Smr2 (submaxillary gland androgen regulated protein 2) - Rat Genome Database

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Gene: Smr2 (submaxillary gland androgen regulated protein 2) Mus musculus
Analyze
Symbol: Smr2
Name: submaxillary gland androgen regulated protein 2
RGD ID: 1615167
MGI Page MGI
Description: Predicted to enable endopeptidase inhibitor activity. Predicted to be involved in regulation of sensory perception of pain. Predicted to act upstream of or within response to toxic substance. Predicted to be located in extracellular region. Orthologous to human SMR3B (submaxillary gland androgen regulated protein 3B).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MGC130573; MSG; MSG2; salivary protein MSG2; salivary protein MSG2, isoform alpha; salivary protein MSG2, isoform beta; salivary protein MSG2, isoform delta; salivary protein MSG2, isoform epsilon; salivary protein MSG2, isoform gamma; submaxillary gland androgen-regulated protein 2, isoform alpha; submaxillary gland androgen-regulated protein 2, isoform beta; submaxillary gland androgen-regulated protein 2, isoform delta; submaxillary gland androgen-regulated protein 2, isoform epsilon; submaxillary gland androgen-regulated protein 2, isoform gamma; Vcs2
RGD Orthologs
Human
Rat
Bonobo
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39588,234,415 - 88,256,912 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl588,234,415 - 88,256,912 (+)EnsemblGRCm39 Ensembl
GRCm38588,086,556 - 88,109,053 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl588,086,556 - 88,109,053 (+)EnsemblGRCm38mm10GRCm38
MGSCv37588,515,581 - 88,538,078 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36589,161,117 - 89,183,614 (+)NCBIMGSCv36mm8
Celera586,261,754 - 86,284,251 (+)NCBICelera
Cytogenetic Map5E1NCBI
cM Map543.56NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8194749   PMID:9409774   PMID:12466851   PMID:12477932   PMID:16252261   PMID:21267068   PMID:21873635   PMID:24803544  


Genomics

Comparative Map Data
Smr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39588,234,415 - 88,256,912 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl588,234,415 - 88,256,912 (+)EnsemblGRCm39 Ensembl
GRCm38588,086,556 - 88,109,053 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl588,086,556 - 88,109,053 (+)EnsemblGRCm38mm10GRCm38
MGSCv37588,515,581 - 88,538,078 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36589,161,117 - 89,183,614 (+)NCBIMGSCv36mm8
Celera586,261,754 - 86,284,251 (+)NCBICelera
Cytogenetic Map5E1NCBI
cM Map543.56NCBI
OPRPN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38470,397,940 - 70,410,195 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl470,397,931 - 70,410,195 (+)EnsemblGRCh38hg38GRCh38
GRCh37471,263,657 - 71,275,912 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36471,298,188 - 71,310,503 (+)NCBINCBI36Build 36hg18NCBI36
Build 34471,444,452 - 71,456,671NCBI
Celera468,621,402 - 68,633,756 (+)NCBICelera
Cytogenetic Map4q13.3NCBI
HuRef467,065,908 - 67,078,224 (+)NCBIHuRef
CHM1_1471,299,691 - 71,312,010 (+)NCBICHM1_1
T2T-CHM13v2.0473,737,473 - 73,749,728 (+)NCBIT2T-CHM13v2.0
Oprpn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81419,986,575 - 20,001,589 (-)NCBIGRCr8
mRatBN7.21419,702,535 - 19,717,550 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1419,702,535 - 19,717,550 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1419,671,787 - 19,685,837 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01420,990,666 - 21,004,716 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01419,713,368 - 19,728,701 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01421,338,464 - 21,353,533 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1421,338,601 - 21,352,491 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01421,252,544 - 21,267,613 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41421,294,053 - 21,308,816 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11421,294,394 - 21,294,762 (-)NCBI
Celera1419,038,353 - 19,052,855 (-)NCBICelera
Cytogenetic Map14p22NCBI
OPRPN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2359,680,693 - 59,693,006 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1459,875,811 - 59,889,597 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0453,820,177 - 53,833,961 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1460,165,212 - 60,177,582 (-)NCBIpanpan1.1PanPan1.1panPan2
OPRPN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1718,913,378 - 18,925,886 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl718,914,978 - 18,925,760 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660843,974,853 - 3,976,934 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Smr2
550 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:38
Count of miRNA genes:37
Interacting mature miRNAs:38
Transcripts:ENSMUST00000087043
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11341716Rvfs3_mRift Valley fever susceptibility 3 (mouse)526441234138455402Mouse
4140990Lgq6_mlate growth QTL 6 (mouse)Not determined32133234100777931Mouse
4141219W10q16_mweight 10 weeks QTL 16 (mouse)Not determined32133234100777931Mouse
1301524Lmb2_mlupus in MRL and B6 F2 cross (mouse)Not determined537581488112465722Mouse
11041665Lmr24_mleishmaniasis resistance 24 (mouse)552694462107321041Mouse
11041899Lmr24a_mleishmaniasis resistance 24a (mouse)552694462107321041Mouse
4142064Tmc1m4_mTmc1 modifier 4 (mouse)Not determined554500177127001072Mouse
1301243Bmd2_mbone mineral density 2 (mouse)Not determined555388334100455525Mouse
4142317Rgcs1_mretinal ganglion cell susceptible 1 (mouse)Not determined55388334108762627Mouse
13464248Ahl13_mage related hearing loss, early onset 13 (mouse)55564587489645995Mouse
10043962Obq27_mobesity QTL 27 (mouse)Not determined55628565590285655Mouse
10044005Ahl7_mage related hearing loss 7 (mouse)Not determined55833050292330641Mouse
11040591Lmr3c_mleishmaniasis resistance 3c (mouse)55960280193602980Mouse
11040592Lmr3d_mleishmaniasis resistance 3d (mouse)55960280193602980Mouse
11040589Lmr3a_mleishmaniasis resistance 3a (mouse)55960280193602980Mouse
11040590Lmr3b_mleishmaniasis resistance 3b (mouse)55960280193602980Mouse
1301843Listr1_mlisteriosis resistance 1 (mouse)Not determined56024608194246203Mouse
13464247Ahl14_mage related hearing loss, early onset 14 (mouse)56040306294403160Mouse
11252124Modvl6_mmodifier of vacuolated lens 6 (mouse)56265056896650688Mouse
4142428Modvl1_mmodifier of vacuolated lens 1 (mouse)Not determined6265056896650688Mouse
1301010ahl2_mage related hearing loss 2 (mouse)Not determined56265056896650688Mouse
13464250Ahl15_mage related hearing loss, early onset 15 (mouse)56265056896650688Mouse
10045972Tir5_mtrypanosome infection response 5 (mouse)Not determined563705442104387065Mouse
11049560Lmr24d_mleishmaniasis resistance 24d (mouse)56437487798374996Mouse
12904739M2fscn2_mmodifier 2 of FSCN2 (mouse)566529661100529661Mouse
12904740M1fscn2_mmodifier 1 of Fscn2 (mouse)566529661100529661Mouse
26884395Humsd2_mhumerus midshaft diameter 2, 10 week (mouse)570057343132528839Mouse
10043993Hbnr10_mHeligmosomoides bakeri nematode resistance 10 (mouse)Not determined572418876106419011Mouse
27226719Tibw6_mtibia width 6, proximal, 16 week (mouse)572857343139985755Mouse
25314315Mlh1fc4_mMLH1 foci count 4 (mouse)574460661132528839Mouse
13506928Recrq8_mrecombination rate in male meiosis QTL 8 (mouse)574460661132528839Mouse
4141124Dshv2_mdorsal hippocampal volume 2 (mouse)Not determined57531534898019803Mouse
1357431Cia27_mcollagen induced arthritis 27 (mouse)Not determined575315348120018629Mouse
4141438Skmw13_mskeletal muscle weight 13 (mouse)Not determined576190263110190479Mouse
4141505Chlq14_mcirculating hormone level QTL 14 (mouse)Not determined576280786110280917Mouse
1300986Hdlq2_mHDL QTL 2 (mouse)Not determined576280786110280917Mouse
1301691Cdcs10_mcytokine deficiency colitis susceptibility 10 (mouse)Not determined576280786110280917Mouse
1301829Thyls2_mthymic lymphoma susceptibility 2 (mouse)Not determined576445064110445225Mouse
1301713Dbsty2_mdiabesity 2 (mouse)Not determined576445064110445225Mouse
13464249Ahl16_mage related hearing loss, early onset 16 (mouse)576445064110445225Mouse
1300931Cocrb6_mcocaine related behavior 6 (mouse)Not determined576445064110445225Mouse
12910784Pwgrq15_mpost-weaning growth rate QTL 15 (mouse)57717582397658215Mouse
12910816Ogrq2_moverall growth rate QTL 2 (mouse)57717582397658215Mouse
10401246Bglu13_mblood glucose level 13 (mouse)Not determined579539640113539786Mouse
10755524Mono1_mmonocyte differential 1 (mouse)580849259114849259Mouse
1301419Cypr3_mcytokine production 3 (mouse)Not determined581019649115019803Mouse
10401245Bglu18_mblood glucose level 18 (mouse)Not determined582838468116838597Mouse
13464242Ahl17_mage related hearing loss, early onset 17 (mouse)582838468116838597Mouse
12738408Lfibq5_mliver fibrosis QTL 5 (mouse)58478385389966041Mouse
10043958Chldq12_mcholesterol and HDL QTL 12 (mouse)Not determined587386871121387065Mouse
1301126Bwem1_mbody weight day 30 males 1 (mouse)Not determined587386871121387065Mouse
13464241Ahl18_mage related hearing loss, early onset 18 (mouse)587386871121387065Mouse
1300801Drb2_mdopamine receptor binding 2 (mouse)Not determined587386871121387065Mouse
1301399Cpfd3_mcerebellum pattern fissures (mouse)Not determined587386871121387065Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000087043   ⟹   ENSMUSP00000084271
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl588,234,415 - 88,256,912 (+)Ensembl
GRCm38.p6 Ensembl588,086,556 - 88,109,053 (+)Ensembl
RefSeq Acc Id: ENSMUST00000196070   ⟹   ENSMUSP00000143443
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl588,234,415 - 88,256,912 (+)Ensembl
GRCm38.p6 Ensembl588,086,556 - 88,109,053 (+)Ensembl
RefSeq Acc Id: ENSMUST00000196477   ⟹   ENSMUSP00000142688
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl588,234,415 - 88,256,912 (+)Ensembl
GRCm38.p6 Ensembl588,086,556 - 88,109,053 (+)Ensembl
RefSeq Acc Id: ENSMUST00000199635   ⟹   ENSMUSP00000142444
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl588,234,415 - 88,246,580 (+)Ensembl
GRCm38.p6 Ensembl588,086,556 - 88,098,721 (+)Ensembl
RefSeq Acc Id: NM_001252679   ⟹   NP_001239608
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39588,234,415 - 88,256,912 (+)NCBI
GRCm38588,086,556 - 88,109,053 (+)ENTREZGENE
Celera586,261,754 - 86,284,251 (+)ENTREZGENE
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001252680   ⟹   NP_001239609
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39588,234,415 - 88,256,912 (+)NCBI
GRCm38588,086,556 - 88,109,053 (+)ENTREZGENE
Celera586,261,754 - 86,284,251 (+)ENTREZGENE
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001252681   ⟹   NP_001239610
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39588,234,415 - 88,256,912 (+)NCBI
GRCm38588,086,556 - 88,109,053 (+)ENTREZGENE
Celera586,261,754 - 86,284,251 (+)ENTREZGENE
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_021289   ⟹   NP_067264
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39588,234,415 - 88,256,912 (+)NCBI
GRCm38588,086,556 - 88,109,053 (+)ENTREZGENE
MGSCv37588,515,581 - 88,538,078 (+)RGD
Celera586,261,754 - 86,284,251 (+)RGD
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_030254268   ⟹   XP_030110128
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39588,234,415 - 88,246,580 (+)NCBI
GRCm38588,086,556 - 88,098,721 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_067264   ⟸   NM_021289
- Peptide Label: isoform 1 precursor
- UniProtKB: O35985 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001239608   ⟸   NM_001252679
- Peptide Label: isoform 2 precursor
- UniProtKB: Q2NKH7 (UniProtKB/Swiss-Prot),   O35979 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001239609   ⟸   NM_001252680
- Peptide Label: isoform 2 precursor
- UniProtKB: Q2NKH7 (UniProtKB/Swiss-Prot),   O35979 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001239610   ⟸   NM_001252681
- Peptide Label: isoform 2 precursor
- UniProtKB: Q2NKH7 (UniProtKB/Swiss-Prot),   O35979 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_030110128   ⟸   XM_030254268
- Peptide Label: isoform X1
- UniProtKB: O09133 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: ENSMUSP00000084271   ⟸   ENSMUST00000087043
RefSeq Acc Id: ENSMUSP00000142444   ⟸   ENSMUST00000199635
RefSeq Acc Id: ENSMUSP00000143443   ⟸   ENSMUST00000196070
RefSeq Acc Id: ENSMUSP00000142688   ⟸   ENSMUST00000196477

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O09133-F1-model_v2 AlphaFold O09133 1-150 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:102762 AgrOrtholog
Ensembl Genes ENSMUSG00000029281 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000087043 ENTREZGENE
  ENSMUST00000087043.8 UniProtKB/Swiss-Prot
  ENSMUST00000196070 ENTREZGENE
  ENSMUST00000196070.2 UniProtKB/Swiss-Prot
  ENSMUST00000196477 ENTREZGENE
  ENSMUST00000196477.5 UniProtKB/Swiss-Prot
  ENSMUST00000199635 ENTREZGENE
  ENSMUST00000199635.5 UniProtKB/Swiss-Prot
InterPro SMR-like UniProtKB/Swiss-Prot
KEGG Report mmu:20600 UniProtKB/Swiss-Prot
MGD MGI:102762 ENTREZGENE
NCBI Gene 20600 ENTREZGENE
PANTHER PTHR14179 UniProtKB/Swiss-Prot
  SUBMAXILLARY GLAND ANDROGEN-REGULATED PROTEIN 3B UniProtKB/Swiss-Prot
Pfam PROL5-SMR UniProtKB/Swiss-Prot
PhenoGen Smr2 PhenoGen
UniProt O09133 ENTREZGENE
  O35961 ENTREZGENE
  O35979 ENTREZGENE
  O35982 ENTREZGENE
  O35985 ENTREZGENE
  Q2NKH7 ENTREZGENE
  SMR2A_MOUSE UniProtKB/Swiss-Prot
  SMR2B_MOUSE UniProtKB/Swiss-Prot
  SMR2C_MOUSE UniProtKB/Swiss-Prot
  SMR2D_MOUSE UniProtKB/Swiss-Prot
  SMR2E_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q2NKH7 UniProtKB/Swiss-Prot