Cytl1 (cytokine-like 1) - Rat Genome Database

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Gene: Cytl1 (cytokine-like 1) Mus musculus
Analyze
Symbol: Cytl1
Name: cytokine-like 1
RGD ID: 1615683
MGI Page MGI
Description: Acts upstream of or within several processes, including cartilage homeostasis; chondrocyte differentiation; and regulation of DNA-templated transcription. Is expressed in several structures, including forelimb; gut; respiratory system; sensory organ; and skeleton. Orthologous to human CYTL1 (cytokine like 1).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 4930443F05Rik; 4Cytl1; C17; Cyt1; cytokine like 1; cytokine-like protein 1; Gm147
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39537,892,863 - 37,897,164 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl537,892,863 - 37,897,164 (+)EnsemblGRCm39 Ensembl
GRCm38537,735,519 - 37,739,820 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl537,735,519 - 37,739,820 (+)EnsemblGRCm38mm10GRCm38
MGSCv37538,126,758 - 38,131,059 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36538,023,768 - 38,028,069 (+)NCBIMGSCv36mm8
Celera535,191,397 - 35,195,691 (+)NCBICelera
Cytogenetic Map5B3NCBI
cM Map520.21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Mouse MP Annotation Import Pipeline RGD automated import pipeline
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:15031101   PMID:16141072   PMID:16141073   PMID:16602821   PMID:17644814   PMID:20562862  
PMID:21267068   PMID:21652695   PMID:21795542   PMID:21799806   PMID:21873635   PMID:24738827   PMID:26273529   PMID:27835665   PMID:30718470   PMID:31823178   PMID:32736681  


Genomics

Comparative Map Data
Cytl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39537,892,863 - 37,897,164 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl537,892,863 - 37,897,164 (+)EnsemblGRCm39 Ensembl
GRCm38537,735,519 - 37,739,820 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl537,735,519 - 37,739,820 (+)EnsemblGRCm38mm10GRCm38
MGSCv37538,126,758 - 38,131,059 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36538,023,768 - 38,028,069 (+)NCBIMGSCv36mm8
Celera535,191,397 - 35,195,691 (+)NCBICelera
Cytogenetic Map5B3NCBI
cM Map520.21NCBI
CYTL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3845,014,586 - 5,019,458 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl45,014,586 - 5,019,458 (-)EnsemblGRCh38hg38GRCh38
GRCh3745,016,313 - 5,021,185 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3645,067,214 - 5,072,098 (-)NCBINCBI36Build 36hg18NCBI36
Build 3445,134,387 - 5,139,269NCBI
Celera44,913,525 - 4,918,414 (-)NCBICelera
Cytogenetic Map4p16.2NCBI
HuRef44,952,728 - 4,957,617 (-)NCBIHuRef
CHM1_145,014,307 - 5,019,195 (-)NCBICHM1_1
T2T-CHM13v2.044,984,228 - 4,989,105 (-)NCBIT2T-CHM13v2.0
Cytl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81477,278,635 - 77,283,645 (-)NCBIGRCr8
mRatBN7.21473,053,876 - 73,058,886 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1473,053,877 - 73,058,886 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1477,508,028 - 77,513,034 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01478,748,888 - 78,753,890 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01475,189,427 - 75,194,462 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01477,805,137 - 77,810,147 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1477,805,130 - 77,810,147 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01477,783,865 - 77,788,875 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41478,349,878 - 78,354,888 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1472,016,197 - 72,021,228 (-)NCBICelera
Cytogenetic Map14q21NCBI
Cytl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555144,826,755 - 4,831,951 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555144,826,792 - 4,831,424 (+)NCBIChiLan1.0ChiLan1.0
CYTL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v235,280,955 - 5,286,058 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan145,214,116 - 5,219,213 (-)NCBINHGRI_mPanPan1
PanPan1.145,092,567 - 5,097,456 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl45,092,144 - 5,098,092 (-)Ensemblpanpan1.1panPan2
CYTL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1370,354,099 - 70,358,521 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl370,354,090 - 70,359,128 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha372,904,811 - 72,909,240 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0371,113,282 - 71,117,712 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl371,113,283 - 71,117,907 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1370,384,321 - 70,388,747 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0370,544,734 - 70,549,165 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0370,929,545 - 70,933,976 (-)NCBIUU_Cfam_GSD_1.0
Cytl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528563,807,132 - 63,813,091 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647717,508,823 - 17,512,663 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647717,508,833 - 17,512,608 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYTL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl85,455,671 - 5,460,861 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.185,455,576 - 5,460,861 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.285,266,914 - 5,272,133 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CYTL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12741,187,925 - 41,192,768 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2741,187,828 - 41,192,690 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604787,982,211 - 87,987,014 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cytl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475521,968,570 - 21,973,397 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475521,968,360 - 21,972,986 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cytl1
330 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:213
Count of miRNA genes:168
Interacting mature miRNAs:189
Transcripts:ENSMUST00000073554
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
36049766Ars22_mantibody response to SARS-CoV 22, day 29, IgG3 (mouse)53695734445457342Mouse
4140990Lgq6_mlate growth QTL 6 (mouse)Not determined32133234100777931Mouse
36049767Ars23_mantibody response to SARS-CoV 23, day 29, Total IgG (mouse)53695734445457342Mouse
10043995Hbnr9_mHeligmosomoides bakeri nematode resistance 9 (mouse)Not determined53348866767488876Mouse
1301776Skts3_mskin tumor susceptibility 3 (mouse)Not determined52166729555667403Mouse
1301845Lxw4_mlupus BXSB x NZW 4 (mouse)Not determined53569446269694594Mouse
1301524Lmb2_mlupus in MRL and B6 F2 cross (mouse)Not determined537581488112465722Mouse
1301403Alcp9_malcohol preference locus 9 (mouse)Not determined53102427565024480Mouse
36049774Ars16_mantibody response to SARS-CoV 16, day 7, Total IgG (mouse)53695734445457342Mouse
36049775Ars17_mantibody response to SARS-CoV 17, day 15, IgG2a+IgG2c (mouse)53695734445457342Mouse
36049772Ars20_mantibody response to SARS-CoV 20, day 15, Total IgG (mouse)53695734445457342Mouse
36049773Ars21_mantibody response to SARS-CoV 21, day 29, IgG2a+IgG2c (mouse)53695734445457342Mouse
36049770Ars14_mantibody response to SARS-CoV 14, day 7, IgG3 (mouse)53695734445457342Mouse
36049771Ars15_mantibody response to SARS-CoV 15, day 7, IgM (mouse)53695734445457342Mouse
1300701Cd8ts1_mCD8 T cell subset 1 (mouse)Not determined52721534861215451Mouse
11353827Hplq1_mhot plate latency 1 (mouse)53157045865570458Mouse
36049768Ars24_mantibody response to SARS-CoV 24, 4 days post-rechallenge, IgG3 (mouse)53695734445457342Mouse
36049769Ars13_mantibody response to SARS-CoV 13, day 7, IgG2a+IgG2c (mouse)53695734445457342Mouse
36049776Ars18_mantibody response to SARS-CoV 18, day 15, IgG3 (mouse)53695734445457342Mouse
36049777Ars19_mantibody response to SARS-CoV 19, day 15, IgM (mouse)53695734445457342Mouse
4141219W10q16_mweight 10 weeks QTL 16 (mouse)Not determined32133234100777931Mouse
1301555Alcp10_malcohol preference locus 10 (mouse)Not determined53102427565024480Mouse
1301170Lith13_mlithogenic gene 13 (mouse)Not determined53649448670494598Mouse
1301685Estq2_mestradiol regulated response QTL 2 (mouse)Not determined51563408449634190Mouse
11537367Hmtb11_mhemostasis and thrombosis 11 (mouse)52210082364806579Mouse
4141207Imrfq1_mimmune response to Factor IX QTL 1 (mouse)Not determined5812411742124239Mouse
11537368Hmtb10_mhemostasis and thrombosis 10 (mouse)52210082354500318Mouse
1300926Hpi2_mhepatic PMN infiltration 2 (mouse)Not determined53758148864806579Mouse
1301693Sle6_msystemic lupus erythematosus susceptibility 6 (mouse)Not determined5889069387841837Mouse
4141647Hrvhf1_mheart rate variability, high frequency 1 (mouse)Not determined3643342370433423Mouse
11049561Lmr24e_mleishmaniasis resistance 24e (mouse)53569446269694594Mouse
13464252Ahl10_mage related hearing loss, early onset 10 (mouse)53585456869854714Mouse
1357478Kdnw1_mkidney weight 1 (mouse)Not determined5891594940529869Mouse
1301223Hdlq7_mHDL QTL 7 (mouse)Not determined53585456869854714Mouse
11341716Rvfs3_mRift Valley fever susceptibility 3 (mouse)526441234138455402Mouse
14696730Kidlq1_mkidney weight, left QTL 1 (mouse)51356315247563152Mouse
13464246Ahl11_mage related hearing loss, early onset 11 (mouse)53764377771643896Mouse
1300719Iba5_minduction of brown adipocytes 5 (mouse)Not determined52068699354687134Mouse
1301806Actd2_mactivity-distance traveled 2 (mouse)Not determined5538452039384652Mouse
11049558Lmr24b_mleishmaniasis resistance 24b (mouse)53569446269694594Mouse
35673310Ari4_mantibody response to influenza 4, day 15-45, IgG2b (mouse)53695734445457342Mouse
11049559Lmr24c_mleishmaniasis resistance 24c (mouse)53569446269694594Mouse

Markers in Region
Cytl1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
cM Map5 UniSTS
cM Map5 UniSTS
Cytl1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5B3UniSTS
cM Map5 UniSTS
Cytl1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5B3UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000073554   ⟹   ENSMUSP00000073244
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl537,892,863 - 37,897,164 (+)Ensembl
GRCm38.p6 Ensembl537,735,519 - 37,739,820 (+)Ensembl
Ensembl Acc Id: ENSMUST00000201048
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl537,894,624 - 37,897,159 (+)Ensembl
GRCm38.p6 Ensembl537,737,280 - 37,739,815 (+)Ensembl
RefSeq Acc Id: NM_001081106   ⟹   NP_001074575
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39537,892,863 - 37,897,164 (+)NCBI
GRCm38537,735,519 - 37,739,820 (+)ENTREZGENE
MGSCv37538,126,758 - 38,131,059 (+)RGD
Celera535,191,397 - 35,195,691 (+)RGD
cM Map5 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_001074575 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH63103 (Get FASTA)   NCBI Sequence Viewer  
  AAI16225 (Get FASTA)   NCBI Sequence Viewer  
  AAI16226 (Get FASTA)   NCBI Sequence Viewer  
  ABL07597 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000073244
  ENSMUSP00000073244.4
RefSeq Acc Id: NP_001074575   ⟸   NM_001081106
- Peptide Label: precursor
- UniProtKB: A1E5L0 (UniProtKB/TrEMBL),   Q6P536 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000073244   ⟸   ENSMUST00000073554

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A1E5L0-F1-model_v2 AlphaFold A1E5L0 1-139 view protein structure

Promoters
RGD ID:6886606
Promoter ID:EPDNEW_M6736
Type:multiple initiation site
Name:Cytl1_1
Description:Mus musculus cytokine-like 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38537,735,538 - 37,735,598EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2684993 AgrOrtholog
Ensembl Genes ENSMUSG00000062329 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000073554 ENTREZGENE
  ENSMUST00000073554.4 UniProtKB/TrEMBL
InterPro CYTL1 UniProtKB/TrEMBL
KEGG Report mmu:231162 UniProtKB/TrEMBL
MGD MGI:2684993 ENTREZGENE
NCBI Gene 231162 ENTREZGENE
PANTHER CYTOKINE-LIKE PROTEIN 1 UniProtKB/TrEMBL
  PTHR15974 UniProtKB/TrEMBL
Pfam CYTL1 UniProtKB/TrEMBL
PhenoGen Cytl1 PhenoGen
UniProt A1E5L0 ENTREZGENE, UniProtKB/TrEMBL
  Q0VG51_MOUSE UniProtKB/TrEMBL
  Q6P536 ENTREZGENE, UniProtKB/TrEMBL