Heca (hdc homolog, cell cycle regulator) - Rat Genome Database

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Gene: Heca (hdc homolog, cell cycle regulator) Mus musculus
Analyze
Symbol: Heca
Name: hdc homolog, cell cycle regulator
RGD ID: 1615528
MGI Page MGI
Description: Predicted to be involved in negative regulation of mitotic cell cycle. Predicted to be located in cytoplasm and nucleus. Orthologous to human HECA (hdc homolog, cell cycle regulator).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Gm869; HDC; HDCL; headcase homolog; headcase protein homolog
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm2038  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391017,774,788 - 17,823,785 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1017,744,360 - 17,823,815 (-)EnsemblGRCm39 Ensembl
GRCm381017,899,040 - 17,948,067 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1017,868,612 - 17,948,067 (-)EnsemblGRCm38mm10GRCm38
MGSCv371017,620,272 - 17,667,873 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361017,589,882 - 17,637,483 (-)NCBIMGSCv36mm8
Celera1017,796,891 - 17,812,404 (-)NCBICelera
Cytogenetic Map10A3NCBI
cM Map107.31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (ISO)
nucleus  (ISO)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:16141072   PMID:16141073   PMID:21267068  


Genomics

Comparative Map Data
Heca
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391017,774,788 - 17,823,785 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1017,744,360 - 17,823,815 (-)EnsemblGRCm39 Ensembl
GRCm381017,899,040 - 17,948,067 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1017,868,612 - 17,948,067 (-)EnsemblGRCm38mm10GRCm38
MGSCv371017,620,272 - 17,667,873 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361017,589,882 - 17,637,483 (-)NCBIMGSCv36mm8
Celera1017,796,891 - 17,812,404 (-)NCBICelera
Cytogenetic Map10A3NCBI
cM Map107.31NCBI
HECA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386139,135,080 - 139,180,802 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6139,135,080 - 139,180,802 (+)EnsemblGRCh38hg38GRCh38
GRCh376139,456,217 - 139,501,939 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366139,497,942 - 139,543,639 (+)NCBINCBI36Build 36hg18NCBI36
Build 346139,497,941 - 139,543,630NCBI
Celera6140,196,318 - 140,242,007 (+)NCBICelera
Cytogenetic Map6q24.1NCBI
HuRef6137,017,966 - 137,063,661 (+)NCBIHuRef
CHM1_16139,719,415 - 139,765,096 (+)NCBICHM1_1
T2T-CHM13v2.06140,323,625 - 140,369,329 (+)NCBIT2T-CHM13v2.0
Heca
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8114,345,306 - 14,395,226 (-)NCBIGRCr8
mRatBN7.2112,525,445 - 12,575,358 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl112,525,135 - 12,576,427 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx112,297,510 - 12,311,261 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.011,262,708 - 1,276,459 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0112,505,476 - 12,519,257 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0113,036,909 - 13,050,644 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl113,036,909 - 13,050,644 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0114,730,556 - 14,744,291 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4112,933,861 - 12,947,642 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1112,937,222 - 12,983,495 (-)NCBI
Celera110,982,933 - 10,996,714 (-)NCBICelera
Cytogenetic Map1p12NCBI
Heca
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543620,523,215 - 20,568,621 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543620,523,215 - 20,569,403 (-)NCBIChiLan1.0ChiLan1.0
HECA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25159,103,549 - 159,149,260 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16156,998,402 - 157,042,983 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06136,898,465 - 136,943,055 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16141,008,515 - 141,021,150 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6141,008,515 - 141,021,150 (+)Ensemblpanpan1.1panPan2
HECA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1131,332,915 - 31,383,688 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl131,363,008 - 31,373,277 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha132,205,754 - 32,257,065 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0131,493,231 - 31,544,548 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl131,492,489 - 31,665,998 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1131,369,117 - 31,413,471 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0131,251,605 - 31,295,973 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0131,563,102 - 31,614,407 (+)NCBIUU_Cfam_GSD_1.0
Heca
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946126,344,690 - 126,431,119 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365606,165,459 - 6,210,357 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365606,165,465 - 6,210,335 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HECA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl125,316,456 - 25,364,297 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1125,316,448 - 25,364,083 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2128,516,816 - 28,531,163 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HECA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11334,205,005 - 34,250,779 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660406,350,815 - 6,396,617 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Heca
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475314,798,487 - 14,849,370 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Heca
2073 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:445
Count of miRNA genes:347
Interacting mature miRNAs:373
Transcripts:ENSMUST00000037879
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11532725Sluc44b_msusceptibility to lung cancer 44b (mouse)10126289265Mouse
11532724Sluc44c_msusceptibility to lung cancer 44c (mouse)10126289265Mouse
11532723Sluc44d_msusceptibility to lung cancer 44d (mouse)10126289265Mouse
11532722Sluc44e_msusceptibility to lung cancer 44e (mouse)10126289265Mouse
11532721Sluc44_msusceptibility to lung cancer 44 (mouse)10126289265Mouse
11532720Sluc44a_msusceptibility to lung cancer 44a (mouse)10126289265Mouse
11532718Sluc44f_msusceptibility to lung cancer 44f (mouse)10126289265Mouse
11532717Sluc44g_msusceptibility to lung cancer 44g (mouse)10126289265Mouse
11533917Mts2_mmammary tumor susceptibility 2 (mouse)10126289265Mouse
1300759Geot_mgeotaxia (mouse)Not determined10126289265Mouse
1300881Sluc29_msusceptibility to lung cancer 29 (mouse)Not determined10126289265Mouse
12879494Facq1_mfear acquisition QTL 1 (mouse)10131279130Mouse
15039341Nmrs28_mNAFLD-associated magnetic resonance shift 28 (mouse)1035100134351001Mouse
1357813Ath20_matherosclerosis 20 (mouse)Not determined10328318537283334Mouse
1300790Pgia6_mproteoglycan induced arthritis 6 (mouse)Not determined10381017137810295Mouse
1300997Eae15_msusceptibility to experimental allergic encephalomyelitis 15 (mouse)Not determined10440815438408276Mouse
13208561Wght8_mweight 8 (mouse)10495000043875996Mouse
1302092Ath11_matherosclerosis 11 (mouse)Not determined10615194558693521Mouse
1357740Obsty3_mobesity 3 (mouse)Not determined108235478116190980Mouse
1558865Lith21_mlithogenic gene 21 (mouse)Not determined10852500342525126Mouse
1301796Mop2_mmorphine preference 2 (mouse)Not determined10928911929028424Mouse
1301448Pas11_mpulmonary adenoma susceptibility 11 (mouse)Not determined10989026443890391Mouse
1301129Alcp15_malcohol preference locus 15 (mouse)Not determined10989026443890391Mouse
1302133Alcp16_malcohol preference locus 16 (mouse)Not determined10989026443890391Mouse
1301386Sysbp1_msystolic blood pressure 1 (mouse)Not determined101010826587401095Mouse
1357825Kidpq2_mkidney weight percentage QTL 2 (mouse)Not determined101270405184079784Mouse
1357656Hrtq3_mheart weight QTL 3 (mouse)Not determined101270405184079784Mouse
1357864Scfpq1_msubcutaneous fat pad percentage QTL 1 (mouse)Not determined101270405184079784Mouse
39128215Lwq17_mliver weight QTL 17 (mouse)101270405184079784Mouse
4141956Egq7_mearly growth QTL 7 (mouse)Not determined1270405184079784Mouse
4141943W6q6_mweight 6 weeks QTL 6 (mouse)Not determined1270405184079784Mouse
4142272W10q5_mweight 10 weeks QTL 5 (mouse)Not determined1270405184079784Mouse
4142380W3q11_mweight 3 weeks QTL 11 (mouse)Not determined1270405184079784Mouse
13208570Bmiq9_mbody mass index QTL 9 (mouse)101287574424875898Mouse
1558857Igan1_mIgA nephropathy 1 (mouse)Not determined101771831329704155Mouse

Markers in Region
UniSTS:236315  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381017,900,595 - 17,900,832UniSTSGRCm38
MGSCv371017,620,401 - 17,620,638UniSTSGRCm37
Celera1017,797,020 - 17,797,257UniSTS
Cytogenetic Map10A2-A3UniSTS
AV077453  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381017,912,097 - 17,912,217UniSTSGRCm38
MGSCv371017,631,903 - 17,632,023UniSTSGRCm37
Celera1017,808,479 - 17,808,599UniSTS
Cytogenetic Map10A2-A3UniSTS
Whitehead/MRC_RH10195.45UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000037879   ⟹   ENSMUSP00000040707
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1017,774,783 - 17,823,815 (-)Ensembl
GRCm38.p6 Ensembl1017,899,035 - 17,948,067 (-)Ensembl
RefSeq Acc Id: ENSMUST00000217949   ⟹   ENSMUSP00000151692
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1017,744,360 - 17,790,970 (-)Ensembl
GRCm38.p6 Ensembl1017,868,612 - 17,915,222 (-)Ensembl
RefSeq Acc Id: ENSMUST00000218268
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1017,778,034 - 17,784,049 (-)Ensembl
GRCm38.p6 Ensembl1017,902,286 - 17,908,301 (-)Ensembl
RefSeq Acc Id: ENSMUST00000218758
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1017,774,790 - 17,790,950 (-)Ensembl
GRCm38.p6 Ensembl1017,899,042 - 17,915,202 (-)Ensembl
RefSeq Acc Id: NM_001033432   ⟹   NP_001028604
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391017,774,790 - 17,823,785 (-)NCBI
GRCm381017,900,466 - 17,948,067 (-)NCBI
MGSCv371017,620,272 - 17,667,873 (-)RGD
Celera1017,796,891 - 17,812,404 (-)RGD
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006512783   ⟹   XP_006512846
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391017,774,788 - 17,823,199 (-)NCBI
GRCm381017,899,040 - 17,947,460 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001028604 (Get FASTA)   NCBI Sequence Viewer  
  XP_006512846 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAE21115 (Get FASTA)   NCBI Sequence Viewer  
  BAE22280 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000040707
  ENSMUSP00000040707.7
  ENSMUSP00000151692.2
Reference Protein Sequences
RefSeq Acc Id: NP_001028604   ⟸   NM_001033432
- UniProtKB: Q3V1N5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006512846   ⟸   XM_006512783
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000151692   ⟸   ENSMUST00000217949
RefSeq Acc Id: ENSMUSP00000040707   ⟸   ENSMUST00000037879
Protein Domains
Headcase middle

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q3V1N5-F1-model_v2 AlphaFold Q3V1N5 1-544 view protein structure

Promoters
RGD ID:6819430
Promoter ID:MM_KWN:3604
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   ES_Cell,   Kidney,   Liver,   Lung
Transcripts:UC007ELW.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361017,667,336 - 17,668,152 (-)MPROMDB
RGD ID:8671540
Promoter ID:EPDNEW_M13801
Type:initiation region
Name:Heca_1
Description:Mus musculus hdc homolog, cell cycle regulator , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381017,948,037 - 17,948,097EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2685715 AgrOrtholog
Ensembl Genes ENSMUSG00000039879 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000037879 ENTREZGENE
  ENSMUST00000037879.8 UniProtKB/TrEMBL
  ENSMUST00000217949.2 UniProtKB/TrEMBL
InterPro Headcase UniProtKB/TrEMBL
  Headcase_mid UniProtKB/TrEMBL
KEGG Report mmu:380629 UniProtKB/TrEMBL
MGD MGI:2685715 ENTREZGENE
NCBI Gene 380629 ENTREZGENE
PANTHER HEADCASE PROTEIN HOMOLOG UniProtKB/TrEMBL
  PTHR13425 UniProtKB/TrEMBL
Pfam Headcase UniProtKB/TrEMBL
  HECA UniProtKB/TrEMBL
PhenoGen Heca PhenoGen
UniProt A0A1W2P7N5_MOUSE UniProtKB/TrEMBL
  Q3UYD2_MOUSE UniProtKB/TrEMBL
  Q3V1N5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-29 Heca  hdc homolog, cell cycle regulator    headcase homolog (Drosophila)  Symbol and/or name change 5135510 APPROVED