Fsip2 (fibrous sheath-interacting protein 2) - Rat Genome Database

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Gene: Fsip2 (fibrous sheath-interacting protein 2) Mus musculus
Analyze
Symbol: Fsip2
Name: fibrous sheath-interacting protein 2
RGD ID: 1615650
MGI Page MGI
Description: Predicted to act upstream of or within with a positive effect on protein localization to cilium and sperm axoneme assembly. Located in mitochondrion. Human ortholog(s) of this gene implicated in spermatogenic failure 34. Orthologous to human FSIP2 (fibrous sheath interacting protein 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: fibrous sheath-interacting protein 2-like
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39282,773,978 - 82,839,281 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl282,773,978 - 82,839,281 (+)EnsemblGRCm39 Ensembl
GRCm38282,943,634 - 83,008,937 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl282,943,634 - 83,008,937 (+)EnsemblGRCm38mm10GRCm38
MGSCv37282,783,797 - 82,849,094 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36282,775,717 - 82,809,716 (+)NCBIMGSCv36mm8
Celera284,586,210 - 84,651,534 (+)NCBICelera
Cytogenetic Map2DNCBI
cM Map249.08NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12606363   PMID:16141072   PMID:18614015   PMID:21267068   PMID:32325033   PMID:34125190  


Genomics

Comparative Map Data
Fsip2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39282,773,978 - 82,839,281 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl282,773,978 - 82,839,281 (+)EnsemblGRCm39 Ensembl
GRCm38282,943,634 - 83,008,937 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl282,943,634 - 83,008,937 (+)EnsemblGRCm38mm10GRCm38
MGSCv37282,783,797 - 82,849,094 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36282,775,717 - 82,809,716 (+)NCBIMGSCv36mm8
Celera284,586,210 - 84,651,534 (+)NCBICelera
Cytogenetic Map2DNCBI
cM Map249.08NCBI
FSIP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382185,737,134 - 185,833,290 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2185,738,804 - 185,833,290 (+)EnsemblGRCh38hg38GRCh38
GRCh372186,603,531 - 186,698,017 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362186,378,006 - 186,406,262 (+)NCBINCBI36Build 36hg18NCBI36
Build 342186,435,772 - 186,456,782RGD
Celera2180,199,128 - 180,293,792 (+)NCBICelera
Cytogenetic Map2q32.1NCBI
HuRef2178,463,445 - 178,558,017 (+)NCBIHuRef
CHM1_12186,609,231 - 186,703,883 (+)NCBICHM1_1
T2T-CHM13v2.02186,226,199 - 186,322,363 (+)NCBIT2T-CHM13v2.0
Fsip2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8388,369,218 - 88,439,756 (+)NCBIGRCr8
mRatBN7.2367,962,345 - 68,032,866 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl367,962,360 - 68,032,868 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0370,285,181 - 70,356,568 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl370,285,219 - 70,356,568 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0376,820,189 - 76,892,139 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4366,015,429 - 66,068,760 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera367,361,512 - 67,431,121 (+)NCBICelera
Cytogenetic Map3q24NCBI
Fsip2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540312,261,208 - 12,334,754 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540312,261,233 - 12,334,754 (-)NCBIChiLan1.0ChiLan1.0
FSIP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21388,402,843 - 88,502,342 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B88,417,823 - 88,517,322 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B73,019,091 - 73,112,974 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B190,821,633 - 190,915,433 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B190,864,813 - 190,915,369 (+)Ensemblpanpan1.1panPan2
FSIP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13628,196,668 - 28,271,660 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3628,196,493 - 28,271,662 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3628,093,889 - 28,168,700 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03628,422,463 - 28,497,082 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3628,422,370 - 28,497,175 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13628,477,094 - 28,554,724 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03628,411,024 - 28,485,830 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03628,583,085 - 28,657,938 (+)NCBIUU_Cfam_GSD_1.0
Fsip2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303145,316,975 - 145,398,264 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493650611,439,867 - 11,521,025 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FSIP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1590,901,868 - 91,001,297 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11590,902,067 - 91,000,873 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215100,859,189 - 100,943,212 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FSIP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11071,304,678 - 71,397,762 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1071,305,374 - 71,397,698 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040128,109,852 - 128,202,711 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Fsip2
2008 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:282
Count of miRNA genes:230
Interacting mature miRNAs:239
Transcripts:ENSMUST00000132967, ENSMUST00000136202, ENSMUST00000143764
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301769Orgwq2_morgan weight QTL 2 (mouse)Not determined2388712693421651Mouse
1357881Estoq1_membryo survival total QTL 1 (mouse)Not determined220897778118894840Mouse
1357454Kidq1_mkidney weight QTL 1 (mouse)Not determined220897778118894840Mouse
1357436Splq1_mspleen weight QTL 1 (mouse)Not determined220897778118894840Mouse
39128209Lwq14_mliver weight QTL 14 (mouse)220897778118894840Mouse
1558899Egq1_mearly growth QTL 1 (mouse)Not determined220897778118894840Mouse
1558966W10q9_mweight 10 weeks QTL 9 (mouse)Not determined220897778118894840Mouse
1558915W3q1_mweight 3 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
1558738W6q1_mweight 6 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
1357681Hrtq1_mheart weight QTL 1 (mouse)Not determined220897778118894840Mouse
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224224632148700377Mouse
1300577Capsq1_mcapsaicin sensitivity related QTL 1 (mouse)Not determined22760206084013384Mouse
4141854T2dm2sa_mtype 2 diabetes mellitus 2 in SMXA RI mice (mouse)Not determined229307947148374934Mouse
4141236Hbnr5_mHeligmosomoides bakeri nematode resistance 5 (mouse)Not determined31214567105143570Mouse
1301109Dntcs2_mdental caries susceptibility 2 (mouse)Not determined240885493114910165Mouse
1301344Lith1_mlithogenic gene 1 (mouse)Not determined245347635145312647Mouse
10755526Lymph1_mlymphocyte differential 1 (mouse)25081931484819314Mouse
1300875Taste1_mtaste-saccharin preference 1 (mouse)Not determined25092317584923278Mouse
1300761Lgth1_mbody length 1 (mouse)Not determined25170327685703425Mouse
13464141Hbbcq3_mhemoglobin concentration QTL 3 (mouse)25244801986448136Mouse
13463471Hctq6_mhematocrit QTL 6 (mouse)25244801986448136Mouse
4141406Alpq2_malcohol preference QTL 2 (mouse)Not determined25752411791524288Mouse
12738429Lfibq18_mliver fibrosis QTL 18 (mouse)25791999191919991Mouse
1357577Trmq3_mT cell ratio modifier QTL 3 (mouse)Not determined260520612119355518Mouse
13824983Vclq1_mcurvilinear velocity QTL 1 (mouse)261830344136841920Mouse
10044002Hdl7_mHDL level 7 (mouse)Not determined26300595497006113Mouse
10053681Lith24_mlithogenic gene 24 (mouse)Not determined26300595497006113Mouse
1301405Etohr_methanol response acute (mouse)Not determined26300595497006113Mouse
1301703Bomd3_mbone mineral density 3 (mouse)Not determined26300595497006113Mouse
1300662Etohila_methanol induced locomotor activity (mouse)Not determined26300595497006113Mouse
1301048Actre2_mactivity response to ethanol 2 (mouse)Not determined26300595497006113Mouse
1301873Hsl1_mhyperoxia susceptibility locus 1 (mouse)Not determined26357015497570301Mouse
5491197Mobq5_mmultigenic obesity QTL 5 (mouse)Not determined265269746162518926Mouse
1301660Iba1_minduction of brown adipocytes 1 (mouse)Not determined267647887101648142Mouse
13463482Mchq17_mmean corpuscular hemoglobin QTL 17 (mouse)267647887101648142Mouse
1301882Etohc2_methanol consumption 2 (mouse)Not determined268724269102724407Mouse
1301948Elsgp3_melevated serum gp70 3 (mouse)Not determined268724269102724407Mouse
4142088Parms1_mpatched associated RMS 1 (mouse)Not determined74524117114123532Mouse
11528549Sluc31_msusceptibility to lung cancer 31 (mouse)274524117129213005Mouse
1301374Cplaq7_mcircadian period of locomotor activity 7 (mouse)Not determined276421483110421651Mouse
4141657Mohg1_mmodifier of hg 1 (mouse)Not determined276678758103095823Mouse
10043894Bw22_mbody weight QTL 22 (mouse)Not determined280895334114895334Mouse
15092054Egrme5_mearly growth rate, maternal effect 5 (mouse)282190187118004745Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000132967   ⟹   ENSMUSP00000122350
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl282,811,140 - 82,839,281 (+)Ensembl
GRCm38.p6 Ensembl282,980,796 - 83,008,937 (+)Ensembl
RefSeq Acc Id: ENSMUST00000136202   ⟹   ENSMUSP00000114196
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl282,779,844 - 82,795,834 (+)Ensembl
GRCm38.p6 Ensembl282,949,500 - 82,965,490 (+)Ensembl
RefSeq Acc Id: ENSMUST00000143764   ⟹   ENSMUSP00000120314
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl282,773,978 - 82,839,281 (+)Ensembl
GRCm38.p6 Ensembl282,943,634 - 83,008,937 (+)Ensembl
RefSeq Acc Id: NM_001370266   ⟹   NP_001357195
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39282,773,978 - 82,839,281 (+)NCBI
GRCm38282,943,634 - 83,008,937 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001357195 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein A2ARZ3 (Get FASTA)   NCBI Sequence Viewer  
  AAM18538 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000114196.2
  ENSMUSP00000120314
  ENSMUSP00000120314.3
  ENSMUSP00000122350.2
Reference Protein Sequences
RefSeq Acc Id: NP_001357195   ⟸   NM_001370266
- UniProtKB: A2ARZ3 (UniProtKB/Swiss-Prot),   A2ARZ1 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: ENSMUSP00000120314   ⟸   ENSMUST00000143764
RefSeq Acc Id: ENSMUSP00000122350   ⟸   ENSMUST00000132967
RefSeq Acc Id: ENSMUSP00000114196   ⟸   ENSMUST00000136202


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2664111 AgrOrtholog
Ensembl Genes ENSMUSG00000075249 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000132967.2 UniProtKB/TrEMBL
  ENSMUST00000136202.2 UniProtKB/TrEMBL
  ENSMUST00000143764 ENTREZGENE
  ENSMUST00000143764.9 UniProtKB/Swiss-Prot
InterPro FSIP2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FSIP2_C UniProtKB/Swiss-Prot
MGD MGI:2664111 ENTREZGENE
NCBI Gene 241516 ENTREZGENE
PANTHER FIBROUS SHEATH-INTERACTING PROTEIN 2 UniProtKB/Swiss-Prot
  FIBROUS SHEATH-INTERACTING PROTEIN 2 UniProtKB/Swiss-Prot
  FIBROUS SHEATH-INTERACTING PROTEIN 2 UniProtKB/TrEMBL
  FIBROUS SHEATH-INTERACTING PROTEIN 2 UniProtKB/TrEMBL
Pfam FSIP2 UniProtKB/Swiss-Prot
PhenoGen Fsip2 PhenoGen
UniProt A2ARZ1 ENTREZGENE
  A2ARZ3 ENTREZGENE
  F6ZQI5_MOUSE UniProtKB/TrEMBL
  F7BGZ6_MOUSE UniProtKB/TrEMBL
  FSIP2_MOUSE UniProtKB/Swiss-Prot
  Q8R4I8_MOUSE UniProtKB/TrEMBL
UniProt Secondary A2ARZ1 UniProtKB/Swiss-Prot