprior incubation determinant 3 (mouse)Not determined116168682088699728Mouse
1301319Dautb4_mdopamine uptake transporter binding 4 (mouse)Not determined116215600596156153Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162590826109390826Mouse
1301999Lmr15_mleishmaniasis resistance 15 (mouse)Not determined116331940781830473Mouse
10044004Stzid3_mstreptozotocin induced diabetes susceptibility 3 (mouse)Not determined116331940794063918Mouse
11039502Ltpr6b_mLeishmania tropica response 6b (mouse)116483033698830473Mouse
11039501Ltpr6a_mLeishmania tropica response 6a (mouse)116483033698830473Mouse
11039515Ltpr6_mLeishmania tropica response 6 (mouse)116483033698830473Mouse
1357766Si5lq6_mserum IGFBP-5 level QTL 6 (mouse)Not determined1166733420100733652Mouse
1301546Pcir2_mperiosteal circumference 2 (mouse)Not determined1166733420100733652Mouse
1301833Tbbmd5_mtotal body bone mineral density 5 (mouse)Not determined1166733420100733652Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166733420100733652Mouse
4141012Femwf6_mfemur work to failure 6 (mouse)Not determined66733420100733652Mouse
1300784Prdt3_mprion disease incubation time 3 (mouse)Not determined1166733420100733652Mouse
4142316Ity2b_mimmunity to S. typhimurium 2b (mouse)Not determined116707819179813912Mouse
27226783Tibl5_mtibia length 5, 5 week (mouse)1168190826101890826Mouse
36049778Ars6_mantibody response to SARS-CoV 6, day 15, IgM (mouse)116899082672490826Mouse
36049779Ars7_mantibody response to SARS-CoV 7, day 29, IgG1 (mouse)116899082672490826Mouse
36049784Ars8_mantibody response to SARS-CoV 8, day 29, IgG2a+IgG2c (mouse)116899082672490826Mouse
36049785Ars9_mantibody response to SARS-CoV 9, day 29, IgM (mouse)116899082672490826Mouse
36049786Ars10_mantibody response to SARS-CoV 10, 4 days post-rechallenge, IgG2a+IgG2c (mouse)116899082672490826Mouse
36049787Ars11_mantibody response to SARS-CoV 11, 4 days post-rechallenge, IgM (mouse)116899082672490826Mouse
36049788Ars1_mantibody response to SARS-CoV 1, day 7, IgG1 (mouse)116899082672490826Mouse
36049789Ars2_mantibody response to SARS-CoV 2, day 7, IgG2a+IgG2c (mouse)116899082672490826Mouse
36049790Ars3_mantibody response to SARS-CoV 3, day 7, IgG2b (mouse)116899082672490826Mouse
36049791Ars4_mantibody response to SARS-CoV 4, day 7, IgG3 (mouse)116899082672490826Mouse
36049792Ars5_mantibody response to SARS-CoV 5, day 7, IgM (mouse)116899082672490826Mouse
35673314Ari2_mantibody response to influenza 2, day 10, IgG3 (mouse)116899082672490826Mouse

Markers in Region
Mgl2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381170,135,796 - 70,137,100UniSTSGRCm38
Celera1177,684,725 - 77,686,029UniSTS
Cytogenetic Map11B3UniSTS
cM Map1142.99UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_145137 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006532912 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006532913 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006532914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006532915 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017314459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK085751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL596185 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL669869 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY103461 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY103462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC106833 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC110475 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC111520 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY198732 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY544307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR933542 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU010011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000041550   ⟹   ENSMUSP00000048568
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1170,021,155 - 70,028,376 (+)Ensembl
GRCm38.p6 Ensembl1170,130,329 - 70,137,550 (+)Ensembl
RefSeq Acc Id: ENSMUST00000108584   ⟹   ENSMUSP00000104225
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1170,024,999 - 70,028,121 (+)Ensembl
GRCm38.p6 Ensembl1170,134,173 - 70,137,295 (+)Ensembl
RefSeq Acc Id: ENSMUST00000132645
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1170,021,236 - 70,025,270 (+)Ensembl
GRCm38.p6 Ensembl1170,130,410 - 70,134,444 (+)Ensembl
RefSeq Acc Id: ENSMUST00000147502
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1170,024,920 - 70,027,058 (+)Ensembl
GRCm38.p6 Ensembl1170,134,094 - 70,136,232 (+)Ensembl
RefSeq Acc Id: ENSMUST00000165951   ⟹   ENSMUSP00000131344
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1170,021,250 - 70,028,374 (+)Ensembl
GRCm38.p6 Ensembl1170,130,424 - 70,137,548 (+)Ensembl
RefSeq Acc Id: NM_145137   ⟹   NP_660119
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391170,021,183 - 70,028,368 (+)NCBI
GRCm381170,130,357 - 70,137,542 (+)NCBI
MGSCv371169,943,859 - 69,951,044 (+)RGD
Celera1177,679,287 - 77,686,471 (+)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006532912   ⟹   XP_006532975
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391170,020,953 - 70,028,129 (+)NCBI
GRCm381170,130,125 - 70,137,303 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006532913   ⟹   XP_006532976
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391170,020,953 - 70,028,129 (+)NCBI
GRCm381170,130,126 - 70,137,303 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006532914   ⟹   XP_006532977
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391170,025,074 - 70,028,129 (+)NCBI
GRCm381170,134,244 - 70,137,303 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006532915   ⟹   XP_006532978
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391170,020,955 - 70,028,129 (+)NCBI
GRCm381170,130,127 - 70,137,303 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017314459   ⟹   XP_017169948
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391170,025,056 - 70,028,129 (+)NCBI
GRCm381170,134,230 - 70,137,303 (+)NCBI
Sequence:
RefSeq Acc Id: NP_660119   ⟸   NM_145137
- UniProtKB: Q8JZN1 (UniProtKB/TrEMBL),   F6QSC4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006532975   ⟸   XM_006532912
- Peptide Label: isoform X1
- UniProtKB: A9XX86 (UniProtKB/TrEMBL),   F6QSC4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006532976   ⟸   XM_006532913
- Peptide Label: isoform X2
- UniProtKB: F6QSC4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006532978   ⟸   XM_006532915
- Peptide Label: isoform X5
- UniProtKB: F6QSC4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006532977   ⟸   XM_006532914
- Peptide Label: isoform X3
- UniProtKB: Q8BUD5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017169948   ⟸   XM_017314459
- Peptide Label: isoform X4
- UniProtKB: Q8BUD5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000104225   ⟸   ENSMUST00000108584
RefSeq Acc Id: ENSMUSP00000131344   ⟸   ENSMUST00000165951
RefSeq Acc Id: ENSMUSP00000048568   ⟸   ENSMUST00000041550
Protein Domains
C-type lectin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A9XX86-F1-model_v2 AlphaFold A9XX86 1-381 view protein structure

Promoters
RGD ID:8675290
Promoter ID:EPDNEW_M15674
Type:multiple initiation site
Name:Mgl2_1
Description:Mus musculus macrophage galactose N-acetyl-galactosamine specificlectin 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M15675  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381170,130,400 - 70,130,460EPDNEW
RGD ID:8675288
Promoter ID:EPDNEW_M15675
Type:multiple initiation site
Name:Mgl2_2
Description:Mus musculus macrophage galactose N-acetyl-galactosamine specificlectin 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M15674  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381170,133,641 - 70,133,701EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2385729 AgrOrtholog
Ensembl Genes ENSMUSG00000040950 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000041550 ENTREZGENE
  ENSMUST00000041550.12 UniProtKB/TrEMBL
  ENSMUST00000108584 ENTREZGENE
  ENSMUST00000108584.2 UniProtKB/TrEMBL
  ENSMUST00000165951 ENTREZGENE
  ENSMUST00000165951.8 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.1490 UniProtKB/TrEMBL
  3.10.100.10 UniProtKB/TrEMBL
InterPro C-type_lectin UniProtKB/TrEMBL
  C-type_lectin-like UniProtKB/TrEMBL
  C-type_lectin_CS UniProtKB/TrEMBL
  C-type_lectin_fold UniProtKB/TrEMBL
  CD209-like_CTLD UniProtKB/TrEMBL
KEGG Report mmu:216864 UniProtKB/TrEMBL
MGD MGI:2385729 ENTREZGENE
NCBI Gene 216864 ENTREZGENE
PANTHER C-TYPE LECTIN DOMAIN FAMILY 10 MEMBER A-RELATED UniProtKB/TrEMBL
  C-TYPE LECTIN SUPERFAMILY MEMBER UniProtKB/TrEMBL
  MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED UniProtKB/TrEMBL
  REGENERATING ISLET-DERIVED PROTEIN 3-GAMMA UniProtKB/TrEMBL
Pfam Lectin_C UniProtKB/TrEMBL
  Lectin_N UniProtKB/TrEMBL
PhenoGen Mgl2 PhenoGen
PROSITE C_TYPE_LECTIN_1 UniProtKB/TrEMBL
  C_TYPE_LECTIN_2 UniProtKB/TrEMBL
SMART CLECT UniProtKB/TrEMBL
Superfamily-SCOP C-type_lectin_fold UniProtKB/TrEMBL
UniProt A9XX86 ENTREZGENE, UniProtKB/TrEMBL
  F6QSC4 ENTREZGENE, UniProtKB/TrEMBL
  Q8BUD5 ENTREZGENE, UniProtKB/TrEMBL
  Q8JZN1 ENTREZGENE, UniProtKB/TrEMBL