Cct8l1 (chaperonin containing TCP1 subunit 8-like 1) - Rat Genome Database

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Gene: Cct8l1 (chaperonin containing TCP1 subunit 8-like 1) Mus musculus
Analyze
Symbol: Cct8l1
Name: chaperonin containing TCP1 subunit 8-like 1 (Ensembl:chaperonin containing TCP1, subunit 8 (theta)-like 1)
RGD ID: 1615639
MGI Page MGI
Description: Predicted to enable unfolded protein binding activity. Predicted to be involved in protein folding. Predicted to be part of chaperonin-containing T-complex. Orthologous to human CCT8L1P (chaperonin containing TCP1 subunit 8 like 1, pseudogene) and CCT8L2 (chaperonin containing TCP1 subunit 8 like 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: chaperonin containing TCP1, subunit 8 (theta)-like 1; Gm443; MGC58709; putative T-complex protein 1 subunit theta-like 2; T-complex protein 1 subunit theta-like 2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39525,721,065 - 25,723,025 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl525,721,065 - 25,723,025 (+)EnsemblGRCm39 Ensembl
GRCm38525,516,067 - 25,518,027 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl525,516,067 - 25,518,027 (+)EnsemblGRCm38mm10GRCm38
MGSCv37525,021,885 - 25,023,845 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36525,026,215 - 25,028,096 (+)NCBIMGSCv36mm8
Celera522,452,648 - 22,454,608 (+)NCBICelera
Cytogenetic Map5B1NCBI
cM Map512.35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:16141072   PMID:16141073   PMID:21873635  


Genomics

Comparative Map Data
Cct8l1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39525,721,065 - 25,723,025 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl525,721,065 - 25,723,025 (+)EnsemblGRCm39 Ensembl
GRCm38525,516,067 - 25,518,027 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl525,516,067 - 25,518,027 (+)EnsemblGRCm38mm10GRCm38
MGSCv37525,021,885 - 25,023,845 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36525,026,215 - 25,028,096 (+)NCBIMGSCv36mm8
Celera522,452,648 - 22,454,608 (+)NCBICelera
Cytogenetic Map5B1NCBI
cM Map512.35NCBI
CCT8L2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382216,590,751 - 16,592,810 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2216,590,751 - 16,592,810 (-)EnsemblGRCh38hg38GRCh38
GRCh372217,071,641 - 17,073,700 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362215,451,648 - 15,453,700 (-)NCBINCBI36Build 36hg18NCBI36
Celera22693,800 - 695,852 (-)NCBICelera
Cytogenetic Map22q11.1NCBI
HuRef22891,116 - 893,168 (-)NCBIHuRef
CHM1_12217,076,472 - 17,078,524 (-)NCBICHM1_1
T2T-CHM13v2.02217,267,300 - 17,269,359 (-)NCBIT2T-CHM13v2.0
Cct8l2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8410,338,882 - 10,340,818 (-)NCBIGRCr8
mRatBN7.249,605,035 - 9,606,971 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl49,605,000 - 9,607,208 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx414,601,253 - 14,603,189 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0410,415,526 - 10,417,462 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.048,768,111 - 8,770,047 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.046,044,744 - 6,046,680 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl46,060,709 - 6,062,641 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl46,044,792 - 6,046,477 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.046,066,927 - 6,068,863 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.445,004,039 - 5,005,975 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera4712,543 - 714,479 (+)NCBICelera
Cytogenetic Map4q11NCBI
Cct8l2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554916,499,186 - 6,500,843 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554916,498,532 - 6,500,957 (+)NCBIChiLan1.0ChiLan1.0
CCT8L2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22327,005,564 - 27,011,795 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12229,555,612 - 29,561,852 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v022125,317 - 127,899 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17156,171,381 - 156,173,466 (+)NCBIpanpan1.1PanPan1.1panPan2
CCT8L2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11616,250,801 - 16,252,784 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1616,251,061 - 16,252,728 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1616,867,836 - 16,869,815 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01617,981,309 - 17,983,288 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1617,981,565 - 17,983,232 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11616,355,482 - 16,357,461 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01616,936,068 - 16,938,047 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01616,987,705 - 16,989,684 (+)NCBIUU_Cfam_GSD_1.0
Cct8l2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244051185,312,201 - 5,315,093 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365277,589,472 - 7,591,169 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365277,588,536 - 7,591,229 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCT8L2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl184,979,436 - 4,981,076 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1184,979,300 - 4,981,545 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2185,324,623 - 5,326,812 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CCT8L2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121120,593,045 - 120,595,405 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl21120,593,611 - 120,595,278 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607216,580,976 - 16,583,355 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cct8l2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248004,501,854 - 4,504,128 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cct8l1
97 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:118
Count of miRNA genes:112
Interacting mature miRNAs:115
Transcripts:ENSMUST00000045016
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12904958Gmmq8_mgastrocnemius muscle mass QTL 8 (mouse)5129421124Mouse
10401122Pgia41_mproteoglycan induced arthritis 41 (mouse)Not determined582314434823280Mouse
15039371Nmrs21_mNAFLD-associated magnetic resonance shift 21 (mouse)5350482337504823Mouse
1301806Actd2_mactivity-distance traveled 2 (mouse)Not determined5538452039384652Mouse
4141207Imrfq1_mimmune response to Factor IX QTL 1 (mouse)Not determined5812411742124239Mouse
7394748Mom5_mmodifier of Min 5 (mouse)Not determined5884767233475637Mouse
1301693Sle6_msystemic lupus erythematosus susceptibility 6 (mouse)Not determined5889069387841837Mouse
1357478Kdnw1_mkidney weight 1 (mouse)Not determined5891594940529869Mouse
14696730Kidlq1_mkidney weight, left QTL 1 (mouse)51356315247563152Mouse
1301685Estq2_mestradiol regulated response QTL 2 (mouse)Not determined51563408449634190Mouse
1300719Iba5_minduction of brown adipocytes 5 (mouse)Not determined52068699354687134Mouse
1301776Skts3_mskin tumor susceptibility 3 (mouse)Not determined52166729555667403Mouse
11537368Hmtb10_mhemostasis and thrombosis 10 (mouse)52210082354500318Mouse
11537367Hmtb11_mhemostasis and thrombosis 11 (mouse)52210082364806579Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000045016   ⟹   ENSMUSP00000044932
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl525,721,065 - 25,723,025 (+)Ensembl
GRCm38.p6 Ensembl525,516,067 - 25,518,027 (+)Ensembl
RefSeq Acc Id: NM_198621   ⟹   NP_941023
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39525,721,065 - 25,723,025 (+)NCBI
GRCm38525,516,067 - 25,518,027 (+)ENTREZGENE
MGSCv37525,021,885 - 25,023,845 (+)RGD
Celera522,452,648 - 22,454,608 (+)RGD
cM Map5 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_941023 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH50797 (Get FASTA)   NCBI Sequence Viewer  
  BAE21621 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000044932
  ENSMUSP00000044932.8
Reference Protein Sequences
RefSeq Acc Id: NP_941023   ⟸   NM_198621
- UniProtKB: Q80YT3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000044932   ⟸   ENSMUST00000045016

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q80YT3-F1-model_v2 AlphaFold Q80YT3 1-562 view protein structure

Promoters
RGD ID:6886202
Promoter ID:EPDNEW_M6552
Type:initiation region
Name:Cct8l1_1
Description:Mus musculus chaperonin containing TCP1, subunit 8 -like 1 ,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38525,516,101 - 25,516,161EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2685289 AgrOrtholog
Ensembl Genes ENSMUSG00000038044 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000045016 ENTREZGENE
  ENSMUST00000045016.9 UniProtKB/TrEMBL
Gene3D-CATH 1.10.560.10 UniProtKB/TrEMBL
  3.30.260.10 UniProtKB/TrEMBL
  3.50.7.10 UniProtKB/TrEMBL
InterPro Chaperone_TCP-1 UniProtKB/TrEMBL
  Chaperonin_TCP-1_CS UniProtKB/TrEMBL
  Cpn60/TCP-1 UniProtKB/TrEMBL
  GroEL-like_apical_dom UniProtKB/TrEMBL
  GROEL-like_equatorial UniProtKB/TrEMBL
  TCP-1-like_intermed UniProtKB/TrEMBL
KEGG Report mmu:242891 UniProtKB/TrEMBL
MGD MGI:2685289 ENTREZGENE
NCBI Gene 242891 ENTREZGENE
PANTHER PTHR11353 UniProtKB/TrEMBL
  T-COMPLEX PROTEIN 1 SUBUNIT THETA-LIKE 1-RELATED UniProtKB/TrEMBL
Pfam Cpn60_TCP1 UniProtKB/TrEMBL
PhenoGen Cct8l1 PhenoGen
PRINTS TCOMPLEXTCP1 UniProtKB/TrEMBL
PROSITE TCP1_1 UniProtKB/TrEMBL
Superfamily-SCOP SSF48592 UniProtKB/TrEMBL
  SSF52029 UniProtKB/TrEMBL
  SSF54849 UniProtKB/TrEMBL
UniProt Q80YT3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-07-04 Cct8l1  chaperonin containing TCP1 subunit 8-like 1  Cct8l1  chaperonin containing TCP1, subunit 8 (theta)-like 1  Symbol and/or name change 5135510 APPROVED