Cox7c (cytochrome c oxidase subunit 7C) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Cox7c (cytochrome c oxidase subunit 7C) Mus musculus
Analyze
Symbol: Cox7c
Name: cytochrome c oxidase subunit 7C
RGD ID: 1615203
MGI Page MGI
Description: Predicted to be involved in mitochondrial electron transport, cytochrome c to oxygen. Located in mitochondrial inner membrane. Part of mitochondrial respiratory chain complex IV. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human COX7C (cytochrome c oxidase subunit 7C).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: COX; Cox7c1; COXVIIc; cytochrome c oxidase polypeptide VIIc; cytochrome c oxidase subunit 7C, mitochondrial; cytochrome c oxidase subunit VIIc; cytochrome c oxidase, subunit VIIc; MGC102143
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Cox7c-ps1   Gm12338   Gm20079   Gm20091   Gm3386  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391386,192,917 - 86,194,914 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1386,192,935 - 86,195,023 (-)EnsemblGRCm39 Ensembl
GRCm381386,044,798 - 86,046,795 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1386,044,816 - 86,046,904 (-)EnsemblGRCm38mm10GRCm38
MGSCv371386,184,403 - 86,186,400 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361386,518,203 - 86,520,174 (-)NCBIMGSCv36mm8
Celera1388,283,958 - 88,285,955 (-)NCBICelera
Cytogenetic Map13C3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Reduced Mitochondrial Activity is Early and Steady in the Entorhinal Cortex but it is Mainly Unmodified in the Frontal Cortex in Alzheimer's Disease. Armand-Ugon M, etal., Curr Alzheimer Res. 2017;14(12):1327-1334. doi: 10.2174/1567205014666170505095921.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. Mouse MP Annotation Import Pipeline RGD automated import pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:2163523   PMID:7535541   PMID:8565329   PMID:9170106   PMID:9182797   PMID:9507200   PMID:9615220   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851  
PMID:12466851   PMID:12477932   PMID:12865426   PMID:14651853   PMID:14681479   PMID:15489334   PMID:16141072   PMID:16141073   PMID:16783635   PMID:18614015   PMID:18799693   PMID:21873635  
PMID:24194600   PMID:26876175   PMID:27626380   PMID:30143541   PMID:30550785   PMID:31536960   PMID:32325033   PMID:35833493  


Genomics

Comparative Map Data
Cox7c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391386,192,917 - 86,194,914 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1386,192,935 - 86,195,023 (-)EnsemblGRCm39 Ensembl
GRCm381386,044,798 - 86,046,795 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1386,044,816 - 86,046,904 (-)EnsemblGRCm38mm10GRCm38
MGSCv371386,184,403 - 86,186,400 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361386,518,203 - 86,520,174 (-)NCBIMGSCv36mm8
Celera1388,283,958 - 88,285,955 (-)NCBICelera
Cytogenetic Map13C3NCBI
COX7C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38586,617,941 - 86,620,962 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl586,617,928 - 86,620,962 (+)EnsemblGRCh38hg38GRCh38
GRCh37585,913,758 - 85,916,779 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36585,949,540 - 85,952,339 (+)NCBINCBI36Build 36hg18NCBI36
Build 34585,949,539 - 85,952,337NCBI
Celera581,805,741 - 81,808,540 (+)NCBICelera
Cytogenetic Map5q14.3NCBI
HuRef581,115,920 - 81,118,719 (+)NCBIHuRef
CHM1_1585,346,717 - 85,349,516 (+)NCBICHM1_1
T2T-CHM13v2.0587,100,950 - 87,103,971 (+)NCBIT2T-CHM13v2.0
Cox7c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8218,577,145 - 18,579,170 (-)NCBIGRCr8
mRatBN7.2216,841,771 - 16,843,796 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl216,840,837 - 16,843,760 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx223,907,988 - 23,910,008 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0222,008,260 - 22,010,280 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0216,708,658 - 16,710,683 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0214,699,878 - 14,701,903 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl214,699,882 - 14,701,903 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0214,553,402 - 14,555,427 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4215,254,040 - 15,256,065 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera213,075,378 - 13,077,403 (-)NCBICelera
Cytogenetic Map2q11NCBI
LOC102008533
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541824,413,883 - 24,416,530 (-)NCBIChiLan1.0ChiLan1.0
LOC100979972
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2428,783,927 - 28,786,975 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1526,937,550 - 26,940,591 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0528,763,336 - 28,766,369 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1528,898,380 - 28,901,243 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl528,898,380 - 28,901,243 (-)Ensemblpanpan1.1panPan2
LOC102155410
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12120,841,405 - 20,841,878 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3011,869,724 - 11,870,148 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03012,016,436 - 12,016,861 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.13011,937,902 - 11,938,326 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03012,043,715 - 12,044,137 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03012,163,728 - 12,164,154 (-)NCBIUU_Cfam_GSD_1.0
LOC101961000
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213177,286,007 - 177,288,428 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364695,337,333 - 5,342,174 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364695,337,331 - 5,339,716 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
COX7C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl294,345,447 - 94,352,651 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1294,345,436 - 94,347,709 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2296,864,369 - 96,866,649 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103231597
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X11,261,111 - 11,261,927 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605613,053,352 - 13,053,741 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101713193
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247436,223,835 - 6,229,258 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247436,224,040 - 6,226,980 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cox7c
4 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:104
Count of miRNA genes:50
Interacting mature miRNAs:52
Transcripts:ENSMUST00000017922, ENSMUST00000078764, ENSMUST00000131011, ENSMUST00000132233
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142147Mvwf4_mmodifier of von Willebrand factor 4 (mouse)Not determined20477612112898424Mouse
10412235Scgq5_mspontaneous crescentic glomerulonephritis QTL 5 (mouse)Not determined133606090896239162Mouse
14746975Manh74_mmandible shape 74 (mouse)135247726986477269Mouse
1302073Pgct1_mprimordial germ cell tumor locus 1 (mouse)Not determined135382078387820897Mouse
1357563Bmch6_mbone mechanical trait 6 (mouse)Not determined135538498089385140Mouse
4142314Tailaq3_mtail length adjusted QTL 3 (mouse)Not determined55720354112431103Mouse
4140959W10q17_mweight 10 weeks QTL 17 (mouse)Not determined55720354112431103Mouse
4141992W6q16_mweight 6 weeks QTL 16 (mouse)Not determined55720354112431103Mouse
4142241Tailq3_mtail length QTL 3 (mouse)Not determined55720354112431103Mouse
10402414Sgp5_mserum gp70 production 5 (mouse)Not determined1356470456105422186Mouse
1357553Cia28_mcollagen induced arthritis 28 (mouse)Not determined135662924996239162Mouse
10412163Wra1_mwheel running activity 1 (mouse)Not determined135913260093132738Mouse
1300941Skl6_mskeletal size (tail length) 6 (mouse)Not determined136425082198250945Mouse
1301949Skull20_mskull morphology 20 (mouse)Not determined136425082198250945Mouse
1301445Listr2_mlisteriosis resistance 2 (mouse)Not determined1366744601100744746Mouse
1301593Heal8_mwound healing/regeneration 8 (mouse)Not determined1368053999102054119Mouse
14696726Kidrq3_mkidney weight, right QTL 3 (mouse)1368217066102217066Mouse
14747007Mancz11_mmandible centroid size 11 (mouse)1370111284104111284Mouse
4141266Mol3_mmodifier of LPS-response 3 (mouse)Not determined76132600112431103Mouse
1301610Dps1_mdelta power in slow-wave sleep 1 (mouse)Not determined137719586295730894Mouse
12880414V125Dq10_mvitamin D active form serum level QTL 10 (mouse)1378036508112036508Mouse
12880402Emlq1_memotional learning QTL 1 (mouse)137810885896866553Mouse
12879495Fexq1_mfear expression QTL 1 (mouse)137826885895836553Mouse
10043997Bw40_mbody weight QTL 40 (mouse)Not determined1479239045113239162Mouse
10045623Heal18_mwound healing regeneration 18 (mouse)Not determined1379239045113239162Mouse
1558741Ses10_msalmonella enteritidis susceptibility 10 (mouse)Not determined1382739968116740106Mouse
4142465Pbwg17_mpostnatal body weight growth 17 (mouse)Not determined1383876060117876256Mouse
14700691Cisaq1_mcoxsackieviral infection serum ALT QTL 1 (mouse)1386148119120461536Mouse

Markers in Region
RH136231  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371175,413,331 - 75,413,529UniSTSGRCm37
MGSCv371439,193,660 - 39,193,858UniSTSGRCm37
Celera1183,108,983 - 83,109,181UniSTS
Celera2120,293,883 - 120,294,081UniSTS
Celera1434,571,760 - 34,571,958UniSTS
Cytogenetic Map13C3UniSTS
Cytogenetic Map14BUniSTS
Cytogenetic Map11B5UniSTS
cM Map1144.11UniSTS
AI648091  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381386,045,146 - 86,045,257UniSTSGRCm38
MGSCv371386,184,751 - 86,184,862UniSTSGRCm37
Celera1388,284,306 - 88,284,417UniSTS
Cytogenetic Map13C3UniSTS
Whitehead/MRC_RH13720.79UniSTS
RH126976  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381386,045,007 - 86,045,211UniSTSGRCm38
MGSCv371386,184,612 - 86,184,816UniSTSGRCm37
Celera1388,284,167 - 88,284,371UniSTS
Cytogenetic Map13C3UniSTS
cM Map1346.0UniSTS
Whitehead/MRC_RH13743.87UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000017922
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1386,193,014 - 86,194,893 (-)Ensembl
GRCm38.p6 Ensembl1386,044,895 - 86,046,774 (-)Ensembl
RefSeq Acc Id: ENSMUST00000078764   ⟹   ENSMUSP00000119276
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1386,192,935 - 86,194,579 (-)Ensembl
GRCm38.p6 Ensembl1386,044,816 - 86,046,460 (-)Ensembl
RefSeq Acc Id: ENSMUST00000131011   ⟹   ENSMUSP00000115419
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1386,192,935 - 86,195,023 (-)Ensembl
GRCm38.p6 Ensembl1386,044,816 - 86,046,904 (-)Ensembl
RefSeq Acc Id: ENSMUST00000132233   ⟹   ENSMUSP00000117385
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1386,192,940 - 86,194,466 (-)Ensembl
GRCm38.p6 Ensembl1386,044,821 - 86,046,347 (-)Ensembl
RefSeq Acc Id: NM_007749   ⟹   NP_031775
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391386,192,917 - 86,194,914 (-)NCBI
GRCm381386,044,798 - 86,046,795 (-)ENTREZGENE
MGSCv371386,184,403 - 86,186,400 (-)RGD
Celera1388,283,958 - 88,285,955 (-)RGD
cM Map13 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_031775   ⟸   NM_007749
- Peptide Label: precursor
- UniProtKB: Q3U5S7 (UniProtKB/Swiss-Prot),   P17665 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000117385   ⟸   ENSMUST00000132233
RefSeq Acc Id: ENSMUSP00000115419   ⟸   ENSMUST00000131011
RefSeq Acc Id: ENSMUSP00000119276   ⟸   ENSMUST00000078764

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P17665-F1-model_v2 AlphaFold P17665 1-63 view protein structure

Promoters
RGD ID:8680936
Promoter ID:EPDNEW_M18499
Type:initiation region
Name:Cox7c_1
Description:Mus musculus cytochrome c oxidase subunit VIIc , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381386,046,790 - 86,046,850EPDNEW
RGD ID:6823786
Promoter ID:MM_KWN:14838
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000082044,   OTTMUST00000082045,   OTTMUST00000082046,   OTTMUST00000082047
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361386,185,561 - 86,186,422 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:103226 AgrOrtholog
Ensembl Genes ENSMUSG00000017778 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000078764.9 UniProtKB/TrEMBL
  ENSMUST00000131011 ENTREZGENE
  ENSMUST00000131011.2 UniProtKB/Swiss-Prot
  ENSMUST00000132233.2 UniProtKB/TrEMBL
Gene3D-CATH 4.10.49.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro COX7C/Cox8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  COX7C/Cox8_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:12867 UniProtKB/Swiss-Prot
MGD MGI:103226 ENTREZGENE
NCBI Gene 12867 ENTREZGENE
PANTHER CYTOCHROME C OXIDASE SUBUNIT 7C, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR13313 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam COX7C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cox7c PhenoGen
Superfamily-SCOP SSF81427 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B8JJA9_MOUSE UniProtKB/TrEMBL
  B8JJB0_MOUSE UniProtKB/TrEMBL
  COX7C_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3U5S7 ENTREZGENE
UniProt Secondary Q3U5S7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-29 Cox7c  cytochrome c oxidase subunit 7C    cytochrome c oxidase subunit VIIc  Symbol and/or name change 5135510 APPROVED
2012-11-27 Cox7c  cytochrome c oxidase subunit VIIc    cytochrome c oxidase, subunit VIIc  Symbol and/or name change 5135510 APPROVED